kynurenine has been researched along with Scleroderma, Systemic in 23 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the metabolism of L-tryptophan (LT) via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome (EMS)." | 7.68 | Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. ( Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM, 1992) |
| "The eosinophilia-myalgia syndrome (EMS) was associated with ingestion of L-tryptophan containing products and was accompanied by altered metabolism of L-tryptophan during the active phase." | 7.68 | Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome. ( Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE, 1992) |
| "An association between the ingestion tryptophan and a syndrome characterized by scleroderma-like skin abnormalities, fasciitis, and eosinophilia has recently been recognized in the United States." | 7.68 | Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. ( Heyes, MP; Maize, JC; Quearry, B; Silver, RM; Sternberg, EM; Vionnet-Fuasset, M, 1990) |
| "To investigate the metabolism of L-tryptophan (LT) via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome (EMS)." | 3.68 | Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. ( Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM, 1992) |
| "The eosinophilia-myalgia syndrome (EMS) was associated with ingestion of L-tryptophan containing products and was accompanied by altered metabolism of L-tryptophan during the active phase." | 3.68 | Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome. ( Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE, 1992) |
| "An association between the ingestion tryptophan and a syndrome characterized by scleroderma-like skin abnormalities, fasciitis, and eosinophilia has recently been recognized in the United States." | 3.68 | Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan. ( Heyes, MP; Maize, JC; Quearry, B; Silver, RM; Sternberg, EM; Vionnet-Fuasset, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (73.91) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campochiaro, C | 1 |
| Lytton, S | 1 |
| Nihtyanova, S | 1 |
| Fuchs, D | 1 |
| Ong, VH | 1 |
| Denton, CP | 1 |
| Filippini, P | 1 |
| Del Papa, N | 1 |
| Sambataro, D | 1 |
| Del Bufalo, A | 1 |
| Locatelli, F | 1 |
| Rutella, S | 1 |
| LEVIT, F | 1 |
| PINALS, RS | 1 |
| BEETHAM, W | 1 |
| FISCHER, S | 1 |
| SCHROHENLOHER, R | 1 |
| Price, JM | 2 |
| Yess, N | 1 |
| Brown, RR | 4 |
| Johnson, AM | 1 |
| Fine, RM | 1 |
| Sternberg, EM | 3 |
| Van Woert, MH | 1 |
| Young, SN | 1 |
| Magnussen, I | 1 |
| Baker, H | 1 |
| Gauthier, S | 1 |
| Osterland, CK | 1 |
| Kreysel, HW | 1 |
| Meyerhoff, K | 1 |
| Kimmig, J | 1 |
| De Antoni, A | 1 |
| Muggeo, M | 1 |
| Costa, C | 1 |
| Allegri, G | 1 |
| Crepaldi, G | 1 |
| Hankes, LV | 4 |
| De Bruin, E | 1 |
| Jansen, CR | 2 |
| Vorster, L | 1 |
| Schmaeler, M | 3 |
| Leklem, JE | 1 |
| Silver, RM | 3 |
| McKinley, K | 1 |
| Smith, EA | 1 |
| Quearry, B | 2 |
| Harati, Y | 1 |
| Heyes, MP | 3 |
| Sutherland, SE | 1 |
| Carreira, P | 1 |
| Maize, JC | 1 |
| Vionnet-Fuasset, M | 1 |
| Connolly, SM | 1 |
| Quimby, SR | 1 |
| Griffing, WL | 1 |
| Winkelmann, RK | 1 |
| Rose, DP | 1 |
| Wolf, H | 1 |
| Houpt, JB | 1 |
| Ogryzlo, MA | 1 |
| Hunt, M | 1 |
| Calandra, P | 2 |
| Binazzi, M | 1 |
| Leklem, J | 1 |
| Jesseph, J | 1 |
| Sönnichsen, N | 1 |
| Feuerstein, M | 1 |
| Kölzsch, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| L-5-Hydroxy-Tryptophan-Related Eosinophilia-Myalgia Syndrome (EMS): Clinical Patient Evaluation[NCT00001918] | 20 participants | Observational | 1999-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenine and Scleroderma, Systemic
| Article | Year |
|---|---|
Emerging concepts on inhibitors of indoleamine 2,3-dioxygenase in rheumatic diseases.
Topics: Animals; Arthritis, Rheumatoid; Enzyme Inhibitors; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kyn | 2012 |
1 trial available for kynurenine and Scleroderma, Systemic
| Article | Year |
|---|---|
Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa.
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Aged; Carbidopa; Clinical Trials as Topic; Drug Therapy, Com | 1980 |
21 other studies available for kynurenine and Scleroderma, Systemic
| Article | Year |
|---|---|
Elevated kynurenine levels in diffuse cutaneous and anti-RNA polymerase III positive systemic sclerosis.
Topics: Autoantibodies; Female; Humans; Hypertension, Pulmonary; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynur | 2019 |
ABSENCE OF KYNURENINE IN HAIR OF PATIENTS WITH SCLERODERMA.
Topics: Chromatography; Hair; Humans; Kynurenine; Metabolism; Metabolism, Inborn Errors; Scleroderma, System | 1964 |
TRYPTOPHAN METABOLISM IN RHEUMATIC DISEASE.
Topics: Amino Acids; Arthritis; Arthritis, Rheumatoid; Chromatography; Humans; Kynurenic Acid; Kynurenine; L | 1964 |
TRYPTOPHAN METABOLITE EXCRETION IN CONNECTIVE TISSUE DISEASES DEMONSTRATING A DIFFERENCE BETWEEN RHEUMATOID SPONDYLITIS AND RHEUMATOID ARTHRITIS.
Topics: Arthritis; Arthritis, Rheumatoid; Connective Tissue Diseases; Diagnosis, Differential; Humans; Kynur | 1964 |
Tryptophan metabolism. A hitherto unreported abnormality occurring in a family.
Topics: Chlorotrianisene; Electroencephalography; Female; Humans; Injections, Intramuscular; Kynurenine; Mal | 1967 |
Drug-related scleroderma-like illness. The Fine page.
Topics: 5-Hydroxytryptophan; Carbidopa; Drug Combinations; Humans; Kynurenine; Scleroderma, Systemic | 1981 |
[Tryptophan-load in progressive scleroderma (author's transl)].
Topics: 3-Hydroxyanthranilic Acid; Female; Humans; Hydroxyindoleacetic Acid; Indoleacetic Acids; Kynurenine; | 1976 |
Tryptophan metabolism "via" nicotimic acid in patients with scleroderma.
Topics: Adult; Aged; Female; Humans; Kynurenine; Middle Aged; Niacinamide; Nicotinic Acids; Pyridoxine; Scle | 1976 |
Metabolism of 14C-labelled L-tryptophan, L-kynurenine and hydroxy-L-kynurenine in miners with scleroderma.
Topics: Carbon Dioxide; Humans; Kynurenine; Male; Middle Aged; Mining; Nicotinic Acids; Occupational Disease | 1977 |
A mechanism for the formation in vivo of the 8-methyl ether of xanthurenic acid in humans.
Topics: Adult; Female; Humans; Kynurenic Acid; Kynurenine; Male; Methionine; Methyl Ethers; Middle Aged; Pel | 1975 |
The uptake of 14C-labeled hydroxyanthranilic acid and enantiomers of tryptophan, kynurenine, and hydroxykynurenine in human blood.
Topics: 3-Hydroxyanthranilic Acid; Adult; Female; Humans; Isomerism; Kynurenine; Middle Aged; ortho-Aminoben | 1975 |
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome.
Topics: Adrenal Cortex Hormones; Adult; Aged; Eosinophilia-Myalgia Syndrome; Female; Humans; Interferon-gamm | 1992 |
Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome.
Topics: Arthritis, Rheumatoid; Biopterins; Brassica; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsatur | 1992 |
Scleroderma, fasciitis, and eosinophilia associated with the ingestion of tryptophan.
Topics: Adult; Aged; Eosinophilia; Fascia; Fasciitis; Female; Humans; Hydroxyindoleacetic Acid; Kynurenine; | 1990 |
Scleroderma and L-tryptophan: a possible explanation of the eosinophilia-myalgia syndrome.
Topics: Adult; Aged; Eosinophilia; Fasciitis; Female; Humans; Kynurenine; Middle Aged; Myositis; Prednisone; | 1990 |
Tryptophan metabolism as affected by anovulatory agents.
Topics: Aminohippuric Acids; Chlorotrianisene; Diethylstilbestrol; Estrogens; Female; Humans; Isoniazid; Kyn | 1969 |
Tryptophan metabolism in man (with special reference to rheumatoid arthritis and scleroderma).
Topics: Arthritis, Rheumatoid; Aspirin; Cystinuria; Drug Synergism; Edetic Acid; Humans; Kynurenic Acid; Kyn | 1973 |
Tryptophan metabolism in man, rat and pig. Determination of tryptophan-pyrrolase and kinureninase in liver.
Topics: Adult; Animals; Dicarboxylic Acids; Erythema; Female; Humans; Hydrolases; Kynurenine; Lichen Planus; | 1972 |
Tryptophan to niacin pathway in scleroderma and in dermatomyositis.
Topics: Adolescent; Adult; Aged; Dermatomyositis; Female; Humans; Hydrolases; Indoleacetic Acids; Indoles; K | 1973 |
Metabolism of C 14 labeled enantiomers of tryptophan, kynurenine and hydroxykynurenine in humans with scleroderma.
Topics: Adult; Carbon Dioxide; Carbon Isotopes; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Phe | 1972 |
[Studies on the excretion of tryptophan metabolites in patients with circumscript and progressive scleroderma].
Topics: Adult; Aged; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Sc | 1968 |