kynurenine has been researched along with Uremia in 10 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Uremia: A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with end-stage renal disease (ESRD) exhibit features of a hypercoagulable state, which may contribute to atherosclerosis." | 5.35 | Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients. ( Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Patients with end-stage renal disease (ESRD) exhibit features of a hypercoagulable state, which may contribute to atherosclerosis." | 1.35 | Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients. ( Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 2 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, JA | 1 |
| Richards, S | 1 |
| Whelan, SA | 1 |
| Yoo, SB | 1 |
| Russell, TL | 1 |
| Arinze, N | 1 |
| Lotfollahzadeh, S | 1 |
| Napoleon, MA | 1 |
| Belghasem, M | 1 |
| Lee, N | 1 |
| Dember, LM | 2 |
| Ravid, K | 2 |
| Chitalia, VC | 2 |
| Pawlak, K | 4 |
| Sieklucka, B | 1 |
| Pawlak, D | 5 |
| Kolachalama, VB | 1 |
| Shashar, M | 1 |
| Alousi, F | 1 |
| Shivanna, S | 1 |
| Rijal, K | 1 |
| Belghasem, ME | 1 |
| Walker, J | 1 |
| Matsuura, S | 1 |
| Chang, GH | 1 |
| Gibson, CM | 1 |
| Francis, JM | 1 |
| Brzosko, S | 1 |
| Mysliwiec, M | 3 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Koenig, P | 1 |
| Nagl, C | 1 |
| Neurauter, G | 1 |
| Schennach, H | 1 |
| Brandacher, G | 1 |
| Fuchs, D | 1 |
| Wikoff, WR | 1 |
| Nagle, MA | 1 |
| Kouznetsova, VL | 1 |
| Tsigelny, IF | 1 |
| Nigam, SK | 1 |
| Topczewska-Bruns, J | 1 |
| Chabielska, E | 1 |
| Tankiewicz, A | 1 |
| Buczko, W | 2 |
| Malyszko, J | 1 |
10 other studies available for kynurenine and Uremia
| Article | Year |
|---|---|
Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.
Topics: Animals; Aorta; Carotid Artery Injuries; Carotid Artery Thrombosis; Culture Media; Enzyme Induction; | 2021 |
Paracrine Kynurenic Pathway Activation in the Bone of Young Uremic Rats Can Antagonize Anabolic Effects of PTH on Bone Turnover and Strength through the Disruption of PTH-Dependent Molecular Signaling.
Topics: Activating Transcription Factor 4; Animals; Cancellous Bone; Cortical Bone; Cyclic AMP; Femur; Kynur | 2021 |
Uremic Solute-Aryl Hydrocarbon Receptor-Tissue Factor Axis Associates with Thrombosis after Vascular Injury in Humans.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Indican; Kynurenine; Male; Metabolomics; Midd | 2018 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients.
Topics: Adult; Aged; Blood Coagulation; Female; Humans; Kidney Failure, Chronic; Kynurenine; Lipoproteins; M | 2009 |
Enhanced degradation of tryptophan in patients on hemodialysis.
Topics: Adult; Aged; Aged, 80 and over; Austria; Biomarkers; Case-Control Studies; Chromatography, High Pres | 2010 |
Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).
Topics: Animals; Cell Membrane Permeability; Fluorescent Dyes; Indican; Kynurenine; Metabolome; Mice; Mice, | 2011 |
Increased levels of 3-hydroxykynurenine in different brain regions of rats with chronic renal insufficiency.
Topics: Animals; Brain; Kidney Failure, Chronic; Kynurenine; Male; Rats; Rats, Wistar; Signal Transduction; | 2002 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinoli | 2001 |