kynurenine has been researched along with Sclerosis, Systemic in 23 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the metabolism of L-tryptophan (LT) via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome (EMS)." | 7.68 | Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. ( Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM, 1992) |
| "The eosinophilia-myalgia syndrome (EMS) was associated with ingestion of L-tryptophan containing products and was accompanied by altered metabolism of L-tryptophan during the active phase." | 7.68 | Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome. ( Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE, 1992) |
| "An association between the ingestion tryptophan and a syndrome characterized by scleroderma-like skin abnormalities, fasciitis, and eosinophilia has recently been recognized in the United States." | 7.68 | Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. ( Heyes, MP; Maize, JC; Quearry, B; Silver, RM; Sternberg, EM; Vionnet-Fuasset, M, 1990) |
| "To investigate the metabolism of L-tryptophan (LT) via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome (EMS)." | 3.68 | Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. ( Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM, 1992) |
| "The eosinophilia-myalgia syndrome (EMS) was associated with ingestion of L-tryptophan containing products and was accompanied by altered metabolism of L-tryptophan during the active phase." | 3.68 | Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome. ( Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE, 1992) |
| "An association between the ingestion tryptophan and a syndrome characterized by scleroderma-like skin abnormalities, fasciitis, and eosinophilia has recently been recognized in the United States." | 3.68 | Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. ( Heyes, MP; Maize, JC; Quearry, B; Silver, RM; Sternberg, EM; Vionnet-Fuasset, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (73.91) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campochiaro, C | 1 |
| Lytton, S | 1 |
| Nihtyanova, S | 1 |
| Fuchs, D | 1 |
| Ong, VH | 1 |
| Denton, CP | 1 |
| Filippini, P | 1 |
| Del Papa, N | 1 |
| Sambataro, D | 1 |
| Del Bufalo, A | 1 |
| Locatelli, F | 1 |
| Rutella, S | 1 |
| LEVIT, F | 1 |
| PINALS, RS | 1 |
| BEETHAM, W | 1 |
| FISCHER, S | 1 |
| SCHROHENLOHER, R | 1 |
| Price, JM | 2 |
| Yess, N | 1 |
| Brown, RR | 4 |
| Johnson, AM | 1 |
| Fine, RM | 1 |
| Sternberg, EM | 3 |
| Van Woert, MH | 1 |
| Young, SN | 1 |
| Magnussen, I | 1 |
| Baker, H | 1 |
| Gauthier, S | 1 |
| Osterland, CK | 1 |
| Kreysel, HW | 1 |
| Meyerhoff, K | 1 |
| Kimmig, J | 1 |
| De Antoni, A | 1 |
| Muggeo, M | 1 |
| Costa, C | 1 |
| Allegri, G | 1 |
| Crepaldi, G | 1 |
| Hankes, LV | 4 |
| De Bruin, E | 1 |
| Jansen, CR | 2 |
| Vorster, L | 1 |
| Schmaeler, M | 3 |
| Leklem, JE | 1 |
| Silver, RM | 3 |
| McKinley, K | 1 |
| Smith, EA | 1 |
| Quearry, B | 2 |
| Harati, Y | 1 |
| Heyes, MP | 3 |
| Sutherland, SE | 1 |
| Carreira, P | 1 |
| Maize, JC | 1 |
| Vionnet-Fuasset, M | 1 |
| Connolly, SM | 1 |
| Quimby, SR | 1 |
| Griffing, WL | 1 |
| Winkelmann, RK | 1 |
| Rose, DP | 1 |
| Wolf, H | 1 |
| Houpt, JB | 1 |
| Ogryzlo, MA | 1 |
| Hunt, M | 1 |
| Calandra, P | 2 |
| Binazzi, M | 1 |
| Leklem, J | 1 |
| Jesseph, J | 1 |
| Sönnichsen, N | 1 |
| Feuerstein, M | 1 |
| Kölzsch, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| L-5-Hydroxy-Tryptophan-Related Eosinophilia-Myalgia Syndrome (EMS): Clinical Patient Evaluation[NCT00001918] | 20 participants | Observational | 1999-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenine and Sclerosis, Systemic
| Article | Year |
|---|---|
Emerging concepts on inhibitors of indoleamine 2,3-dioxygenase in rheumatic diseases.
Topics: Animals; Arthritis, Rheumatoid; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kyn | 2012 |
1 trial available for kynurenine and Sclerosis, Systemic
| Article | Year |
|---|---|
Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Carbidopa; Clinical Trials as Topic; Drug Therapy, Com | 1980 |
21 other studies available for kynurenine and Sclerosis, Systemic
| Article | Year |
|---|---|
Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.
Topics: Autoantibodies; Female; Humans; Hypertension, Pulmonary; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynur | 2019 |
ABSENCE OF KYNURENINE IN HAIR OF PATIENTS WITH SCLERODERMA.
Topics: Chromatography; Hair; Humans; Kynurenine; Metabolism; Metabolism, Inborn Errors; Scleroderma, System | 1964 |
TRYPTOPHAN METABOLISM IN RHEUMATIC DISEASE.
Topics: Amino Acids; Arthritis; Arthritis, Rheumatoid; Chromatography; Humans; Kynurenic Acid; Kynurenine; L | 1964 |
TRYPTOPHAN METABOLITE EXCRETION IN CONNECTIVE TISSUE DISEASES DEMONSTRATING A DIFFERENCE BETWEEN RHEUMATOID SPONDYLITIS AND RHEUMATOID ARTHRITIS.
Topics: Arthritis; Arthritis, Rheumatoid; Connective Tissue Diseases; Diagnosis, Differential; Humans; Kynur | 1964 |
Tryptophan metabolism. A hitherto unreported abnormality occurring in a family.
Topics: Chlorotrianisene; Electroencephalography; Female; Humans; Injections, Intramuscular; Kynurenine; Mal | 1967 |
Drug-related scleroderma-like illness. The Fine page.
Topics: 5-Hydroxytryptophan; Carbidopa; Drug Combinations; Humans; Kynurenine; Scleroderma, Systemic | 1981 |
[Tryptophan-load in progressive scleroderma (author's transl)].
Topics: 3-Hydroxyanthranilic Acid; Female; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; | 1976 |
Tryptophan metabolism "via" nicotimic acid in patients with scleroderma.
Topics: Adult; Aged; Female; Humans; Kynurenine; Middle Aged; Niacinamide; Nicotinic Acids; Pyridoxine; Scle | 1976 |
Metabolism of 14C-labelled L-tryptophan, L-kynurenine and hydroxy-L-kynurenine in miners with scleroderma.
Topics: Carbon Dioxide; Humans; Kynurenine; Male; Middle Aged; Mining; Nicotinic Acids; Occupational Disease | 1977 |
A mechanism for the formation in vivo of the 8-methyl ether of xanthurenic acid in humans.
Topics: Adult; Female; Humans; Kynurenic Acid; Kynurenine; Male; Methionine; Methyl Ethers; Middle Aged; Pel | 1975 |
The uptake of 14C-labeled hydroxyanthranilic acid and enantiomers of tryptophan, kynurenine, and hydroxykynurenine in human blood.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Isomerism; Kynurenine; Middle Aged; ortho-Aminoben | 1975 |
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome.
Topics: Adrenal Cortex Hormones; Adult; Aged; Eosinophilia-Myalgia Syndrome; Female; Humans; Interferon-gamm | 1992 |
Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome.
Topics: Arthritis, Rheumatoid; Biopterins; Brassica; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsatur | 1992 |
Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan.
Topics: Adult; Aged; Eosinophilia; Fascia; Fasciitis; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; | 1990 |
Scleroderma and L-tryptophan: a possible explanation of the eosinophilia-myalgia syndrome.
Topics: Adult; Aged; Eosinophilia; Fasciitis; Female; Humans; Kynurenine; Middle Aged; Myositis; Prednisone; | 1990 |
Tryptophan metabolism as affected by anovulatory agents.
Topics: Aminohippuric Acids; Chlorotrianisene; Diethylstilbestrol; Estrogens; Female; Humans; Isoniazid; Kyn | 1969 |
Tryptophan metabolism in man (with special reference to rheumatoid arthritis and scleroderma).
Topics: Arthritis, Rheumatoid; Aspirin; Cystinuria; Drug Synergism; Edetic Acid; Humans; Kynurenic Acid; Kyn | 1973 |
Tryptophan metabolism in man, rat and pig. Determination of tryptophan-pyrrolase and kinureninase in liver.
Topics: Adult; Animals; Dicarboxylic Acids; Erythema; Female; Humans; Hydrolases; Kynurenine; Lichen Planus; | 1972 |
Tryptophan to niacin pathway in scleroderma and in dermatomyositis.
Topics: Adolescent; Adult; Aged; Dermatomyositis; Female; Humans; Hydrolases; Indoleacetic Acids; Indoles; K | 1973 |
Metabolism of C 14 labeled enantiomers of tryptophan, kynurenine and hydroxykynurenine in humans with scleroderma.
Topics: Adult; Carbon Dioxide; Carbon Isotopes; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Phe | 1972 |
[Studies on the excretion of tryptophan metabolites in patients with circumscript and progressive scleroderma].
Topics: Adult; Aged; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Sc | 1968 |