Page last updated: 2024-10-18

kynurenine and Meningioma

kynurenine has been researched along with Meningioma in 3 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)

Research Excerpts

ExcerptRelevanceReference
"Increased tryptophan metabolism via the kynurenine pathway (KP) is a key mechanism of tumoral immune suppression in gliomas."7.81Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas. ( Bosnyák, E; Guastella, AR; Juhász, C; Kamson, DO; Kupsky, WJ; Michelhaugh, SK; Mittal, S; Muzik, O; Robinette, NL; Varadarajan, K, 2015)
"Meningiomas are the neoplasms that arise from the arachnoid cells of the meninges."5.43Altered tryptophan metabolism in human meningioma. ( Challa, S; Madigubba, S; Panigrahi, M; Phanithi, PB; Talari, NK, 2016)
"We examined the protein expression levels (in 73 gliomas and 48 meningiomas) of the KP rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO) 1, IDO2, and tryptophan 2,3-dioxygenase (TDO2), as well as, the aryl hydrocarbon receptor (AhR), a carcinogenic transcription factor activated by KP metabolites."3.88Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. ( Ali-Fehmi, R; Fadel, HA; Guastella, AR; Juhász, C; Kiousis, S; Klinger, NV; Kupsky, WJ; Michelhaugh, SK; Mittal, S, 2018)
"Increased tryptophan metabolism via the kynurenine pathway (KP) is a key mechanism of tumoral immune suppression in gliomas."3.81Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas. ( Bosnyák, E; Guastella, AR; Juhász, C; Kamson, DO; Kupsky, WJ; Michelhaugh, SK; Mittal, S; Muzik, O; Robinette, NL; Varadarajan, K, 2015)
"Meningiomas are the neoplasms that arise from the arachnoid cells of the meninges."1.43Altered tryptophan metabolism in human meningioma. ( Challa, S; Madigubba, S; Panigrahi, M; Phanithi, PB; Talari, NK, 2016)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Guastella, AR2
Michelhaugh, SK2
Klinger, NV1
Fadel, HA1
Kiousis, S1
Ali-Fehmi, R1
Kupsky, WJ2
Juhász, C2
Mittal, S2
Bosnyák, E1
Kamson, DO1
Varadarajan, K1
Robinette, NL1
Muzik, O1
Talari, NK1
Panigrahi, M1
Madigubba, S1
Challa, S1
Phanithi, PB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Tryptophan Metabolism in Human Brain Tumors[NCT02367469]105 participants (Anticipated)Observational2014-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for kynurenine and Meningioma

ArticleYear
Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors.
    Journal of neuro-oncology, 2018, Volume: 139, Issue:2

    Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gl

2018
Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.
    Neuro-oncology, 2015, Volume: 17, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain; Child; Female; Glioma; Humans; Kynurenine; Male;

2015
Altered tryptophan metabolism in human meningioma.
    Journal of neuro-oncology, 2016, Volume: 130, Issue:1

    Topics: Analysis of Variance; Autopsy; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyindoleac

2016