kynurenine has been researched along with Retinoblastoma in 1 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| " At concentrations in excess of 100 microM, 3HK was toxic to greater than 85% of cultured cells over the course of 24 h." | 1.28 | Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line. ( Eastman, CL; Guilarte, TR, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eastman, CL | 1 |
| Guilarte, TR | 1 |
1 other study available for kynurenine and Retinoblastoma
| Article | Year |
|---|---|
Cytotoxicity of 3-hydroxykynurenine in a neuronal hybrid cell line.
Topics: Animals; Cell Line; Eye Neoplasms; Hybridomas; Kynurenine; Mice; Neurons; Rats; Retina; Retinoblasto | 1989 |