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kynurenine and Nerve Pain

kynurenine has been researched along with Nerve Pain in 8 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Research Excerpts

ExcerptRelevanceReference
"Since chronic painful conditions and depression have common pathophysiological patterns, and the kynurenine signaling pathway is involved in both of them, future clinical studies should aim to have outcomes targeting not only pain, but also functionality, mood changes, and quality of life."6.66The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents. ( Candido, KD; Jovanovic, F; Knezevic, NN, 2020)
"Since chronic painful conditions and depression have common pathophysiological patterns, and the kynurenine signaling pathway is involved in both of them, future clinical studies should aim to have outcomes targeting not only pain, but also functionality, mood changes, and quality of life."2.66The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents. ( Candido, KD; Jovanovic, F; Knezevic, NN, 2020)
"Migraine and neuropathic pain are common causes of chronic pain."2.52Drug targets of migraine and neuropathy: treatment of hyperexcitability. ( Balog, A; Majláth, Z; Tajti, J; Vécsei, L, 2015)
"However, the significance of KP in neuropathic pain is still poorly understood."1.91Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain. ( Ciapała, K; Ciechanowska, A; Mika, J; Pawlik, K; Rojewska, E, 2023)
"OBJECTIVE: Neuropathic pain is regulated by several metabolites of the kynurenine pathway (KYNA-kynurenic acid, and QA-quinolinic acid)."1.91Nociceptive improvements and kynurenine pathway alterations with diclofenac treatment in a rat model of neuropathic pain created by partial sciatic nerve ligation. ( Debbag, S; Saricaoglu, F; Yalcinkaya, A, 2023)
"In this study, we found that neuropathic pain is abrogated when the kynurenine metabolic pathway (KYNPATH) initiated by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is ablated pharmacologically or genetically."1.72Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice. ( Alves-Filho, JC; Arruda, LM; Buqui, GA; Cecilio, NT; Cunha, FQ; Cunha, TM; Dagostin, A; Davoli-Ferreira, M; Fernandes Gomes, FI; Fonseca, MD; Gonçalves, WA; Guimarães, RM; Huang, L; Kusuda, R; Leão, RM; Lemos, H; Lopes, AH; Lopes, NP; Maganin, AG; Mauriz Marques, LM; Mellor, A; Mendes, AS; O'Connor, JC; Pacholczyk, G; Sant'Anna, MB; Santana, DA; Santana-Coelho, D; Silva, CE; Silva, RL; Souza, GR; Talbot, J, 2022)
"Chronic pain was evaluated by thermal hyperalgesia in Hargreaves test and mechanical allodynia in von Frey test, depressive-like behaviors were evaluated by immobility time in forced swim test and tail suspension test."1.48Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain. ( Ding, L; Jiang, X; Jing, C; Liu, F; Pang, C; Yan, Q; Zhang, L, 2018)
"l-Kynurenine has antinociceptive effects in acute and inflammatory pain."1.39The L-kynurenine-probenecid combination reduces neuropathic pain in rats. ( Aguilera, P; Barragán-Iglesias, P; Bravo-Hernández, M; Cervantes-Durán, C; González-Esquivel, DF; Granados-Soto, V; Pérez-Severiano, F; Pineda-Farias, JB; Ríos, C, 2013)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (37.50)24.3611
2020's5 (62.50)2.80

Authors

AuthorsStudies
Ciapała, K2
Mika, J2
Rojewska, E2
Maganin, AG1
Souza, GR1
Fonseca, MD1
Lopes, AH1
Guimarães, RM1
Dagostin, A1
Cecilio, NT1
Mendes, AS1
Gonçalves, WA1
Silva, CE1
Fernandes Gomes, FI1
Mauriz Marques, LM1
Silva, RL1
Arruda, LM1
Santana, DA1
Lemos, H1
Huang, L1
Davoli-Ferreira, M1
Santana-Coelho, D1
Sant'Anna, MB1
Kusuda, R1
Talbot, J1
Pacholczyk, G1
Buqui, GA1
Lopes, NP1
Alves-Filho, JC1
Leão, RM1
O'Connor, JC1
Cunha, FQ1
Mellor, A1
Cunha, TM1
Pawlik, K1
Ciechanowska, A1
Debbag, S1
Yalcinkaya, A1
Saricaoglu, F1
Jovanovic, F1
Candido, KD1
Knezevic, NN1
Jiang, X1
Yan, Q1
Liu, F1
Jing, C1
Ding, L1
Zhang, L1
Pang, C1
Pineda-Farias, JB1
Pérez-Severiano, F1
González-Esquivel, DF1
Barragán-Iglesias, P1
Bravo-Hernández, M1
Cervantes-Durán, C1
Aguilera, P1
Ríos, C1
Granados-Soto, V1
Vécsei, L1
Majláth, Z1
Balog, A1
Tajti, J1

Reviews

3 reviews available for kynurenine and Nerve Pain

ArticleYear
The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives.
    International journal of molecular sciences, 2021, Oct-13, Volume: 22, Issue:20

    Topics: Analgesics; Animals; Biomarkers; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Mono

2021
The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents.
    International journal of molecular sciences, 2020, Aug-22, Volume: 21, Issue:17

    Topics: Analgesics; Animals; Chronic Pain; Depression; Headache; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenas

2020
Drug targets of migraine and neuropathy: treatment of hyperexcitability.
    CNS & neurological disorders drug targets, 2015, Volume: 14, Issue:5

    Topics: Animals; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Hyperalgesia; Kynurenine; Migraine Dis

2015

Other Studies

5 other studies available for kynurenine and Nerve Pain

ArticleYear
Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice.
    The Journal of clinical investigation, 2022, 12-01, Volume: 132, Issue:23

    Topics: Animals; Dendritic Cells; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Metabolic Networks and P

2022
Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain.
    Toxicology and applied pharmacology, 2023, 02-15, Volume: 461

    Topics: Analgesia; Analgesics, Opioid; Animals; Kynurenine; Mice; Neuralgia; RNA, Messenger; Tryptophan Oxyg

2023
Nociceptive improvements and kynurenine pathway alterations with diclofenac treatment in a rat model of neuropathic pain created by partial sciatic nerve ligation.
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:9

    Topics: Animals; Diclofenac; Hyperalgesia; Kynurenine; Neuralgia; Nociception; Rats; Rats, Sprague-Dawley; S

2023
Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain.
    Neuroscience letters, 2018, Jan-01, Volume: 662

    Topics: Analgesics; Animals; Behavior, Animal; Chronic Pain; Cytokines; Depression; Hydroxyindoleacetic Acid

2018
The L-kynurenine-probenecid combination reduces neuropathic pain in rats.
    European journal of pain (London, England), 2013, Volume: 17, Issue:9

    Topics: Animals; Drug Therapy, Combination; Female; Hyperalgesia; Kynurenine; Motor Activity; Neuralgia; Pai

2013