kynurenine has been researched along with Metabolic Syndrome in 9 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
| Excerpt | Relevance | Reference |
|---|---|---|
| "TRP catabolism is altered in metabolic syndrome; however, further studies are needed to understand role of kynurenine in pathology and disease outcomes." | 7.88 | Dysregulation of Tryptophan Catabolism in Metabolic Syndrome. ( Lalwani, P; Lima, ES; Mallmann, NH, 2018) |
| " We assessed downstream tryptophan metabolites of the kynurenine pathway as predictors of acute myocardial infarction in patients with suspected stable angina pectoris." | 7.81 | Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. ( Eussen, SJ; Mellgren, G; Meyer, K; Midttun, Ø; Nilsen, DW; Nordrehaug, JE; Nygård, O; Pedersen, ER; Strand, E; Svingen, GF; Tuseth, N; Ueland, PM; Ulvik, A, 2015) |
| "Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan (TRP)-kynurenine (KYN) pathway." | 7.80 | Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome. ( Almer, G; Fuchs, D; Mangge, H; Meinitzer, A; Paulmichl, K; Prassl, R; Reininghaus, E; Schnedl, WJ; Summers, KL; Weghuber, D; Zelzer, S, 2014) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 7.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| "TRP catabolism is altered in metabolic syndrome; however, further studies are needed to understand role of kynurenine in pathology and disease outcomes." | 3.88 | Dysregulation of Tryptophan Catabolism in Metabolic Syndrome. ( Lalwani, P; Lima, ES; Mallmann, NH, 2018) |
| " We assessed downstream tryptophan metabolites of the kynurenine pathway as predictors of acute myocardial infarction in patients with suspected stable angina pectoris." | 3.81 | Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. ( Eussen, SJ; Mellgren, G; Meyer, K; Midttun, Ø; Nilsen, DW; Nordrehaug, JE; Nygård, O; Pedersen, ER; Strand, E; Svingen, GF; Tuseth, N; Ueland, PM; Ulvik, A, 2015) |
| "Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan (TRP)-kynurenine (KYN) pathway." | 3.80 | Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome. ( Almer, G; Fuchs, D; Mangge, H; Meinitzer, A; Paulmichl, K; Prassl, R; Reininghaus, E; Schnedl, WJ; Summers, KL; Weghuber, D; Zelzer, S, 2014) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 3.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Tan, KM | 1 |
| Tint, MT | 1 |
| Kothandaraman, N | 1 |
| Yap, F | 1 |
| Godfrey, KM | 1 |
| Lee, YS | 1 |
| Tan, KH | 1 |
| Gluckman, PD | 1 |
| Chong, YS | 1 |
| Chong, MFF | 1 |
| Eriksson, JG | 1 |
| Cameron-Smith, D | 1 |
| Oxenkrug, G | 1 |
| Summergrad, P | 1 |
| Mallmann, NH | 1 |
| Lima, ES | 1 |
| Lalwani, P | 1 |
| Agus, A | 1 |
| Planchais, J | 1 |
| Sokol, H | 1 |
| Mangge, H | 1 |
| Summers, KL | 1 |
| Meinitzer, A | 1 |
| Zelzer, S | 1 |
| Almer, G | 1 |
| Prassl, R | 1 |
| Schnedl, WJ | 1 |
| Reininghaus, E | 1 |
| Paulmichl, K | 1 |
| Weghuber, D | 1 |
| Fuchs, D | 1 |
| Dinel, AL | 1 |
| André, C | 1 |
| Aubert, A | 1 |
| Ferreira, G | 1 |
| Layé, S | 1 |
| Castanon, N | 1 |
| Pedersen, ER | 1 |
| Tuseth, N | 1 |
| Eussen, SJ | 1 |
| Ueland, PM | 1 |
| Strand, E | 1 |
| Svingen, GF | 1 |
| Midttun, Ø | 1 |
| Meyer, K | 1 |
| Mellgren, G | 1 |
| Ulvik, A | 1 |
| Nordrehaug, JE | 1 |
| Nilsen, DW | 1 |
| Nygård, O | 1 |
| Oxenkrug, GF | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Involvement of the Gut Microbiota and Its Metabolites in the Pathophysiology of Calcified Aortic Stenosis[NCT06021535] | 100 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| Study for the Investigation of New Individual Risk Profiles and Therapeutic Strategies in Obesity Related Cardiovascular and Metabolic Disorders.[NCT00482924] | 1,500 participants (Anticipated) | Observational | 2003-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenine and Metabolic Syndrome
| Article | Year |
|---|---|
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Topics: Autistic Disorder; Colitis; Communicable Diseases; Crohn Disease; Gastrointestinal Microbiome; Gastr | 2018 |
Metabolic syndrome, age-associated neuroendocrine disorders, and dysregulation of tryptophan-kynurenine metabolism.
Topics: Aging; Animals; Endocrine System Diseases; Humans; Kynurenine; Metabolic Syndrome; Nervous System Di | 2010 |
7 other studies available for kynurenine and Metabolic Syndrome
| Article | Year |
|---|---|
Association of plasma kynurenine pathway metabolite concentrations with metabolic health risk in prepubertal Asian children.
Topics: Child; Cohort Studies; Fatty Liver; Humans; Kynurenine; Metabolic Syndrome; Overweight; Pediatric Ob | 2022 |
Benserazide, an Inhibitor of Peripheral Kynurenine Metabolism, Attenuates Olanzapine-Induced Weight Gain, Insulin Resistance, and Dyslipidemia in C57Bl/6j Mice.
Topics: Animals; Antipsychotic Agents; Benserazide; Dyslipidemias; Female; Insulin Resistance; Kynurenine; M | 2020 |
Dysregulation of Tryptophan Catabolism in Metabolic Syndrome.
Topics: Adult; Body Mass Index; C-Reactive Protein; Case-Control Studies; Cross-Sectional Studies; Female; H | 2018 |
Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome.
Topics: Adolescent; Adult; Age Factors; Aged; C-Reactive Protein; Child; Female; Humans; Interleukin-6; Kynu | 2014 |
Lipopolysaccharide-induced brain activation of the indoleamine 2,3-dioxygenase and depressive-like behavior are impaired in a mouse model of metabolic syndrome.
Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; Enzyme Activation; Indoleamine | 2014 |
Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris.
Topics: Aged; Angina, Stable; Biomarkers; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus, | 2015 |
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders.
Topics: Aging; Animals; Humans; Inflammation; Interferon-gamma; Kynurenine; Mental Disorders; Metabolic Synd | 2011 |