l-663536 and Seizures

Several very selective leukotriene inhibitors, and a PAF inhibitor, suitable for in vivo use, have been tested for their effects on hyperbaric oxygen toxicity. The leukotriene D4 inhibitor, L660771, and the 5-lipoxygenase pathway inhibitor L663536, failed to affect convulsions or lung damage induced by hyperbaric oxygen (pressure range 515-615 kPa) in either rats or mice. The specific PAF antagonist L659989 showed marginal protection against hyperoxic convulsions and did not alter pulmonary damage. The specific LTB4 antagonist SC-41930 was very effective in inhibiting hyperbaric oxygen-induced convulsions in both rats and mice. SC-41930 also very significantly protected rats against pulmonary oxygen toxicity, but had only marginally significant effects on pulmonary protection in mice.

Topics: Animals; Benzopyrans; Female; Furans; Indoles; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Lung; Male; Mice; Mice, Inbred BALB C; Oxygen; Platelet Activating Factor; Pressure; Propionates; Quinolines; Rats; Seizures; Specific Pathogen-Free Organisms; SRS-A