l-683590 and Zika-Virus-Infection

Zika virus (ZIKV) infection could lead to Guillain-Barré syndrome in adults and microcephaly in the newborns from infected pregnant women. To date, there is no specific drug for the treatment of ZIKV infection. In this study, we sought to screen inhibitors against ZIKV infection from a natural product library. A ZIKV replicon was used to screen a library containing 1680 natural compounds. We explored the antiviral mechanism of the compound candidate in vitro and in vivo infection models. Ascomycin, a macrolide from Streptomyces hygroscopicus, was identified with inhibitory effect against ZIKV in Vero cells (IC

Topics: Animals; Antiviral Agents; Biological Products; Chlorocebus aethiops; Drug Discovery; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Mice; Small Molecule Libraries; Tacrolimus; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection