kynurenine has been researched along with Multiple Organ Failure in 6 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now." | 8.31 | Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. ( Baillie, JK; Baily, J; Binnie, M; Bochkina, NA; Garden, OJ; Hayes, AJ; Homer, NZM; Howie, SEM; Iredale, JP; Just, G; Liddle, J; McGuire, K; Mole, DJ; Murray, TBJ; Neyton, LPA; O'Kelly, J; Skouras, C; Uings, I; Webster, SP; Zheng, X, 2023) |
| "These results support the concept that mesenteric lymph-borne kynurenines may contribute to pancreatitis-associated MOF." | 7.74 | Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure. ( Collett, G; Deitch, EA; Diamond, T; Garden, OJ; Kylanpaa, L; McFerran, NV; Mole, DJ; O'Neill, C; Repo, H, 2008) |
| "Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now." | 4.31 | Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. ( Baillie, JK; Baily, J; Binnie, M; Bochkina, NA; Garden, OJ; Hayes, AJ; Homer, NZM; Howie, SEM; Iredale, JP; Just, G; Liddle, J; McGuire, K; Mole, DJ; Murray, TBJ; Neyton, LPA; O'Kelly, J; Skouras, C; Uings, I; Webster, SP; Zheng, X, 2023) |
| "These results support the concept that mesenteric lymph-borne kynurenines may contribute to pancreatitis-associated MOF." | 3.74 | Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure. ( Collett, G; Deitch, EA; Diamond, T; Garden, OJ; Kylanpaa, L; McFerran, NV; Mole, DJ; O'Neill, C; Repo, H, 2008) |
| "The incidence of bacteremic sepsis (BS), adult respiratory distress syndrome (ARDS), multiple organ dysfunction/failure syndromes (MODS/MOF), and death was prospectively documented in 22 trauma patients with a mean ISS of 24." | 1.33 | Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma. ( Fleming, AW; Fuchs, D; Neurauter, G; Pellegrin, K; Peterson, VM; Wirleitner, B, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Hayes, AJ | 1 |
| Zheng, X | 1 |
| O'Kelly, J | 1 |
| Neyton, LPA | 1 |
| Bochkina, NA | 1 |
| Uings, I | 1 |
| Liddle, J | 1 |
| Baillie, JK | 1 |
| Just, G | 1 |
| Binnie, M | 1 |
| Homer, NZM | 1 |
| Murray, TBJ | 1 |
| Baily, J | 1 |
| McGuire, K | 1 |
| Skouras, C | 1 |
| Garden, OJ | 2 |
| Webster, SP | 1 |
| Iredale, JP | 1 |
| Howie, SEM | 1 |
| Mole, DJ | 2 |
| Turski, WA | 1 |
| Wnorowski, A | 1 |
| Turski, GN | 1 |
| Turski, CA | 1 |
| Turski, L | 1 |
| Lögters, TT | 1 |
| Laryea, MD | 1 |
| Altrichter, J | 1 |
| Sokolowski, J | 1 |
| Cinatl, J | 1 |
| Reipen, J | 1 |
| Linhart, W | 1 |
| Windolf, J | 1 |
| Scholz, M | 1 |
| Wild, M | 1 |
| Girgin, G | 1 |
| Sahin, TT | 1 |
| Fuchs, D | 2 |
| Yuksel, O | 1 |
| Kurukahvecioglu, O | 1 |
| Sare, M | 1 |
| Baydar, T | 1 |
| Pellegrin, K | 1 |
| Neurauter, G | 1 |
| Wirleitner, B | 1 |
| Fleming, AW | 1 |
| Peterson, VM | 1 |
| McFerran, NV | 1 |
| Collett, G | 1 |
| O'Neill, C | 1 |
| Diamond, T | 1 |
| Kylanpaa, L | 1 |
| Repo, H | 1 |
| Deitch, EA | 1 |
1 review available for kynurenine and Multiple Organ Failure
| Article | Year |
|---|---|
AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome:" a translational review and therapeutic perspectives.
Topics: Air Pollutants; Betacoronavirus; Calcitriol; Coronavirus Infections; COVID-19; COVID-19 Drug Treatme | 2020 |
5 other studies available for kynurenine and Multiple Organ Failure
| Article | Year |
|---|---|
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Critical Illness; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice | 2023 |
Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Injury Severity Score; Kinetics; Kynurenine; Male; M | 2009 |
Tryptophan degradation and serum neopterin concentrations in intensive care unit patients.
Topics: Aged; APACHE; Biomarkers; Critical Care; Female; Humans; Immune System; Kynurenine; Male; Middle Age | 2011 |
Enhanced enzymatic degradation of tryptophan by indoleamine 2,3-dioxygenase contributes to the tryptophan-deficient state seen after major trauma.
Topics: Adolescent; Adult; Bacteremia; Case-Control Studies; Child; Female; Humans; Indoleamine-Pyrrole 2,3, | 2005 |
Tryptophan catabolites in mesenteric lymph may contribute to pancreatitis-associated organ failure.
Topics: Acute Disease; Animals; Kynurenine; Ligation; Lymph; Male; Mesentery; Multiple Organ Failure; Neutro | 2008 |