kynurenine has been researched along with Meningitis, Pneumococcal in 4 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pneumococcal meningitis is a lethal form of bacterial infection in the central nervous system that often causes lifelong neurological sequelae, despite therapeutic advances." | 5.40 | The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. ( Ball, HJ; Funakoshi, H; Hunt, NH; Kanai, M; McGregor, IS; McQuillan, JA; Nakamura, T; Too, LK, 2014) |
| "Acute bacterial meningitis (ABM) causes excessive activation of N-methyl-D-aspartate receptors (NMDAr), leading to cortical and hippocampal neuron death." | 1.91 | The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis. ( Campi-Azevedo, AC; Candiani, TMS; Cassiano, LMG; Coimbra, RS; de Oliveira, DB; Kohlhoff, M; Kroon, EG; Martins-Filho, OA, 2023) |
| "Pneumococcal meningitis is a lethal form of bacterial infection in the central nervous system that often causes lifelong neurological sequelae, despite therapeutic advances." | 1.40 | The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. ( Ball, HJ; Funakoshi, H; Hunt, NH; Kanai, M; McGregor, IS; McQuillan, JA; Nakamura, T; Too, LK, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cassiano, LMG | 1 |
| de Oliveira, DB | 1 |
| Candiani, TMS | 1 |
| Campi-Azevedo, AC | 1 |
| Martins-Filho, OA | 1 |
| Kroon, EG | 1 |
| Kohlhoff, M | 1 |
| Coimbra, RS | 3 |
| Too, LK | 1 |
| McQuillan, JA | 1 |
| Ball, HJ | 1 |
| Kanai, M | 1 |
| Nakamura, T | 1 |
| Funakoshi, H | 1 |
| McGregor, IS | 1 |
| Hunt, NH | 1 |
| Bellac, CL | 2 |
| Christen, S | 2 |
| Leib, SL | 2 |
4 other studies available for kynurenine and Meningitis, Pneumococcal
| Article | Year |
|---|---|
The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis.
Topics: Central Nervous System; Child; Humans; Interleukin-10; Interleukin-6; Kynurenine; Meningitis, Bacter | 2023 |
The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cognition; Disease Models, Animal; Female; Indoleamine- | 2014 |
Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis.
Topics: Animals; Animals, Newborn; Apoptosis; Chromatography, High Pressure Liquid; Cytokines; Disease Model | 2010 |
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Brain; Disease Models, Animal; Encephalitis; Enzyme A | 2006 |