Page last updated: 2024-10-18

kynurenine and Toxoplasmosis

kynurenine has been researched along with Toxoplasmosis in 8 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Toxoplasmosis: The acquired form of infection by Toxoplasma gondii in animals and man.

Research Excerpts

ExcerptRelevanceReference
" Notably, the anti-parasitic drugs pyrimethamine and sulfadiazine, a standard treatment of toxoplasmosis, significantly reduced 3-HK and KYNA levels in the brain of infected mice when applied between 28 and 56 days post-infection."3.80Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia. ( Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH, 2014)
"In the present study, the effects of Toxoplasma gondii infection on IDO were investigated by using wild-type and IFN-gamma-gene-deficient (knockout) (IFN-gamma KO) mice."1.31L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase. ( Fujigaki, S; Maekawa, N; Saito, K; Seishima, M; Takemura, M; Wada, H; Yamada, Y, 2002)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's6 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Peng, X1
Brenner, LA2
Mathai, AJ1
Cook, TB1
Fuchs, D2
Postolache, N1
Groer, MW2
Pandey, JP1
Mohyuddin, F1
Giegling, I2
Wadhawan, A1
Hartmann, AM2
Konte, B2
Brundin, L2
Friedl, M2
Stiller, JW1
Lowry, CA2
Rujescu, D2
Postolache, TT2
Majumdar, T1
Sharma, S1
Kumar, M1
Hussain, MA1
Chauhan, N1
Kalia, I1
Sahu, AK1
Rana, VS1
Bharti, R1
Haldar, AK1
Singh, AP1
Mazumder, S1
Vondroušová, J1
Mikoška, M1
Syslová, K1
Böhmová, A1
Tejkalová, H1
Vacek, L1
Kodym, P1
Krsek, D1
Horáček, J1
Notarangelo, FM1
Wilson, EH1
Horning, KJ1
Thomas, MA1
Harris, TH1
Fang, Q1
Hunter, CA1
Schwarcz, R1
Okusaga, O1
Duncan, E1
Langenberg, P1
Stearns-Yoder, KA1
Donley, DW1
Olson, AR1
Raisbeck, MF1
Fox, JH1
Gigley, JP1
Fujigaki, S1
Saito, K1
Takemura, M1
Maekawa, N1
Yamada, Y1
Wada, H1
Seishima, M1
Silva, NM1
Rodrigues, CV1
Santoro, MM1
Reis, LF1
Alvarez-Leite, JI1
Gazzinelli, RT1

Other Studies

8 other studies available for kynurenine and Toxoplasmosis

ArticleYear
Moderation of the relationship between Toxoplasma gondii seropositivity and trait impulsivity in younger men by the phenylalanine-tyrosine ratio.
    Psychiatry research, 2018, Volume: 270

    Topics: Adult; Age Factors; Aged; Antibodies, Protozoan; Chromatography, High Pressure Liquid; Dopamine; Enz

2018
Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection.
    Cell death & disease, 2019, 02-15, Volume: 10, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis; beta Catenin; Caco-2 Cells; Crotonates; Ge

2019
Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis.
    Journal of pharmaceutical and biomedical analysis, 2019, Jun-05, Volume: 170

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenine; Male; Ne

2019
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
    Schizophrenia research, 2014, Volume: 152, Issue:1

    Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic

2014
Combined Toxoplasma gondii seropositivity and high blood kynurenine--Linked with nonfatal suicidal self-directed violence in patients with schizophrenia.
    Journal of psychiatric research, 2016, Volume: 72

    Topics: Adult; Female; Humans; Kynurenine; Male; Odds Ratio; Schizophrenia; Self-Injurious Behavior; Suicide

2016
Huntingtons Disease Mice Infected with Toxoplasma gondii Demonstrate Early Kynurenine Pathway Activation, Altered CD8+ T-Cell Responses, and Premature Mortality.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Animals; Biomarkers; Brain; CD8-Positive T-Lymphocytes; Disease Models, Animal; Enzyme Activation; F

2016
L-tryptophan-L-kynurenine pathway metabolism accelerated by Toxoplasma gondii infection is abolished in gamma interferon-gene-deficient mice: cross-regulation between inducible nitric oxide synthase and indoleamine-2,3-dioxygenase.
    Infection and immunity, 2002, Volume: 70, Issue:2

    Topics: Animals; Antigens, Protozoan; Antigens, Surface; Brain; Disease Models, Animal; Enzyme Inhibitors; G

2002
Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1.
    Infection and immunity, 2002, Volume: 70, Issue:2

    Topics: Acute Disease; Animals; Disease Susceptibility; DNA-Binding Proteins; Gene Expression; Interferon Re

2002