l-162313 and Stroke
l-162313 has been researched along with Stroke* in 1 studies
Reviews
1 review(s) available for l-162313 and Stroke
| Article | Year |
|---|---|
Non-peptide AT2-receptor agonists.
The renin-angiotensin-system harbours two main receptor subtypes binding angiotensin II which are the AT1-receptor and the AT2-receptor. While the AT1-receptor has been a drug target in cardiovascular disease for many years, the AT2-receptor was only a subject of academic interest. This has changed with the design and synthesis of a first non-peptide, orally active AT2-receptor agonist, compound 21 (C21). First data using C21 revealed tissue protective effects and functional improvement after myocardial infarction and in hypertension-induced end organ damage, notably in a blood-pressure independent way. In all of these models, AT2-receptor mediated anti-inflammation seemed an important underlying mechanism. C21 is awaited to enter a phase I clinical study in 2011. Topics: Animals; Anti-Inflammatory Agents; Biphenyl Compounds; Blood Pressure; Drug Design; Heart; Humans; Imidazoles; Kidney; Receptor, Angiotensin, Type 2; Stroke | 2011 |