l-663536 and Hypoxia-Ischemia--Brain

Resveratrol (trans-3,4',5-trihydroxystilbene, Res) is a natural polyphenol. A recent experiment confirmed that Res can selectively activate both peroxisome proliferators-activated receptors (PPAR) alpha and gamma. In addition, Res can protect neurons by matrix metalloproteinase-9 (MMP-9) down-regulation. The relationship between Res, MMP-9 and PPAR alpha or gamma was studied in an oxygen glucose deprivation-exposed neuron model. It showed that Res can inhibit mRNA and protein expression of MMP-9, while it up-regulates the expression of PPAR alpha and gamma. The effect of Res on both PPAR alpha and MMP-9 can be offset partially by MK886. However, PPAR gamma antagonist GW9662 had little effect on MMP-9 expression. These results suggest that Res can inhibit MMP-9 expression by up-regulating PPAR alpha.

Topics: Animals; Antioxidants; Cells, Cultured; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; Indoles; Lipoxygenase Inhibitors; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Neurons; PPAR alpha; Resveratrol; RNA, Messenger; Stilbenes; Up-Regulation