l-706000 and Neuralgia

l-706000 has been researched along with Neuralgia* in 1 studies

Other Studies

1 other study(ies) available for l-706000 and Neuralgia

Article	Year
Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists. ACS chemical neuroscience, 2011, Jul-20, Volume: 2, Issue:7 A series of 3-substituted aminocyclopentanes has been identified as highly potent and selective NR2B receptor antagonists. Incorporation of a 1,2,4-oxadiazole linker and substitution of the pendant phenyl ring led to the discovery of orally bioavailable analogues that showed efficient NR2B receptor occupancy in rats. Unlike nonselective NMDA antagonists, the NR2B-selective antagonist 22 showed no adverse affects on motor coordination in the rotarod assay at high dose. Compound 22 was efficacious following oral administration in a spinal nerve ligation model of neuropathic pain and in an acute model of Parkinson's disease in a dose dependent manner. Topics: Administration, Oral; Animals; Benzopyrans; Biological Availability; Catalepsy; Cyclopentanes; Dogs; Drug Discovery; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Excitatory Amino Acid Antagonists; Female; Half-Life; Indicators and Reagents; Isomerism; Ligation; Macaca mulatta; Male; Neuralgia; Oxadiazoles; Parkinson Disease; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Nerves	2011

Article

Year

Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.

ACS chemical neuroscience, 2011, Jul-20, Volume: 2, Issue:7

A series of 3-substituted aminocyclopentanes has been identified as highly potent and selective NR2B receptor antagonists. Incorporation of a 1,2,4-oxadiazole linker and substitution of the pendant phenyl ring led to the discovery of orally bioavailable analogues that showed efficient NR2B receptor occupancy in rats. Unlike nonselective NMDA antagonists, the NR2B-selective antagonist 22 showed no adverse affects on motor coordination in the rotarod assay at high dose. Compound 22 was efficacious following oral administration in a spinal nerve ligation model of neuropathic pain and in an acute model of Parkinson's disease in a dose dependent manner.

Topics: Administration, Oral; Animals; Benzopyrans; Biological Availability; Catalepsy; Cyclopentanes; Dogs; Drug Discovery; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Excitatory Amino Acid Antagonists; Female; Half-Life; Indicators and Reagents; Isomerism; Ligation; Macaca mulatta; Male; Neuralgia; Oxadiazoles; Parkinson Disease; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Nerves

2011