l-365260 has been researched along with Agoraphobia* in 2 studies
2 trial(s) available for l-365260 and Agoraphobia
| Article | Year |
|---|---|
Effect of the cholecystokinin-B receptor antagonist L-365,260 on lactate-induced panic attacks in panic disorder patients.
Topics: Adult; Agoraphobia; Arousal; Benzodiazepinones; Double-Blind Method; Female; Humans; Lactic Acid; Male; Middle Aged; Pain Measurement; Panic Disorder; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1996 |
A placebo-controlled trial of L-365,260, a CCKB antagonist, in panic disorder.
The functional role of cholecystokinin in the central nervous system is unknown. The tetra peptide CCK-4 was previously observed to induce panic attacks in a majority of normal volunteers and patients with panic disorder. Furthermore, it had been demonstrated that pretreatment with 10-50 mg of L-365,260, a selective CCKB antagonist, blocked CCK-4 induced panic in patients with panic disorder. Therefore, the present multicenter, placebo-controlled, double-blind trial was designed to investigate the efficacy of L-365,260, a CCKB antagonist, in patients with panic disorder with or without agoraphobia. Following a 1-week, single-blind placebo period, 88 patients were randomized to double-blind treatment in which they received either L-365,260, 30 mg qid, or placebo for 6 weeks. At the dose tested, there were no clinically significant differences between L-365,260 and placebo in global improvement ratings, Hamilton anxiety rating scale scores, panic attack frequency, panic attack intensity, or disability measures. The possible reasons for lack of effect with L-365,260 are discussed. Topics: Adult; Agoraphobia; Arousal; Benzodiazepinones; Double-Blind Method; Female; Humans; Male; Middle Aged; Panic Disorder; Personality Inventory; Phenylurea Compounds; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Tetragastrin; Treatment Outcome | 1995 |