kynurenine has been researched along with Melanoma in 19 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-six patients with malignant melanoma were randomly assigned in double-blind fashion to receive either placebo or paroxetine, beginning 2 weeks before IFN-alpha treatment and continuing for the first 12 weeks of IFN-alpha therapy." | 9.10 | Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment. ( Capuron, L; Fuchs, D; Lawson, DH; Miller, AH; Musselman, DL; Nemeroff, CB; Neurauter, G, 2003) |
| "A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas." | 7.83 | Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells. ( Assmann, N; Campa, A; Clara, RO; Coimbra, JB; Dettmer-Wilde, K; Nurenberger, N; Oefner, PJ; Ramos Moreno, AC, 2016) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 7.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "Tryptophan metabolism has been studied in mice with Harding-Passey melanoma and in controls, after a load of 1." | 7.66 | Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma. ( Allegri, G; Baccichetti, F; Cardin de' Stefani, EL; Costa, C; De Antoni, A; Vanzan, S, 1983) |
| "The kynurenine pathway is a major pathway of tryptophan metabolism leading to nicotinamide adenine dinucleotide (NAD+) production." | 7.01 | PPARs and the Kynurenine Pathway in Melanoma-Potential Biological Interactions. ( Gerkowicz, A; Krasowska, D; Walczak, K, 2023) |
| "Twenty-six patients with malignant melanoma were randomly assigned in double-blind fashion to receive either placebo or paroxetine, beginning 2 weeks before IFN-alpha treatment and continuing for the first 12 weeks of IFN-alpha therapy." | 5.10 | Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment. ( Capuron, L; Fuchs, D; Lawson, DH; Miller, AH; Musselman, DL; Nemeroff, CB; Neurauter, G, 2003) |
| " This study investigated the clinical relevance of IDO1 expression by immune cells in the lymph nodes and blood and of the serum kynurenine/tryptophan (Kyn/Trp) ratio in 65 systemic treatment naïve stage I-III melanoma patients." | 4.02 | Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFNγ-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma. ( Allorge, D; Brochez, L; Demeyer, A; Ferdinande, L; Haspeslagh, M; Hennart, B; Meireson, A; Ost, P; Spaas, M; Sundahl, N, 2021) |
| "A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas." | 3.83 | Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells. ( Assmann, N; Campa, A; Clara, RO; Coimbra, JB; Dettmer-Wilde, K; Nurenberger, N; Oefner, PJ; Ramos Moreno, AC, 2016) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 3.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "Tryptophan metabolism has been studied in mice with Harding-Passey melanoma and in controls, after a load of 1." | 3.66 | Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma. ( Allegri, G; Baccichetti, F; Cardin de' Stefani, EL; Costa, C; De Antoni, A; Vanzan, S, 1983) |
| "The kynurenine pathway is a major pathway of tryptophan metabolism leading to nicotinamide adenine dinucleotide (NAD+) production." | 3.01 | PPARs and the Kynurenine Pathway in Melanoma-Potential Biological Interactions. ( Gerkowicz, A; Krasowska, D; Walczak, K, 2023) |
| "Kynurenine metabolites inhibit T-cell proliferation resulting in cell growth arrest." | 2.82 | The involvement of a chemokine receptor antagonist CTCE-9908 and kynurenine metabolites in cancer development. ( Basson, C; Bipath, P; Hlophe, Y; Joubert, AM; Nkandeu, DS; Nyakudya, T; Serem, JC, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 10 (52.63) | 2.80 |
| Authors | Studies |
|---|---|
| Meireson, A | 1 |
| Ferdinande, L | 1 |
| Haspeslagh, M | 1 |
| Hennart, B | 1 |
| Allorge, D | 1 |
| Ost, P | 1 |
| Sundahl, N | 1 |
| Spaas, M | 1 |
| Demeyer, A | 1 |
| Brochez, L | 1 |
| Nkandeu, DS | 1 |
| Basson, C | 1 |
| Joubert, AM | 1 |
| Serem, JC | 1 |
| Bipath, P | 1 |
| Nyakudya, T | 1 |
| Hlophe, Y | 1 |
| Hubková, B | 1 |
| Valko-Rokytovská, M | 1 |
| Čižmárová, B | 1 |
| Zábavníková, M | 1 |
| Mareková, M | 1 |
| Birková, A | 1 |
| Fujiwara, Y | 1 |
| Kato, S | 1 |
| Nesline, MK | 1 |
| Conroy, JM | 1 |
| DePietro, P | 1 |
| Pabla, S | 1 |
| Kurzrock, R | 1 |
| Walczak, K | 4 |
| Gerkowicz, A | 1 |
| Krasowska, D | 1 |
| Panfili, E | 1 |
| Mondanelli, G | 1 |
| Orabona, C | 1 |
| Gargaro, M | 1 |
| Volpi, C | 1 |
| Belladonna, ML | 1 |
| Rossini, S | 1 |
| Suvieri, C | 1 |
| Pallotta, MT | 1 |
| Oldan, JD | 1 |
| Giglio, BC | 1 |
| Smith, E | 1 |
| Zhao, W | 1 |
| Bouchard, DM | 1 |
| Ivanovic, M | 1 |
| Lee, YZ | 1 |
| Collichio, FA | 1 |
| Meyers, MO | 1 |
| Wallack, DE | 1 |
| Abernethy-Leinwand, A | 1 |
| Long, PK | 1 |
| Trembath, DG | 1 |
| Googe, PB | 1 |
| Kowalski, MH | 1 |
| Ivanova, A | 1 |
| Ezzell, JA | 1 |
| Nikolaishvili-Feinberg, N | 1 |
| Thomas, NE | 1 |
| Wong, TZ | 1 |
| Ollila, DW | 1 |
| Li, Z | 1 |
| Moschos, SJ | 1 |
| Rad Pour, S | 1 |
| Morikawa, H | 1 |
| Kiani, NA | 1 |
| Yang, M | 1 |
| Azimi, A | 1 |
| Shafi, G | 1 |
| Shang, M | 1 |
| Baumgartner, R | 1 |
| Ketelhuth, DFJ | 1 |
| Kamleh, MA | 1 |
| Wheelock, CE | 1 |
| Lundqvist, A | 1 |
| Hansson, J | 1 |
| Tegnér, J | 1 |
| Li, H | 1 |
| Bullock, K | 1 |
| Gurjao, C | 1 |
| Braun, D | 1 |
| Shukla, SA | 1 |
| Bossé, D | 1 |
| Lalani, AA | 1 |
| Gopal, S | 1 |
| Jin, C | 1 |
| Horak, C | 1 |
| Wind-Rotolo, M | 1 |
| Signoretti, S | 1 |
| McDermott, DF | 1 |
| Freeman, GJ | 1 |
| Van Allen, EM | 1 |
| Schreiber, SL | 1 |
| Stephen Hodi, F | 1 |
| Sellers, WR | 1 |
| Garraway, LA | 1 |
| Clish, CB | 1 |
| Choueiri, TK | 1 |
| Giannakis, M | 1 |
| Langner, E | 1 |
| Makuch-Kocka, A | 1 |
| Szelest, M | 2 |
| Szalast, K | 2 |
| Marciniak, S | 1 |
| Plech, T | 3 |
| Kazimierczak, P | 1 |
| Clara, RO | 1 |
| Assmann, N | 1 |
| Ramos Moreno, AC | 1 |
| Coimbra, JB | 1 |
| Nurenberger, N | 1 |
| Dettmer-Wilde, K | 1 |
| Oefner, PJ | 1 |
| Campa, A | 1 |
| Capuron, L | 2 |
| Neurauter, G | 1 |
| Musselman, DL | 2 |
| Lawson, DH | 2 |
| Nemeroff, CB | 2 |
| Fuchs, D | 2 |
| Miller, AH | 2 |
| Frick, B | 1 |
| Schröcksnadel, K | 1 |
| Weber, WP | 1 |
| Feder-Mengus, C | 1 |
| Chiarugi, A | 1 |
| Rosenthal, R | 1 |
| Reschner, A | 1 |
| Schumacher, R | 1 |
| Zajac, P | 1 |
| Misteli, H | 1 |
| Frey, DM | 1 |
| Oertli, D | 1 |
| Heberer, M | 1 |
| Spagnoli, GC | 1 |
| De Antoni, A | 2 |
| Costa, C | 2 |
| Baccichetti, F | 1 |
| Cardin de' Stefani, EL | 1 |
| Vanzan, S | 1 |
| Allegri, G | 2 |
| Hu, DN | 1 |
| McCormick, SA | 1 |
| Roberts, JE | 1 |
| Bordin, F | 1 |
4 reviews available for kynurenine and Melanoma
| Article | Year |
|---|---|
The involvement of a chemokine receptor antagonist CTCE-9908 and kynurenine metabolites in cancer development.
Topics: Chemokine CXCL12; Chemokines, CXC; Child; Humans; Kynurenine; Melanoma; Peptides; Receptors, CXCR4; | 2022 |
Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy.
Topics: B7-H1 Antigen; Class I Phosphatidylinositol 3-Kinases; CTLA-4 Antigen; Enzyme Inhibitors; Humans; Im | 2022 |
PPARs and the Kynurenine Pathway in Melanoma-Potential Biological Interactions.
Topics: Humans; Kynurenine; Melanoma; Peroxisome Proliferator-Activated Receptors; Skin Neoplasms; Tryptopha | 2023 |
A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes.
Topics: Animals; Carbazoles; Chloracne; Dermatitis, Atopic; Humans; Hyperpigmentation; Kynurenic Acid; Kynur | 2021 |
1 trial available for kynurenine and Melanoma
| Article | Year |
|---|---|
Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Anxiety; Depression; Double-Blind Method; Fem | 2003 |
14 other studies available for kynurenine and Melanoma
| Article | Year |
|---|---|
Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFNγ-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma.
Topics: Adult; Cells, Cultured; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inte | 2021 |
Tryptophan: Its Metabolism along the Kynurenine, Serotonin, and Indole Pathway in Malignant Melanoma.
Topics: Humans; Indoles; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Serotonin; Skin Neoplasms; Try | 2022 |
The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1.
Topics: Humans; Kynurenine; Melanoma; Oximes; Tryptophan | 2023 |
Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma.
Topics: Fluorodeoxyglucose F18; Glucose; Humans; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Prospe | 2023 |
Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma.
Topics: B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Coculture Techniques; Cult | 2019 |
Metabolomic adaptations and correlates of survival to immune checkpoint blockade.
Topics: Adaptation, Physiological; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Clinical Trials as To | 2019 |
Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies.
Topics: Basic Helix-Loop-Helix Transcription Factors; Carbazoles; Cell Cycle; Cell Line, Tumor; Cell Prolife | 2020 |
UVB Radiation and Selected Tryptophan-Derived AhR Ligands-Potential Biological Interactions in Melanoma Cells.
Topics: Basic Helix-Loop-Helix Transcription Factors; Excitatory Amino Acid Antagonists; Humans; Kynurenic A | 2021 |
Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells.
Topics: Cell Line, Tumor; Humans; Interferon-gamma; Kynurenine; Melanocytes; Melanoma | 2016 |
Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha.
Topics: Adult; Aged; Antineoplastic Agents; Female; Folic Acid; Homocysteine; Humans; Interferon alpha-2; In | 2004 |
Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines.
Topics: 3-Hydroxyanthranilic Acid; Antigen Presentation; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell | 2006 |
Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma.
Topics: Animals; Hydrolases; Kynurenine; Lyases; Melanoma; Mice; Neoplasm Transplantation; Transaminases; Tr | 1983 |
Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells.
Topics: Cell Division; Dose-Response Relationship, Drug; Humans; Kynurenine; Melanoma; Melatonin; Serotonin; | 1998 |
Melanogenesis from tryptophan. Biogenetic experiments with Harding-Passey mouse melanoma.
Topics: Animals; Carbon Radioisotopes; Kynurenine; Melanins; Melanoma; Mice; Neoplasm Transplantation; Neopl | 1974 |