kynurenine has been researched along with Kidney Failure, Chronic in 25 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown." | 7.75 | The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. ( Domaniewski, T; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function have shown that hyperkynureninemia in 22." | 7.70 | Kynurenine and neopterin in chronic glomerulonephritis. ( Bratslavska, O; Fuchs, D; Groma, V; Martinsons, A; Rudzite, V; Widner, B, 1999) |
| "Patients with end-stage renal disease (ESRD) exhibit features of a hypercoagulable state, which may contribute to atherosclerosis." | 5.35 | Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients. ( Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown." | 3.75 | The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. ( Domaniewski, T; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function have shown that hyperkynureninemia in 22." | 3.70 | Kynurenine and neopterin in chronic glomerulonephritis. ( Bratslavska, O; Fuchs, D; Groma, V; Martinsons, A; Rudzite, V; Widner, B, 1999) |
| "Serum samples of 32 patients with ESRD (n = 13) and CKD (n = 19) were analyzed using chemical isotope labeling liquid chromatography-mass spectrometry metabolomics approach." | 1.91 | Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients. ( Abdel Rahman, A; Alabdaljabar, MS; Dahabiyeh, LA; Hussein, MH; Jacob, M; Nimer, RM; Sabi, EM; Sumaily, KM, 2023) |
| "Kynurenines were positively associated with vWF, TM, sICAM-1 and sVCAM-1, whereas sP-selectin was inversely associated with the most of kynurenines." | 1.36 | Kynurenine pathway - a new link between endothelial dysfunction and carotid atherosclerosis in chronic kidney disease patients. ( Myśliwiec, M; Pawlak, D; Pawlak, K, 2010) |
| "Patients with end-stage renal disease (ESRD) exhibit features of a hypercoagulable state, which may contribute to atherosclerosis." | 1.35 | Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients. ( Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "We conclude that chronic renal failure is associated with the accumulation of L-kynurenine metabolites, which may be involved in the pathogenesis of certain uremic syndromes." | 1.32 | Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure. ( Buczko, W; Matys, T; Pawlak, D; Tankiewicz, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 14 (56.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, M | 1 |
| Wang, Q | 1 |
| Kou, S | 1 |
| Li, X | 1 |
| Jiang, Z | 1 |
| Sun, L | 1 |
| Huang, X | 1 |
| Dahabiyeh, LA | 1 |
| Nimer, RM | 1 |
| Sumaily, KM | 1 |
| Alabdaljabar, MS | 1 |
| Jacob, M | 1 |
| Sabi, EM | 1 |
| Hussein, MH | 1 |
| Abdel Rahman, A | 1 |
| Liu, JJ | 1 |
| Ching, J | 1 |
| Wee, HN | 1 |
| Liu, S | 1 |
| Gurung, RL | 1 |
| Lee, J | 1 |
| M, Y | 1 |
| Zheng, H | 1 |
| Lee, LS | 1 |
| Ang, K | 1 |
| Shao, YM | 1 |
| Kovalik, JP | 1 |
| Subramaniam, T | 1 |
| Sum, CF | 1 |
| Sharma, K | 1 |
| Kestenbaum, BR | 1 |
| Lim, SC | 1 |
| Silva, RE | 1 |
| Baldim, JL | 1 |
| Chagas-Paula, DA | 1 |
| Soares, MG | 1 |
| Lago, JHG | 1 |
| Gonçalves, RV | 1 |
| Novaes, RD | 1 |
| Yilmaz, N | 1 |
| Ustundag, Y | 1 |
| Kivrak, S | 1 |
| Kahvecioglu, S | 1 |
| Celik, H | 1 |
| Kivrak, I | 1 |
| Huysal, K | 1 |
| Pawlak, K | 8 |
| Domaniewski, T | 2 |
| Mysliwiec, M | 8 |
| Pawlak, D | 15 |
| Brzosko, S | 1 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Myśliwiec, P | 2 |
| Myśliwiec, H | 1 |
| Dadan, J | 1 |
| Buczko, W | 8 |
| Kowalewska, A | 1 |
| Buraczewska-Buczko, A | 1 |
| Kato, A | 1 |
| Suzuki, Y | 1 |
| Suda, T | 1 |
| Suzuki, M | 1 |
| Fujie, M | 1 |
| Takita, T | 1 |
| Furuhashi, M | 1 |
| Maruyama, Y | 1 |
| Chida, K | 1 |
| Hishida, A | 1 |
| Lahdou, I | 1 |
| Sadeghi, M | 1 |
| Daniel, V | 1 |
| Schenk, M | 1 |
| Renner, F | 1 |
| Weimer, R | 1 |
| Löb, S | 1 |
| Schmidt, J | 1 |
| Mehrabi, A | 1 |
| Schnitzler, P | 1 |
| Königsrainer, A | 1 |
| Döhler, B | 1 |
| Opelz, G | 1 |
| Terness, P | 1 |
| Topczewska-Bruns, J | 3 |
| Chabielska, E | 2 |
| Tankiewicz, A | 6 |
| Matys, T | 1 |
| Koda, M | 1 |
| Wołczyński, S | 1 |
| Martinsons, A | 1 |
| Rudzite, V | 1 |
| Groma, V | 1 |
| Bratslavska, O | 1 |
| Widner, B | 1 |
| Fuchs, D | 1 |
| Holmes, EW | 1 |
25 other studies available for kynurenine and Kidney Failure, Chronic
| Article | Year |
|---|---|
A sensitive UPLC-MS/MS method for the simultaneous determination of the metabolites in the tryptophan pathway in rat plasma.
Topics: Acute Kidney Injury; Animals; Biomarkers; Chromatography, High Pressure Liquid; Chromatography, Liqu | 2022 |
Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Kynure | 2023 |
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kyn | 2023 |
Predictive metabolomic signatures of end-stage renal disease: A multivariate analysis of population-based data.
Topics: Biomarkers; Case-Control Studies; Cresols; Female; Humans; Kidney Failure, Chronic; Kynurenine; Male | 2018 |
Serum indoleamine 2,3 dioxygenase and tryptophan and kynurenine ratio using the UPLC-MS/MS method, in patients undergoing peritoneal dialysis, hemodialysis, and kidney transplantation.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Indoleamine-Pyrro | 2016 |
The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.
Topics: Adult; Age Factors; Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Stud | 2009 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease.
Topics: Biomarkers; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Kynurenine; Male; Middle | 2009 |
Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients.
Topics: Adult; Aged; Blood Coagulation; Female; Humans; Kidney Failure, Chronic; Kynurenine; Lipoproteins; M | 2009 |
[Tryptophan and its metabolites in renal allograft recipients].
Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine | 2009 |
Kynurenine and its metabolites--kynurenic acid and anthranilic acid are associated with soluble endothelial adhesion molecules and oxidative status in patients with chronic kidney disease.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Intercellular Adhesion Molecule-1; Kidney Failure | 2009 |
Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment.
Topics: Adult; Aged; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Female; Fibrinolysis; Hum | 2010 |
Kynurenine pathway - a new link between endothelial dysfunction and carotid atherosclerosis in chronic kidney disease patients.
Topics: Adult; Carotid Artery Diseases; Cell Adhesion Molecules; Chromatography, High Pressure Liquid; Cross | 2010 |
Relationship between an increased serum kynurenine/tryptophan ratio and atherosclerotic parameters in hemodialysis patients.
Topics: Adult; Aged; Ankle Brachial Index; Atherosclerosis; Carotid Arteries; Female; Humans; Indoleamine-Py | 2010 |
Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection.
Topics: Acute Disease; Adult; Aged; Biopsy; Female; Graft Rejection; Humans; Kidney Cortex Necrosis; Kidney | 2010 |
Increased levels of 3-hydroxykynurenine in different brain regions of rats with chronic renal insufficiency.
Topics: Animals; Brain; Kidney Failure, Chronic; Kynurenine; Male; Rats; Rats, Wistar; Signal Transduction; | 2002 |
Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Dioxygenases; Enzyme Activation; Kidney Failure, Chr | 2003 |
Kynurenine metabolism in central nervous system in experimental chronic renal failure.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Kidney Failure, Chronic; Kynurenin | 2003 |
Mechanism of inhibitory effect of 3-hydroxykynurenine on erythropoiesis in patients with renal insufficiency.
Topics: Adult; Aged; Anemia; Case-Control Studies; Cell Line; Erythropoiesis; Erythropoietin; Female; Humans | 2003 |
Kidney and liver kynurenine pathway enzymes in chronic renal failure.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Failure, Chronic; Kynurenine; Kynureni | 2003 |
Kynurenine and neopterin in chronic glomerulonephritis.
Topics: Biomarkers; Chronic Disease; Creatinine; Fasting; Glomerular Filtration Rate; Glomerulonephritis; Gl | 1999 |
Kynurenine and its metabolites in the rat with experimental renal insufficiency.
Topics: Animals; Drinking; Eating; Kidney Failure, Chronic; Kynurenine; Male; Quinolinic Acid; Rats; Rats, W | 2001 |
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynureni | 2002 |
Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Kynurenine; Liver; M | 1988 |