kynurenine has been researched along with Pregnancy in 132 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflammatory response system." | 9.10 | Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. ( Bonaccorso, S; Bosmans, E; Maes, M; Ombelet, W; Scharpé, S; Verkerk, R, 2002) |
| "We hypothesize that: (1) L-tryptophan (Trp) is greatly utilized and not depleted in pregnancy; (2) fetal tolerance is achieved in part through immunosuppressive kynurenine (Kyn) metabolites produced by the flux of plasma free (non-albumin-bound) Trp down the Kyn pathway; (3) the role of indoleamine 2,3-dioxygenase (IDO) in infection is not related to limitation of an essential amino acid, but is rather associated with stress responses and the production of Kyn metabolites that regulate the activities of antigen presenting cells and T-cells, as well as increased NAD(+) synthesis in IDO-expressing cells; (4) Trp depletion is not a host defence mechanism, but is a consequence of Trp utilization." | 8.93 | The end of the road for the tryptophan depletion concept in pregnancy and infection. ( Badawy, AA; Moffett, JR; Namboodiri, AM, 2016) |
| "The LC-MS/MS method is able to accurately quantify kynurenine- and serotonin pathway metabolites in pregnant women, providing an opportunity to investigate the role of the TRP metabolism in the (patho)physiology of pregnancy." | 8.31 | Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy. ( de Rijke, YB; Griffioen, PH; Mirzaian, M; Steegers-Theunissen, RPM; van Rossem, L; van Schaik, RHN; van Zundert, SKM; Willemsen, SP, 2023) |
| " The present study examined the diagnostic ability of tryptophan catabolites (TRYCATs) and insulin resistance (IR) parameters in women with PE." | 8.31 | Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia. ( Al-Hakeim, HK; Jasim, ZA; Stanek, A; Zolghadri, S, 2023) |
| "Higher estimated tryptophan intake was cross-sectionally independently associated with a lower prevalence of depressive symptoms during pregnancy in Japanese women." | 8.12 | Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study. ( Arakawa, M; Miyake, Y; Okubo, H; Sasaki, S; Tanaka, K, 2022) |
| " Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation." | 7.91 | Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. ( Kubo, H; Morikawa, M; Mouri, A; Nabeshima, T; Nakamura, Y; Okada, T; Ozaki, N; Saito, K; Shiino, T; Teshigawara, T; Yamamoto, Y, 2019) |
| "Several studies suggest a pathophysiologically relevant association between increased brain levels of the neuroinhibitory tryptophan metabolite kynurenic acid and cognitive dysfunctions in people with schizophrenia." | 7.88 | Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia. ( Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R, 2018) |
| "To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood." | 7.88 | Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. ( D'Agata, A; Duffy, A; Fuchs, D; Groer, M; Louis-Jacques, A; Postolache, TT, 2018) |
| "Our findings indicate that high maternal levels of neopterin, a marker of cellular immune activation, during pregnancy were positively associated with asthma in offspring." | 7.83 | Maternal plasma total neopterin and kynurenine/tryptophan levels during pregnancy in relation to asthma development in the offspring. ( Håberg, SE; Karlstad, Ø; London, SJ; Magnus, MC; Midtun, Ø; Nafstad, P; Nilsen, RM; Nystad, W; Parr, CL; Tunheim, G; Ueland, PM, 2016) |
| "The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ)." | 7.81 | Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. ( Bortz, DM; Bruno, JP; Fredericks, PJ; Jørgensen, CV; Leuner, B; Pershing, ML; Pocivavsek, A; Schwarcz, R; Vunck, SA, 2015) |
| "Oxalate, a marker of pyridoxine deficiency, was elevated in the amniotic fluid of fetuses with Down syndrome." | 7.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| "In mice, activation of indoleamine-2,3-dioxygenase (IDO), an enzyme converting tryptophan to N-formyl-kynurenine, was found to be necessary requirement to achieve immunotolerance against the fetus and thus uncomplicated pregnancy." | 7.72 | Longitudinal study of tryptophan degradation during and after pregnancy. ( Bergant, A; Fuchs, D; Neurauter, G; Schennach, H; Schröcksnadel, H; Schröcksnadel, K; Widner, B, 2003) |
| "Tryptophan levels decrease during normal pregnancy and the decrease may be related to immune activation phenomena." | 7.69 | Decreased plasma tryptophan in pregnancy. ( Baier-Bitterlich, G; Dapunt, O; Fuchs, D; Schröcksnadel, H; Wachter, H, 1996) |
| "The kynurenine pathway (KP) is a major route of the essential amino acid L-tryptophan (Trp) catabolism in mammalian cells." | 7.01 | Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder. ( Fang, K; Imamura, Y; Kasahara, Y; Konishi, Y; Momono, Y; Murakami, Y; Nishiyama, T; Sakai, D; Yoshida, C, 2023) |
| "The prevalence of preeclampsia was significantly higher among women with plasma kynurenic acid concentrations greater than the 95th percentile than among those with concentrations in the 25th-75th percentile (11." | 5.38 | Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia. ( Bjørke-Monsen, AL; Gjessing, HK; Magnus, P; Midttun, O; Nilsen, RM; Nygård, O; Pedersen, ER; Ueland, PM; Ulvik, A; Vollset, SE, 2012) |
| "There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflammatory response system." | 5.10 | Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. ( Bonaccorso, S; Bosmans, E; Maes, M; Ombelet, W; Scharpé, S; Verkerk, R, 2002) |
| "We hypothesize that: (1) L-tryptophan (Trp) is greatly utilized and not depleted in pregnancy; (2) fetal tolerance is achieved in part through immunosuppressive kynurenine (Kyn) metabolites produced by the flux of plasma free (non-albumin-bound) Trp down the Kyn pathway; (3) the role of indoleamine 2,3-dioxygenase (IDO) in infection is not related to limitation of an essential amino acid, but is rather associated with stress responses and the production of Kyn metabolites that regulate the activities of antigen presenting cells and T-cells, as well as increased NAD(+) synthesis in IDO-expressing cells; (4) Trp depletion is not a host defence mechanism, but is a consequence of Trp utilization." | 4.93 | The end of the road for the tryptophan depletion concept in pregnancy and infection. ( Badawy, AA; Moffett, JR; Namboodiri, AM, 2016) |
| "The LC-MS/MS method is able to accurately quantify kynurenine- and serotonin pathway metabolites in pregnant women, providing an opportunity to investigate the role of the TRP metabolism in the (patho)physiology of pregnancy." | 4.31 | Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy. ( de Rijke, YB; Griffioen, PH; Mirzaian, M; Steegers-Theunissen, RPM; van Rossem, L; van Schaik, RHN; van Zundert, SKM; Willemsen, SP, 2023) |
| "Tryptophan breakdown metabolites formed along the kynurenine pathway play a significant role in pregnancy and fetal development." | 4.31 | LC-MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples. ( Deuschle, M; Fornal, E; Gilles, M; Kozub, A; Lamadé, EK; Marszalek-Grabska, M; Pedraz-Petrozzi, B; Stachniuk, A; Szalaj, K; Trzpil, A; Turski, WA, 2023) |
| " The present study examined the diagnostic ability of tryptophan catabolites (TRYCATs) and insulin resistance (IR) parameters in women with PE." | 4.31 | Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia. ( Al-Hakeim, HK; Jasim, ZA; Stanek, A; Zolghadri, S, 2023) |
| "GM changes accompanying pregnancy shift IDO1-dependent tryptophan metabolism toward kynurenine production, intestinal inflammation, and gestational IR, a phenotype reversed by genetic deletion or inhibition of IDO1." | 4.12 | Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis. ( Allard, S; Bernabe, BP; Chlipala, GE; Dai, Y; Garcia, MS; Gilbert, J; Gill, RK; Khan, MW; Layden, BT; Lednovich, K; Maki, PM; Manzella, CR; Navarro, G; Perdew, GH; Priyadarshini, M; Reiman, DJ; Sharma, A; Szynal, B; Wicksteed, B; Xu, K, 2022) |
| "Higher estimated tryptophan intake was cross-sectionally independently associated with a lower prevalence of depressive symptoms during pregnancy in Japanese women." | 4.12 | Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study. ( Arakawa, M; Miyake, Y; Okubo, H; Sasaki, S; Tanaka, K, 2022) |
| " Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation." | 3.91 | Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. ( Kubo, H; Morikawa, M; Mouri, A; Nabeshima, T; Nakamura, Y; Okada, T; Ozaki, N; Saito, K; Shiino, T; Teshigawara, T; Yamamoto, Y, 2019) |
| " As KP metabolism during pregnancy is still insufficiently understood, we designed this study to examine the de novo synthesis of KYNA and 3-hydroxykynurenine (3-HK), an alternative biologically active product of kynurenine degradation, in tissue slices obtained from pregnant mice on gestational day (GD) 18." | 3.91 | Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice. ( Beggiato, S; Notarangelo, FM; Schwarcz, R, 2019) |
| "Several studies suggest a pathophysiologically relevant association between increased brain levels of the neuroinhibitory tryptophan metabolite kynurenic acid and cognitive dysfunctions in people with schizophrenia." | 3.88 | Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia. ( Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R, 2018) |
| "To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood." | 3.88 | Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. ( D'Agata, A; Duffy, A; Fuchs, D; Groer, M; Louis-Jacques, A; Postolache, TT, 2018) |
| "Our findings indicate that high maternal levels of neopterin, a marker of cellular immune activation, during pregnancy were positively associated with asthma in offspring." | 3.83 | Maternal plasma total neopterin and kynurenine/tryptophan levels during pregnancy in relation to asthma development in the offspring. ( Håberg, SE; Karlstad, Ø; London, SJ; Magnus, MC; Midtun, Ø; Nafstad, P; Nilsen, RM; Nystad, W; Parr, CL; Tunheim, G; Ueland, PM, 2016) |
| " Maternal serum levels of kynurenine, kynurenic acid, anthranilic acid, tryptophan, nicotinamide and N1-methylnicotinamide were measured in late pregnancy by mass spectrometry (n = 497) and related to the odds ratio of infantile atopic eczema." | 3.83 | Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months. ( Cooper, C; Crozier, SR; El-Heis, S; Godfrey, KM; Harvey, NC; Inskip, HM; Robinson, SM, 2016) |
| "Levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha 7 nicotinic acetylcholine receptors (α7nAChRs) and antagonist at glutamatergic N-methyl-D-aspartate receptors (NMDARs), are elevated in the brain of patients with schizophrenia (SZ)." | 3.83 | Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding. ( Bruno, JP; Lindquist, DH; Pershing, ML; Phenis, D; Pocivavsek, A; Schwarcz, R; Valentini, V, 2016) |
| "To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography - tandem mass spectrometry method was developed and used to analyse brain extracts of rodents treated with the kynurenine-3-mono-oxygenase (KMO) inhibitor Ro61-8048 during pregnancy." | 3.83 | Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2 ( Cobb, SR; Dalton, RN; Darlington, LG; Forrest, CM; Kennedy, PG; Rodgers, J; Stone, TW; Turner, C, 2016) |
| "The levels of kynurenic acid (KYNA), an endogenous negative modulator of alpha7 nicotinic acetylcholine receptors (α7nAChRs), are elevated in the brains of patients with schizophrenia (SZ)." | 3.81 | Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. ( Bortz, DM; Bruno, JP; Fredericks, PJ; Jørgensen, CV; Leuner, B; Pershing, ML; Pocivavsek, A; Schwarcz, R; Vunck, SA, 2015) |
| "Oxalate, a marker of pyridoxine deficiency, was elevated in the amniotic fluid of fetuses with Down syndrome." | 3.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| "In mice, activation of indoleamine-2,3-dioxygenase (IDO), an enzyme converting tryptophan to N-formyl-kynurenine, was found to be necessary requirement to achieve immunotolerance against the fetus and thus uncomplicated pregnancy." | 3.72 | Longitudinal study of tryptophan degradation during and after pregnancy. ( Bergant, A; Fuchs, D; Neurauter, G; Schennach, H; Schröcksnadel, H; Schröcksnadel, K; Widner, B, 2003) |
| "In mice, activation of indoleamine-(2,3)-dioxygenase (IDO), an enzyme converting tryptophan to N-formyl-kynurenine, is required to achieve immunotolerance against the fetus and thus uncomplicated pregnancy." | 3.72 | Tryptophan degradation during and after gestation. ( Bergant, A; Fuchs, D; Neurauter, G; Schröcksnadel, H; Schröcksnadel, K; Widner, B, 2003) |
| "Tryptophan levels decrease during normal pregnancy and the decrease may be related to immune activation phenomena." | 3.69 | Decreased plasma tryptophan in pregnancy. ( Baier-Bitterlich, G; Dapunt, O; Fuchs, D; Schröcksnadel, H; Wachter, H, 1996) |
| "The kynurenine pathway (KP) is a major route of the essential amino acid L-tryptophan (Trp) catabolism in mammalian cells." | 3.01 | Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder. ( Fang, K; Imamura, Y; Kasahara, Y; Konishi, Y; Momono, Y; Murakami, Y; Nishiyama, T; Sakai, D; Yoshida, C, 2023) |
| "Early pregnancy is accompanied by immune stimulation at insemination and conceptus secretion of IFN-τ, pregnancy-associated glycoproteins, prostaglandins, and other molecules whose effects on immune function during early pregnancy have not been determined." | 2.61 | Symposium review: Immunological detection of the bovine conceptus during early pregnancy. ( Ott, TL, 2019) |
| "Triphenyl phosphate (TPhP) is an organophosphate flame retardant widely distributed in the environment." | 1.91 | Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB. ( Hong, J; Liao, G; Liu, Q; Liu, X; Lu, X; Shi, Y; Tang, H; Zhang, J, 2023) |
| "Pregnancy is marked by robust changes, including brain changes to volume, structure, connectivity and neuroplasticity." | 1.91 | Cellular and molecular signatures of motherhood in the adult and ageing rat brain. ( Duarte-Guterman, P; Eid, RS; Galea, LAM; Lamers, Y; Lieblich, SE; Richard, JE, 2023) |
| "Quinolinic acid was positively associated with sSAT at birth." | 1.72 | The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity. ( Cameron-Smith, D; Chong, MFF; Chong, YS; Eriksson, JG; Fortier, MV; Gluckman, PD; Godfrey, KM; Kothandaraman, N; Lee, YS; Michael, N; Sadananthan, SA; Tan, KH; Tan, KM; Tint, MT; Velan, SS; Yap, F, 2022) |
| "Clinical pregnancy was associated with higher serum 5-HT (p<0." | 1.56 | Tryptophan catabolism to serotonin and kynurenine in women undergoing in-vitro fertilization. ( Bódis, J; Gödöny, K; Koppán, M; Prémusz, V; Rascher, W; Rauh, M; Sulyok, E; Várnagy, Á, 2020) |
| "PDS was determined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13." | 1.56 | The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women. ( Duan, K; Hu, N; Huang, Z; Long, G; Ma, J; Quan, C; Wang, S; Yang, M; Yu, H; Zeng, G, 2020) |
| "PDS was determined by an Edinburgh Postnatal Depression Scale (EPDS) score ≥ 13." | 1.51 | The IDO genetic polymorphisms and postpartum depressive symptoms: an association study in Chinese parturients who underwent cesarean section. ( Duan, KM; Huang, ZD; Li, X; Liu, ZQ; Ma, JH; Wang, SY; Yang, M; Yin, JY; Yu, HY; Zhou, HH; Zhou, YY, 2019) |
| "PPD was diagnosed with an Edinburgh Postnatal Depression Scale (EPDS) score ≥13." | 1.48 | [Correlation between kynurenine metabolites and postpartum depression]. ( Duan, K; Quan, C; Tan, Y; Wang, S; Wen, S; Zhang, J, 2018) |
| "These results show that early protein deficiency induces selective and long-lasting changes in brain kynurenine metabolism." | 1.46 | Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring. ( Aguesse, A; Bolaños-Jiménez, F; Croyal, M; de Sa Braga Oliveira, A; Ferchaud-Roucher, V; Grit, I; Honório de Melo Martimiano, P; Kaeffer, B; Lopes de Souza, S; Ouguerram, K, 2017) |
| "l-Kynurenine treatment raised forebrain KYNA levels ∼3-fold at PD2 and ∼2." | 1.39 | Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine. ( Alexander, KS; Bruno, JP; Pershing, ML; Pocivavsek, A; Schwarcz, R; Wu, HQ, 2013) |
| "The prevalence of preeclampsia was significantly higher among women with plasma kynurenic acid concentrations greater than the 95th percentile than among those with concentrations in the 25th-75th percentile (11." | 1.38 | Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia. ( Bjørke-Monsen, AL; Gjessing, HK; Magnus, P; Midttun, O; Nilsen, RM; Nygård, O; Pedersen, ER; Ueland, PM; Ulvik, A; Vollset, SE, 2012) |
| "In 13 cases of early-onset severe preeclampsia and 14 cases of late-onset severe preeclampsia, the placentas were sampled at the surface of the maternal placenta." | 1.37 | [Metabolic footprint in conditioned culture medium of placental explants: a comparison between early-onset and late-onset severe preeclampsia]. ( Chen, SL; Huang, FF; Liu, DY; Luo, XM; Wang, CH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (17.42) | 18.7374 |
| 1990's | 9 (6.82) | 18.2507 |
| 2000's | 17 (12.88) | 29.6817 |
| 2010's | 43 (32.58) | 24.3611 |
| 2020's | 40 (30.30) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, YJ | 1 |
| Zhou, C | 1 |
| Wei, YY | 1 |
| Li, HH | 1 |
| Lei, W | 1 |
| Boeldt, DS | 1 |
| Wang, K | 1 |
| Zheng, J | 1 |
| Kimmel, M | 1 |
| Jin, W | 1 |
| Xia, K | 1 |
| Lun, K | 1 |
| Azcarate-Peril, A | 1 |
| Plantinga, A | 1 |
| Wu, M | 1 |
| Ataei, S | 1 |
| Rackers, H | 1 |
| Carroll, I | 1 |
| Meltzer-Brody, S | 1 |
| Fransson, E | 1 |
| Knickmeyer, R | 1 |
| Broekhuizen, M | 2 |
| Danser, AHJ | 2 |
| Reiss, IKM | 2 |
| Merkus, D | 2 |
| Filipe, J | 1 |
| Inglesi, A | 1 |
| Amadori, M | 1 |
| Guarneri, F | 1 |
| Menchetti, L | 1 |
| Curone, G | 1 |
| Brecchia, G | 1 |
| Vigo, D | 1 |
| Riva, F | 1 |
| Priyadarshini, M | 1 |
| Navarro, G | 1 |
| Reiman, DJ | 1 |
| Sharma, A | 1 |
| Xu, K | 1 |
| Lednovich, K | 1 |
| Manzella, CR | 1 |
| Khan, MW | 1 |
| Garcia, MS | 1 |
| Allard, S | 1 |
| Wicksteed, B | 1 |
| Chlipala, GE | 1 |
| Szynal, B | 1 |
| Bernabe, BP | 1 |
| Maki, PM | 1 |
| Gill, RK | 1 |
| Perdew, GH | 1 |
| Gilbert, J | 1 |
| Dai, Y | 1 |
| Layden, BT | 1 |
| Sha, Q | 2 |
| Madaj, Z | 1 |
| Keaton, S | 2 |
| Escobar Galvis, ML | 2 |
| Smart, L | 3 |
| Krzyzanowski, S | 2 |
| Fazleabas, AT | 1 |
| Leach, R | 3 |
| Postolache, TT | 3 |
| Achtyes, ED | 1 |
| Brundin, L | 3 |
| Tan, KM | 1 |
| Tint, MT | 1 |
| Kothandaraman, N | 1 |
| Michael, N | 1 |
| Sadananthan, SA | 1 |
| Velan, SS | 1 |
| Fortier, MV | 1 |
| Yap, F | 1 |
| Tan, KH | 1 |
| Gluckman, PD | 1 |
| Chong, YS | 1 |
| Chong, MFF | 1 |
| Lee, YS | 1 |
| Godfrey, KM | 2 |
| Eriksson, JG | 1 |
| Cameron-Smith, D | 1 |
| Miyake, Y | 1 |
| Tanaka, K | 1 |
| Okubo, H | 1 |
| Sasaki, S | 1 |
| Arakawa, M | 1 |
| Dupont, V | 1 |
| Berg, AH | 1 |
| Yamashita, M | 1 |
| Huang, C | 1 |
| Covarrubias, AE | 1 |
| Ali, S | 1 |
| Stotland, A | 1 |
| Van Eyk, JE | 1 |
| Jim, B | 2 |
| Thadhani, R | 1 |
| Karumanchi, SA | 1 |
| Moura, CA | 1 |
| Cagni, FC | 1 |
| Costa, LRF | 1 |
| Tiago, PRF | 1 |
| Croyal, M | 2 |
| Aguesse, A | 3 |
| Reyes-Castro, LA | 1 |
| Zambrano, E | 1 |
| Bolaños-Jiménez, F | 2 |
| Gavioli, EC | 1 |
| Marsden, PA | 1 |
| van Zundert, SKM | 3 |
| Griffioen, PH | 3 |
| van Rossem, L | 3 |
| Willemsen, SP | 3 |
| de Rijke, YB | 4 |
| van Schaik, RHN | 3 |
| Steegers-Theunissen, RPM | 3 |
| Mirzaian, M | 3 |
| Yaman, S | 1 |
| Ceyhan, M | 1 |
| Hancerliogullari, N | 1 |
| Koc, EM | 1 |
| Candar, T | 1 |
| Tokmak, A | 1 |
| Gupta, S | 1 |
| Petras, L | 1 |
| Tufail, MU | 1 |
| Rodriguez Salazar, JD | 1 |
| Silvano, A | 2 |
| Seravalli, V | 2 |
| Strambi, N | 2 |
| Vallario, A | 1 |
| Tofani, L | 1 |
| Parenti, A | 2 |
| Di Tommaso, M | 2 |
| Milosavljevic, S | 1 |
| Smith, AK | 1 |
| Wright, CJ | 1 |
| Valafar, H | 1 |
| Pocivavsek, A | 9 |
| Murakami, Y | 1 |
| Imamura, Y | 1 |
| Kasahara, Y | 1 |
| Yoshida, C | 1 |
| Momono, Y | 1 |
| Fang, K | 1 |
| Sakai, D | 1 |
| Konishi, Y | 1 |
| Nishiyama, T | 1 |
| Shen, J | 1 |
| Zhao, W | 1 |
| Cheng, J | 2 |
| Zhao, L | 1 |
| Dai, C | 1 |
| Fu, Y | 1 |
| Li, B | 1 |
| Chen, Z | 1 |
| Shi, D | 1 |
| Li, H | 2 |
| Deng, Y | 1 |
| Pedraz-Petrozzi, B | 1 |
| Marszalek-Grabska, M | 2 |
| Kozub, A | 1 |
| Szalaj, K | 1 |
| Trzpil, A | 1 |
| Stachniuk, A | 1 |
| Lamadé, EK | 1 |
| Gilles, M | 1 |
| Deuschle, M | 1 |
| Turski, WA | 3 |
| Fornal, E | 1 |
| Lu, X | 1 |
| Hong, J | 1 |
| Zhang, J | 2 |
| Liu, Q | 1 |
| Liao, G | 1 |
| Shi, Y | 1 |
| Tang, H | 1 |
| Liu, X | 1 |
| Gawel, K | 1 |
| Kosheva, N | 1 |
| Kocki, T | 1 |
| Bjørke-Monsen, AL | 2 |
| Varsi, K | 1 |
| Sakkestad, ST | 1 |
| Ulvik, A | 3 |
| Ebbing, C | 1 |
| Ueland, PM | 4 |
| Jasim, ZA | 1 |
| Al-Hakeim, HK | 1 |
| Zolghadri, S | 1 |
| Stanek, A | 1 |
| Duarte-Guterman, P | 1 |
| Richard, JE | 1 |
| Lieblich, SE | 1 |
| Eid, RS | 1 |
| Lamers, Y | 2 |
| Galea, LAM | 2 |
| Achtyes, E | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality[NCT02566980] | 209 participants (Actual) | Observational | 2014-10-23 | Completed | |||
| Genetic Risk Factors Predictive of the Occurrence of Maternally Diagnosed Perinatal Depression in Women[NCT05175755] | 3,000 participants (Anticipated) | Interventional | 2023-09-25 | Not yet recruiting | |||
| Pregnancy and Anxious Thoughts: The Role of the Immune and Endocrine Systems[NCT03664128] | 157 participants (Actual) | Observational | 2016-06-24 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for kynurenine and Pregnancy
| Article | Year |
|---|---|
The Function of the Kynurenine Pathway in the Placenta: A Novel Pharmacotherapeutic Target?
Topics: Animals; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Mice; Placenta; Pregnancy; Premat | 2021 |
Hypertension in Pregnancy: What We Now Know.
Topics: Animals; Female; Fetus; Humans; Hypertension; Kynurenine; Mice; Pre-Eclampsia; Pregnancy | 2023 |
Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Female; Inflammation; Kynurenine; Mammals; Pregnancy; Tryp | 2023 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome:" a translational review and therapeutic perspectives.
Topics: Air Pollutants; Betacoronavirus; Calcitriol; Coronavirus Infections; COVID-19; COVID-19 Drug Treatme | 2020 |
Tryptophan metabolism and immune regulation in the human placenta.
Topics: Female; Histocompatibility, Maternal-Fetal; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxy | 2021 |
Symposium review: Immunological detection of the bovine conceptus during early pregnancy.
Topics: Animals; Cattle; Embryo, Mammalian; Endometrium; Female; Gene Expression; Gestational Age; Immune To | 2019 |
RETRACTED: Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus.
Topics: Diabetes, Gestational; Embryonic Development; Female; Fetal Development; Homeostasis; Humans; Inflam | 2020 |
The kynurenine pathway; A new target for treating maternal features of preeclampsia?
Topics: Apoptosis; Cell Differentiation; Drug Development; Female; Humans; Immunomodulation; Kynurenine; Met | 2019 |
Direct and Functional Biomarkers of Vitamin B6 Status.
Topics: Amino Acids; Biomarkers; Body Mass Index; Female; Health Status; Humans; Infant; Infant, Newborn; In | 2015 |
The end of the road for the tryptophan depletion concept in pregnancy and infection.
Topics: Antigen-Presenting Cells; Communicable Diseases; Female; Fetus; Humans; Immune Tolerance; Indoleamin | 2016 |
Tolerance, DCs and tryptophan: much ado about IDO.
Topics: Animals; Dendritic Cells; Female; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ky | 2003 |
ASPECTS OF DISORDERS OF THE KYNURENINE PATHWAY OF TRYPTOPHAN METABOLISM IN MAN.
Topics: Amino Acids; Diabetes Mellitus; Fluids and Secretions; Geriatrics; Hodgkin Disease; Humans; Kidney C | 1964 |
Immunosuppression routed via the kynurenine pathway: a biochemical and pathophysiologic approach.
Topics: Female; Fetal Death; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Pre | 2008 |
Clinical chemistry of vitamin B6.
Topics: Animals; Biological Assay; Biological Availability; Biological Transport; Chemical Phenomena; Chemis | 1983 |
[On the regulatory mechanism of kynurenine metabolism in mitochondrial membranes with special reference to the problem of hyperinsulinemia or diabetic state (author's transl)].
Topics: Animals; Diabetes Mellitus; Electron Transport; Female; Flavin-Adenine Dinucleotide; Glucose; Humans | 1974 |
Excretion of tryptophan metabolites as affected by pregnancy, contraceptive steroids, and steroid hormones.
Topics: Androsterone; Animals; Contraceptives, Oral; Enzyme Induction; Estradiol; Female; Humans; Hydrocorti | 1971 |
Physicochemical properties, development, and regulation of central and peripheral monoamine oxidase activity.
Topics: Adrenal Glands; Allosteric Regulation; Animals; Binding Sites; Brain; Carbon Radioisotopes; Estrogen | 1974 |
2 trials available for kynurenine and Pregnancy
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation.
Topics: Adult; Anxiety; Depression; Female; Humans; Immunity; Inflammation; Interleukin-6; Interleukin-8; Ky | 2002 |
113 other studies available for kynurenine and Pregnancy
| Article | Year |
|---|---|
Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies.
Topics: Female; Fetus; Human Umbilical Vein Endothelial Cells; Humans; Kynurenine; Pre-Eclampsia; Pregnancy; | 2022 |
Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition.
Topics: Adult; Anxiety; Bile Acids and Salts; Chromatography, Liquid; Depression; Dietary Fiber; Fatty Acids | 2022 |
Preliminary Evidence of Endotoxin Tolerance in Dairy Cows during the Transition Period.
Topics: Animals; Cattle; Female; Interleukins; Kynurenine; Leukocytes, Mononuclear; Lipopolysaccharides; Lym | 2021 |
Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis.
Topics: Animals; Female; Gastrointestinal Microbiome; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflamma | 2022 |
Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy.
Topics: Cytokines; Depression; Female; Humans; Kynurenine; Neuroinflammatory Diseases; Pregnancy; Tryptophan | 2022 |
The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.
Topics: Adiposity; Adult; Birth Weight; Cesarean Section; Child; Child, Preschool; Female; Fetal Blood; Huma | 2022 |
Tryptophan intake is related to a lower prevalence of depressive symptoms during pregnancy in Japan: baseline data from the Kyushu Okinawa Maternal and Child Health Study.
Topics: Calcium; Child; Child Health; Cross-Sectional Studies; Depression; Docosahexaenoic Acids; Eicosapent | 2022 |
Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms-like tyrosine kinase 1 pathway.
Topics: Animals; Female; Humans; Hypertension; Ischemia; Kidney; Kynurenine; Mice; Nephrectomy; Placenta; Pl | 2022 |
Maternal Stress during Pregnancy in Mice Induces Sex-Dependent Behavioral Alterations in Offspring along with Impaired Serotonin and Kynurenine Pathways of Tryptophan Metabolism.
Topics: Animals; Anxiety; Behavior, Animal; Female; Kynurenine; Mice; Pregnancy; Serotonin; Tryptophan | 2022 |
The curious case of tryptophan in pregnancy.
Topics: Animals; Female; Humans; Kynurenine; Mice; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnanc | 2022 |
Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy.
Topics: 5-Hydroxytryptophan; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; H | 2023 |
Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy.
Topics: 5-Hydroxytryptophan; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; H | 2023 |
Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy.
Topics: 5-Hydroxytryptophan; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; H | 2023 |
Simultaneous quantification of tryptophan metabolites by liquid chromatography tandem mass spectrometry during early human pregnancy.
Topics: 5-Hydroxytryptophan; Chromatography, High Pressure Liquid; Chromatography, Liquid; Female; Humans; H | 2023 |
Serum levels of kynurenine in pregnancies with fetal growth restriction and oligohydramnios.
Topics: Case-Control Studies; Cross-Sectional Studies; Female; Fetal Growth Retardation; Humans; Kynurenine; | 2023 |
Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section.
Topics: Cesarean Section; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Placenta; Pregna | 2023 |
Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult.
Topics: Animals; Brain; Female; Kynurenine; Male; Pregnancy; Rats; Rats, Wistar; Sleep | 2023 |
Lipopolysaccharide accelerates tryptophan degradation in the ovary and the derivative kynurenine disturbs hormone biosynthesis and reproductive performance.
Topics: Animals; Estradiol; Female; Humans; Kynurenine; Lipopolysaccharides; Mammals; Ovary; Pregnancy; Tryp | 2023 |
LC-MS/MS-based quantification of tryptophan, kynurenine, and kynurenic acid in human placental, fetal membranes, and umbilical cord samples.
Topics: Chromatography, Liquid; Extraembryonic Membranes; Female; Humans; Kynurenic Acid; Kynurenine; Placen | 2023 |
Triphenyl phosphate disrupts placental tryptophan metabolism by activating MAOA/ROS/NFκB.
Topics: Animals; Cell Line, Tumor; Female; Flame Retardants; Humans; Kynurenine; Male; Mice; Monoamine Oxida | 2023 |
Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior.
Topics: Animals; Female; Kynurenine; Pregnancy; Rats; Zebrafish | 2023 |
Lower levels of the neuroprotective tryptophan metabolite, kynurenic acid, in users of estrogen contraceptives.
Topics: Contraceptives, Oral, Hormonal; Estrogens; Female; Humans; Kynurenic Acid; Kynurenine; Pregnancy; Py | 2023 |
Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia.
Topics: Case-Control Studies; Female; Humans; Insulin Resistance; Kynurenic Acid; Kynurenine; Pre-Eclampsia; | 2023 |
Cellular and molecular signatures of motherhood in the adult and ageing rat brain.
Topics: Animals; Brain; Female; Humans; Kynurenine; Phosphoproteins; Postpartum Period; Pregnancy; Rats; Try | 2023 |
Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression.
Topics: Adult; Cross-Sectional Studies; Depression, Postpartum; Female; Humans; Inflammation; Kynurenine; Po | 2020 |
The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women.
Topics: Adult; Alleles; Cesarean Section; Depression, Postpartum; Female; Genotype; Humans; Kynurenic Acid; | 2020 |
Seasonality of plasma tryptophan and kynurenine in pregnant mothers with a history of seasonal affective disorder: Vulnerability or adaptation?
Topics: Female; Humans; Kynurenine; Mothers; Plasma; Pregnancy; Seasonal Affective Disorder; Tryptophan | 2020 |
l-Tryptophan-Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Arteries; Carrier Protein | 2020 |
Prenatal IL-6 levels and activation of the tryptophan to kynurenine pathway are associated with depressive but not anxiety symptoms across the perinatal and the post-partum period in a low-risk sample.
Topics: Anxiety; Female; Humans; Interleukin-6; Kynurenine; Postpartum Period; Pregnancy; Tryptophan | 2020 |
Tryptophan catabolism to serotonin and kynurenine in women undergoing in-vitro fertilization.
Topics: Adult; Cross-Sectional Studies; Endometriosis; Female; Fertilization in Vitro; Humans; Kynurenine; O | 2020 |
Associations between estrogen and progesterone, the kynurenine pathway, and inflammation in the post-partum.
Topics: Depression, Postpartum; Estrogens; Female; Humans; Inflammation; Kynurenine; Postpartum Period; Preg | 2021 |
Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance.
Topics: Animals; Decidua; Female; Fertility; Gestational Age; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dio | 2020 |
Kynurenine promotes the cytotoxicity of NK cells through aryl hydrocarbon receptor in early pregnancy.
Topics: Abortion, Habitual; Adult; Basic Helix-Loop-Helix Transcription Factors; Case-Control Studies; Cells | 2021 |
Kynurenine Relaxes Arteries of Normotensive Women and Those With Preeclampsia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenylyl Cyclase Inhibitors; Adu | 2021 |
Plasma Kynurenine-to-Tryptophan Ratio, a Highly Sensitive Blood-Based Diagnostic Tool for Tuberculosis in Pregnant Women Living With Human Immunodeficiency Virus (HIV).
Topics: Diagnostic Tests, Routine; Female; HIV; HIV Infections; Humans; Kynurenine; Pregnancy; Pregnant Wome | 2021 |
Postpartum corticosterone and fluoxetine shift the tryptophan-kynurenine pathway in dams.
Topics: Animals; Corticosterone; Depression, Postpartum; Depressive Disorder, Major; Female; Fluoxetine; Hum | 2021 |
A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice.
Topics: Animals; Female; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice; Placenta; Pregnancy; Q | 2021 |
Altered placental tryptophan metabolic pathway in human fetal growth restriction.
Topics: Adult; Female; Fetal Blood; Fetal Growth Retardation; Humans; Kynurenine; Metabolic Networks and Pat | 2017 |
IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYC
Topics: Adult; Autoimmunity; Bacterial Translocation; Biomarkers; Cytokines; Depression, Postpartum; Depress | 2017 |
Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Mice; Placenta; Pregnancy; Tryptophan | 2017 |
Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood.
Topics: Age Factors; Animals; Attention; Brain; Cognition; Cognition Disorders; Female; Kynurenine; Locomoti | 2018 |
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Topics: Adult; Biomarkers; Body Mass Index; Cross-Sectional Studies; Female; Humans; Indoleamine-Pyrrole 2,3 | 2018 |
The IDO genetic polymorphisms and postpartum depressive symptoms: an association study in Chinese parturients who underwent cesarean section.
Topics: Adult; Asian People; Case-Control Studies; Cesarean Section; China; Depression, Postpartum; Female; | 2019 |
[Correlation between kynurenine metabolites and postpartum depression].
Topics: Biomarkers; Cesarean Section; China; Depression, Postpartum; Female; Humans; Incidence; Kynurenic Ac | 2018 |
Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood.
Topics: Animals; Brain; Cytokines; Disease Models, Animal; Female; Gene Expression; Inflammation; Kynurenine | 2019 |
Inhibition of kynurenine aminotransferase II attenuates hippocampus-dependent memory deficit in adult rats treated prenatally with kynurenine.
Topics: Age Factors; Animals; Female; Heterocyclic Compounds, 3-Ring; Hippocampus; Kynurenine; Male; Memory | 2019 |
Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
Topics: Animals; Brain; Cognitive Dysfunction; Female; Genotype; Kynurenic Acid; Kynurenine; Kynurenine 3-Mo | 2018 |
Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice.
Topics: Animals; Brain; Female; Fetus; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Knockout; Organ Cultur | 2019 |
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms.
Topics: Adult; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Postpartum Period; Preg | 2019 |
Prenatal activation of maternal TLR3 receptors by viral-mimetic poly(I:C) modifies GluN2B expression in embryos and sonic hedgehog in offspring in the absence of kynurenine pathway activation.
Topics: alpha-Synuclein; Animals; Antiviral Agents; Cyclooxygenase 2; DCC Receptor; Doublecortin Protein; Fe | 2013 |
[Simultaneous determination of tryptophan and its metabolites in plasma by high performance liquid chromatography with on-column derivatization].
Topics: Acetonitriles; Chromatography, High Pressure Liquid; Female; Fluorescence; Humans; Hydroxyindoleacet | 2013 |
Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway.
Topics: Age Factors; Animals; Brain; Doublecortin Protein; Down-Regulation; Excitatory Postsynaptic Potentia | 2013 |
Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats.
Topics: Age Factors; Animals; Avoidance Learning; Behavior, Animal; Cognition Disorders; Female; Hippocampus | 2014 |
Prenatal inhibition of the kynurenine pathway leads to structural changes in the hippocampus of adult rat offspring.
Topics: Animals; Antigens, Nuclear; Dendrites; Dendritic Spines; Doublecortin Domain Proteins; Doublecortin | 2014 |
Simultaneous detection of stable isotope-labeled and unlabeled L-tryptophan and of its main metabolites, L-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry.
Topics: Adult; Animals; Female; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Kynurenine; | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; | 2014 |
Modified neocortical and cerebellar protein expression and morphology in adult rats following prenatal inhibition of the kynurenine pathway.
Topics: Animals; Cerebellum; Dendrites; Doublecortin Protein; Embryonic Development; Female; Gene Expression | 2014 |
B7 costimulation and intracellular indoleamine-2,3-dioxygenase (IDO) expression in peripheral blood of healthy pregnant and non-pregnant women.
Topics: Adult; B7 Antigens; CD28 Antigens; CD4 Lymphocyte Count; CTLA-4 Antigen; Female; Flow Cytometry; Hum | 2014 |
Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Brain; Cognition; Dendritic Spines; Die | 2015 |
Altered hippocampal plasticity by prenatal kynurenine administration, kynurenine-3-monoxygenase (KMO) deletion or galantamine.
Topics: Adjuvants, Pharmaceutic; Animals; Doublecortin Domain Proteins; Doublecortin Protein; Female; Galant | 2015 |
Maternal plasma total neopterin and kynurenine/tryptophan levels during pregnancy in relation to asthma development in the offspring.
Topics: Adult; Asthma; Child; Drug Prescriptions; Female; Humans; Interferon-gamma; Kynurenine; Neopterin; N | 2016 |
Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months.
Topics: Adult; Age Factors; Biomarkers; Comorbidity; Dermatitis, Atopic; Female; Humans; Infant; Kynurenine; | 2016 |
Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding.
Topics: Age Factors; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cognition; Conditioning, Psych | 2016 |
Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2
Topics: Animals; Autism Spectrum Disorder; Brain; Chromatography, Liquid; Female; Kynurenic Acid; Kynurenine | 2016 |
Maternal protein restriction during gestation and lactation in the rat results in increased brain levels of kynurenine and kynurenic acid in their adult offspring.
Topics: Age Factors; Animals; Brain; Dietary Proteins; Female; Kynurenic Acid; Kynurenine; Lactation; Male; | 2017 |
Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression.
Topics: Antigens, CD; Base Sequence; Cell Communication; CTLA-4 Antigen; Decidua; DNA Primers; Female; Human | 2010 |
NFκB-dependent increase of kynurenine pathway activity in human placenta: inhibition by sulfasalazine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Cytokines; Female; Gene Expression Regulation | 2010 |
Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain.
Topics: Adult; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Choline; Female; GABA-A | 2011 |
Immunological mechanisms to establish embryo tolerance in early bovine pregnancy.
Topics: Animals; Cattle; Cells, Cultured; Coculture Techniques; Embryo Implantation; Embryo, Mammalian; Endo | 2011 |
An exploration of the associations of pregnancy and perinatal features with cytokines and tryptophan/kynurenine metabolism in children with attention-deficit hyperactivity disorder (ADHD).
Topics: Adult; Alcohol Drinking; Attention Deficit Disorder with Hyperactivity; Case-Control Studies; Child; | 2011 |
[Metabolic footprint in conditioned culture medium of placental explants: a comparison between early-onset and late-onset severe preeclampsia].
Topics: Chorionic Villi; Culture Media, Conditioned; Female; Humans; In Vitro Techniques; Kynurenine; Ornith | 2011 |
Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Chromatography, High Pressure Liquid; | 2012 |
Maternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia.
Topics: Adult; Female; Humans; Kynurenine; Norway; Overweight; Pre-Eclampsia; Pregnancy; Prevalence; Risk; T | 2012 |
Prenatal inhibition of the tryptophan-kynurenine pathway alters synaptic plasticity and protein expression in the rat hippocampus.
Topics: Animals; Doublecortin Protein; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Hippoc | 2013 |
Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine.
Topics: Animals; Attention; Brain; Cognition; Female; Galantamine; Glutamic Acid; Kynurenic Acid; Kynurenine | 2013 |
Longitudinal study of tryptophan degradation during and after pregnancy.
Topics: Adult; Alanine Transaminase; Antigens, CD; Biomarkers; Chromatography, High Pressure Liquid; Enzyme- | 2003 |
THE METABOLISM OF ALPHA-N-MONOMETHYL-L-TRYPTOPHAN (L-ABRIN) IN MAN AND IN NORMAL AND PYRIDOXINE DEFICIENT RATS.
Topics: Abrin; Amino Acids; Body Fluids; Eclampsia; Female; Humans; Kynurenine; Male; Niacin; Niacinamide; P | 1964 |
Tryptophan degradation during and after gestation.
Topics: Adult; Alanine Transaminase; Antigens, CD; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kyn | 2003 |
Increased mRNA expression of kynurenine pathway enzymes in human placentae exposed to bacterial endotoxin.
Topics: Female; Gene Expression; Humans; In Vitro Techniques; Kynurenine; Lipopolysaccharides; Placenta; Pre | 2003 |
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; | 2004 |
Inhibition of allogeneic T-cell responses by dendritic cells expressing transduced indoleamine 2,3-dioxygenase.
Topics: Adenoviridae; Animals; Blotting, Western; Cell Cycle; Cell Proliferation; Coculture Techniques; Dend | 2005 |
Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: up-regulation by inflammatory stimuli and with clinical infection.
Topics: Case-Control Studies; Female; Humans; Kynurenine; Lipopolysaccharides; Placenta; Pregnancy; Pregnanc | 2005 |
Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues.
Topics: Adult; Austria; Depression, Postpartum; Female; Humans; Kynurenine; Labor, Obstetric; Neopterin; Pos | 2005 |
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Sch | 2007 |
Effect of Kidney-replenishing herb on the indoleamine 2,3-dioxygenase of human syncytiotrophoblasts cultured in vitro and the balance of helper T-cell cytokines.
Topics: Animals; Coculture Techniques; Codonopsis; Culture Media, Conditioned; Cytokines; Embryo Culture Tec | 2007 |
Study of the plasmatic levels of tryptophan and kynurenine throughout pregnancy.
Topics: Case-Control Studies; Female; Humans; Kynurenine; Pregnancy; Tryptophan | 2008 |
Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid.
Topics: Amniotic Fluid; Biomarkers; Case-Control Studies; Down Syndrome; Female; Humans; Kynurenine; Oxalic | 2008 |
Comparative study of tumorigenicity in mice administered transplacentally or neonatally with metabolites of tryptophan and its related compounds.
Topics: 3-Hydroxyanthranilic Acid; Adenoma; Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellula | 1980 |
Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6.
Topics: Animals; Diet; Female; Hydrolases; Kynurenine; Liver; Lyases; Mice; Mice, Inbred A; Mice, Inbred DBA | 1995 |
Decreased plasma tryptophan in pregnancy.
Topics: Biopterins; Female; Humans; Kynurenine; Neopterin; Postpartum Period; Pregnancy; Tryptophan | 1996 |
Activated cellular immunity and decreased serum tryptophan in healthy pregnancy.
Topics: Biopterins; Chromatography, High Pressure Liquid; Female; Gestational Age; Humans; Immunity, Cellula | 1996 |
Maternal, umbilical, and amniotic fluid concentrations of tryptophan and kynurenine after labor or cesarean section.
Topics: Adult; Amniotic Fluid; Cesarean Section; Female; Fetal Blood; Humans; Kynurenine; Pregnancy; Tryptop | 1998 |
Tryptophan metabolism in pregnant sheep: increased fetal kynurenine production in response to maternal tryptophan loading.
Topics: Animals; Female; Fetal Blood; Fetus; Gestational Age; Hydrocortisone; Infusions, Intravenous; Kynure | 1999 |
Perinatal kynurenine pathway metabolism in the normal and asphyctic rat brain.
Topics: Animals; Asphyxia; Brain; Female; Fetus; Kynurenine; Liver; Pregnancy; Rats; Rats, Sprague-Dawley | 2000 |
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Ne | 2001 |
Neonatal asphyxia in rats: acute effects on cerebral kynurenine metabolism.
Topics: Animals; Animals, Newborn; Asphyxia Neonatorum; Behavior, Animal; Brain; Female; Humans; Infant, New | 2001 |
NAD precursors as antiteratogens against aminothiadiazole.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Resorption; Gestational Age; Kynurenine; Ma | 1976 |
On hepatic mitochondrial monoamine oxidase activity in lipid deficiency.
Topics: Animals; Female; Intracellular Membranes; Kynurenine; Lipids; Male; Mitochondria, Liver; Mixed Funct | 1979 |
The effect of environment on tryptophan metabolism "via kynurenine" in oral contraceptives users.
Topics: Aminohippuric Acids; Contraceptives, Oral; Contraceptives, Oral, Combined; Environment; Ethinyl Estr | 1978 |
[Tryptophan metabolism via the kynurenine and serotonin pathways in pregnancy nephropathy].
Topics: Female; Humans; Kidney Diseases; Kynurenine; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnancy | 1978 |
[State of interstitial metabolism of tryptophan during pregnancy and labor in women having received estrogen-progestagenic preparations].
Topics: Adult; Contraceptives, Oral; Estradiol Congeners; Female; Humans; Kynurenic Acid; Kynurenine; Labor, | 1975 |
The problem of some naturally occurring substances and their correlated compounds interfering with B6-dependent enzyme activities involved in tryptophan degradation. Xanthurenic acid accumulation in B6-deficiency.
Topics: Animals; Enzyme Activation; Female; Humans; Hydrolases; Kidney; Kinetics; Kynurenine; Male; Pigments | 1975 |
[Tryptophan and its metabolite concentrations in human plasma during the perinatal period].
Topics: Chromatography, High Pressure Liquid; Embryonic and Fetal Development; Female; Fetal Blood; Humans; | 1992 |
Urinary neopterin and kynurenine in herpes gestationis.
Topics: Biopterins; Female; Humans; Kynurenine; Neopterin; Pemphigoid Gestationis; Pregnancy | 1991 |
Tryptophan and its metabolite concentrations in human plasma and breast milk during the perinatal period.
Topics: Chromatography, High Pressure Liquid; Female; Fetal Blood; Humans; Infant, Newborn; Kynurenine; Labo | 1991 |
[Tryptophan metabolism during the perinatal period].
Topics: Adult; Circadian Rhythm; Female; Humans; Infant, Newborn; Kynurenine; Labor, Obstetric; Pregnancy; T | 1990 |
3-Hydroxykynurenine as a possible mechanism of epileptic seizures associated with neonatal vitamin B6 deficiency.
Topics: Animals; Animals, Newborn; Brain; Epilepsy; Female; Kynurenine; Pregnancy; Rats; Synaptic Transmissi | 1986 |
Tryptophan metabolism as affected by anovulatory agents.
Topics: Aminohippuric Acids; Chlorotrianisene; Diethylstilbestrol; Estrogens; Female; Humans; Isoniazid; Kyn | 1969 |
[Functional exploration at various levels of the tryptophan--nicotinic acid metabolic line].
Topics: Diabetes Mellitus; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; Hydroxylation; Kynurenin | 1972 |
The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway.
Topics: Adolescent; Adult; Aged; Androgens; Animals; Estrogens; Female; Humans; Hydrocortisone; Hydrolases; | 1974 |
Proceedings: Normal and pathological factors which affect tryptophan metabolism in man.
Topics: Breast Neoplasms; Female; Humans; Kynurenine; Pregnancy; Tryptophan; Tryptophan Oxygenase | 1972 |
Oral contraceptives, pyridoxine, and depression.
Topics: Animals; Brain Chemistry; Contraceptives, Oral; Depression; Estrogens; Female; Humans; Kynurenine; N | 1973 |
[Changes of tryptophan-nicotinic acid metabolism and the blood levels of ceruloplasmin and transferrin during pregnancy and treatment with contraceptives or estrogens].
Topics: Ceruloplasmin; Contraceptives, Oral; Estrogens; Female; Humans; Kynurenine; Male; Nicotinic Acids; P | 1970 |
Tryptophan pyrrolase activity during pregnancy.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Body Weight; Estrone; Female; Kynurenine; Liver; O | 1968 |
Some new aspects of tryptophan degradation.
Topics: Adult; Age Factors; Chromatography; Female; Humans; Kynurenine; Male; Pregnancy; Sex Factors; Trypto | 1968 |
[On the influence of ovulation inhibitors on tryptophan metabolism in relation to vitamin B6].
Topics: Adult; Contraceptives, Oral; Female; Gestational Age; Humans; Kynurenic Acid; Kynurenine; Pregnancy; | 1968 |