kynurenine has been researched along with Lassitude in 14 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metabolism of tryptophan through the kynurenine pathway is reduced after a 10-week treatment with a higher dose HC and plays a role in the effect of HC on fatigue and physical functioning in patients with secondary AI." | 9.27 | Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial. ( Bos, EH; Kema, IP; Sorgdrager, FJH; Van Beek, AP; Werumeus Buning, J, 2018) |
| " Tryptophan (TRP) and its metabolites may play a prominent role in neural pathways related to sleep, fatigue, and depression." | 7.85 | Tryptophan and Kynurenine Levels and Its Association With Sleep, Nonphysical Fatigue, and Depression in Chronic Hemodialysis Patients. ( Brown, J; Finkelstein, FO; Garimella, PS; Handelman, GJ; Ikizler, A; Ix, JH; Kooman, J; Kotanko, P; Levin, NW; Malhotra, R; Persic, V; Rosales, L; Tao, X; Thijssen, S; Unruh, ML; Zhang, W, 2017) |
| "Brain tryptophan and its neuroactive metabolites play key roles in central fatigue." | 7.85 | Tryptophan circuit in fatigue: From blood to brain and cognition. ( Yamamoto, T; Yamashita, M, 2017) |
| "Many patients with cancer suffer from anemia, depression, and an impaired quality of life (QoL)." | 6.66 | Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer. ( Egger, EM; Fuchs, D; Kink, P; Kurz, K; Lanser, L; Weiss, G; Willenbacher, W, 2020) |
| " These findings indicate that stroke patients with PSF have a lower bioavailability of TRP for 5-HT synthesis in the brain in the acute stroke phase." | 5.40 | Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke. ( Amthor, KF; Ormstad, H; Sandvik, L; Verkerk, R, 2014) |
| "Metabolism of tryptophan through the kynurenine pathway is reduced after a 10-week treatment with a higher dose HC and plays a role in the effect of HC on fatigue and physical functioning in patients with secondary AI." | 5.27 | Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial. ( Bos, EH; Kema, IP; Sorgdrager, FJH; Van Beek, AP; Werumeus Buning, J, 2018) |
| " In addition to hsCRP, Kynurenine seems to be a reliable biomarker to monitor acute and regenerative inflammation status of alloSCT patients, while Musclin and Galectin-3 may be added to physiological assessment regarding myopathy and sarcopenia." | 4.31 | Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients - a pilot study for novel biomarker and risk stratification determination. ( Bizjak, DA; Bunjes, D; John, L; Kirsten, J; Moebes, E; Sala, E; Schulz, SVW; Steinacker, JM; Wais, V, 2023) |
| " Tryptophan (TRP) and its metabolites may play a prominent role in neural pathways related to sleep, fatigue, and depression." | 3.85 | Tryptophan and Kynurenine Levels and Its Association With Sleep, Nonphysical Fatigue, and Depression in Chronic Hemodialysis Patients. ( Brown, J; Finkelstein, FO; Garimella, PS; Handelman, GJ; Ikizler, A; Ix, JH; Kooman, J; Kotanko, P; Levin, NW; Malhotra, R; Persic, V; Rosales, L; Tao, X; Thijssen, S; Unruh, ML; Zhang, W, 2017) |
| "Brain tryptophan and its neuroactive metabolites play key roles in central fatigue." | 3.85 | Tryptophan circuit in fatigue: From blood to brain and cognition. ( Yamamoto, T; Yamashita, M, 2017) |
| " The current study investigated associations between fatigue, depression and inflammatory cytokine (IFN-γ, IL-6, TNF-α) and CRP concentrations, as well as kynurenine pathway (KP) activation, in 61 breast cancer patients prior to chemotherapy." | 3.79 | C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy. ( Boyle, NT; Collier, S; Connor, TJ; Harkin, A; Hevey, D; Hughes, MM; Kennedy, MJ; O'Dwyer, AM; Pertl, MM, 2013) |
| "Many patients with cancer suffer from anemia, depression, and an impaired quality of life (QoL)." | 2.66 | Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer. ( Egger, EM; Fuchs, D; Kink, P; Kurz, K; Lanser, L; Weiss, G; Willenbacher, W, 2020) |
| "Poststroke fatigue is a debilitating symptom and is poorly understood." | 2.58 | Mechanisms of poststroke fatigue. ( Dantzer, R; De Doncker, W; Kuppuswamy, A; Ormstad, H, 2018) |
| "Somatoform disorders are troubling to both patients and physicians." | 2.44 | A biological substrate for somatoform disorders: importance of pathophysiology. ( Dantzer, R; Dimsdale, JE, 2007) |
| " These findings indicate that stroke patients with PSF have a lower bioavailability of TRP for 5-HT synthesis in the brain in the acute stroke phase." | 1.40 | Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke. ( Amthor, KF; Ormstad, H; Sandvik, L; Verkerk, R, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 10 (71.43) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Schulz, SVW | 1 |
| Bizjak, DA | 1 |
| Moebes, E | 1 |
| John, L | 1 |
| Wais, V | 1 |
| Bunjes, D | 1 |
| Sala, E | 1 |
| Steinacker, JM | 1 |
| Kirsten, J | 1 |
| Lanser, L | 1 |
| Kink, P | 1 |
| Egger, EM | 1 |
| Willenbacher, W | 1 |
| Fuchs, D | 4 |
| Weiss, G | 1 |
| Kurz, K | 1 |
| Malhotra, R | 1 |
| Persic, V | 1 |
| Zhang, W | 1 |
| Brown, J | 1 |
| Tao, X | 1 |
| Rosales, L | 1 |
| Thijssen, S | 1 |
| Finkelstein, FO | 1 |
| Unruh, ML | 1 |
| Ikizler, A | 1 |
| Garimella, PS | 1 |
| Ix, JH | 1 |
| Kooman, J | 1 |
| Levin, NW | 1 |
| Handelman, GJ | 1 |
| Kotanko, P | 1 |
| Yamashita, M | 1 |
| Yamamoto, T | 1 |
| De Doncker, W | 1 |
| Dantzer, R | 2 |
| Ormstad, H | 3 |
| Kuppuswamy, A | 1 |
| Sorgdrager, FJH | 1 |
| Werumeus Buning, J | 1 |
| Bos, EH | 1 |
| Van Beek, AP | 1 |
| Kema, IP | 1 |
| Agudelo, LZ | 1 |
| Ferreira, DMS | 1 |
| Dadvar, S | 1 |
| Cervenka, I | 1 |
| Ketscher, L | 1 |
| Izadi, M | 1 |
| Zhengye, L | 1 |
| Furrer, R | 1 |
| Handschin, C | 1 |
| Venckunas, T | 1 |
| Brazaitis, M | 1 |
| Kamandulis, S | 1 |
| Lanner, JT | 1 |
| Ruas, JL | 1 |
| Pertl, MM | 1 |
| Hevey, D | 1 |
| Boyle, NT | 1 |
| Hughes, MM | 1 |
| Collier, S | 1 |
| O'Dwyer, AM | 1 |
| Harkin, A | 1 |
| Kennedy, MJ | 1 |
| Connor, TJ | 1 |
| Verkerk, R | 1 |
| Amthor, KF | 1 |
| Sandvik, L | 1 |
| Eilertsen, G | 1 |
| Strasser, B | 1 |
| Geiger, D | 1 |
| Schauer, M | 1 |
| Gatterer, H | 1 |
| Burtscher, M | 1 |
| Barat, P | 1 |
| Meiffred, MC | 1 |
| Brossaud, J | 1 |
| Corcuff, JB | 1 |
| Thibault, H | 1 |
| Capuron, L | 1 |
| Schroecksnadel, K | 1 |
| Fiegl, M | 1 |
| Prassl, K | 1 |
| Winkler, C | 1 |
| Denz, HA | 1 |
| Dimsdale, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double Blind Cross-over Study of the Effects of Low Dose and High Dose Hydrocortisone Replacement Therapy on Cognition, Quality of Life, Metabolic Profile and Somatosensation in Patients With Secondary Adrenal Insufficiency[NCT01546922] | Phase 4 | 63 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Cognitive domains to be tested: memory, executive functioning, attention and social cognition.~The psychological tests consist of oral and written questions or computer tasks.~Data is given as Z-scores based on normative data. Higher Z-scores represent a better performance." (NCT01546922)
Timeframe: After completion of treatment period 1 (that is after 10 weeks from baseline) and after treatment period 2 (that is after 20 weeks from baseline).
| Intervention | Z-scores based on normative data. (Mean) | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RBMT-Immediate Memory | RBMT-Delayed Memory | RBMT-Delayed corrected for immediate memory | 15 Words Test-Short-term memory | 15 Words Test-Total immediate memory | 15 Words Test - Learning Score | 15 Words Test - Delayed Memory | 15 Words Test - Delayed corrected for total memory | 15 Words Test-Recognition | Digit Span forward - Short term memory | Rey Complex Figure - Immediate memory | Rey Complex Figure - Delayed memory | Divided attention-reaction time auditory response | Divided attention-reaction time visual response | Divided attention - Number of omission errors | Divided attention - Number of commission errors | Visual scanning - Reaction time for target stimuli | Visual scanning - Number of omission errors | Visual scanning - Number of commission errors | Alertness - Reaction time tonic alertness | Alertness - Reaction time phasic alertness | Semantic fluency | Phonemic fluency | Digit Span backwards-Working memory | Trail Making Test - Time condition A | Trail Making Test - Time condition B | Trail Making Test - Condition B/A | Social Cognition | |
| High Dose of Hydrocortisone | -0.42 | 0.10 | 0.89 | -0.03 | 0.25 | 0.38 | 0.23 | -0.16 | 0.08 | 0.56 | 1.40 | 1.28 | -0.89 | 0.03 | -0.14 | 0.34 | -0.36 | 0.08 | -0.70 | -0.99 | -1.10 | 0.09 | 0.21 | -0.01 | -0.26 | 0.18 | 0.36 | -0.71 |
| Low Dose of Hydrocortisone | -0.41 | 0.07 | 0.85 | 0.36 | 0.43 | 0.08 | 0.02 | -0.30 | -0.11 | 0.49 | 1.14 | 1.11 | -0.87 | -0.06 | -0.02 | 0.30 | -0.38 | -0.03 | -0.72 | -0.90 | -1.03 | 0.02 | 0.32 | 0.05 | -0.32 | 0.16 | 0.37 | -0.67 |
3 reviews available for kynurenine and Lassitude
| Article | Year |
|---|---|
Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer.
Topics: Anemia; Animals; Depression; Fatigue; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ky | 2020 |
Mechanisms of poststroke fatigue.
Topics: Fatigue; Humans; Inflammation; Kynurenine; Signal Transduction; Stroke; Tryptophan | 2018 |
A biological substrate for somatoform disorders: importance of pathophysiology.
Topics: Acute-Phase Reaction; Animals; Brain; Depression; Diagnosis, Differential; Fatigue; Inflammation Med | 2007 |
1 trial available for kynurenine and Lassitude
| Article | Year |
|---|---|
Hydrocortisone Affects Fatigue and Physical Functioning Through Metabolism of Tryptophan: A Randomized Controlled Trial.
Topics: Adrenal Insufficiency; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Met | 2018 |
10 other studies available for kynurenine and Lassitude
| Article | Year |
|---|---|
Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients - a pilot study for novel biomarker and risk stratification determination.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Fatigue; Female; Galectin 3; Hematopoietic Stem Cell Tr | 2023 |
Tryptophan and Kynurenine Levels and Its Association With Sleep, Nonphysical Fatigue, and Depression in Chronic Hemodialysis Patients.
Topics: Adult; Aged; Body Mass Index; Case-Control Studies; Cross-Sectional Studies; Depression; Fatigue; Fe | 2017 |
Tryptophan circuit in fatigue: From blood to brain and cognition.
Topics: Animals; Blood-Brain Barrier; Brain; Cognition; Fatigue; Female; Kynurenine; Maze Learning; Rats; Ra | 2017 |
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.
Topics: Adaptation, Physiological; Animals; Aspartate Aminotransferases; Aspartic Acid; Carbidopa; Cell Resp | 2019 |
C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy.
Topics: Biomarkers; Breast Neoplasms; C-Reactive Protein; Cytokines; Depression; Fatigue; Female; Humans; In | 2013 |
Activation of the kynurenine pathway in the acute phase of stroke and its role in fatigue and depression following stroke.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Case-Control Studies; Depression; Fatigu | 2014 |
A biopsychosocial model of fatigue and depression following stroke.
Topics: Acute Disease; Brain Ischemia; Cytokines; Depression; Fatigue; Humans; Immune System; Kynurenine; Mo | 2015 |
Effects of Exhaustive Aerobic Exercise on Tryptophan-Kynurenine Metabolism in Trained Athletes.
Topics: Adult; Athletes; Biomarkers; Exercise; Fatigue; Female; Humans; Immune System; Indoleamine-Pyrrole 2 | 2016 |
Inflammatory, endocrine and metabolic correlates of fatigue in obese children.
Topics: Adolescent; Anhedonia; Apathy; Body Mass Index; C-Reactive Protein; Child; Fatigue; Female; Humans; | 2016 |
Diminished quality of life in patients with cancer correlates with tryptophan degradation.
Topics: Aged; Disease Progression; Fatigue; Female; Humans; Immunity, Cellular; Karnofsky Performance Status | 2007 |