kynurenine has been researched along with Streptococcal Infections in 1 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Streptococcal Infections: Infections with bacteria of the genus STREPTOCOCCUS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murr, C | 1 |
| Gerlach, D | 1 |
| Widner, B | 1 |
| Dierich, MP | 1 |
| Fuchs, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Antibiotic Treatment Trial for the PANDAS/PANS Phenotype[NCT01617083] | Phase 2 | 47 participants (Actual) | Interventional | 2012-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The CYBOCS is a clinician rated, semi-structured interview for rating the severity of OCD (Scahill, et al., 1997). Total scores range from 0 to 50, with higher scores representing greater severity. The total score is comprised of two subscores, obsessions and compulsions, each with a range of 0-25. (NCT01617083)
Timeframe: Before and after 4 week randomization
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | After 4 week randomization | |
| Azithromycin | 29.49 | 20.53 |
| Placebo | 28.43 | 23.45 |
The CGI-S scale is a 7-point clinician rating of severity of psychopathology. Severity ratings range from 1 (no illness) to 7 (extremely severe). This instrument has been successfully used in treatment studies (Cook, et al., 2001; Storch, et al., 2007). (NCT01617083)
Timeframe: Before and after 4 week randomization
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | After 4 week randomization | |
| Azithromycin | 5.24 | 4.06 |
| Placebo | 5.00 | 4.93 |
The Screen for Childhood Anxiety-Related Emotional Disorders (SCARED) is a 41-item parent and participant-completed tool used to measure symptoms of anxiety, including the most common symptoms of panic/somatic, generalized anxiety, separation anxiety, social phobia, and school phobia. Scores range from 0-82, with higher scores indicating more severe symptoms.The child and parent versions of the SCARED have moderate parent-child agreement and good internal consistency, test-retest reliability, and discriminant validity; it is also sensitive to treatment response (Birmaher et al. 1999). The target population for this rating is 8-18 years of age (Birmaher et al. 1997). The parent and child version of the SCARED were administered before and after week 4 randomization. This measure is not validated for use in 4-7 year olds. (NCT01617083)
Timeframe: Before and after 4 week randomization
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Baseline | After 4 week randomization | |
| Azithromycin | 31.82 | 30.88 |
| Placebo | 20.43 | 21.97 |
1 other study available for kynurenine and Streptococcal Infections
| Article | Year |
|---|---|
Neopterin production and tryptophan degradation in humans infected by Streptococcus pyogenes.
Topics: Humans; Kynurenine; Neopterin; Streptococcal Infections; Streptococcus pyogenes; Tonsillitis; Trypto | 2001 |