kynurenine has been researched along with Nerve Degeneration in 13 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 7.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| " The purpose of this study was to investigate the effects of glutathione on 3-hydroxykynurenine, 6-hydroxydopamine and salsolinol mediated neurotoxicity in the human neuroblastoma SH-SY5Y cell line in order to find a possible therapeutic application of this compound to neurodegenerative disorders." | 3.78 | Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line. ( Melzig, MF; Wszelaki, N, 2012) |
| "These changes preceded the onset of EEG seizures, which had a mean onset of 108 h after inoculation." | 1.35 | Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. ( Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bohár, Z | 1 |
| Toldi, J | 2 |
| Fülöp, F | 1 |
| Vécsei, L | 3 |
| Amori, L | 1 |
| Wu, HQ | 1 |
| Marinozzi, M | 1 |
| Pellicciari, R | 1 |
| Guidetti, P | 2 |
| Schwarcz, R | 6 |
| Kincses, ZT | 1 |
| Campesan, S | 1 |
| Green, EW | 1 |
| Breda, C | 1 |
| Sathyasaikumar, KV | 1 |
| Muchowski, PJ | 1 |
| Kyriacou, CP | 1 |
| Giorgini, F | 1 |
| Wszelaki, N | 1 |
| Melzig, MF | 1 |
| Roy, EJ | 1 |
| Takikawa, O | 1 |
| Kranz, DM | 1 |
| Brown, AR | 1 |
| Thomas, DL | 1 |
| Bellac, CL | 1 |
| Coimbra, RS | 1 |
| Christen, S | 1 |
| Leib, SL | 1 |
| Rajda, C | 1 |
| Bergquist, J | 1 |
| Lehrmann, E | 1 |
| Löve, A | 1 |
| Williamson, J | 2 |
| Bertram, EH | 1 |
| Du, F | 2 |
| Bertram, E | 1 |
| Lothman, E | 1 |
| Okuno, E | 1 |
| Stone, TW | 1 |
| Lee, SC | 1 |
5 reviews available for kynurenine and Nerve Degeneration
| Article | Year |
|---|---|
Changing the face of kynurenines and neurotoxicity: therapeutic considerations.
Topics: Animals; Humans; Kynurenine; Nerve Degeneration; Neurotoxins | 2015 |
Kynurenines, neurodegeneration and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Struc | 2010 |
Kynurenines, redox disturbances and neurodegeneration in multiple sclerosis.
Topics: Animals; Antioxidants; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Humans; Kynur | 2007 |
Inhibitors of the kynurenine pathway.
Topics: Animals; Humans; Kynurenine; Nerve Degeneration | 2000 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Tra | 1991 |
8 other studies available for kynurenine and Nerve Degeneration
| Article | Year |
|---|---|
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.
Topics: Adenosine; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; D | 2009 |
The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Drosophila melanogaster; Huntington | 2011 |
Low level of glutathione can intensify the toxic effect of salsolinol in SH-SY5Y neuroblastoma cell line.
Topics: Adenosine Triphosphate; Apoptosis; Caspase 3; Caspase 7; Cell Death; Cell Line, Tumor; Dose-Response | 2012 |
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynureni | 2005 |
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Brain; Disease Models, Animal; Encephalitis; Enzyme A | 2006 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Di | 2008 |
Kynurenine pathway enzymes in a rat model of chronic epilepsy: immunohistochemical study of activated glial cells.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Astrocytes; Cell Death; Cerebral Cortex; Chronic Dis | 1993 |
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degen | 2001 |