kynurenine has been researched along with Renal Insufficiency in 7 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major trauma patients." | 7.76 | Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients. ( Domanska, G; Fusch, G; Gruendling, M; Haas, JP; Holtfreter, B; Reinke, P; Schefold, JC; Schuett, C; Westerholt, A; Zeden, JP, 2010) |
| "Marked increases in metabolites of the L-tryptophan-kynurenine pathway, L-kynurenine and quinolinic acid (Quin), were observed in serum and cerebrospinal fluid (CSF) of both the rat and human with renal insufficiency." | 7.70 | Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. ( Fujigaki, S; Fujii, H; Heyes, MP; Noma, A; Saito, K; Seishima, M; Shibata, K; Takemura, M; Wada, H, 2000) |
| "It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major trauma patients." | 3.76 | Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients. ( Domanska, G; Fusch, G; Gruendling, M; Haas, JP; Holtfreter, B; Reinke, P; Schefold, JC; Schuett, C; Westerholt, A; Zeden, JP, 2010) |
| "Marked increases in metabolites of the L-tryptophan-kynurenine pathway, L-kynurenine and quinolinic acid (Quin), were observed in serum and cerebrospinal fluid (CSF) of both the rat and human with renal insufficiency." | 3.70 | Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. ( Fujigaki, S; Fujii, H; Heyes, MP; Noma, A; Saito, K; Seishima, M; Shibata, K; Takemura, M; Wada, H, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, T | 1 |
| Stefanoni, D | 1 |
| Reisz, JA | 1 |
| Nemkov, T | 1 |
| Bertolone, L | 1 |
| Francis, RO | 1 |
| Hudson, KE | 1 |
| Zimring, JC | 1 |
| Hansen, KC | 1 |
| Hod, EA | 1 |
| Spitalnik, SL | 1 |
| D'Alessandro, A | 1 |
| Clària, J | 1 |
| Moreau, R | 1 |
| Fenaille, F | 1 |
| Amorós, A | 1 |
| Junot, C | 1 |
| Gronbaek, H | 1 |
| Coenraad, MJ | 1 |
| Pruvost, A | 1 |
| Ghettas, A | 1 |
| Chu-Van, E | 1 |
| López-Vicario, C | 1 |
| Oettl, K | 1 |
| Caraceni, P | 1 |
| Alessandria, C | 1 |
| Trebicka, J | 1 |
| Pavesi, M | 1 |
| Deulofeu, C | 1 |
| Albillos, A | 1 |
| Gustot, T | 1 |
| Welzel, TM | 1 |
| Fernández, J | 1 |
| Stauber, RE | 1 |
| Saliba, F | 1 |
| Butin, N | 1 |
| Colsch, B | 1 |
| Moreno, C | 1 |
| Durand, F | 1 |
| Nevens, F | 1 |
| Bañares, R | 1 |
| Benten, D | 1 |
| Ginès, P | 1 |
| Gerbes, A | 1 |
| Jalan, R | 1 |
| Angeli, P | 1 |
| Bernardi, M | 1 |
| Arroyo, V | 1 |
| Zeden, JP | 1 |
| Fusch, G | 1 |
| Holtfreter, B | 1 |
| Schefold, JC | 1 |
| Reinke, P | 1 |
| Domanska, G | 1 |
| Haas, JP | 1 |
| Gruendling, M | 1 |
| Westerholt, A | 1 |
| Schuett, C | 1 |
| Outinen, TK | 1 |
| Mäkelä, SM | 1 |
| Ala-Houhala, IO | 1 |
| Huhtala, HS | 1 |
| Hurme, M | 1 |
| Libraty, DH | 1 |
| Oja, SS | 1 |
| Pörsti, IH | 1 |
| Syrjänen, JT | 1 |
| Vaheri, A | 1 |
| Mustonen, JT | 1 |
| Arioka, Y | 1 |
| Yamamoto, Y | 1 |
| Hoshi, M | 1 |
| Matsumoto, K | 1 |
| Takamatsu, M | 1 |
| Hara, A | 1 |
| Seishima, M | 2 |
| Saito, K | 2 |
| Dobrovolsky, VN | 1 |
| Bowyer, JF | 1 |
| Pabarcus, MK | 1 |
| Heflich, RH | 1 |
| Williams, LD | 1 |
| Doerge, DR | 1 |
| Arvidsson, B | 1 |
| Bergquist, J | 1 |
| Casida, JE | 1 |
| Fujigaki, S | 1 |
| Heyes, MP | 1 |
| Shibata, K | 1 |
| Takemura, M | 1 |
| Fujii, H | 1 |
| Wada, H | 1 |
| Noma, A | 1 |
7 other studies available for kynurenine and Renal Insufficiency
| Article | Year |
|---|---|
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.
Topics: Adult; Aged; Amino Acids; Betacoronavirus; Blood Glucose; Case-Control Studies; Coronavirus Infectio | 2020 |
Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis.
Topics: Acute-On-Chronic Liver Failure; Aged; Bacterial Infections; Case-Control Studies; Europe; Female; He | 2019 |
Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients.
Topics: Adult; Critical Illness; Female; Humans; Kynurenine; Male; Middle Aged; NAD; Renal Insufficiency; Se | 2010 |
High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
Topics: Adult; Aged; Biomarkers; Blood Cell Count; C-Reactive Protein; Creatinine; Female; Hemorrhagic Fever | 2011 |
Pre-administration of L-tryptophan improved ADR-induced early renal failure in mice.
Topics: Animals; Chromatography, High Pressure Liquid; Down-Regulation; Doxorubicin; Eosine Yellowish-(YS); | 2012 |
Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype.
Topics: Animals; Arylformamidase; Gene Silencing; Kidney; Kynurenine; Liver; Lymphocyte Activation; Mice; Mi | 2005 |
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
Topics: Adult; Albuminuria; Animals; Carboxy-Lyases; Enzyme Inhibitors; Female; Humans; Hydrolases; Kynureni | 2000 |