kynurenine has been researched along with Obesity in 31 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood." | 7.88 | Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. ( D'Agata, A; Duffy, A; Fuchs, D; Groer, M; Louis-Jacques, A; Postolache, TT, 2018) |
| "TRP catabolism is altered in metabolic syndrome; however, further studies are needed to understand role of kynurenine in pathology and disease outcomes." | 7.88 | Dysregulation of Tryptophan Catabolism in Metabolic Syndrome. ( Lalwani, P; Lima, ES; Mallmann, NH, 2018) |
| "This study characterized the kynurenine pathway (KP) in human obesity by evaluating circulating levels of kynurenines and the expression of KP enzymes in adipose tissue." | 7.81 | The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. ( Allorge, D; Arredouani, A; Balkau, B; Bessede, A; Caiazzo, R; Chinetti, G; Favennec, M; Froguel, P; Guillemin, GJ; Hennart, B; Leloire, A; Marre, M; Pattou, F; Pigeyre, M; Poulain-Godefroy, O; Staels, B; Verbanck, M; Yengo, L, 2015) |
| "Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan (TRP)-kynurenine (KYN) pathway." | 7.80 | Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome. ( Almer, G; Fuchs, D; Mangge, H; Meinitzer, A; Paulmichl, K; Prassl, R; Reininghaus, E; Schnedl, WJ; Summers, KL; Weghuber, D; Zelzer, S, 2014) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 7.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| "Hence, abdominal obesity is associated with vascular endothelial dysfunction and reduced nitric oxide (NO) availability." | 6.55 | The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity. ( Engin, A; Engin, AB, 2017) |
| "Obesity is associated with impaired learning, but the mechanisms underlying this cognitive dysfunction are poorly understood." | 5.91 | Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism. ( Bolaños-Jiménez, F; Croyal, M; García Santillán, JA; Gourdel, M; Mezo-González, CE; Reyes-Castro, LA, 2023) |
| "Obesity is a metabolic disease characterized by a state of chronic, low-grade inflammation and dominated by pro-inflammatory cytokines such as IL-6." | 5.62 | Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity. ( Albini, E; Belladonna, ML; Grohmann, U; Mondanelli, G; Orabona, C; Orecchini, E; Pallotta, MT; Ricci, G, 2021) |
| "Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated." | 5.43 | Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. ( Collins, AJ; Gimi, B; Hazlett, HF; Kerley-Hamilton, JS; Kinlaw, WB; Lupien, LE; Moyer, BJ; Nemani, KV; Ringelberg, CS; Rojas, IY; Tomlinson, CR; Trask, HW; West, RJ, 2016) |
| "Although we are far from a complete understanding of the role of kynurenine pathway in the modulation of energy homeostasis, targeting kynurenine pathway harbors high potential to expand the range of therapies to prevent and treat metabolic diseases." | 5.01 | Emerging role for kynurenines in metabolic pathologies. ( Liu, JJ; Movassat, J; Portha, B, 2019) |
| "To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood." | 3.88 | Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. ( D'Agata, A; Duffy, A; Fuchs, D; Groer, M; Louis-Jacques, A; Postolache, TT, 2018) |
| "In patients with obesity subjected to bariatric surgery, levels of 3-hydroxykynurenine and 3-hydroxyanthranilic acid seemed to be positively correlated to impaired glucose tolerance." | 3.88 | Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery. ( Andersen, JR; Christensen, MHE; Fadnes, DJ; Mellgren, G; Midttun, Ø; Nygård, OK; Pedersen, ER; Røst, TH; Ueland, PM; Ulvik, A; Våge, V, 2018) |
| "TRP catabolism is altered in metabolic syndrome; however, further studies are needed to understand role of kynurenine in pathology and disease outcomes." | 3.88 | Dysregulation of Tryptophan Catabolism in Metabolic Syndrome. ( Lalwani, P; Lima, ES; Mallmann, NH, 2018) |
| " Obese women had significantly higher circulating BCAA and kynurenine/tryptophan (Kyn/Trp) ratio than lean or overweight women (P < 0." | 3.81 | Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk. ( Adamski, J; Boulet, MM; Chevrier, G; Grenier-Larouche, T; Marette, A; Nadeau, M; Pelletier, M; Prehn, C; Scarpa, J; Tchernof, A, 2015) |
| "Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan (TRP)-kynurenine (KYN) pathway." | 3.80 | Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome. ( Almer, G; Fuchs, D; Mangge, H; Meinitzer, A; Paulmichl, K; Prassl, R; Reininghaus, E; Schnedl, WJ; Summers, KL; Weghuber, D; Zelzer, S, 2014) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 3.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| "Hence, abdominal obesity is associated with vascular endothelial dysfunction and reduced nitric oxide (NO) availability." | 2.55 | The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity. ( Engin, A; Engin, AB, 2017) |
| "Obesity is associated with impaired learning, but the mechanisms underlying this cognitive dysfunction are poorly understood." | 1.91 | Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism. ( Bolaños-Jiménez, F; Croyal, M; García Santillán, JA; Gourdel, M; Mezo-González, CE; Reyes-Castro, LA, 2023) |
| "Half were diagnosed with type 2 diabetes." | 1.72 | The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites. ( Ashrafian, H; Darzi, A; Holmes, E; Lewis, MR; Penney, N; Purkayastha, S; Whiley, L; Yeung, KTD, 2022) |
| "Obesity is a metabolic disease characterized by a state of chronic, low-grade inflammation and dominated by pro-inflammatory cytokines such as IL-6." | 1.62 | Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity. ( Albini, E; Belladonna, ML; Grohmann, U; Mondanelli, G; Orabona, C; Orecchini, E; Pallotta, MT; Ricci, G, 2021) |
| "Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated." | 1.43 | Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. ( Collins, AJ; Gimi, B; Hazlett, HF; Kerley-Hamilton, JS; Kinlaw, WB; Lupien, LE; Moyer, BJ; Nemani, KV; Ringelberg, CS; Rojas, IY; Tomlinson, CR; Trask, HW; West, RJ, 2016) |
| "Human obesity is characterized by chronic low-grade inflammation in white adipose tissue and is often associated with hypertension." | 1.38 | Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone. ( Allorge, D; Bessede, A; Caiazzo, R; Froguel, P; Guillemin, GJ; Hennart, B; Leloire, A; Pattou, F; Pigeyre, M; Poulain-Godefroy, O; Raverdy, V; Soichot, M; Taront, S; Wolowczuk, I, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 18 (58.06) | 24.3611 |
| 2020's | 11 (35.48) | 2.80 |
| Authors | Studies |
|---|---|
| Yeung, KTD | 1 |
| Penney, N | 1 |
| Whiley, L | 1 |
| Ashrafian, H | 1 |
| Lewis, MR | 1 |
| Purkayastha, S | 1 |
| Darzi, A | 1 |
| Holmes, E | 1 |
| Delgado, I | 1 |
| Cussotto, S | 1 |
| Anesi, A | 1 |
| Dexpert, S | 1 |
| Aubert, A | 1 |
| Aouizerate, B | 1 |
| Beau, C | 1 |
| Forestier, D | 1 |
| Ledaguenel, P | 1 |
| Magne, E | 1 |
| Mattivi, F | 1 |
| Capuron, L | 1 |
| Hyland, NP | 1 |
| Cavanaugh, CR | 1 |
| Hornby, PJ | 1 |
| Huang, T | 1 |
| Song, J | 1 |
| Gao, J | 1 |
| Cheng, J | 1 |
| Xie, H | 1 |
| Zhang, L | 1 |
| Wang, YH | 1 |
| Gao, Z | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| He, J | 1 |
| Liu, S | 2 |
| Yu, Q | 1 |
| Zhang, S | 1 |
| Xiong, F | 1 |
| Zhou, Q | 1 |
| Wang, CY | 1 |
| Mezo-González, CE | 1 |
| García Santillán, JA | 1 |
| Reyes-Castro, LA | 1 |
| Gourdel, M | 1 |
| Croyal, M | 1 |
| Bolaños-Jiménez, F | 1 |
| Vints, WAJ | 1 |
| Kušleikienė, S | 1 |
| Sheoran, S | 1 |
| Valatkevičienė, K | 1 |
| Gleiznienė, R | 1 |
| Himmelreich, U | 1 |
| Pääsuke, M | 1 |
| Česnaitienė, VJ | 1 |
| Levin, O | 1 |
| Verbunt, J | 1 |
| Masiulis, N | 1 |
| Rosario, SR | 1 |
| Dong, B | 1 |
| Zhang, Y | 1 |
| Hsiao, HH | 1 |
| Isenhart, E | 1 |
| Wang, J | 1 |
| Siegel, EM | 1 |
| Monjazeb, AM | 1 |
| Owen, DH | 1 |
| Dey, P | 1 |
| Tabung, FK | 1 |
| Spakowicz, DJ | 1 |
| Murphy, WJ | 1 |
| Edge, S | 1 |
| Yendamuri, S | 1 |
| Ibrahimi, S | 1 |
| Kolesar, JM | 1 |
| McDonald, PH | 1 |
| Vadehra, D | 1 |
| Churchman, M | 1 |
| Kalinski, P | 1 |
| Mukherjee, S | 1 |
| Oxenkrug, G | 2 |
| Summergrad, P | 2 |
| Bellet, MM | 1 |
| Borghi, M | 1 |
| Pariano, M | 1 |
| Renga, G | 1 |
| Stincardini, C | 1 |
| D'Onofrio, F | 1 |
| Brancorsini, S | 1 |
| Garaci, E | 1 |
| Costantini, C | 1 |
| Romani, L | 1 |
| Bernard, A | 1 |
| Le May, C | 1 |
| Dastugue, A | 1 |
| Ayer, A | 1 |
| Blanchard, C | 1 |
| Martin, JC | 1 |
| Pais de Barros, JP | 1 |
| Delaby, P | 1 |
| Le Bourgot, C | 1 |
| Ledoux, S | 1 |
| Besnard, P | 1 |
| Mondanelli, G | 1 |
| Albini, E | 1 |
| Orecchini, E | 1 |
| Pallotta, MT | 1 |
| Belladonna, ML | 1 |
| Ricci, G | 1 |
| Grohmann, U | 1 |
| Orabona, C | 1 |
| Song, P | 1 |
| Ramprasath, T | 1 |
| Wang, H | 1 |
| Zou, MH | 1 |
| Engin, AB | 1 |
| Engin, A | 1 |
| Dalkner, N | 1 |
| Platzer, M | 1 |
| Bengesser, SA | 1 |
| Birner, A | 1 |
| Fellendorf, FT | 1 |
| Queissner, R | 1 |
| Painold, A | 1 |
| Mangge, H | 2 |
| Fuchs, D | 3 |
| Reininghaus, B | 1 |
| Kapfhammer, HP | 1 |
| Holasek, SJ | 1 |
| Reininghaus, EZ | 1 |
| Razny, U | 1 |
| Goralska, J | 1 |
| Zdzienicka, A | 1 |
| Fedak, D | 1 |
| Masania, J | 1 |
| Rabbani, N | 1 |
| Thornalley, P | 1 |
| Pawlica-Gosiewska, D | 1 |
| Gawlik, K | 1 |
| Dembinska-Kiec, A | 1 |
| Solnica, B | 1 |
| Malczewska-Malec, M | 1 |
| Groer, M | 1 |
| Duffy, A | 1 |
| Louis-Jacques, A | 1 |
| D'Agata, A | 1 |
| Postolache, TT | 1 |
| Christensen, MHE | 1 |
| Fadnes, DJ | 1 |
| Røst, TH | 1 |
| Pedersen, ER | 1 |
| Andersen, JR | 1 |
| Våge, V | 1 |
| Ulvik, A | 1 |
| Midttun, Ø | 1 |
| Ueland, PM | 1 |
| Nygård, OK | 1 |
| Mellgren, G | 1 |
| Mallmann, NH | 1 |
| Lima, ES | 1 |
| Lalwani, P | 1 |
| Agus, A | 1 |
| Planchais, J | 1 |
| Sokol, H | 2 |
| Laurans, L | 1 |
| Venteclef, N | 1 |
| Haddad, Y | 1 |
| Chajadine, M | 1 |
| Alzaid, F | 1 |
| Metghalchi, S | 1 |
| Sovran, B | 1 |
| Denis, RGP | 1 |
| Dairou, J | 1 |
| Cardellini, M | 1 |
| Moreno-Navarrete, JM | 1 |
| Straub, M | 1 |
| Jegou, S | 1 |
| McQuitty, C | 1 |
| Viel, T | 1 |
| Esposito, B | 1 |
| Tavitian, B | 1 |
| Callebert, J | 1 |
| Luquet, SH | 1 |
| Federici, M | 1 |
| Fernandez-Real, JM | 1 |
| Burcelin, R | 1 |
| Launay, JM | 1 |
| Tedgui, A | 1 |
| Mallat, Z | 1 |
| Taleb, S | 1 |
| Dadvar, S | 1 |
| Ferreira, DMS | 1 |
| Cervenka, I | 1 |
| Ruas, JL | 1 |
| Liu, JJ | 1 |
| Movassat, J | 1 |
| Portha, B | 1 |
| Bernstein, HG | 1 |
| Guest, PC | 1 |
| van der Hart, M | 1 |
| Roeser, J | 1 |
| Steiner, J | 1 |
| Summers, KL | 1 |
| Meinitzer, A | 1 |
| Zelzer, S | 1 |
| Almer, G | 1 |
| Prassl, R | 1 |
| Schnedl, WJ | 1 |
| Reininghaus, E | 1 |
| Paulmichl, K | 1 |
| Weghuber, D | 1 |
| Boulet, MM | 1 |
| Chevrier, G | 1 |
| Grenier-Larouche, T | 1 |
| Pelletier, M | 1 |
| Nadeau, M | 1 |
| Scarpa, J | 1 |
| Prehn, C | 1 |
| Marette, A | 1 |
| Adamski, J | 1 |
| Tchernof, A | 1 |
| Favennec, M | 1 |
| Hennart, B | 2 |
| Caiazzo, R | 2 |
| Leloire, A | 2 |
| Yengo, L | 1 |
| Verbanck, M | 1 |
| Arredouani, A | 1 |
| Marre, M | 1 |
| Pigeyre, M | 2 |
| Bessede, A | 2 |
| Guillemin, GJ | 2 |
| Chinetti, G | 1 |
| Staels, B | 1 |
| Pattou, F | 2 |
| Balkau, B | 1 |
| Allorge, D | 2 |
| Froguel, P | 2 |
| Poulain-Godefroy, O | 2 |
| Moyer, BJ | 1 |
| Rojas, IY | 1 |
| Kerley-Hamilton, JS | 1 |
| Hazlett, HF | 1 |
| Nemani, KV | 1 |
| Trask, HW | 1 |
| West, RJ | 1 |
| Lupien, LE | 1 |
| Collins, AJ | 1 |
| Ringelberg, CS | 1 |
| Gimi, B | 1 |
| Kinlaw, WB | 1 |
| Tomlinson, CR | 1 |
| Oxenkrug, GF | 1 |
| Wolowczuk, I | 1 |
| Soichot, M | 1 |
| Taront, S | 1 |
| Raverdy, V | 1 |
| Vinyard, E | 1 |
| Joven, CB | 1 |
| Swendseid, ME | 1 |
| Drenick, EJ | 1 |
| Grosser, V | 1 |
| Knapp, A | 1 |
| Wolfram, G | 1 |
| Grimm, U | 1 |
| Lubs, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Involvement of the Gut Microbiota and Its Metabolites in the Pathophysiology of Calcified Aortic Stenosis[NCT06021535] | 100 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients With Metabolic Syndrome[NCT05275608] | 40 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
| Study for the Investigation of New Individual Risk Profiles and Therapeutic Strategies in Obesity Related Cardiovascular and Metabolic Disorders.[NCT00482924] | 1,500 participants (Anticipated) | Observational | 2003-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for kynurenine and Obesity
| Article | Year |
|---|---|
Emerging effects of tryptophan pathway metabolites and intestinal microbiota on metabolism and intestinal function.
Topics: Animals; Gastrointestinal Microbiome; Intestines; Kynurenine; Mice; Obesity; Tryptophan | 2022 |
Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases.
Topics: Aging; Animals; Blood Pressure; Cardiovascular Diseases; Diabetes Mellitus; Drug Discovery; Endothel | 2017 |
The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity.
Topics: Animals; Folic Acid; Humans; Inflammation; Kynurenine; Methionine; Obesity; Pteridines; Signal Trans | 2017 |
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Topics: Autistic Disorder; Colitis; Communicable Diseases; Crohn Disease; Gastrointestinal Microbiome; Gastr | 2018 |
The weight of nutrients: kynurenine metabolites in obesity and exercise.
Topics: Adipocytes; Animals; Energy Metabolism; Exercise; Humans; Kynurenine; Nutrients; Obesity | 2018 |
Emerging role for kynurenines in metabolic pathologies.
Topics: Aging; Animals; Atherosclerosis; Biomarkers; Diabetes Mellitus; Homeostasis; Humans; Islets of Lange | 2019 |
25 other studies available for kynurenine and Obesity
| Article | Year |
|---|---|
The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites.
Topics: Adult; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gastrectomy; Gastric Bypass; | 2022 |
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study.
Topics: C-Reactive Protein; Depression; Humans; Indoles; Inflammation; Kynurenine; Obesity; Tryptophan | 2022 |
Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling.
Topics: Adipocytes; Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Insulin Resistance; Interleukin-6 | 2022 |
Obesity-Induced Memory Deficits in Female Rats Are Oestrous Cycle Dependent and Linked to Impaired Brain Kynurenine Pathway Metabolism.
Topics: Animals; Brain; Female; Kynurenic Acid; Kynurenine; Memory Disorders; NAD; Obesity; Rats; Tryptophan | 2023 |
Body fat and components of sarcopenia relate to inflammation, brain volume, and neurometabolism in older adults.
Topics: Adipose Tissue; Aged; Aged, 80 and over; Biomarkers; Brain; Creatine; Encephalitis; Hand Strength; H | 2023 |
Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers.
Topics: Adenocarcinoma; Female; Gastrointestinal Neoplasms; Humans; Kynurenine; Leukocytes, Mononuclear; Mal | 2023 |
Benserazide, an Inhibitor of Peripheral Kynurenine Metabolism, Attenuates Olanzapine-Induced Weight Gain, Insulin Resistance, and Dyslipidemia in C57Bl/6j Mice.
Topics: Animals; Antipsychotic Agents; Benserazide; Dyslipidemias; Female; Insulin Resistance; Kynurenine; M | 2020 |
Thymosin alpha 1 exerts beneficial extrapulmonary effects in cystic fibrosis.
Topics: Animals; Candida albicans; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dis | 2021 |
The Tryptophan/Kynurenine Pathway: A Novel Cross-Talk between Nutritional Obesity, Bariatric Surgery and Taste of Fat.
Topics: Adult; Animals; Dietary Fats; Female; Food Preferences; Gastrectomy; Humans; Kynurenine; Male; Metab | 2021 |
Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity.
Topics: Adipose Tissue; Animals; Biomarkers; Cytokines; Diet, High-Fat; Disease Models, Animal; Disease Susc | 2021 |
The role of tryptophan metabolism and food craving in the relationship between obesity and bipolar disorder.
Topics: Adult; Bipolar Disorder; Body Mass Index; Craving; Eating; Energy Metabolism; Female; Food; Humans; | 2018 |
Relation of the protein glycation, oxidation and nitration to the osteocalcin level in obese subjects.
Topics: Adult; Aged; Antioxidants; Biomarkers; Case-Control Studies; Female; Glycation End Products, Advance | 2017 |
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Topics: Adult; Biomarkers; Body Mass Index; Cross-Sectional Studies; Female; Humans; Indoleamine-Pyrrole 2,3 | 2018 |
Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.
Topics: Adult; Bariatric Surgery; Biomarkers; C-Reactive Protein; Female; Glycated Hemoglobin; Humans; Infla | 2018 |
Dysregulation of Tryptophan Catabolism in Metabolic Syndrome.
Topics: Adult; Body Mass Index; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Female; H | 2018 |
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Topics: Animals; Diabetes Mellitus, Type 2; Fatty Liver; Gastrointestinal Microbiome; Health; Humans; Indole | 2018 |
Plasma xanthurenic acid in a context of insulin resistance and obesity in schizophrenia.
Topics: Case-Control Studies; Humans; Insulin Resistance; Kynurenic Acid; Kynurenine; Obesity; Schizophrenia | 2019 |
Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome.
Topics: Adolescent; Adult; Age Factors; Aged; C-Reactive Protein; Child; Female; Humans; Interleukin-6; Kynu | 2014 |
Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Adipocytes; Adipokines; Adipose Tissue; Adult; Am | 2015 |
The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation.
Topics: Case-Control Studies; Cohort Studies; Female; Humans; Kynurenine; Kynurenine 3-Monooxygenase; Obesit | 2015 |
Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.
Topics: Adiposity; Animals; Azo Compounds; Benzoflavones; Diet, Western; Fatty Liver; Hepatocytes; Indoleami | 2016 |
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders.
Topics: Aging; Animals; Humans; Inflammation; Interferon-gamma; Kynurenine; Mental Disorders; Metabolic Synd | 2011 |
Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone.
Topics: Adipose Tissue; Adult; Blood Pressure; Case-Control Studies; Cell Count; Female; Homeostasis; Humans | 2012 |
Vitamin B6 nutriture studied in obese subjects during 8 weeks of starvation.
Topics: Female; Humans; Kynurenic Acid; Kynurenine; Male; Obesity; Oxalates; Pyridoxine; Starvation; Transam | 1967 |
[Tryptophan loading during fasting].
Topics: Fasting; Female; Humans; Kynurenine; Male; Obesity; Tryptophan; Xanthurenates | 1973 |