l-683590 and Hypothermia

l-683590 has been researched along with Hypothermia* in 2 studies

Other Studies

2 other study(ies) available for l-683590 and Hypothermia

Article	Year
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity. Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14 The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is described. Topics: Administration, Oral; Animals; Calcineurin Inhibitors; Drug Evaluation, Preclinical; Hypothermia; Immunophilins; Immunosuppressive Agents; Inhibitory Concentration 50; Injections, Intravenous; Kidney Diseases; Macrolides; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; T-Lymphocytes; Tacrolimus; Tacrolimus Binding Proteins; Toxicity Tests	1999
C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential. Bioorganic & medicinal chemistry letters, 1998, Aug-18, Volume: 8, Issue:16 A series of C32-O-aralkyl ether derivatives of the FK-506 related macrolide ascomycin have been prepared based on an earlier reported C32-O-cinnamyl ether design. In the present study, the nature of the aryl tethering group was varied in an attempt to improve oral activity. An imidazol-2-yl-methyl tether was found to be superior among those investigated and has resulted in an ascomycin analog, L-733,725, with in vivo immunosuppressive activity comparable to FK-506 but with an improved therapeutic index. Topics: Animals; Biological Availability; Hypothermia; Imidazoles; Immunophilins; Immunosuppressive Agents; Indicators and Reagents; Kidney; Mice; Mice, Inbred BALB C; Molecular Conformation; Molecular Structure; Neurotoxins; Rats; Structure-Activity Relationship; T-Lymphocytes; Tacrolimus; Tacrolimus Binding Proteins	1998

Article

Year

Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.

Bioorganic & medicinal chemistry letters, 1999, Jul-19, Volume: 9, Issue:14

The synthesis of C32-O-arylethyl ether derivatives of ascomycin that possess equivalent immunosuppressant activity but reduced toxicity, compared to FK-506, is described.

Topics: Administration, Oral; Animals; Calcineurin Inhibitors; Drug Evaluation, Preclinical; Hypothermia; Immunophilins; Immunosuppressive Agents; Inhibitory Concentration 50; Injections, Intravenous; Kidney Diseases; Macrolides; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; T-Lymphocytes; Tacrolimus; Tacrolimus Binding Proteins; Toxicity Tests

1999

C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.

Bioorganic & medicinal chemistry letters, 1998, Aug-18, Volume: 8, Issue:16

A series of C32-O-aralkyl ether derivatives of the FK-506 related macrolide ascomycin have been prepared based on an earlier reported C32-O-cinnamyl ether design. In the present study, the nature of the aryl tethering group was varied in an attempt to improve oral activity. An imidazol-2-yl-methyl tether was found to be superior among those investigated and has resulted in an ascomycin analog, L-733,725, with in vivo immunosuppressive activity comparable to FK-506 but with an improved therapeutic index.

Topics: Animals; Biological Availability; Hypothermia; Imidazoles; Immunophilins; Immunosuppressive Agents; Indicators and Reagents; Kidney; Mice; Mice, Inbred BALB C; Molecular Conformation; Molecular Structure; Neurotoxins; Rats; Structure-Activity Relationship; T-Lymphocytes; Tacrolimus; Tacrolimus Binding Proteins

1998