l-365260 and Feeding-and-Eating-Disorders

l-365260 has been researched along with Feeding-and-Eating-Disorders* in 1 studies

Other Studies

1 other study(ies) available for l-365260 and Feeding-and-Eating-Disorders

ArticleYear
SCH 23390-induced hypophagia is blocked by the selective CCK-A receptor antagonist devazepide, but not by the CCK-B/gastrin receptor antagonist L-365,260.
    Brain research bulletin, 1990, Volume: 24, Issue:4

    The selective dopamine D-1 receptor antagonist SCH 23390 (30 micrograms/kg, SC) significantly reduced palatable food consumption by nondeprived rats in a 30-min test period. Prior administration of the selective CCK-A receptor antagonist devazepide (MK 329; L-364,718) blocked the hypophagic effect of SCH 23390. In contrast, prior administration of the selective CCK-B/gastrin receptor antagonist L-365,260 had no effect. Devazepide did not antagonize a matched hypophagic effect produced by the dopamine D-2 receptor antagonist raclopride (0.1 mg/kg, SC). These data direct attention to possible dopamine-cholecystokinin interactions in relation to the control of ingestional responses, and, more specifically, indicate possible functional relationships between D-1 and CCK-A receptor mechanisms.

    Topics: Animals; Benzazepines; Benzodiazepinones; Cholecystokinin; Devazepide; Dopamine; Dopamine Antagonists; Feeding and Eating Disorders; Male; Phenylurea Compounds; Rats; Receptors, Cholecystokinin; Receptors, Dopamine; Receptors, Dopamine D1

1990