kynurenine has been researched along with Meningioma in 3 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased tryptophan metabolism via the kynurenine pathway (KP) is a key mechanism of tumoral immune suppression in gliomas." | 7.81 | Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas. ( Bosnyák, E; Guastella, AR; Juhász, C; Kamson, DO; Kupsky, WJ; Michelhaugh, SK; Mittal, S; Muzik, O; Robinette, NL; Varadarajan, K, 2015) |
| "Meningiomas are the neoplasms that arise from the arachnoid cells of the meninges." | 5.43 | Altered tryptophan metabolism in human meningioma. ( Challa, S; Madigubba, S; Panigrahi, M; Phanithi, PB; Talari, NK, 2016) |
| "We examined the protein expression levels (in 73 gliomas and 48 meningiomas) of the KP rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO) 1, IDO2, and tryptophan 2,3-dioxygenase (TDO2), as well as, the aryl hydrocarbon receptor (AhR), a carcinogenic transcription factor activated by KP metabolites." | 3.88 | Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors. ( Ali-Fehmi, R; Fadel, HA; Guastella, AR; Juhász, C; Kiousis, S; Klinger, NV; Kupsky, WJ; Michelhaugh, SK; Mittal, S, 2018) |
| "Increased tryptophan metabolism via the kynurenine pathway (KP) is a key mechanism of tumoral immune suppression in gliomas." | 3.81 | Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas. ( Bosnyák, E; Guastella, AR; Juhász, C; Kamson, DO; Kupsky, WJ; Michelhaugh, SK; Mittal, S; Muzik, O; Robinette, NL; Varadarajan, K, 2015) |
| "Meningiomas are the neoplasms that arise from the arachnoid cells of the meninges." | 1.43 | Altered tryptophan metabolism in human meningioma. ( Challa, S; Madigubba, S; Panigrahi, M; Phanithi, PB; Talari, NK, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guastella, AR | 2 |
| Michelhaugh, SK | 2 |
| Klinger, NV | 1 |
| Fadel, HA | 1 |
| Kiousis, S | 1 |
| Ali-Fehmi, R | 1 |
| Kupsky, WJ | 2 |
| Juhász, C | 2 |
| Mittal, S | 2 |
| Bosnyák, E | 1 |
| Kamson, DO | 1 |
| Varadarajan, K | 1 |
| Robinette, NL | 1 |
| Muzik, O | 1 |
| Talari, NK | 1 |
| Panigrahi, M | 1 |
| Madigubba, S | 1 |
| Challa, S | 1 |
| Phanithi, PB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tryptophan Metabolism in Human Brain Tumors[NCT02367469] | 105 participants (Anticipated) | Observational | 2014-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for kynurenine and Meningioma
| Article | Year |
|---|---|
Investigation of the aryl hydrocarbon receptor and the intrinsic tumoral component of the kynurenine pathway of tryptophan metabolism in primary brain tumors.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gl | 2018 |
Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brain; Child; Female; Glioma; Humans; Kynurenine; Male; | 2015 |
Altered tryptophan metabolism in human meningioma.
Topics: Analysis of Variance; Autopsy; Chromatography, High Pressure Liquid; Female; Humans; Hydroxyindoleac | 2016 |