kynurenine has been researched along with Malignant Melanoma in 19 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-six patients with malignant melanoma were randomly assigned in double-blind fashion to receive either placebo or paroxetine, beginning 2 weeks before IFN-alpha treatment and continuing for the first 12 weeks of IFN-alpha therapy." | 9.10 | Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment. ( Capuron, L; Fuchs, D; Lawson, DH; Miller, AH; Musselman, DL; Nemeroff, CB; Neurauter, G, 2003) |
| "A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas." | 7.83 | Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells. ( Assmann, N; Campa, A; Clara, RO; Coimbra, JB; Dettmer-Wilde, K; Nurenberger, N; Oefner, PJ; Ramos Moreno, AC, 2016) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 7.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "Tryptophan metabolism has been studied in mice with Harding-Passey melanoma and in controls, after a load of 1." | 7.66 | Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma. ( Allegri, G; Baccichetti, F; Cardin de' Stefani, EL; Costa, C; De Antoni, A; Vanzan, S, 1983) |
| "The kynurenine pathway is a major pathway of tryptophan metabolism leading to nicotinamide adenine dinucleotide (NAD+) production." | 7.01 | PPARs and the Kynurenine Pathway in Melanoma-Potential Biological Interactions. ( Gerkowicz, A; Krasowska, D; Walczak, K, 2023) |
| "Twenty-six patients with malignant melanoma were randomly assigned in double-blind fashion to receive either placebo or paroxetine, beginning 2 weeks before IFN-alpha treatment and continuing for the first 12 weeks of IFN-alpha therapy." | 5.10 | Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment. ( Capuron, L; Fuchs, D; Lawson, DH; Miller, AH; Musselman, DL; Nemeroff, CB; Neurauter, G, 2003) |
| " This study investigated the clinical relevance of IDO1 expression by immune cells in the lymph nodes and blood and of the serum kynurenine/tryptophan (Kyn/Trp) ratio in 65 systemic treatment naïve stage I-III melanoma patients." | 4.02 | Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFNγ-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma. ( Allorge, D; Brochez, L; Demeyer, A; Ferdinande, L; Haspeslagh, M; Hennart, B; Meireson, A; Ost, P; Spaas, M; Sundahl, N, 2021) |
| "A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas." | 3.83 | Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells. ( Assmann, N; Campa, A; Clara, RO; Coimbra, JB; Dettmer-Wilde, K; Nurenberger, N; Oefner, PJ; Ramos Moreno, AC, 2016) |
| "The effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells were studied." | 3.70 | Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells. ( Hu, DN; McCormick, SA; Roberts, JE, 1998) |
| "Tryptophan metabolism has been studied in mice with Harding-Passey melanoma and in controls, after a load of 1." | 3.66 | Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma. ( Allegri, G; Baccichetti, F; Cardin de' Stefani, EL; Costa, C; De Antoni, A; Vanzan, S, 1983) |
| "The kynurenine pathway is a major pathway of tryptophan metabolism leading to nicotinamide adenine dinucleotide (NAD+) production." | 3.01 | PPARs and the Kynurenine Pathway in Melanoma-Potential Biological Interactions. ( Gerkowicz, A; Krasowska, D; Walczak, K, 2023) |
| "Kynurenine metabolites inhibit T-cell proliferation resulting in cell growth arrest." | 2.82 | The involvement of a chemokine receptor antagonist CTCE-9908 and kynurenine metabolites in cancer development. ( Basson, C; Bipath, P; Hlophe, Y; Joubert, AM; Nkandeu, DS; Nyakudya, T; Serem, JC, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.53) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 10 (52.63) | 2.80 |
| Authors | Studies |
|---|---|
| Meireson, A | 1 |
| Ferdinande, L | 1 |
| Haspeslagh, M | 1 |
| Hennart, B | 1 |
| Allorge, D | 1 |
| Ost, P | 1 |
| Sundahl, N | 1 |
| Spaas, M | 1 |
| Demeyer, A | 1 |
| Brochez, L | 1 |
| Nkandeu, DS | 1 |
| Basson, C | 1 |
| Joubert, AM | 1 |
| Serem, JC | 1 |
| Bipath, P | 1 |
| Nyakudya, T | 1 |
| Hlophe, Y | 1 |
| Hubková, B | 1 |
| Valko-Rokytovská, M | 1 |
| Čižmárová, B | 1 |
| Zábavníková, M | 1 |
| Mareková, M | 1 |
| Birková, A | 1 |
| Fujiwara, Y | 1 |
| Kato, S | 1 |
| Nesline, MK | 1 |
| Conroy, JM | 1 |
| DePietro, P | 1 |
| Pabla, S | 1 |
| Kurzrock, R | 1 |
| Walczak, K | 4 |
| Gerkowicz, A | 1 |
| Krasowska, D | 1 |
| Panfili, E | 1 |
| Mondanelli, G | 1 |
| Orabona, C | 1 |
| Gargaro, M | 1 |
| Volpi, C | 1 |
| Belladonna, ML | 1 |
| Rossini, S | 1 |
| Suvieri, C | 1 |
| Pallotta, MT | 1 |
| Oldan, JD | 1 |
| Giglio, BC | 1 |
| Smith, E | 1 |
| Zhao, W | 1 |
| Bouchard, DM | 1 |
| Ivanovic, M | 1 |
| Lee, YZ | 1 |
| Collichio, FA | 1 |
| Meyers, MO | 1 |
| Wallack, DE | 1 |
| Abernethy-Leinwand, A | 1 |
| Long, PK | 1 |
| Trembath, DG | 1 |
| Googe, PB | 1 |
| Kowalski, MH | 1 |
| Ivanova, A | 1 |
| Ezzell, JA | 1 |
| Nikolaishvili-Feinberg, N | 1 |
| Thomas, NE | 1 |
| Wong, TZ | 1 |
| Ollila, DW | 1 |
| Li, Z | 1 |
| Moschos, SJ | 1 |
| Rad Pour, S | 1 |
| Morikawa, H | 1 |
| Kiani, NA | 1 |
| Yang, M | 1 |
| Azimi, A | 1 |
| Shafi, G | 1 |
| Shang, M | 1 |
| Baumgartner, R | 1 |
| Ketelhuth, DFJ | 1 |
| Kamleh, MA | 1 |
| Wheelock, CE | 1 |
| Lundqvist, A | 1 |
| Hansson, J | 1 |
| Tegnér, J | 1 |
| Li, H | 1 |
| Bullock, K | 1 |
| Gurjao, C | 1 |
| Braun, D | 1 |
| Shukla, SA | 1 |
| Bossé, D | 1 |
| Lalani, AA | 1 |
| Gopal, S | 1 |
| Jin, C | 1 |
| Horak, C | 1 |
| Wind-Rotolo, M | 1 |
| Signoretti, S | 1 |
| McDermott, DF | 1 |
| Freeman, GJ | 1 |
| Van Allen, EM | 1 |
| Schreiber, SL | 1 |
| Stephen Hodi, F | 1 |
| Sellers, WR | 1 |
| Garraway, LA | 1 |
| Clish, CB | 1 |
| Choueiri, TK | 1 |
| Giannakis, M | 1 |
| Langner, E | 1 |
| Makuch-Kocka, A | 1 |
| Szelest, M | 2 |
| Szalast, K | 2 |
| Marciniak, S | 1 |
| Plech, T | 3 |
| Kazimierczak, P | 1 |
| Clara, RO | 1 |
| Assmann, N | 1 |
| Ramos Moreno, AC | 1 |
| Coimbra, JB | 1 |
| Nurenberger, N | 1 |
| Dettmer-Wilde, K | 1 |
| Oefner, PJ | 1 |
| Campa, A | 1 |
| Capuron, L | 2 |
| Neurauter, G | 1 |
| Musselman, DL | 2 |
| Lawson, DH | 2 |
| Nemeroff, CB | 2 |
| Fuchs, D | 2 |
| Miller, AH | 2 |
| Frick, B | 1 |
| Schröcksnadel, K | 1 |
| Weber, WP | 1 |
| Feder-Mengus, C | 1 |
| Chiarugi, A | 1 |
| Rosenthal, R | 1 |
| Reschner, A | 1 |
| Schumacher, R | 1 |
| Zajac, P | 1 |
| Misteli, H | 1 |
| Frey, DM | 1 |
| Oertli, D | 1 |
| Heberer, M | 1 |
| Spagnoli, GC | 1 |
| De Antoni, A | 2 |
| Costa, C | 2 |
| Baccichetti, F | 1 |
| Cardin de' Stefani, EL | 1 |
| Vanzan, S | 1 |
| Allegri, G | 2 |
| Hu, DN | 1 |
| McCormick, SA | 1 |
| Roberts, JE | 1 |
| Bordin, F | 1 |
4 reviews available for kynurenine and Malignant Melanoma
| Article | Year |
|---|---|
The involvement of a chemokine receptor antagonist CTCE-9908 and kynurenine metabolites in cancer development.
Topics: Chemokine CXCL12; Chemokines, CXC; Child; Humans; Kynurenine; Melanoma; Peptides; Receptors, CXCR4; | 2022 |
Indoleamine 2,3-dioxygenase (IDO) inhibitors and cancer immunotherapy.
Topics: B7-H1 Antigen; Class I Phosphatidylinositol 3-Kinases; CTLA-4 Antigen; Enzyme Inhibitors; Humans; Im | 2022 |
PPARs and the Kynurenine Pathway in Melanoma-Potential Biological Interactions.
Topics: Humans; Kynurenine; Melanoma; Peroxisome Proliferator-Activated Receptors; Skin Neoplasms; Tryptopha | 2023 |
A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes.
Topics: Animals; Carbazoles; Chloracne; Dermatitis, Atopic; Humans; Hyperpigmentation; Kynurenic Acid; Kynur | 2021 |
1 trial available for kynurenine and Malignant Melanoma
| Article | Year |
|---|---|
Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Anxiety; Depression; Double-Blind Method; Fem | 2003 |
14 other studies available for kynurenine and Malignant Melanoma
| Article | Year |
|---|---|
Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFNγ-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma.
Topics: Adult; Cells, Cultured; Enzyme Induction; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inte | 2021 |
Tryptophan: Its Metabolism along the Kynurenine, Serotonin, and Indole Pathway in Malignant Melanoma.
Topics: Humans; Indoles; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Serotonin; Skin Neoplasms; Try | 2022 |
The catalytic inhibitor epacadostat can affect the non-enzymatic function of IDO1.
Topics: Humans; Kynurenine; Melanoma; Oximes; Tryptophan | 2023 |
Increased tryptophan, but not increased glucose metabolism, predict resistance of pembrolizumab in stage III/IV melanoma.
Topics: Fluorodeoxyglucose F18; Glucose; Humans; Kynurenine; Melanoma; Melanoma, Cutaneous Malignant; Prospe | 2023 |
Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma.
Topics: B7-H1 Antigen; CD4-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Coculture Techniques; Cult | 2019 |
Metabolomic adaptations and correlates of survival to immune checkpoint blockade.
Topics: Adaptation, Physiological; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Clinical Trials as To | 2019 |
Effect of Tryptophan-Derived AhR Ligands, Kynurenine, Kynurenic Acid and FICZ, on Proliferation, Cell Cycle Regulation and Cell Death of Melanoma Cells-In Vitro Studies.
Topics: Basic Helix-Loop-Helix Transcription Factors; Carbazoles; Cell Cycle; Cell Line, Tumor; Cell Prolife | 2020 |
UVB Radiation and Selected Tryptophan-Derived AhR Ligands-Potential Biological Interactions in Melanoma Cells.
Topics: Basic Helix-Loop-Helix Transcription Factors; Excitatory Amino Acid Antagonists; Humans; Kynurenic A | 2021 |
Melanocytes are more responsive to IFN-γ and produce higher amounts of kynurenine than melanoma cells.
Topics: Cell Line, Tumor; Humans; Interferon-gamma; Kynurenine; Melanocytes; Melanoma | 2016 |
Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha.
Topics: Adult; Aged; Antineoplastic Agents; Female; Folic Acid; Homocysteine; Humans; Interferon alpha-2; In | 2004 |
Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines.
Topics: 3-Hydroxyanthranilic Acid; Antigen Presentation; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell | 2006 |
Enzyme activities and metabolites along the kynurenine pathway in mice with Harding-Passey melanoma.
Topics: Animals; Hydrolases; Kynurenine; Lyases; Melanoma; Mice; Neoplasm Transplantation; Transaminases; Tr | 1983 |
Effects of melatonin, its precursors and derivatives on the growth of cultured human uveal melanoma cells.
Topics: Cell Division; Dose-Response Relationship, Drug; Humans; Kynurenine; Melanoma; Melatonin; Serotonin; | 1998 |
Melanogenesis from tryptophan. Biogenetic experiments with Harding-Passey mouse melanoma.
Topics: Animals; Carbon Radioisotopes; Kynurenine; Melanins; Melanoma; Mice; Neoplasm Transplantation; Neopl | 1974 |