l-365260 has been researched along with Bradycardia* in 1 studies
1 other study(ies) available for l-365260 and Bradycardia
| Article | Year |
|---|---|
Cholecystokinin-8 (CCK-8) has no effect on heart rate in rats lacking CCK-A receptors.
Heart rate responses to i.v. administration of cholecystokinin-8 (CCK-8) were investigated in Otsuka Long-Evans Tokushima Fatty (OLETF) rats lacking CCK-A receptors and control Long-Evans Tokushima Otsuka (LETO) rats. The heart rate decreased after i.v. administration of 3 nmol.kg(-)(1) of CCK-8 in LETO rats, but not in OLETF rats. Bradycardia in the LETO rats disappeared after treatment with MK-329, but not after treatment with L-365,260. The expression of CCK-A receptor precursor mRNA was found exclusively in the atrium in LETO rats. These results suggest that CCK-8 decreases heart rate via CCK-A receptors located in the atrium of the rats. Topics: Animals; Benzodiazepinones; Blotting, Southern; Bradycardia; Devazepide; DNA, Complementary; Dose-Response Relationship, Drug; Heart Atria; Heart Rate; Hormone Antagonists; Male; Phenylurea Compounds; Polymerase Chain Reaction; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; RNA, Messenger; Sincalide; Time Factors | 2001 |