l-708906 and HIV-Infections

l-708906 has been researched along with HIV-Infections* in 1 studies

Other Studies

1 other study(ies) available for l-708906 and HIV-Infections

Article	Year
Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor. Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18 (E)-N-[3-(4-cinnamoylpiperazin-1-yl)propyl]-3,4-dihydroxybenzamide and (E)-N-[3-(4-cinnamoylpiperazin-1-yl)propyl]-3,4,5-trihydroxybenzamide were designed and synthesized as potential HIV-1 integrase inhibitors and evaluated their inhibition to the strand transfer process of HIV-1 integrase. The result indicates that 3,4,5-trihydroxylated aromatic derivatives exhibit good inhibition to HIV-1 integrase, however, corresponding 3,4-dihydroxylated aromatic derivatives appear little inhibition of HIV-1 integrase. Topics: HIV Infections; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Piperazine; Piperazines; Structure-Activity Relationship	2010

Article

Year

Synthesis of polyhydroxylated aromatics having amidation of piperazine nitrogen as HIV-1 integrase inhibitor.

Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18

(E)-N-[3-(4-cinnamoylpiperazin-1-yl)propyl]-3,4-dihydroxybenzamide and (E)-N-[3-(4-cinnamoylpiperazin-1-yl)propyl]-3,4,5-trihydroxybenzamide were designed and synthesized as potential HIV-1 integrase inhibitors and evaluated their inhibition to the strand transfer process of HIV-1 integrase. The result indicates that 3,4,5-trihydroxylated aromatic derivatives exhibit good inhibition to HIV-1 integrase, however, corresponding 3,4-dihydroxylated aromatic derivatives appear little inhibition of HIV-1 integrase.

Topics: HIV Infections; HIV Integrase; HIV Integrase Inhibitors; HIV-1; Humans; Piperazine; Piperazines; Structure-Activity Relationship

2010