kynurenine has been researched along with Innate Inflammatory Response in 274 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Pro-inflammatory cytokines from persistent low-grade inflammation not only contribute to the development of chronic pain conditions, but also regulate various aspects of the tryptophan metabolism, especially that of the kynurenine pathway (KP)." | 9.41 | Glucocorticoid Hormones as Modulators of the Kynurenine Pathway in Chronic Pain Conditions. ( Jovanovic, F; Jovanovic, V; Knezevic, NN, 2023) |
| "To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investigated the associations of PLP with metabolites of one-carbon metabolism, tryptophan catabolism, and inflammation in OC users, and evaluated the effects of OCs on these metabolites." | 9.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| " Depression could result from changes in tryptophan availability caused by activation of the kynurenine pathway as a result of inflammation." | 9.14 | Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. ( Bridel, MA; Christofides, J; Cowlard, R; Darlington, LG; Forrest, CM; Mackay, GM; Mitchell, S; Stone, TW, 2009) |
| "Tryptophan catabolites (TRYCATs) are implicated in the pathophysiology of mood disorders by mediating immune-inflammation and neurodegenerative processes." | 9.12 | Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis. ( Coppens, V; De Picker, L; Giltay, EJ; Hebbrecht, K; Morrens, M; Skorobogatov, K, 2021) |
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 9.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| "There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflammatory response system." | 9.10 | Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. ( Bonaccorso, S; Bosmans, E; Maes, M; Ombelet, W; Scharpé, S; Verkerk, R, 2002) |
| "The tryptophan metabolite kynurenine increases with aging and inflammation, and appears to contribute directly to the development and progression of several age-related conditions." | 9.05 | Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan. ( Hamrick, MW; Kaiser, H; Parker, E, 2020) |
| "In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia." | 9.05 | Effects of inflammation on the kynurenine pathway in schizophrenia - a systematic review. ( Elyamany, O; Mulert, C; Pedraz-Petrozzi, B; Rummel, C, 2020) |
| " In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role in the development and persistence of both diseases." | 9.01 | Inflammation in cancer and depression: a starring role for the kynurenine pathway. ( Mondelli, V; Nettis, MA; Pariante, CM; Sforzini, L, 2019) |
| " However, other pathophysiological features of the disease have emerged including neuroinflammation and dysregulation of the kynurenine pathway (KP)." | 9.01 | Microbiota Alterations in Alzheimer's Disease: Involvement of the Kynurenine Pathway and Inflammation. ( Garcez, ML; Guillemin, GJ; Jacobs, KR, 2019) |
| "Recently, neuroinflammation and the immune-kynurenine pathway have received increased attention in the psychoimmunology field of major depressive disorder (MDD), while studies related to anxiety disorders have been very limited." | 8.98 | Neuroinflammation and the Immune-Kynurenine Pathway in Anxiety Disorders. ( Jeon, SW; Kim, YK, 2018) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 8.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| " The aim of this article is to present results of contemporary research studies over mutual connections between social cognition, cognitive processes and inflammatory factors significant for the aetiology of recurrent depressive disorders, with particular reference to the role of kynurenine pathways." | 8.93 | Cognition and Emotions in Recurrent Depressive Disorders - The Role of Inflammation and the Kynurenine Pathway. ( Galecki, P; Talarowska, M, 2016) |
| "BACKGROUNDThe kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation." | 8.31 | Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. ( Fang, EF; Figved, W; Frihagen, F; Giil, LM; Godø, A; Halaas, NB; Hassel, B; Henjum, K; Idland, AV; Knapskog, AB; McCann, A; Myrstad, M; Neerland, BE; Pollmann, CT; Quist-Paulsen, E; Raeder, J; Selbæk, G; Ueland, PM; Watne, LO; Zetterberg, H, 2023) |
| "This work aimed to characterize the kynurenine pathway, activated during interferon-γ (IFN-γ)-mediated inflammation and cellular (T-helper type 1 [Th1] type) immunity, in GD patients with and without thyroid eye disease (TED)." | 8.31 | Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy. ( Breivik, LE; Husebye, E; Løvås, K; Nilsen, RM; Rødahl, E; Stokland, AM; Ueland, GÅ; Ueland, HO; Ulvik, A; Wolff, ASB, 2023) |
| " Studies have shown that both stress and MDD, especially the more severe conditions of the disorder, are associated with inflammation and neuroinflammation and the relationship to an imbalance in tryptophan metabolism towards the kynurenine pathway (KP) through the enzymes indoleamine-2,3-dioxygenase (IDO), which is mainly stimulated by pro-inflammatory cytokines and tryptophan-2,3-dioxygenase (TDO) which is activated primarily by glucocorticoids." | 8.31 | Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder. ( Bertollo, AG; de Oliveira, T; Ignácio, ZM; Mingoti, MED, 2023) |
| "There were statistically significant increases of CSF neopterin, kynurenine, quinolinic acid and kynurenine/tryptophan ratio (KYN/TRP) in the inflammation group compared to all control groups (all p < 0." | 8.31 | CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. ( Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J, 2023) |
| "Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now." | 8.31 | Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. ( Baillie, JK; Baily, J; Binnie, M; Bochkina, NA; Garden, OJ; Hayes, AJ; Homer, NZM; Howie, SEM; Iredale, JP; Just, G; Liddle, J; McGuire, K; Mole, DJ; Murray, TBJ; Neyton, LPA; O'Kelly, J; Skouras, C; Uings, I; Webster, SP; Zheng, X, 2023) |
| " The kynurenine and catecholamine metabolic pathways are modulated by inflammation and can affect systemic levels of serotonin and dopamine." | 8.31 | The effect of inflammation, SARS-CoV-2 infection, age and mental health on serotonin, and kynurenine and catecholamine pathway metabolites. ( Bruckner, T; Deisenhammer, EA; Egeter, J; Galffy, M; Giesinger, JM; Gostner, JM; Holzner, B; Hüfner, K; Lehmann, J; Nelles, P; Oberhammer, M; Rockenschaub, J; Sacher, M; Sperner-Unterweger, B; Tymoszuk, P; Vedova, S, 2023) |
| "The aim of this study was to identify the effects of smoking and periodontal inflammation on tryptophan-kynurenine metabolism as well as the correlation between these findings and clinical periodontal parameters." | 8.31 | Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study. ( Akdoğan, N; Balci, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, CC; Serdar, MA, 2023) |
| "This study analyzed the difference in serum metabolic profiles between patients with severe pneumonia and health individuals through metabolomics, aiming to uncover the correlation between the Tryptophan-Kynurenine pathway and the severity of severe pneumonia, as well as N-3/N-6 polyunsaturated fatty acids (PUFAs)." | 8.31 | Correlation between immune-related Tryptophan-Kynurenine pathway and severity of severe pneumonia and inflammation-related polyunsaturated fatty acids. ( Gan, H; Guo, B; Liao, Y; Lin, R; Liu, M; Lyu, J; Sun, B; Xue, M; Zhang, T; Zheng, P, 2023) |
| "An inflammation panel of 13 metabolites (neopterin, tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine, xanthurenic acid, anthranilic acid, 3-hydroxyanthranilic acid, quinolinic acid, picolinic acid, arginine, citrulline and methylhistamine) was measured based on a simple precipitation and filtration method using minimal CSF volume." | 8.12 | Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites. ( Bandodkar, S; Dale, RC; Guillemin, GJ; Han, VX; Heng, B; Yan, J, 2022) |
| "Our results suggest that periodontal inflammation plays a role in local and systemic tryptophan-kynurenine metabolism." | 8.12 | Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study. ( Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA, 2022) |
| "The kynurenine pathway (KP) and inflammation are substantial in depression pathogenesis." | 8.12 | A kynurenine pathway enzyme aminocarboxymuconate-semialdehyde decarboxylase may be involved in treatment-resistant depression, and baseline inflammation status of patients predicts treatment response: a pilot study. ( Aslan, S; Bolu, A; Bozkurt, A; Bukan, N; Cevik, C; Cicek, S; Ekmekci Ertek, I; Karadag, RF; Kocak, C; Sen, B; Ucar, H; Yilmaz, NS, 2022) |
| "Inflammation and glutamate (GLU) are widely thought to participate in the pathogenesis of depression, and current evidence suggests that the development of depression is associated with the activation of the kynurenine pathway (KP)." | 8.12 | Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model. ( Chen, B; Di, Z; Guo, Q; Hu, R; Jiang, S; Liu, J; Ma, R; Shi, M; Song, Z; Sun, S; Wu, X; Xu, H, 2022) |
| "Thirty-four blood markers relating to inflammation, B vitamin status, and the kynurenine pathway were measured in 976 participants in the Melbourne Collaborative Cohort Study at baseline (median age = 59 years) and follow-up (median age = 70 years)." | 8.12 | Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging. ( Dugué, PA; English, DR; Flicker, L; Giles, GG; Hodge, AM; Li, SX; MacInnis, RJ; Meyer, K; Midttun, Ø; Milne, RL; Navionis, AS; Rinaldi, S; Severi, G; Southey, MC; Tell, GS; Ueland, PM; Ulvik, A; Vineis, P, 2022) |
| "Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a role in depression pathophysiology." | 8.02 | The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation. ( Allers, KA; Beekman, ATF; Giltay, EJ; Keller, S; Milaneschi, Y; Niessen, HG; Penninx, BWJH; Schoevers, RA; Süssmuth, SD, 2021) |
| "Mania and chronic depressive symptoms in BD are accompanied by a strong interaction between inflammation and a potentially neurotoxic kynurenine metabolism." | 7.96 | A mood state-specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder. ( Coppens, V; de Boer, P; Fransen, E; Lai, FY; Morrens, M; Sabbe, B; Schuermans, J; Timmers, M; van den Ameele, S; van Diermen, L; van Nuijs, AL; Verkerk, R, 2020) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 7.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| "Kynurenine pathway (KP) metabolites are believed to be a link between inflammation and depression through effects on brain glutamate receptors." | 7.96 | Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression. ( Baer, W; Felger, JC; Goldsmith, DR; Haroon, E; Miller, AH; Patel, T; Welle, JR; Woolwine, BJ, 2020) |
| "We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 221 cerebrospinal fluid samples from patients with bacterial and viral (due to herpes simplex, varicella zoster, and enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (due to anti-N-methyl-D-aspartate receptor [NMDA] encephalitis and multiple sclerosis), and noninflamed controls (ie, individuals with Bell palsy, normal pressure hydrocephalus, or Tourette syndrome)." | 7.91 | Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections. ( Kaever, V; Kuhn, M; Müller-Vahl, K; Novoselova, N; Pessler, F; Seegers, L; Skripuletz, T; Stangel, M; Sühs, KW; Trebst, C, 2019) |
| " Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation." | 7.91 | Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. ( Kubo, H; Morikawa, M; Mouri, A; Nabeshima, T; Nakamura, Y; Okada, T; Ozaki, N; Saito, K; Shiino, T; Teshigawara, T; Yamamoto, Y, 2019) |
| "To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood." | 7.88 | Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. ( D'Agata, A; Duffy, A; Fuchs, D; Groer, M; Louis-Jacques, A; Postolache, TT, 2018) |
| "Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors." | 7.88 | Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation. ( Delgado, J; Garrison, AM; O'Connor, JC; Parrott, JM; Redus, L; Tuñon, A, 2018) |
| "In both cohorts, inflammation as measured by higher levels of CRP, sVCAM1 and sICAM1 was associated with kynurenine/tryptophan ratio and thus enhanced tryptophan breakdown (beta: 0." | 7.88 | Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts. ( Carvalho, LA; Clarke, G; Díaz, LE; Gómez-Martínez, S; Marcos, A; Michels, N; Olavarria-Ramirez, L; Widhalm, K, 2018) |
| " Inflammation induces tryptophan metabolism along the kynurenine pathway (KP) and yields immunologically relevant metabolites." | 7.88 | Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. ( Bissonnette, M; Ciorba, MA; Guillemin, GJ; Lim, CK; Meckel, K; Pekow, JR; Sofia, MA; Weber, CR, 2018) |
| " The aim of this study was to investigate the changes of inflammation markers with chronic Pb exposure by analyzing neopterin levels and kynurenine (Kyn) to tryptophan (Trp) ratio that reflects indolamine 2,3-dioxygenase activity and to compare with healthy volunteers' parameters." | 7.85 | Possible changes of New-Generation inflammation markers with occupational lead exposure. ( Baydar, T; Girgin, G; Palabiyik, SS; Sipahi, H; Tutkun, E; Yilmaz, OH, 2017) |
| "We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause and cause-specific mortality in a general population sample." | 7.83 | Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study. ( Eussen, SJ; Meyer, K; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE; Zuo, H, 2016) |
| "Inflammatory proteins are thought to be causally involved in the generation of aggression, possibly due to direct effects of cytokines in the central nervous system and/or by generation of inflammatory metabolites along the tryptophan-kynurenine (TRP/KYN) pathway, including KYN and its active metabolites kynurenic acid (KA), quinolinic acid (QA), and picolinic acid (PA)." | 7.83 | Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects. ( Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R, 2016) |
| "The kynurenine pathway of tryptophan metabolism has an important role in mediating the behavioral effects of inflammation, which has implications in understanding neuropsychiatric comorbidity and for the development of novel therapies." | 7.83 | Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. ( Gao, X; Morales, J; O'Connor, JC; Parrott, JM; Redus, L; Santana-Coelho, D, 2016) |
| "A negative association between systemic markers of inflammation and plasma vitamin B-6 has been observed in population-based and patient cohorts; however, vitamin B-6 (pyridoxine) treatment has mostly failed to improve inflammatory indexes." | 7.78 | Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris. ( Midttun, Ø; Nygård, O; Pedersen, ER; Ueland, PM; Ulvik, A, 2012) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 7.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| " In plasma from 3035 patients undergoing coronary angiography for suspected coronary heart disease, we investigated if plasma concentrations of any metabolites in the kynurenine pathway, which depend on PLP as cofactor, may serve as metabolic marker(s) of vitamin B-6 status." | 7.77 | Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. ( Bleie, O; Ebbing, M; Midttun, O; Nilsen, RM; Nygård, O; Ringdal Pedersen, E; Schartum-Hansen, H; Ueland, PM; Ulvik, A, 2011) |
| "Patients (n = 16) with septic shock had indoleamine 2,3-dioxygenase activity assessed as the kynurenine-to-tryptophan ratio, and the severity of hypotension was determined by their inotrope requirements." | 7.77 | Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. ( Celermajer, DS; Changsirivathanathamrong, D; dos Remedios, CG; Duflou, J; Gebski, V; Maghzal, GJ; Mak, WM; Rajbhandari, D; Stocker, R; Wang, Y; Woolfe, C, 2011) |
| " The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS." | 7.76 | The kynurenine pathway and inflammation in amyotrophic lateral sclerosis. ( Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R, 2010) |
| "Post-stroke inflammation may induce upregulation of the kynurenine (KYN) pathway for tryptophan (TRP) oxidation, resulting in neuroprotective (kynurenic acid, KA) and neurotoxic metabolites (3-hydroxyanthranillic acid, 3-HAA)." | 7.76 | The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke. ( Aerts, T; Brouns, R; De Deyn, PP; De Surgeloose, D; Scharpé, S; Verkerk, R; Wauters, A, 2010) |
| "Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown." | 7.75 | The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. ( Domaniewski, T; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| " Here we show that a superoxide-dependent step in tryptophan metabolism along the kynurenine pathway is blocked in CGD mice with lethal pulmonary aspergillosis, leading to unrestrained Vgamma1(+) gammadelta T-cell reactivity, dominant production of interleukin (IL)-17, defective regulatory T-cell activity and acute inflammatory lung injury." | 7.74 | Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. ( Bistoni, F; D'Angelo, C; De Luca, A; Fallarino, F; Fioretti, MC; Grohmann, U; Montagnoli, C; Puccetti, P; Romani, L; Segal, BH; Vacca, C; Zelante, T, 2008) |
| "Although depression is categorized as a brain disorder, its symptomatology includes some behaviors that also occur during chronic inflammatory stress." | 7.01 | The Interrelation between Oxidative Stress, Depression and Inflammation through the Kynurenine Pathway. ( Aydin, A; Mat, AF; Ozhan, Y; Sipahi, H, 2023) |
| "The kynurenine pathway (KP) is a major route of the essential amino acid L-tryptophan (Trp) catabolism in mammalian cells." | 7.01 | Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder. ( Fang, K; Imamura, Y; Kasahara, Y; Konishi, Y; Momono, Y; Murakami, Y; Nishiyama, T; Sakai, D; Yoshida, C, 2023) |
| "Inflammation has an important physiological influence on mood and behavior." | 6.90 | Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019) |
| "A chronic low-grade inflammation is associated with the aging process, a state called inflammaging." | 6.82 | Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process. ( Salminen, A, 2022) |
| "contribute to the development of coronary atherosclerosis and subsequent coronary artery disease." | 6.72 | Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease. ( Berkecz, R; Csont, T; Demján, V; Gáspár, R; Halmi, D; Pipicz, M, 2021) |
| "Ketamine is a novel rapid-acting antidepressant with high efficacy in treatment-resistant patients." | 6.72 | Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review. ( Kopra, E; Mondelli, V; Nikkheslat, N; Pariante, C, 2021) |
| "Many patients with cancer suffer from anemia, depression, and an impaired quality of life (QoL)." | 6.66 | Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer. ( Egger, EM; Fuchs, D; Kink, P; Kurz, K; Lanser, L; Weiss, G; Willenbacher, W, 2020) |
| "Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor dysfunctions to psychobehavioral manifestations." | 6.66 | Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines. ( Tanaka, M; Toldi, J; Vécsei, L, 2020) |
| "The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial disturbances, glutamate excitotoxicity, and neuroinflammation." | 6.58 | Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines. ( Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D, 2018) |
| "Hence, abdominal obesity is associated with vascular endothelial dysfunction and reduced nitric oxide (NO) availability." | 6.55 | The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity. ( Engin, A; Engin, AB, 2017) |
| "Some degree of inflammation is required for protection, particularly in mucosal tissues, during the transitional response occurring between the rapid innate and slower adaptive response." | 6.44 | IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi. ( De Luca, A; Fallarino, F; Puccetti, P; Romani, L; Zelante, T, 2008) |
| "The kynurenine pathway (KP) is a major route of L-tryptophan catabolism leading to production of several neurobiologically active molecules." | 6.43 | Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis. ( Brew, BJ; Guillemin, GJ; Meininger, V, 2005) |
| "The kynurenine pathway (KP) has been considered an important player in inflammation and immune response." | 5.91 | Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever. ( Gülcemal, S; Hakbilen, S; Körez, MK; Onmaz, DE; Sivrikaya, A; Tezcan, D; Yılmaz, S, 2023) |
| "Chronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs)." | 5.91 | A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation. ( Bagaglia, F; Bianconi, V; Colangelo, C; Cosentini, E; Cucci, A; Fallarino, F; Figorilli, F; Follenzi, A; Franceschini, L; Fuchs, D; Gargaro, M; Giglioni, F; Mannarino, MR; Manni, G; Mencarelli, G; Padiglioni, E; Pieroni, B; Pirro, M; Puccetti, P; Ricciuti, D; Scalisi, G, 2023) |
| "Chronic low-grade inflammation is suggested to play a pathophysiological role in bipolar disorder (BD) and its related cognitive dysfunctions." | 5.72 | The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder. ( Giltay, EJ; Hebbrecht, K; Morrens, M; Sabbe, B; van den Ameele, S; van Nuijs, ALN, 2022) |
| "In 58 cognitively normal, 396 mild cognitive impairment, and 112 AD participants from the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI1) cohort, serum markers of 5-HT, tryptophan, and Kyn were measured and their relationships investigated with immunologic markers, affect and functional outcomes, CSF markers of beta-amyloid (Aβ) and tau, and regional gray matter." | 5.62 | Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway. ( Allenspach, K; Collazo-Martinez, AD; Dantzer, R; Hoth, N; Klinedinst, B; Larsen, B; Le, S; Li, T; Mochel, JP; Pappas, C; Pollpeter, A; Wang, Q; Willette, AA; Willette, SA, 2021) |
| "Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood." | 5.56 | Kynurenines link chronic inflammation to functional decline and physical frailty. ( Abadir, PM; Chung, T; de Cabo, R; Ferrucci, L; Hoke, A; Joca, H; Khadeer, M; Le, A; Lovett, J; Moaddel, R; Tian, J; Walston, J; Ward, C; Westbrook, R; Xue, QL; Yang, H, 2020) |
| "Chronic, low-level inflammation is associated with symptomatic bipolar disorder (BD) and with chronic insomnia." | 5.48 | Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder. ( Can, A; Fuchs, D; Groer, M; Krishnamurthy, VB; Millett, CE; Mukherjee, D; Postolache, TT; Reider, A; Saunders, EFH, 2018) |
| " Pro-inflammatory cytokines from persistent low-grade inflammation not only contribute to the development of chronic pain conditions, but also regulate various aspects of the tryptophan metabolism, especially that of the kynurenine pathway (KP)." | 5.41 | Glucocorticoid Hormones as Modulators of the Kynurenine Pathway in Chronic Pain Conditions. ( Jovanovic, F; Jovanovic, V; Knezevic, NN, 2023) |
| "In this narrative review, we examine the association between gut dysbiosis, neuroinflammation, and stress-linked disorders, including depression, anxiety, and post-traumatic stress disorder (PTSD), and investigate whether tryptophan (TRP) metabolism and platelets play a role in this association." | 5.41 | Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review. ( Hemmings, SMJ; Malan-Muller, S; Pretorius, E; Rust, C; Seedat, S; Tonge, D; van den Heuvel, LL, 2023) |
| "To determine whether functional vitamin B-6 insufficiency occurs in OC users and is attributable to OCs, we investigated the associations of PLP with metabolites of one-carbon metabolism, tryptophan catabolism, and inflammation in OC users, and evaluated the effects of OCs on these metabolites." | 5.20 | Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o ( Chi, YY; Coats, B; Gregory, JF; Midttun, Ø; Rios-Avila, L; Stacpoole, PW; Ueland, PM, 2015) |
| "Amelioration of both oxidative and inflammation status after cholesterol lowering treatment in CKD might be mediated by restoration of antioxidant taurine concentrations during therapy (from 51." | 5.20 | Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement. ( Carru, C; Mangoni, AA; Sanna, M; Satta, AE; Sotgia, S; Zinellu, A, 2015) |
| " Depression could result from changes in tryptophan availability caused by activation of the kynurenine pathway as a result of inflammation." | 5.14 | Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling. ( Bridel, MA; Christofides, J; Cowlard, R; Darlington, LG; Forrest, CM; Mackay, GM; Mitchell, S; Stone, TW, 2009) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| " The ratios of tryptophan to kynurenine, mainly mediated by indoleamine 2,3-dioxygenase activity, is a key parameter in the inflammation as well as immunomodulation of both aseptic and septic diseases." | 5.12 | Latest developments in tryptophan metabolism: Understanding its role in B cell immunity. ( Beji, C; Dagenais-Lussier, X; Loucif, H; Routy, JP; Telittchenko, R; van Grevenynghe, J, 2021) |
| "Tryptophan catabolites (TRYCATs) are implicated in the pathophysiology of mood disorders by mediating immune-inflammation and neurodegenerative processes." | 5.12 | Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis. ( Coppens, V; De Picker, L; Giltay, EJ; Hebbrecht, K; Morrens, M; Skorobogatov, K, 2021) |
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 5.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| " We review the literature concerning SARS-CoV2 infiltration and infection in the CNS and the prospects of synergy between stress, inflammation, and kynurenine pathway function during illness and recovery from Covid-19." | 5.12 | Covid-19 interface with drug misuse and substance use disorders. ( Cisneros, IE; Cunningham, KA, 2021) |
| "There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflammatory response system." | 5.10 | Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. ( Bonaccorso, S; Bosmans, E; Maes, M; Ombelet, W; Scharpé, S; Verkerk, R, 2002) |
| "The tryptophan metabolite kynurenine increases with aging and inflammation, and appears to contribute directly to the development and progression of several age-related conditions." | 5.05 | Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan. ( Hamrick, MW; Kaiser, H; Parker, E, 2020) |
| "In the last decade, there has been growing evidence that an interaction exists between inflammation and the kynurenine pathway in schizophrenia." | 5.05 | Effects of inflammation on the kynurenine pathway in schizophrenia - a systematic review. ( Elyamany, O; Mulert, C; Pedraz-Petrozzi, B; Rummel, C, 2020) |
| " Recent research suggests that gut inflammation can induce neuroinflammation which, in turn, stimulates microglia activation and the kynurenine pathway and can activate systemic inflammation-inducing depressive symptoms." | 5.01 | Microbiome and Mental Health, Specifically as It Relates to Adolescents. ( Simkin, DR, 2019) |
| " In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role in the development and persistence of both diseases." | 5.01 | Inflammation in cancer and depression: a starring role for the kynurenine pathway. ( Mondelli, V; Nettis, MA; Pariante, CM; Sforzini, L, 2019) |
| " However, other pathophysiological features of the disease have emerged including neuroinflammation and dysregulation of the kynurenine pathway (KP)." | 5.01 | Microbiota Alterations in Alzheimer's Disease: Involvement of the Kynurenine Pathway and Inflammation. ( Garcez, ML; Guillemin, GJ; Jacobs, KR, 2019) |
| "Recently, neuroinflammation and the immune-kynurenine pathway have received increased attention in the psychoimmunology field of major depressive disorder (MDD), while studies related to anxiety disorders have been very limited." | 4.98 | Neuroinflammation and the Immune-Kynurenine Pathway in Anxiety Disorders. ( Jeon, SW; Kim, YK, 2018) |
| "Inflammation is not the only cause of depression and cannot explain its entire pathophysiology, but it is an important pathogenic factor that explains one possible mechanism of depression, with the kynurenine (KYN) pathway of tryptophan at its center." | 4.95 | Inflammation-induced depression: Its pathophysiology and therapeutic implications. ( Jeon, SW; Kim, YK, 2017) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 4.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| " The aim of this article is to present results of contemporary research studies over mutual connections between social cognition, cognitive processes and inflammatory factors significant for the aetiology of recurrent depressive disorders, with particular reference to the role of kynurenine pathways." | 4.93 | Cognition and Emotions in Recurrent Depressive Disorders - The Role of Inflammation and the Kynurenine Pathway. ( Galecki, P; Talarowska, M, 2016) |
| "Tryptophan metabolism is critical for cell proliferation, inflammation and immunoregulation." | 4.91 | The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment. ( Becker, K; Fuchs, D; Gostner, JM; Überall, F, 2015) |
| "Future research on the cerebral cell-type specific distribution of kynurenine metabolites and their brain-regional concentration imbalances will be required to connect peripheral immune changes, the hypotheses of blood-brain barrier dysfunction and glial pathology with concepts of altered neurotransmission in schizophrenia and major depression." | 4.88 | Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity. ( Bernstein, HG; Bogerts, B; Gos, T; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M, 2012) |
| "There was a significant accumulation of kynurenine and kynurenic acid (KYNA) in children and adults with ADPKD as compared to healthy subjects." | 4.31 | Kynurenines in polycystic kidney disease. ( Cadnapaphornchai, MA; Chonchol, M; Christians, U; Gitomer, BY; Hopp, K; Jackson, MJ; Klawitter, J; Smith, PH, 2023) |
| "BACKGROUNDThe kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation." | 4.31 | Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. ( Fang, EF; Figved, W; Frihagen, F; Giil, LM; Godø, A; Halaas, NB; Hassel, B; Henjum, K; Idland, AV; Knapskog, AB; McCann, A; Myrstad, M; Neerland, BE; Pollmann, CT; Quist-Paulsen, E; Raeder, J; Selbæk, G; Ueland, PM; Watne, LO; Zetterberg, H, 2023) |
| "This work aimed to characterize the kynurenine pathway, activated during interferon-γ (IFN-γ)-mediated inflammation and cellular (T-helper type 1 [Th1] type) immunity, in GD patients with and without thyroid eye disease (TED)." | 4.31 | Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy. ( Breivik, LE; Husebye, E; Løvås, K; Nilsen, RM; Rødahl, E; Stokland, AM; Ueland, GÅ; Ueland, HO; Ulvik, A; Wolff, ASB, 2023) |
| "Circulating concentrations of metabolites (collectively called kynurenines) in the kynurenine pathway of tryptophan metabolism increase during inflammation, particularly in response to interferon-gamma (IFN-γ)." | 4.31 | A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium. ( Arslan, AA; Behndig, AF; Brennan, P; Cai, Q; Chen, C; Chen, Y; Fanidi, A; Freedman, ND; Gaziano, JM; Giles, GG; Huang, WY; Johansson, M; Koh, WP; Langhammer, A; Le Marchand, L; Manjer, J; Meyer, K; Midttun, Ø; Prentice, R; Robbins, HA; Sandsveden, M; Sesso, HD; Shu, XO; Stevens, VL; Sørgjerd, EP; Ueland, PM; Ulvik, A; Visvanathan, K; Wang, Y; Weinstein, SJ; Yuan, JM; Zahed, H; Zhang, X; Zheng, W, 2023) |
| " Studies have shown that both stress and MDD, especially the more severe conditions of the disorder, are associated with inflammation and neuroinflammation and the relationship to an imbalance in tryptophan metabolism towards the kynurenine pathway (KP) through the enzymes indoleamine-2,3-dioxygenase (IDO), which is mainly stimulated by pro-inflammatory cytokines and tryptophan-2,3-dioxygenase (TDO) which is activated primarily by glucocorticoids." | 4.31 | Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder. ( Bertollo, AG; de Oliveira, T; Ignácio, ZM; Mingoti, MED, 2023) |
| "There were statistically significant increases of CSF neopterin, kynurenine, quinolinic acid and kynurenine/tryptophan ratio (KYN/TRP) in the inflammation group compared to all control groups (all p < 0." | 4.31 | CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation. ( Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J, 2023) |
| " In addition to hsCRP, Kynurenine seems to be a reliable biomarker to monitor acute and regenerative inflammation status of alloSCT patients, while Musclin and Galectin-3 may be added to physiological assessment regarding myopathy and sarcopenia." | 4.31 | Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients - a pilot study for novel biomarker and risk stratification determination. ( Bizjak, DA; Bunjes, D; John, L; Kirsten, J; Moebes, E; Sala, E; Schulz, SVW; Steinacker, JM; Wais, V, 2023) |
| "Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now." | 4.31 | Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. ( Baillie, JK; Baily, J; Binnie, M; Bochkina, NA; Garden, OJ; Hayes, AJ; Homer, NZM; Howie, SEM; Iredale, JP; Just, G; Liddle, J; McGuire, K; Mole, DJ; Murray, TBJ; Neyton, LPA; O'Kelly, J; Skouras, C; Uings, I; Webster, SP; Zheng, X, 2023) |
| " The kynurenine and catecholamine metabolic pathways are modulated by inflammation and can affect systemic levels of serotonin and dopamine." | 4.31 | The effect of inflammation, SARS-CoV-2 infection, age and mental health on serotonin, and kynurenine and catecholamine pathway metabolites. ( Bruckner, T; Deisenhammer, EA; Egeter, J; Galffy, M; Giesinger, JM; Gostner, JM; Holzner, B; Hüfner, K; Lehmann, J; Nelles, P; Oberhammer, M; Rockenschaub, J; Sacher, M; Sperner-Unterweger, B; Tymoszuk, P; Vedova, S, 2023) |
| "The aim of this study was to identify the effects of smoking and periodontal inflammation on tryptophan-kynurenine metabolism as well as the correlation between these findings and clinical periodontal parameters." | 4.31 | Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study. ( Akdoğan, N; Balci, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, CC; Serdar, MA, 2023) |
| "Depression can be associated with chronic systemic inflammation, and production of peripheral proinflammatory cytokines and upregulation of the kynurenine pathway have been implicated in pathogenesis of depression." | 4.31 | Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. ( Bibb, JA; Chakraborti, A; Funakoshi, H; Kanai, M; Kawahara, Y; Kuroiwa, M; Murakami, Y; Nishi, A; Ohnishi, YN; Shuto, T; Sin, R; Sotogaku, N; Sugiyama, K, 2023) |
| "This study analyzed the difference in serum metabolic profiles between patients with severe pneumonia and health individuals through metabolomics, aiming to uncover the correlation between the Tryptophan-Kynurenine pathway and the severity of severe pneumonia, as well as N-3/N-6 polyunsaturated fatty acids (PUFAs)." | 4.31 | Correlation between immune-related Tryptophan-Kynurenine pathway and severity of severe pneumonia and inflammation-related polyunsaturated fatty acids. ( Gan, H; Guo, B; Liao, Y; Lin, R; Liu, M; Lyu, J; Sun, B; Xue, M; Zhang, T; Zheng, P, 2023) |
| "Abnormal kynurenine (Kyn) metabolism has been closely linked to the pathogenesis of rheumatoid arthritis (RA)." | 4.12 | Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis. ( Chang, Y; Han, P; Jia, C; Li, S; Wang, X; Wang, Y; Wei, W; Yang, X; Zhang, B; Zhao, Y, 2022) |
| "GM changes accompanying pregnancy shift IDO1-dependent tryptophan metabolism toward kynurenine production, intestinal inflammation, and gestational IR, a phenotype reversed by genetic deletion or inhibition of IDO1." | 4.12 | Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis. ( Allard, S; Bernabe, BP; Chlipala, GE; Dai, Y; Garcia, MS; Gilbert, J; Gill, RK; Khan, MW; Layden, BT; Lednovich, K; Maki, PM; Manzella, CR; Navarro, G; Perdew, GH; Priyadarshini, M; Reiman, DJ; Sharma, A; Szynal, B; Wicksteed, B; Xu, K, 2022) |
| "An inflammation panel of 13 metabolites (neopterin, tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine, xanthurenic acid, anthranilic acid, 3-hydroxyanthranilic acid, quinolinic acid, picolinic acid, arginine, citrulline and methylhistamine) was measured based on a simple precipitation and filtration method using minimal CSF volume." | 4.12 | Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites. ( Bandodkar, S; Dale, RC; Guillemin, GJ; Han, VX; Heng, B; Yan, J, 2022) |
| "Our results suggest that periodontal inflammation plays a role in local and systemic tryptophan-kynurenine metabolism." | 4.12 | Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study. ( Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA, 2022) |
| "The kynurenine pathway (KP) and inflammation are substantial in depression pathogenesis." | 4.12 | A kynurenine pathway enzyme aminocarboxymuconate-semialdehyde decarboxylase may be involved in treatment-resistant depression, and baseline inflammation status of patients predicts treatment response: a pilot study. ( Aslan, S; Bolu, A; Bozkurt, A; Bukan, N; Cevik, C; Cicek, S; Ekmekci Ertek, I; Karadag, RF; Kocak, C; Sen, B; Ucar, H; Yilmaz, NS, 2022) |
| "Inflammation and glutamate (GLU) are widely thought to participate in the pathogenesis of depression, and current evidence suggests that the development of depression is associated with the activation of the kynurenine pathway (KP)." | 4.12 | Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model. ( Chen, B; Di, Z; Guo, Q; Hu, R; Jiang, S; Liu, J; Ma, R; Shi, M; Song, Z; Sun, S; Wu, X; Xu, H, 2022) |
| "Thirty-four blood markers relating to inflammation, B vitamin status, and the kynurenine pathway were measured in 976 participants in the Melbourne Collaborative Cohort Study at baseline (median age = 59 years) and follow-up (median age = 70 years)." | 4.12 | Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging. ( Dugué, PA; English, DR; Flicker, L; Giles, GG; Hodge, AM; Li, SX; MacInnis, RJ; Meyer, K; Midttun, Ø; Milne, RL; Navionis, AS; Rinaldi, S; Severi, G; Southey, MC; Tell, GS; Ueland, PM; Ulvik, A; Vineis, P, 2022) |
| "Tryptophan catabolites ("TRYCATs") produced by the kynurenine pathway (KP) may play a role in depression pathophysiology." | 4.02 | The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation. ( Allers, KA; Beekman, ATF; Giltay, EJ; Keller, S; Milaneschi, Y; Niessen, HG; Penninx, BWJH; Schoevers, RA; Süssmuth, SD, 2021) |
| "Mania and chronic depressive symptoms in BD are accompanied by a strong interaction between inflammation and a potentially neurotoxic kynurenine metabolism." | 3.96 | A mood state-specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder. ( Coppens, V; de Boer, P; Fransen, E; Lai, FY; Morrens, M; Sabbe, B; Schuermans, J; Timmers, M; van den Ameele, S; van Diermen, L; van Nuijs, AL; Verkerk, R, 2020) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 3.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| "Kynurenine pathway (KP) metabolites are believed to be a link between inflammation and depression through effects on brain glutamate receptors." | 3.96 | Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression. ( Baer, W; Felger, JC; Goldsmith, DR; Haroon, E; Miller, AH; Patel, T; Welle, JR; Woolwine, BJ, 2020) |
| " Evidence has suggested that the activation of indoleamine-2,3-dioxygenase (IDO), the rate-limiting enzyme in the kynurenine pathway (KP), plays a crucial role in inflammation-related diseases." | 3.96 | Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice. ( Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS, 2020) |
| " We investigated the associations for circulating levels of tryptophan, kynurenine, kynurenine:tryptophan ratio (KTR), quinolinic acid (QA) and neopterin as markers of immune regulation and inflammation with lung cancer risk in 5,364 smoking-matched case-control pairs from 20 prospective cohorts included in the international Lung Cancer Cohort Consortium." | 3.96 | Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). ( Albanes, D; Alcala, K; Arslan, AA; Blot, WJ; Brennan, P; Buring, JE; Cai, Q; Caporaso, NE; Fanidi, A; Freedman, ND; Gao, YT; Gaziano, JM; Giles, GG; Grankvist, K; Haiman, CA; Han, J; Hodge, AM; Huang, JY; Hveem, K; Johansson, M; Koh, WP; Lan, Q; Langhammer, A; Larose, TL; Le Marchand, L; Lee, IM; Li, HL; Luu, HN; Manjer, J; Midttun, Ø; Pettinger, M; Prentice, RL; Purdue, MP; Relton, C; Sesso, HD; Severi, G; Shu, XO; Stampfer, MJ; Stevens, VL; Thomson, CA; Ueland, PM; Ulvi, A; Visvanathan, K; Wang, R; Weinstein, SJ; Wilkens, LR; Wu, J; Xiang, YB; Yuan, JM; Zeleniuch-Jacquotte, A; Zhang, X; Zheng, W; Ziegler, RG, 2020) |
| " The aim of the present study was to analyze gut microbiota composition in bipolar disorder (BD) and its relation to inflammation, serum lipids, oxidative stress, tryptophan (TRP)/kynurenine (KYN) levels, anthropometric measurements and parameters of metabolic syndrome." | 3.91 | A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode. ( Bengesser, S; Birner, A; Dalkner, N; Fellendorf, F; Gorkiewicz, G; Halwachs, B; Holl, AK; Holzer, P; Kapfhammer, HP; Kashofer, K; Moll, N; Mörkl, S; Painold, A; Platzer, M; Queissner, R; Reininghaus, EZ; Schütze, G; Schwarz, MJ, 2019) |
| "In participants with intermediate-stage AMD at enrollment in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) and 2:1 controls matched for age and sex, cryopreserved baseline plasma specimens were assayed for biomarkers of inflammation, including high-sensitivity C-reactive protein (CRP), interleukin (IL)-6, interferon-γ inducible protein (IP)-10, soluble CD14 (sCD14), soluble CD163 (sCD163), kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding protein (I-FABP)." | 3.91 | Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation. ( Cheu, R; Danis, RP; Hunt, PW; Jabs, DA; Jones, NG; Klatt, NR; Milush, JM; Trang, G; Van Natta, ML, 2019) |
| "Tryptophan, its downstream metabolites in the kynurenine pathway and neopterin have been associated with inflammation and dementia." | 3.91 | The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study. ( Aarsland, D; Giil, LM; McCann, A; Meyer, K; Midttun, Ø; Nordrehaug, JE; Nygård, O; Refsum, H; Smith, AD; Solvang, SH; Tell, GS; Ueland, PM; Vedeler, CA, 2019) |
| "We measured concentrations of kynurenine (Kyn) and tryptophan (Trp) in 221 cerebrospinal fluid samples from patients with bacterial and viral (due to herpes simplex, varicella zoster, and enteroviruses) meningitis/encephalitis, neuroborreliosis, autoimmune neuroinflammation (due to anti-N-methyl-D-aspartate receptor [NMDA] encephalitis and multiple sclerosis), and noninflamed controls (ie, individuals with Bell palsy, normal pressure hydrocephalus, or Tourette syndrome)." | 3.91 | Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections. ( Kaever, V; Kuhn, M; Müller-Vahl, K; Novoselova, N; Pessler, F; Seegers, L; Skripuletz, T; Stangel, M; Sühs, KW; Trebst, C, 2019) |
| " Tryptophan (TRP) metabolism has attracted considerable attention due to its influence on the onset of depression via induction of inflammation." | 3.91 | Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms. ( Kubo, H; Morikawa, M; Mouri, A; Nabeshima, T; Nakamura, Y; Okada, T; Ozaki, N; Saito, K; Shiino, T; Teshigawara, T; Yamamoto, Y, 2019) |
| "To evaluate relationships among obesity in pregnancy and plasma levels of tryptophan (TRP) and kynurenine (KYN), inflammatory markers, and depressed mood." | 3.88 | Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy. ( D'Agata, A; Duffy, A; Fuchs, D; Groer, M; Louis-Jacques, A; Postolache, TT, 2018) |
| "In patients with obesity subjected to bariatric surgery, levels of 3-hydroxykynurenine and 3-hydroxyanthranilic acid seemed to be positively correlated to impaired glucose tolerance." | 3.88 | Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery. ( Andersen, JR; Christensen, MHE; Fadnes, DJ; Mellgren, G; Midttun, Ø; Nygård, OK; Pedersen, ER; Røst, TH; Ueland, PM; Ulvik, A; Våge, V, 2018) |
| "Chronic stress or inflammation increases tryptophan metabolism along the kynurenine pathway (KP), and the generation of neuroactive kynurenine metabolites contributes to subsequent depressive-like behaviors." | 3.88 | Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation. ( Delgado, J; Garrison, AM; O'Connor, JC; Parrott, JM; Redus, L; Tuñon, A, 2018) |
| "In both cohorts, inflammation as measured by higher levels of CRP, sVCAM1 and sICAM1 was associated with kynurenine/tryptophan ratio and thus enhanced tryptophan breakdown (beta: 0." | 3.88 | Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts. ( Carvalho, LA; Clarke, G; Díaz, LE; Gómez-Martínez, S; Marcos, A; Michels, N; Olavarria-Ramirez, L; Widhalm, K, 2018) |
| " Inflammation induces tryptophan metabolism along the kynurenine pathway (KP) and yields immunologically relevant metabolites." | 3.88 | Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. ( Bissonnette, M; Ciorba, MA; Guillemin, GJ; Lim, CK; Meckel, K; Pekow, JR; Sofia, MA; Weber, CR, 2018) |
| "Patients who were symptomatic had the highest depression and anxiety scores, together with increased intestinal expression of IL-1β, IL-6 and matrix metalloproteinase-9, increased circulating IL-6 and CRP, and an increased circulating kynurenine:tryptophan ratio." | 3.85 | Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease. ( Abautret-Daly, Á; Connor, TJ; de Francisco-García, R; Dempsey, E; Harkin, A; Medina, C; Parra-Blanco, A; Riestra, S; Rodrigo, L, 2017) |
| " Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist." | 3.85 | Serum kynurenic acid is reduced in affective psychosis. ( Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE, 2017) |
| " The aim of this study was to investigate the changes of inflammation markers with chronic Pb exposure by analyzing neopterin levels and kynurenine (Kyn) to tryptophan (Trp) ratio that reflects indolamine 2,3-dioxygenase activity and to compare with healthy volunteers' parameters." | 3.85 | Possible changes of New-Generation inflammation markers with occupational lead exposure. ( Baydar, T; Girgin, G; Palabiyik, SS; Sipahi, H; Tutkun, E; Yilmaz, OH, 2017) |
| "We aimed to evaluate 10 biomarkers related to inflammation and the kynurenine pathway, including neopterin, kynurenine:tryptophan ratio, C-reactive protein, tryptophan, and 6 kynurenines, as potential predictors of all-cause and cause-specific mortality in a general population sample." | 3.83 | Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study. ( Eussen, SJ; Meyer, K; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE; Zuo, H, 2016) |
| " Increasing evidence has been proposed the activation of the tryptophan-degrading indoleamine-2,3-dyoxigenase (IDO), the rate-limiting enzyme of kynurerine pathway (KP), as a pathogenic factor of amyloid-beta (Aβ)-related inflammation in AD." | 3.83 | Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice. ( Antunes, MS; Boeira, SP; de Oliveira Espinosa, D; Donato, F; Giacomeli, R; Gomes, NS; Jesse, CR; Ruff, JR; Souza, LC, 2016) |
| "Inflammatory proteins are thought to be causally involved in the generation of aggression, possibly due to direct effects of cytokines in the central nervous system and/or by generation of inflammatory metabolites along the tryptophan-kynurenine (TRP/KYN) pathway, including KYN and its active metabolites kynurenic acid (KA), quinolinic acid (QA), and picolinic acid (PA)." | 3.83 | Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects. ( Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R, 2016) |
| " Plasma MED concentrations, inflammation and oxidative stress indices [Kynurenine/Tryptophan (Kyn/Trp) ratio, malondialdehyde (MDA) and allantoin/uric acid (All/UA) ratio] were measured in 30 CKD patients randomized to three cholesterol lowering regimens for 12 months (simvastatin 40mg/day, ezetimibe/simvastatin 10/20mg/day, or ezetimibe/simvastatin 10/40mg/day)." | 3.83 | Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease. ( Carru, C; Ena, S; Mangoni, AA; Satta, AE; Sotgia, S; Sotgiu, E; Zinellu, A, 2016) |
| "Healthy young adults (n = 737) aged 18-28 y without any known diseases or clinical evidence of inflammation provided blood samples for analysis of serum tryptophan/kynurenine metabolites, neopterin, C-reactive protein (CRP), and plasma pyridoxal 5'-phosphate (PLP) with LC-tandem mass spectrometry methodologies." | 3.83 | Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults. ( Brody, LC; Deac, OM; Fan, R; Gardiner, CM; Lu, Z; McCann, A; Meyer, K; Midttun, Ø; Mills, JL; Molloy, AM; Quinn, L; Shane, B; Ueland, PM, 2016) |
| "The kynurenine pathway of tryptophan metabolism has an important role in mediating the behavioral effects of inflammation, which has implications in understanding neuropsychiatric comorbidity and for the development of novel therapies." | 3.83 | Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. ( Gao, X; Morales, J; O'Connor, JC; Parrott, JM; Redus, L; Santana-Coelho, D, 2016) |
| "Several studies have suggested that induced tryptophan (TRP) degradation through the kynurenine (KYN) pathway by the enzyme indoleamine 2,3-dioxygenase (IDO) is implicated in the relation between depression and inflammation." | 3.80 | Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms? ( de Jonge, P; Doornbos, B; Duivis, HE; Kema, IP; Nolen, WA; Penninx, BW; Quak, J; Roest, AM; Vogelzangs, N, 2014) |
| " Activation of the kynurenine (KYN) pathway (KP) has been reported in various neurological diseases as a consequence of inflammation." | 3.80 | The kynurenine pathway is involved in bacterial meningitis. ( Agnez-Lima, LF; Bellac, CL; Christen, S; Coutinho, LG; Fontes, FL; Grandgirard, D; Leib, SL; Souza, FR, 2014) |
| "Circulating neopterin and kynurenine/tryptophan ratio (KTR) increase during inflammation and serve as markers of cellular immune activation, but data are sparse on other determinants of these markers and metabolites of the kynurenine pathway." | 3.79 | A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study. ( Eussen, SJ; Midttun, Ø; Nygård, O; Tell, GS; Theofylaktopoulou, D; Ueland, PM; Ulvik, A; Vollset, SE, 2013) |
| " The current study investigated associations between fatigue, depression and inflammatory cytokine (IFN-γ, IL-6, TNF-α) and CRP concentrations, as well as kynurenine pathway (KP) activation, in 61 breast cancer patients prior to chemotherapy." | 3.79 | C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy. ( Boyle, NT; Collier, S; Connor, TJ; Harkin, A; Hevey, D; Hughes, MM; Kennedy, MJ; O'Dwyer, AM; Pertl, MM, 2013) |
| "A negative association between systemic markers of inflammation and plasma vitamin B-6 has been observed in population-based and patient cohorts; however, vitamin B-6 (pyridoxine) treatment has mostly failed to improve inflammatory indexes." | 3.78 | Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris. ( Midttun, Ø; Nygård, O; Pedersen, ER; Ueland, PM; Ulvik, A, 2012) |
| " In contrast, resolution of inflammation coincided with the decreased concentration of tryptophan and accumulation of its catabolites: kynurenine, anthranilic acid, and 3-hydroxyanthranilic acid in lymph nodes but not in the spleen." | 3.78 | An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis. ( Kolodziej, L, 2012) |
| "This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment)." | 3.77 | Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. ( Oxenkrug, GF, 2011) |
| " In plasma from 3035 patients undergoing coronary angiography for suspected coronary heart disease, we investigated if plasma concentrations of any metabolites in the kynurenine pathway, which depend on PLP as cofactor, may serve as metabolic marker(s) of vitamin B-6 status." | 3.77 | Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation. ( Bleie, O; Ebbing, M; Midttun, O; Nilsen, RM; Nygård, O; Ringdal Pedersen, E; Schartum-Hansen, H; Ueland, PM; Ulvik, A, 2011) |
| "Patients (n = 16) with septic shock had indoleamine 2,3-dioxygenase activity assessed as the kynurenine-to-tryptophan ratio, and the severity of hypotension was determined by their inotrope requirements." | 3.77 | Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. ( Celermajer, DS; Changsirivathanathamrong, D; dos Remedios, CG; Duflou, J; Gebski, V; Maghzal, GJ; Mak, WM; Rajbhandari, D; Stocker, R; Wang, Y; Woolfe, C, 2011) |
| " As such surgery is associated with signs of inflammation and pro-inflammatory mediators activate tryptophan oxidation to neuroactive kynurenines which modulate NMDA receptor function and oxidative stress, we have measured blood concentrations of kynurenines and inflammatory markers in 28 patients undergoing coronary arterial graft surgery and, for comparison, 28 patients undergoing non-bypass thoracic surgery." | 3.77 | Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery. ( Darlington, LG; Forrest, CM; Higgins, MJ; Mackay, GM; Millar, K; Oxford, L; Stone, TW, 2011) |
| " The kynurenine pathway (KP), activated during neuroinflammation, is emerging as a possible contributory factor in ALS." | 3.76 | The kynurenine pathway and inflammation in amyotrophic lateral sclerosis. ( Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R, 2010) |
| "New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway--via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2--and chronic inflammation in progressive HIV disease." | 3.76 | Insights into therapy: tryptophan oxidation and HIV infection. ( Murray, MF, 2010) |
| "Post-stroke inflammation may induce upregulation of the kynurenine (KYN) pathway for tryptophan (TRP) oxidation, resulting in neuroprotective (kynurenic acid, KA) and neurotoxic metabolites (3-hydroxyanthranillic acid, 3-HAA)." | 3.76 | The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke. ( Aerts, T; Brouns, R; De Deyn, PP; De Surgeloose, D; Scharpé, S; Verkerk, R; Wauters, A, 2010) |
| "Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown." | 3.75 | The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. ( Domaniewski, T; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| " Here we show that a superoxide-dependent step in tryptophan metabolism along the kynurenine pathway is blocked in CGD mice with lethal pulmonary aspergillosis, leading to unrestrained Vgamma1(+) gammadelta T-cell reactivity, dominant production of interleukin (IL)-17, defective regulatory T-cell activity and acute inflammatory lung injury." | 3.74 | Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. ( Bistoni, F; D'Angelo, C; De Luca, A; Fallarino, F; Fioretti, MC; Grohmann, U; Montagnoli, C; Puccetti, P; Romani, L; Segal, BH; Vacca, C; Zelante, T, 2008) |
| "Although depression is categorized as a brain disorder, its symptomatology includes some behaviors that also occur during chronic inflammatory stress." | 3.01 | The Interrelation between Oxidative Stress, Depression and Inflammation through the Kynurenine Pathway. ( Aydin, A; Mat, AF; Ozhan, Y; Sipahi, H, 2023) |
| "The kynurenine pathway (KP) is a major route of the essential amino acid L-tryptophan (Trp) catabolism in mammalian cells." | 3.01 | Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder. ( Fang, K; Imamura, Y; Kasahara, Y; Konishi, Y; Momono, Y; Murakami, Y; Nishiyama, T; Sakai, D; Yoshida, C, 2023) |
| "Inflammation is known to trigger the kynurenine pathway to a pathological level in various impulsivity-related disorders." | 3.01 | Toward a neuroprotective shift: Eight weeks of high intensity interval training reduces the neurotoxic kynurenine activity concurrently to impulsivity in emotionally impulsive humans - A randomized controlled trial. ( Bloch, W; Guillemin, GJ; Javelle, F; Knoop, A; Zimmer, P, 2021) |
| "Inflammation has an important physiological influence on mood and behavior." | 2.90 | Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study. ( Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R, 2019) |
| "A chronic low-grade inflammation is associated with the aging process, a state called inflammaging." | 2.82 | Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process. ( Salminen, A, 2022) |
| "Schizophrenia is a major psychotic disorder affecting nearly 23." | 2.72 | Role and Perspectives of Inflammation and C-Reactive Protein (CRP) in Psychosis: An Economic and Widespread Tool for Assessing the Disease. ( Aamir, A; Awan, HA; Awan, S; De Berardis, D; de Filippis, R; Di Giannantonio, M; Diwan, MN; Fornaro, M; Irfan, M; Martinotti, G; Pettorruso, M; Ullah, I; Vellante, F; Ventriglio, A, 2021) |
| "Neuroinflammation is one of the most frequently studied topics of neurosciences as it is a common feature in almost all neurological disorders." | 2.72 | Neurological Infection, Kynurenine Pathway, and Parasitic Infection by ( Argolo, DS; Costa, MFD; Costa, SL; Del'Arco, AE; Guillemin, G; Pinheiro, AM, 2021) |
| "contribute to the development of coronary atherosclerosis and subsequent coronary artery disease." | 2.72 | Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease. ( Berkecz, R; Csont, T; Demján, V; Gáspár, R; Halmi, D; Pipicz, M, 2021) |
| "Ketamine is a novel rapid-acting antidepressant with high efficacy in treatment-resistant patients." | 2.72 | Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review. ( Kopra, E; Mondelli, V; Nikkheslat, N; Pariante, C, 2021) |
| "Osteoporosis is also associated with abnormalities of the kynurenine pathway, reflected in an inversion of the ratio between blood levels of the metabolites anthranilic acid and 3-hydroxy-anthranilic acid." | 2.66 | IDO activation, inflammation and musculoskeletal disease. ( Clanchy, FI; Huang, YS; Ogbechi, J; Stone, TW; Topping, LM; Williams, RO, 2020) |
| "Many patients with cancer suffer from anemia, depression, and an impaired quality of life (QoL)." | 2.66 | Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer. ( Egger, EM; Fuchs, D; Kink, P; Kurz, K; Lanser, L; Weiss, G; Willenbacher, W, 2020) |
| "Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor dysfunctions to psychobehavioral manifestations." | 2.66 | Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines. ( Tanaka, M; Toldi, J; Vécsei, L, 2020) |
| "During stress and major depressive disorders, it is generally accepted that inflammation induces an imbalance toward the excitotoxic branch of the TRY/CAT pathway, causing changes in brain connectivity in corticolimbic structures and therefore psychocognitive abnormalities." | 2.61 | The 'Yin' and the 'Yang' of the kynurenine pathway: excitotoxicity and neuroprotection imbalance in stress-induced disorders. ( Barone, P, 2019) |
| "Poststroke fatigue is a debilitating symptom and is poorly understood." | 2.58 | Mechanisms of poststroke fatigue. ( Dantzer, R; De Doncker, W; Kuppuswamy, A; Ormstad, H, 2018) |
| "The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial disturbances, glutamate excitotoxicity, and neuroinflammation." | 2.58 | Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines. ( Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D, 2018) |
| "Hence, abdominal obesity is associated with vascular endothelial dysfunction and reduced nitric oxide (NO) availability." | 2.55 | The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity. ( Engin, A; Engin, AB, 2017) |
| "Chronic inflammation has been shown to contribute to the development of a wide variety of disorders by means of a number of proposed mechanisms." | 2.50 | The common inflammatory etiology of depression and cognitive impairment: a therapeutic target. ( Allison, DJ; Ditor, DS, 2014) |
| "Some degree of inflammation is required for protection, particularly in mucosal tissues, during the transitional response occurring between the rapid innate and slower adaptive response." | 2.44 | IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi. ( De Luca, A; Fallarino, F; Puccetti, P; Romani, L; Zelante, T, 2008) |
| "The kynurenine pathway (KP) is a major route of L-tryptophan catabolism leading to production of several neurobiologically active molecules." | 2.43 | Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis. ( Brew, BJ; Guillemin, GJ; Meininger, V, 2005) |
| "The kynurenine pathway (KP) has been considered an important player in inflammation and immune response." | 1.91 | Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever. ( Gülcemal, S; Hakbilen, S; Körez, MK; Onmaz, DE; Sivrikaya, A; Tezcan, D; Yılmaz, S, 2023) |
| "Posttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder associated with different somatic comorbidities, especially cardiovascular and metabolic disorders, and with chronic low-grade inflammation." | 1.91 | PTSD, Immune System, and Inflammation. ( Konjevod, M; Kozumplik, O; Mimica, N; Nedic Erjavec, G; Nikolac Perkovic, M; Pivac, N; Sagud, M; Svob Strac, D; Tudor, L; Uzun, S; Vuic, B, 2023) |
| "Chronic systemic inflammation reduces the bioavailability of circulating endothelial progenitor cells (EPCs)." | 1.91 | A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation. ( Bagaglia, F; Bianconi, V; Colangelo, C; Cosentini, E; Cucci, A; Fallarino, F; Figorilli, F; Follenzi, A; Franceschini, L; Fuchs, D; Gargaro, M; Giglioni, F; Mannarino, MR; Manni, G; Mencarelli, G; Padiglioni, E; Pieroni, B; Pirro, M; Puccetti, P; Ricciuti, D; Scalisi, G, 2023) |
| "Chronic low-grade inflammation is suggested to play a pathophysiological role in bipolar disorder (BD) and its related cognitive dysfunctions." | 1.72 | The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder. ( Giltay, EJ; Hebbrecht, K; Morrens, M; Sabbe, B; van den Ameele, S; van Nuijs, ALN, 2022) |
| "Death rate is increased in type 2 diabetes." | 1.72 | Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. ( Adamski, J; Copetti, M; De Cosmo, S; Mastroianno, M; Menzaghi, C; Prehn, C; Salvemini, L; Scarale, MG; Trischitta, V, 2022) |
| "Recessive dystrophic epidermolysis bullosa (RDEB) is a hereditary blistering disorder characterized by skin fragility, chronic inflammation, malnutrition, and fibrosis." | 1.72 | Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa. ( Aala, WJ; Chen, YF; Chen, YL; Hou, PC; Hsu, CK; Lin, YC; Lu, HC; McGrath, JA; Onoufriadis, A, 2022) |
| "In 58 cognitively normal, 396 mild cognitive impairment, and 112 AD participants from the Alzheimer's Disease Neuroimaging Initiative-1 (ADNI1) cohort, serum markers of 5-HT, tryptophan, and Kyn were measured and their relationships investigated with immunologic markers, affect and functional outcomes, CSF markers of beta-amyloid (Aβ) and tau, and regional gray matter." | 1.62 | Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway. ( Allenspach, K; Collazo-Martinez, AD; Dantzer, R; Hoth, N; Klinedinst, B; Larsen, B; Le, S; Li, T; Mochel, JP; Pappas, C; Pollpeter, A; Wang, Q; Willette, AA; Willette, SA, 2021) |
| "The kynurenine (KYN) pathway plays an important role in degrading molecules responsible for oxidative stress in the central nervous system (CNS), but can also have neurotoxic effects." | 1.56 | Impaired metabolism of kynurenine and its metabolites in CSF of parkinson's disease. ( Iwaoka, K; Kato, K; Maeda, T; Otsuka, C; Takahashi, K; Terayama, Y; Yamahara, K, 2020) |
| "Chronic inflammation is associated with physical frailty and functional decline in older adults; however, the molecular mechanisms of this linkage are not understood." | 1.56 | Kynurenines link chronic inflammation to functional decline and physical frailty. ( Abadir, PM; Chung, T; de Cabo, R; Ferrucci, L; Hoke, A; Joca, H; Khadeer, M; Le, A; Lovett, J; Moaddel, R; Tian, J; Walston, J; Ward, C; Westbrook, R; Xue, QL; Yang, H, 2020) |
| "Cognitive dysfunction is a prominent feature of psychiatric disorders." | 1.56 | C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders. ( Bengesser, SA; Birner, A; Dalkner, N; Falzberger, VS; Fellendorf, FT; Hamm, C; Lenger, M; Mangge, H; McIntyre, RS; Pilz, R; Platzer, M; Queissner, R; Reininghaus, B; Reininghaus, E; Rieger, A; Schwalsberger, K; Weiss, EM, 2020) |
| "Chronic, low-level inflammation is associated with symptomatic bipolar disorder (BD) and with chronic insomnia." | 1.48 | Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder. ( Can, A; Fuchs, D; Groer, M; Krishnamurthy, VB; Millett, CE; Mukherjee, D; Postolache, TT; Reider, A; Saunders, EFH, 2018) |
| "HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk." | 1.48 | Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction. ( Aukrust, P; Gaardbo, JC; Gelpi, M; Gerstoft, J; Hoel, H; Holm, K; Hov, JR; Hove-Skovsgaard, M; Kummen, M; Nielsen, SD; Nwosu, F; Rudi, K; Seljeflot, I; Trøseid, M; Ueland, PM; Ullum, H; Valeur, J, 2018) |
| "As chronic inflammation is known to precipitate increased apoptosis of neurons and astrocytes, this could be a contributing factor to brain dysfunction." | 1.46 | Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence? ( Leonard, BE, 2017) |
| "Mastocytosis is a rare disease in which chronic symptoms, including depression, are related to mast cell accumulation and activation." | 1.43 | Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis. ( Alyanakian, MA; Aouba, A; Bachmeyer, C; Barète, S; Bonin, B; Chandesris, MO; Chauvet-Gelinier, JC; Côté, F; Damaj, G; Dubreuil, P; Gaillard, R; Georgin-Lavialle, S; Grandpeix-Guyodo, C; Haffen, E; Hermine, O; Launay, JM; Lortholary, O; Moura, DS; Salvador, A; Soucié, E; Teyssier, JR; Trojak, B; Vandel, P, 2016) |
| "Quinolinic acid was increased and kynurenic acid decreased over time in suicidal patients versus healthy controls." | 1.42 | A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality. ( Bay-Richter, C; Brundin, L; Erhardt, S; Guillemin, GJ; Lim, CK; Linderholm, KR; Samuelsson, M; Träskman-Bendz, L, 2015) |
| "Atherosclerosis is a chronic inflammatory disease that is initiated by the retention and accumulation of low-density lipoprotein in the artery, leading to maladaptive response of cells from the immune system and vessel wall." | 1.42 | Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice. ( Agardh, H; Assinger, A; Bäck, M; Baumgartner, R; Berg, M; Gisterå, A; Hansson, GK; Ketelhuth, DF; Laguna-Fernandez, A; Ovchinnikova, O; Pirault, J; Polyzos, KA, 2015) |
| "About 350 million people worldwide have type 2 diabetes (T2D)." | 1.42 | Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes. ( Oxenkrug, GF, 2015) |
| "A total of 971 incident cancer cases (507 men and 464 women) were identified over a median follow-up time of 12 years." | 1.40 | Interferon-γ-induced inflammatory markers and the risk of cancer: the Hordaland Health Study. ( Eussen, SJ; Meyer, K; Midttun, Ø; Nygård, O; Tell, GS; Ueland, PM; Ulvik, A; Vollset, SE; Zuo, H, 2014) |
| "Geriatric depression is a costly health issue, but little is known about its physiological underpinnings." | 1.39 | Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin. ( Dantzer, R; Kelley, KW; Lawson, MA; McCusker, RH; O'Connor, JC; Rodriguez-Zas, SL, 2013) |
| " In the H2O2/FeCl3/ascorbic acid variant of the deoxyribose degradation assay, the dose-response curve was U-shaped." | 1.39 | Quinolinic acid: neurotoxin or oxidative stress modulator? ( Chobot, V; Hadacek, F; Kubicova, L, 2013) |
| "Inflammation has been linked to depression and suicide risk." | 1.37 | Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder. ( Fuchs, D; Galfalvy, HC; Grunebaum, MF; Lapidus, M; Mann, JJ; Oquendo, MA; Postolache, TT; Sublette, ME, 2011) |
| "L-kynurenine is a tryptophan metabolite, which may render activated T-cells apoptotic and therefore might modulate an allogenous transplant reaction." | 1.35 | Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells. ( Aboul-Enein, F; Höftberger, R; Lahdou, I; Scheuerle, A; Serbecic, N, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (0.73) | 18.2507 |
| 2000's | 14 (5.11) | 29.6817 |
| 2010's | 148 (54.01) | 24.3611 |
| 2020's | 110 (40.15) | 2.80 |
| Authors | Studies |
|---|---|
| Haq, S | 1 |
| Grondin, JA | 1 |
| Khan, WI | 1 |
| Jadhav, S | 1 |
| Nema, V | 1 |
| Leclercq, S | 1 |
| Schwarz, M | 2 |
| Delzenne, NM | 1 |
| Stärkel, P | 1 |
| de Timary, P | 1 |
| Fang, J | 1 |
| Feng, C | 1 |
| Chen, W | 1 |
| Hou, P | 1 |
| Liu, Z | 1 |
| Zuo, M | 1 |
| Han, Y | 1 |
| Xu, C | 1 |
| Melino, G | 1 |
| Verkhratsky, A | 1 |
| Wang, Y | 6 |
| Shao, C | 1 |
| Shi, Y | 1 |
| Kanova, M | 1 |
| Kohout, P | 1 |
| Göttert, R | 1 |
| Fidzinski, P | 1 |
| Kraus, L | 1 |
| Schneider, UC | 1 |
| Holtkamp, M | 1 |
| Endres, M | 1 |
| Gertz, K | 1 |
| Kronenberg, G | 1 |
| Hebbrecht, K | 2 |
| Morrens, M | 3 |
| Giltay, EJ | 3 |
| van Nuijs, ALN | 1 |
| Sabbe, B | 2 |
| van den Ameele, S | 2 |
| Ullah, I | 1 |
| Awan, HA | 1 |
| Aamir, A | 1 |
| Diwan, MN | 1 |
| de Filippis, R | 1 |
| Awan, S | 1 |
| Irfan, M | 1 |
| Fornaro, M | 1 |
| Ventriglio, A | 1 |
| Vellante, F | 1 |
| Pettorruso, M | 1 |
| Martinotti, G | 1 |
| Di Giannantonio, M | 1 |
| De Berardis, D | 1 |
| Chang, Y | 1 |
| Han, P | 1 |
| Jia, C | 1 |
| Zhang, B | 1 |
| Zhao, Y | 1 |
| Li, S | 3 |
| Wang, X | 1 |
| Yang, X | 2 |
| Wei, W | 1 |
| Delgado, I | 1 |
| Cussotto, S | 1 |
| Anesi, A | 1 |
| Dexpert, S | 1 |
| Aubert, A | 1 |
| Aouizerate, B | 1 |
| Beau, C | 1 |
| Forestier, D | 1 |
| Ledaguenel, P | 1 |
| Magne, E | 1 |
| Mattivi, F | 1 |
| Capuron, L | 2 |
| Hughes, TD | 1 |
| Güner, OF | 1 |
| Iradukunda, EC | 1 |
| Phillips, RS | 1 |
| Bowen, JP | 1 |
| Priyadarshini, M | 1 |
| Navarro, G | 1 |
| Reiman, DJ | 1 |
| Sharma, A | 1 |
| Xu, K | 1 |
| Lednovich, K | 1 |
| Manzella, CR | 1 |
| Khan, MW | 1 |
| Garcia, MS | 1 |
| Allard, S | 1 |
| Wicksteed, B | 1 |
| Chlipala, GE | 1 |
| Szynal, B | 1 |
| Bernabe, BP | 1 |
| Maki, PM | 1 |
| Gill, RK | 1 |
| Perdew, GH | 1 |
| Gilbert, J | 1 |
| Dai, Y | 1 |
| Layden, BT | 1 |
| Salminen, A | 1 |
| Tezcan, D | 2 |
| Onmaz, DE | 1 |
| Sivrikaya, A | 1 |
| Körez, MK | 1 |
| Hakbilen, S | 1 |
| Gülcemal, S | 1 |
| Yılmaz, S | 2 |
| Del'Arco, AE | 1 |
| Argolo, DS | 1 |
| Guillemin, G | 2 |
| Costa, MFD | 1 |
| Costa, SL | 1 |
| Pinheiro, AM | 1 |
| Guarnieri, T | 2 |
| Gáspár, R | 1 |
| Halmi, D | 1 |
| Demján, V | 1 |
| Berkecz, R | 1 |
| Pipicz, M | 1 |
| Csont, T | 1 |
| Mándi, Y | 2 |
| Stone, TW | 6 |
| Guillemin, GJ | 15 |
| Vécsei, L | 5 |
| Williams, RO | 3 |
| Yan, J | 2 |
| Han, VX | 2 |
| Heng, B | 2 |
| Bandodkar, S | 2 |
| Dale, RC | 2 |
| Mingoti, MED | 2 |
| Bertollo, AG | 2 |
| Simões, JLB | 1 |
| Francisco, GR | 1 |
| Bagatini, MD | 1 |
| Ignácio, ZM | 2 |
| Scarale, MG | 1 |
| Mastroianno, M | 1 |
| Prehn, C | 1 |
| Copetti, M | 1 |
| Salvemini, L | 1 |
| Adamski, J | 1 |
| De Cosmo, S | 1 |
| Trischitta, V | 1 |
| Menzaghi, C | 1 |
| Dawood, S | 1 |
| Bano, S | 1 |
| Badawy, AA | 4 |
| Kurgan, Ş | 2 |
| Önder, C | 2 |
| Balcı, N | 2 |
| Akdoğan, N | 2 |
| Altıngöz, SM | 1 |
| Serdar, MA | 2 |
| Günhan, M | 2 |
| Agrawal, S | 1 |
| Monteiro, C | 1 |
| Baca, CF | 1 |
| Mohammadi, R | 1 |
| Subramanian, V | 1 |
| de Melo Bento, CA | 1 |
| Agrawal, A | 1 |
| Jamshed, L | 1 |
| Debnath, A | 1 |
| Jamshed, S | 1 |
| Wish, JV | 1 |
| Raine, JC | 1 |
| Tomy, GT | 1 |
| Thomas, PJ | 1 |
| Holloway, AC | 1 |
| Dewulf, JP | 1 |
| Martin, M | 1 |
| Marie, S | 1 |
| Oguz, F | 1 |
| Belkhir, L | 1 |
| De Greef, J | 1 |
| Yombi, JC | 1 |
| Wittebole, X | 1 |
| Laterre, PF | 1 |
| Jadoul, M | 1 |
| Gatto, L | 1 |
| Bommer, GT | 1 |
| Morelle, J | 1 |
| Klawitter, J | 2 |
| Jackson, MJ | 1 |
| Smith, PH | 1 |
| Hopp, K | 1 |
| Chonchol, M | 1 |
| Gitomer, BY | 1 |
| Cadnapaphornchai, MA | 1 |
| Christians, U | 1 |
| Chen, YF | 1 |
| Lu, HC | 1 |
| Hou, PC | 1 |
| Lin, YC | 1 |
| Aala, WJ | 1 |
| Onoufriadis, A | 1 |
| McGrath, JA | 1 |
| Chen, YL | 1 |
| Hsu, CK | 1 |
| Gong, X | 1 |
| Chang, R | 1 |
| Zou, J | 1 |
| Tan, S | 1 |
| Huang, Z | 2 |
| Wei, J | 1 |
| Zhang, Z | 1 |
| Du, Y | 1 |
| Zhao, L | 1 |
| Ni, P | 1 |
| Ni, R | 1 |
| Gong, M | 1 |
| Ma, X | 1 |
| Machado, M | 1 |
| Peixoto, D | 1 |
| Santos, P | 1 |
| Ricardo, A | 1 |
| Duarte, I | 1 |
| Carvalho, I | 1 |
| Aragão, C | 1 |
| Azeredo, R | 1 |
| Costas, B | 1 |
| Yilmaz, NS | 1 |
| Sen, B | 1 |
| Karadag, RF | 1 |
| Aslan, S | 1 |
| Ekmekci Ertek, I | 1 |
| Bozkurt, A | 1 |
| Cicek, S | 1 |
| Bolu, A | 1 |
| Ucar, H | 1 |
| Kocak, C | 1 |
| Cevik, C | 1 |
| Bukan, N | 1 |
| Wu, X | 1 |
| Chen, B | 1 |
| Di, Z | 1 |
| Jiang, S | 1 |
| Xu, H | 1 |
| Shi, M | 2 |
| Hu, R | 1 |
| Sun, S | 1 |
| Song, Z | 1 |
| Liu, J | 1 |
| Ma, R | 1 |
| Guo, Q | 1 |
| Watne, LO | 3 |
| Pollmann, CT | 3 |
| Neerland, BE | 3 |
| Quist-Paulsen, E | 3 |
| Halaas, NB | 3 |
| Idland, AV | 3 |
| Hassel, B | 3 |
| Henjum, K | 3 |
| Knapskog, AB | 3 |
| Frihagen, F | 3 |
| Raeder, J | 3 |
| Godø, A | 3 |
| Ueland, PM | 25 |
| McCann, A | 5 |
| Figved, W | 3 |
| Selbæk, G | 3 |
| Zetterberg, H | 3 |
| Fang, EF | 3 |
| Myrstad, M | 3 |
| Giil, LM | 4 |
| Sipahi, H | 2 |
| Mat, AF | 1 |
| Ozhan, Y | 1 |
| Aydin, A | 1 |
| Ueland, HO | 1 |
| Ulvik, A | 14 |
| Løvås, K | 1 |
| Wolff, ASB | 1 |
| Breivik, LE | 1 |
| Stokland, AM | 1 |
| Rødahl, E | 1 |
| Nilsen, RM | 2 |
| Husebye, E | 1 |
| Ueland, GÅ | 1 |
| Midttun, Ø | 19 |
| Meyer, K | 7 |
| Zahed, H | 2 |
| Giles, GG | 4 |
| Manjer, J | 3 |
| Sandsveden, M | 2 |
| Langhammer, A | 3 |
| Sørgjerd, EP | 2 |
| Behndig, AF | 1 |
| Johansson, M | 6 |
| Freedman, ND | 3 |
| Huang, WY | 2 |
| Chen, C | 2 |
| Prentice, R | 2 |
| Stevens, VL | 3 |
| Le Marchand, L | 3 |
| Weinstein, SJ | 3 |
| Cai, Q | 3 |
| Arslan, AA | 3 |
| Chen, Y | 2 |
| Shu, XO | 3 |
| Zheng, W | 3 |
| Yuan, JM | 3 |
| Koh, WP | 3 |
| Visvanathan, K | 3 |
| Sesso, HD | 3 |
| Zhang, X | 3 |
| Gaziano, JM | 3 |
| Fanidi, A | 3 |
| Robbins, HA | 2 |
| Brennan, P | 3 |
| Eryavuz Onmaz, D | 1 |
| Abusoglu, S | 1 |
| Sak, F | 1 |
| Humeyra Yerlikaya, F | 1 |
| Abusoglu, G | 1 |
| Kazim Korez, M | 1 |
| Unlu, A | 1 |
| MacCann, R | 1 |
| Landay, AL | 1 |
| Mallon, PWG | 1 |
| Lai, W | 1 |
| Li, XG | 1 |
| Luo, D | 1 |
| Bjørke-Monsen, AL | 1 |
| Varsi, K | 1 |
| Sakkestad, ST | 1 |
| de Oliveira, T | 1 |
| Pivac, N | 1 |
| Vuic, B | 1 |
| Sagud, M | 1 |
| Nedic Erjavec, G | 1 |
| Nikolac Perkovic, M | 1 |
| Konjevod, M | 1 |
| Tudor, L | 1 |
| Svob Strac, D | 1 |
| Uzun, S | 2 |
| Kozumplik, O | 1 |
| Mimica, N | 1 |
| Vints, WAJ | 1 |
| Kušleikienė, S | 1 |
| Sheoran, S | 1 |
| Valatkevičienė, K | 1 |
| Gleiznienė, R | 1 |
| Himmelreich, U | 1 |
| Pääsuke, M | 1 |
| Česnaitienė, VJ | 1 |
| Levin, O | 1 |
| Verbunt, J | 1 |
| Masiulis, N | 1 |
| Murakami, Y | 2 |
| Imamura, Y | 1 |
| Kasahara, Y | 1 |
| Yoshida, C | 1 |
| Momono, Y | 1 |
| Fang, K | 1 |
| Sakai, D | 1 |
| Konishi, Y | 1 |
| Nishiyama, T | 1 |
| Mannarino, MR | 1 |
| Bianconi, V | 1 |
| Scalisi, G | 1 |
| Franceschini, L | 1 |
| Manni, G | 2 |
| Cucci, A | 1 |
| Bagaglia, F | 1 |
| Mencarelli, G | 1 |
| Giglioni, F | 1 |
| Ricciuti, D | 1 |
| Figorilli, F | 1 |
| Pieroni, B | 1 |
| Cosentini, E | 1 |
| Padiglioni, E | 1 |
| Colangelo, C | 1 |
| Fuchs, D | 12 |
| Puccetti, P | 5 |
| Follenzi, A | 1 |
| Pirro, M | 2 |
| Gargaro, M | 4 |
| Fallarino, F | 6 |
| Levin, G | 1 |
| Ein-Dor, T | 1 |
| Kothur, K | 1 |
| Mohammad, S | 1 |
| Chung, J | 1 |
| Patel, S | 1 |
| Jones, HF | 1 |
| Keating, BA | 1 |
| Webster, R | 1 |
| Ardern-Holmes, S | 1 |
| Antony, J | 1 |
| Menezes, MP | 1 |
| Tantsis, E | 1 |
| Gill, D | 1 |
| Gupta, S | 1 |
| Kandula, T | 1 |
| Sampaio, H | 1 |
| Farrar, MA | 1 |
| Troedson, C | 1 |
| Andrews, PI | 1 |
| Pillai, SC | 1 |
| Guller, A | 1 |
| Lashgari, NA | 1 |
| Roudsari, NM | 1 |
| Shayan, M | 1 |
| Niazi Shahraki, F | 1 |
| Hosseini, Y | 1 |
| Momtaz, S | 1 |
| Abdolghaffari, AH | 1 |
| Ardiansyah, E | 1 |
| Avila-Pacheco, J | 1 |
| Nhat, LTH | 1 |
| Dian, S | 1 |
| Vinh, DN | 1 |
| Hai, HT | 1 |
| Bullock, K | 1 |
| Alisjahbana, B | 1 |
| Netea, MG | 1 |
| Estiasari, R | 1 |
| Tram, TTB | 1 |
| Donovan, J | 1 |
| Heemskerk, D | 1 |
| Chau, TTH | 1 |
| Bang, ND | 1 |
| Ganiem, AR | 1 |
| Ruslami, R | 1 |
| Koeken, VACM | 1 |
| Hamers, RL | 1 |
| Imran, D | 1 |
| Maharani, K | 1 |
| Kumar, V | 1 |
| Clish, CB | 1 |
| van Crevel, R | 1 |
| Thwaites, G | 1 |
| van Laarhoven, A | 1 |
| Thuong, NTT | 1 |
| Jovanovic, F | 1 |
| Jovanovic, V | 1 |
| Knezevic, NN | 1 |
| Schulz, SVW | 1 |
| Bizjak, DA | 1 |
| Moebes, E | 1 |
| John, L | 1 |
| Wais, V | 1 |
| Bunjes, D | 1 |
| Sala, E | 1 |
| Steinacker, JM | 1 |
| Kirsten, J | 1 |
| Chen, P | 1 |
| Geng, X | 1 |
| Hayes, AJ | 1 |
| Zheng, X | 1 |
| O'Kelly, J | 1 |
| Neyton, LPA | 1 |
| Bochkina, NA | 1 |
| Uings, I | 1 |
| Liddle, J | 1 |
| Baillie, JK | 1 |
| Just, G | 1 |
| Binnie, M | 1 |
| Homer, NZM | 1 |
| Murray, TBJ | 1 |
| Baily, J | 1 |
| McGuire, K | 1 |
| Skouras, C | 1 |
| Garden, OJ | 1 |
| Webster, SP | 1 |
| Iredale, JP | 1 |
| Howie, SEM | 1 |
| Mole, DJ | 1 |
| Hüfner, K | 2 |
| Vedova, S | 1 |
| Tymoszuk, P | 1 |
| Nelles, P | 1 |
| Bruckner, T | 1 |
| Deisenhammer, EA | 1 |
| Egeter, J | 1 |
| Galffy, M | 1 |
| Giesinger, JM | 1 |
| Lehmann, J | 1 |
| Oberhammer, M | 1 |
| Rockenschaub, J | 1 |
| Sacher, M | 1 |
| Holzner, B | 1 |
| Gostner, JM | 2 |
| Sperner-Unterweger, B | 2 |
| Rust, C | 1 |
| Malan-Muller, S | 1 |
| van den Heuvel, LL | 1 |
| Tonge, D | 1 |
| Seedat, S | 1 |
| Pretorius, E | 1 |
| Hemmings, SMJ | 1 |
| Serdar, CC | 1 |
| Sin, R | 1 |
| Sotogaku, N | 1 |
| Ohnishi, YN | 1 |
| Shuto, T | 1 |
| Kuroiwa, M | 1 |
| Kawahara, Y | 1 |
| Sugiyama, K | 1 |
| Kanai, M | 1 |
| Funakoshi, H | 3 |
| Chakraborti, A | 1 |
| Bibb, JA | 1 |
| Nishi, A | 1 |
| Patel, VD | 1 |
| Shamsi, SA | 1 |
| Miller, A | 1 |
| Liu, A | 1 |
| Powell, M | 1 |
| Sadok, I | 1 |
| Jędruchniewicz, K | 1 |
| Guo, B | 1 |
| Xue, M | 1 |
| Zhang, T | 1 |
| Gan, H | 1 |
| Lin, R | 1 |
| Liu, M | 1 |
| Liao, Y | 1 |
| Lyu, J | 1 |
| Zheng, P | 1 |
| Sun, B | 1 |
| van Nuijs, AL | 1 |
| Lai, FY | 1 |
| Schuermans, J | 1 |
| Verkerk, R | 3 |
| van Diermen, L | 1 |
| Coppens, V | 2 |
| Fransen, E | 1 |
| de Boer, P | 1 |
| Timmers, M | 1 |
| Simkin, DR | 1 |
| Heilman, P | 1 |
| Hill, MN | 1 |
| Coussons-Read, M | 2 |
| Brundin, L | 8 |
| Coccaro, EF | 2 |
| Gelpi, M | 2 |
| Trøseid, M | 2 |
| Mocroft, A | 1 |
| Lebech, AM | 1 |
| Ullum, H | 2 |
| Lundgren, J | 1 |
| Nielsen, SD | 2 |
| Guaraldi, G | 1 |
| Milic, J | 1 |
| Iwaoka, K | 1 |
| Otsuka, C | 1 |
| Maeda, T | 1 |
| Yamahara, K | 1 |
| Kato, K | 1 |
| Takahashi, K | 2 |
| Terayama, Y | 1 |
| Achtyes, E | 3 |
| Keaton, SA | 1 |
| Smart, L | 2 |
| Burmeister, AR | 1 |
| Heilman, PL | 1 |
| Krzyzanowski, S | 1 |
| Nagalla, M | 2 |
| Escobar Galvis, ML | 1 |
| Lim, CK | 4 |
| Muzik, M | 1 |
| Postolache, TT | 5 |
| Leach, R | 2 |
| Sepe, V | 1 |
| Gregorini, M | 1 |
| Rampino, T | 1 |
| Esposito, P | 1 |
| Coppo, R | 1 |
| Galli, F | 1 |
| Libetta, C | 1 |
| Imbeault, S | 2 |
| Goiny, M | 3 |
| Liu, X | 1 |
| Erhardt, S | 6 |
| Kaiser, H | 1 |
| Parker, E | 1 |
| Hamrick, MW | 1 |
| Ogbechi, J | 1 |
| Clanchy, FI | 1 |
| Huang, YS | 1 |
| Topping, LM | 1 |
| Haroon, E | 1 |
| Welle, JR | 1 |
| Woolwine, BJ | 1 |
| Goldsmith, DR | 1 |
| Baer, W | 1 |
| Patel, T | 1 |
| Felger, JC | 1 |
| Miller, AH | 1 |
| Pedraz-Petrozzi, B | 1 |
| Elyamany, O | 1 |
| Rummel, C | 1 |
| Mulert, C | 1 |
| Moffett, JR | 1 |
| Arun, P | 1 |
| Puthillathu, N | 1 |
| Vengilote, R | 1 |
| Ives, JA | 1 |
| Namboodiri, AM | 1 |
| Lanser, L | 1 |
| Kink, P | 1 |
| Egger, EM | 1 |
| Willenbacher, W | 1 |
| Weiss, G | 1 |
| Kurz, K | 1 |
| Abruzzo, PM | 1 |
| Bolotta, A | 1 |
| Tanaka, M | 1 |
| Toldi, J | 1 |
| Turski, WA | 1 |
| Wnorowski, A | 1 |
| Turski, GN | 1 |
| Turski, CA | 1 |
| Turski, L | 1 |
| Baumgartner, R | 3 |
| Berg, M | 2 |
| Matic, L | 1 |
| Polyzos, KP | 1 |
| Forteza, MJ | 2 |
| Hjorth, SA | 1 |
| Schwartz, TW | 1 |
| Paulsson-Berne, G | 1 |
| Hansson, GK | 2 |
| Hedin, U | 1 |
| Ketelhuth, DFJ | 2 |
| Westbrook, R | 1 |
| Chung, T | 1 |
| Lovett, J | 1 |
| Ward, C | 1 |
| Joca, H | 1 |
| Yang, H | 1 |
| Khadeer, M | 1 |
| Tian, J | 1 |
| Xue, QL | 1 |
| Le, A | 1 |
| Ferrucci, L | 1 |
| Moaddel, R | 1 |
| de Cabo, R | 1 |
| Hoke, A | 1 |
| Walston, J | 1 |
| Abadir, PM | 1 |
| Guenin-Macé, L | 1 |
| Morel, JD | 1 |
| Doisne, JM | 1 |
| Schiavo, A | 1 |
| Boulet, L | 1 |
| Mayau, V | 1 |
| Goncalves, P | 1 |
| Duchatelet, S | 1 |
| Hovnanian, A | 1 |
| Bondet, V | 1 |
| Duffy, D | 1 |
| Ungeheuer, MN | 1 |
| Delage, M | 1 |
| Nassif, A | 1 |
| Di Santo, JP | 1 |
| Demangel, C | 1 |
| Dalkner, N | 3 |
| Reininghaus, E | 1 |
| Schwalsberger, K | 1 |
| Rieger, A | 1 |
| Hamm, C | 2 |
| Pilz, R | 2 |
| Lenger, M | 1 |
| Queissner, R | 3 |
| Falzberger, VS | 1 |
| Platzer, M | 3 |
| Fellendorf, FT | 2 |
| Birner, A | 3 |
| Bengesser, SA | 2 |
| Weiss, EM | 1 |
| McIntyre, RS | 1 |
| Mangge, H | 2 |
| Reininghaus, B | 2 |
| Zarzecki, MS | 1 |
| Cattelan Souza, L | 1 |
| Giacomeli, R | 2 |
| Silva, MRP | 1 |
| Prigol, M | 2 |
| Boeira, SP | 3 |
| Jesse, CR | 3 |
| Lercher, A | 1 |
| Popa, AM | 1 |
| Viczenczova, C | 1 |
| Kosack, L | 1 |
| Klavins, K | 1 |
| Agerer, B | 1 |
| Opitz, CA | 1 |
| Lanz, TV | 2 |
| Platten, M | 3 |
| Bergthaler, A | 1 |
| Gazi, MA | 1 |
| Das, S | 1 |
| Siddique, MA | 1 |
| Alam, MA | 1 |
| Fahim, SM | 1 |
| Hasan, MM | 1 |
| Hossaini, F | 1 |
| Kabir, MM | 1 |
| Noor, Z | 1 |
| Haque, R | 1 |
| Mahfuz, M | 1 |
| Ahmed, T | 1 |
| Sha, Q | 1 |
| Keaton, S | 1 |
| Isung, J | 1 |
| Granqvist, M | 1 |
| Trepci, A | 2 |
| Huang, J | 1 |
| Schwieler, L | 3 |
| Kierkegaard, M | 1 |
| Jokinen, J | 1 |
| Piehl, F | 1 |
| Collier, ME | 1 |
| Zhang, S | 1 |
| Scrutton, NS | 1 |
| Giorgini, F | 1 |
| Dagenais-Lussier, X | 1 |
| Loucif, H | 1 |
| Beji, C | 1 |
| Telittchenko, R | 1 |
| Routy, JP | 2 |
| van Grevenynghe, J | 1 |
| Park, HJ | 2 |
| Kim, SA | 1 |
| Kang, WS | 1 |
| Kim, JW | 1 |
| Willette, AA | 1 |
| Pappas, C | 1 |
| Hoth, N | 1 |
| Wang, Q | 3 |
| Klinedinst, B | 1 |
| Willette, SA | 1 |
| Larsen, B | 1 |
| Pollpeter, A | 1 |
| Li, T | 1 |
| Le, S | 1 |
| Collazo-Martinez, AD | 1 |
| Mochel, JP | 1 |
| Allenspach, K | 1 |
| Dantzer, R | 8 |
| Javelle, F | 1 |
| Bloch, W | 1 |
| Knoop, A | 1 |
| Zimmer, P | 1 |
| Zádor, F | 1 |
| Joca, S | 1 |
| Nagy-Grócz, G | 1 |
| Dvorácskó, S | 1 |
| Szűcs, E | 1 |
| Tömböly, C | 1 |
| Benyhe, S | 1 |
| Skorobogatov, K | 1 |
| De Picker, L | 1 |
| Dugué, PA | 1 |
| Hodge, AM | 2 |
| Rinaldi, S | 1 |
| MacInnis, RJ | 1 |
| Li, SX | 1 |
| Navionis, AS | 1 |
| Flicker, L | 1 |
| Severi, G | 2 |
| English, DR | 1 |
| Vineis, P | 1 |
| Tell, GS | 6 |
| Southey, MC | 1 |
| Milne, RL | 2 |
| Chen, LM | 1 |
| Bao, CH | 1 |
| Wu, Y | 1 |
| Liang, SH | 1 |
| Wang, D | 1 |
| Wu, LY | 1 |
| Huang, Y | 2 |
| Liu, HR | 1 |
| Wu, HG | 1 |
| Kopra, E | 1 |
| Mondelli, V | 2 |
| Pariante, C | 1 |
| Nikkheslat, N | 1 |
| Mithaiwala, MN | 1 |
| Santana-Coelho, D | 2 |
| Porter, GA | 1 |
| O'Connor, JC | 6 |
| Qin, WH | 1 |
| Liu, CL | 1 |
| Jiang, YH | 1 |
| Hu, B | 1 |
| Wang, HY | 1 |
| Fu, J | 1 |
| Grankvist, K | 2 |
| Wilkens, LR | 2 |
| Albanes, D | 2 |
| Blot, WJ | 2 |
| Zeleniuch-Jacquotte, A | 2 |
| Muller, D | 1 |
| Guida, F | 1 |
| Milaneschi, Y | 1 |
| Allers, KA | 1 |
| Beekman, ATF | 1 |
| Keller, S | 1 |
| Schoevers, RA | 1 |
| Süssmuth, SD | 1 |
| Niessen, HG | 1 |
| Penninx, BWJH | 1 |
| Meier, TB | 1 |
| Savitz, J | 1 |
| Millischer, V | 1 |
| Heinzl, M | 1 |
| Faka, A | 2 |
| Resl, M | 1 |
| Klammer, C | 1 |
| Egger, M | 1 |
| Dieplinger, B | 1 |
| Clodi, M | 1 |
| Clement, CC | 1 |
| D'Alessandro, A | 1 |
| Thangaswamy, S | 1 |
| Chalmers, S | 1 |
| Furtado, R | 1 |
| Spada, S | 1 |
| Mondanelli, G | 1 |
| Ianni, F | 1 |
| Gehrke, S | 1 |
| Cara, LCL | 1 |
| Runge, P | 1 |
| Tsai, WL | 1 |
| Karaman, S | 1 |
| Arasa, J | 1 |
| Fernandez-Rodriguez, R | 1 |
| Beck, A | 1 |
| Macchiarulo, A | 2 |
| Gadina, M | 1 |
| Halin, C | 1 |
| Skobe, M | 1 |
| Veldhoen, M | 1 |
| Moretti, S | 1 |
| Formenti, S | 1 |
| Demaria, S | 1 |
| Soni, RK | 1 |
| Galarini, R | 1 |
| Sardella, R | 1 |
| Lauvau, G | 1 |
| Putterman, C | 1 |
| Alitalo, K | 1 |
| Grohmann, U | 3 |
| Santambrogio, L | 1 |
| Bagheri, M | 1 |
| Wang, C | 1 |
| Manouchehri, A | 1 |
| Murray, KT | 1 |
| Murphy, MB | 1 |
| Shaffer, CM | 1 |
| Singh, K | 1 |
| Davis, LK | 1 |
| Jarvik, GP | 1 |
| Stanaway, IB | 1 |
| Hebbring, S | 1 |
| Reilly, MP | 1 |
| Gerszten, RE | 1 |
| Wang, TJ | 1 |
| Mosley, JD | 1 |
| Ferguson, JF | 1 |
| Torosyan, R | 1 |
| Huang, S | 1 |
| Bommi, PV | 1 |
| Tiwari, R | 1 |
| An, SY | 1 |
| Schonfeld, M | 1 |
| Rajendran, G | 1 |
| Kavanaugh, MA | 1 |
| Gibbs, B | 1 |
| Truax, AD | 1 |
| Bohney, S | 1 |
| Calcutt, MW | 1 |
| Kerr, EW | 1 |
| Leonardi, R | 1 |
| Gao, P | 1 |
| Chandel, NS | 1 |
| Kapitsinou, PP | 1 |
| Cisneros, IE | 1 |
| Cunningham, KA | 1 |
| Abautret-Daly, Á | 1 |
| Dempsey, E | 1 |
| Riestra, S | 1 |
| de Francisco-García, R | 1 |
| Parra-Blanco, A | 1 |
| Rodrigo, L | 1 |
| Medina, C | 1 |
| Connor, TJ | 2 |
| Harkin, A | 3 |
| Liu, G | 1 |
| Chen, S | 2 |
| Zhong, J | 1 |
| Teng, K | 1 |
| Yin, Y | 1 |
| Verheyen, N | 1 |
| Meinitzer, A | 1 |
| Grübler, MR | 1 |
| Ablasser, K | 1 |
| Kolesnik, E | 1 |
| Fahrleitner-Pammer, A | 1 |
| Belyavskiy, E | 1 |
| Trummer, C | 1 |
| Schwetz, V | 1 |
| Pieske-Kraigher, E | 1 |
| Voelkl, J | 1 |
| Alesutan, I | 1 |
| Catena, C | 1 |
| Sechi, LA | 1 |
| Brussee, H | 1 |
| Lewinski, DV | 1 |
| März, W | 1 |
| Pieske, B | 1 |
| Pilz, S | 1 |
| Tomaschitz, A | 1 |
| Garcia-Contreras, M | 1 |
| Tamayo-Garcia, A | 1 |
| Pappan, KL | 1 |
| Michelotti, GA | 1 |
| Stabler, CL | 1 |
| Ricordi, C | 1 |
| Buchwald, P | 1 |
| Wurfel, BE | 1 |
| Drevets, WC | 1 |
| Bliss, SA | 1 |
| McMillin, JR | 1 |
| Suzuki, H | 1 |
| Ford, BN | 1 |
| Morris, HM | 1 |
| Teague, TK | 1 |
| Savitz, JB | 1 |
| de Vries, LV | 1 |
| Minović, I | 1 |
| Franssen, CFM | 1 |
| van Faassen, M | 1 |
| Sanders, JS | 1 |
| Berger, SP | 1 |
| Navis, G | 1 |
| Kema, IP | 2 |
| Bakker, SJL | 1 |
| Borsini, A | 1 |
| Alboni, S | 2 |
| Horowitz, MA | 1 |
| Tojo, LM | 1 |
| Cannazza, G | 1 |
| Su, KP | 1 |
| Pariante, CM | 3 |
| Zunszain, PA | 2 |
| Engin, AB | 1 |
| Engin, A | 1 |
| Girgin, G | 1 |
| Palabiyik, SS | 1 |
| Tutkun, E | 1 |
| Yilmaz, OH | 1 |
| Baydar, T | 1 |
| Roomruangwong, C | 1 |
| Kanchanatawan, B | 1 |
| Sirivichayakul, S | 1 |
| Anderson, G | 1 |
| Carvalho, AF | 1 |
| Duleu, S | 1 |
| Geffard, M | 2 |
| Maes, M | 3 |
| Leonard, BE | 1 |
| Cervenka, I | 1 |
| Agudelo, LZ | 1 |
| Ruas, JL | 2 |
| Mukherjee, D | 1 |
| Krishnamurthy, VB | 1 |
| Millett, CE | 1 |
| Reider, A | 1 |
| Can, A | 1 |
| Groer, M | 2 |
| Saunders, EFH | 1 |
| Kim, YK | 2 |
| Jeon, SW | 2 |
| Thomas, J | 1 |
| Khanam, R | 1 |
| Vohora, D | 1 |
| De Doncker, W | 1 |
| Ormstad, H | 1 |
| Kuppuswamy, A | 1 |
| Yap, SH | 1 |
| Abdullah, NK | 1 |
| McStea, M | 1 |
| Takayama, K | 1 |
| Chong, ML | 1 |
| Crisci, E | 1 |
| Larsson, M | 1 |
| Azwa, I | 1 |
| Kamarulzaman, A | 1 |
| Leong, KH | 1 |
| Woo, YL | 1 |
| Rajasuriar, R | 1 |
| Duffy, A | 1 |
| Louis-Jacques, A | 1 |
| D'Agata, A | 1 |
| Wigner, P | 1 |
| Czarny, P | 1 |
| Galecki, P | 2 |
| Sliwinski, T | 1 |
| Dostal, CR | 1 |
| Gamsby, NS | 1 |
| Lawson, MA | 4 |
| McCusker, RH | 4 |
| Christensen, MHE | 1 |
| Fadnes, DJ | 1 |
| Røst, TH | 1 |
| Pedersen, ER | 3 |
| Andersen, JR | 1 |
| Våge, V | 1 |
| Nygård, OK | 2 |
| Mellgren, G | 2 |
| Fazio, F | 1 |
| Ulivieri, M | 1 |
| Volpi, C | 2 |
| Zádori, D | 1 |
| Veres, G | 1 |
| Szalárdy, L | 1 |
| Klivényi, P | 1 |
| Hoel, H | 1 |
| Hove-Skovsgaard, M | 1 |
| Hov, JR | 1 |
| Gaardbo, JC | 1 |
| Holm, K | 1 |
| Kummen, M | 1 |
| Rudi, K | 1 |
| Nwosu, F | 1 |
| Valeur, J | 1 |
| Seljeflot, I | 1 |
| Gerstoft, J | 1 |
| Aukrust, P | 1 |
| Garrison, AM | 1 |
| Parrott, JM | 2 |
| Tuñon, A | 1 |
| Delgado, J | 1 |
| Redus, L | 2 |
| Michels, N | 1 |
| Clarke, G | 1 |
| Olavarria-Ramirez, L | 1 |
| Gómez-Martínez, S | 1 |
| Díaz, LE | 1 |
| Marcos, A | 1 |
| Widhalm, K | 1 |
| Carvalho, LA | 1 |
| Sofia, MA | 1 |
| Ciorba, MA | 2 |
| Meckel, K | 1 |
| Weber, CR | 1 |
| Bissonnette, M | 1 |
| Pekow, JR | 1 |
| de Gomes, MG | 1 |
| Souza, LC | 2 |
| Goes, AR | 1 |
| Del Fabbro, L | 1 |
| Filho, CB | 1 |
| Donato, F | 2 |
| Luchese, C | 1 |
| Roman, SS | 1 |
| Puntel, RL | 1 |
| Ishida, Y | 1 |
| Fujita, H | 1 |
| Aratani, S | 1 |
| Chijiiwa, M | 1 |
| Taniguchi, N | 1 |
| Yokota, M | 1 |
| Ogihara, Y | 1 |
| Uoshima, N | 1 |
| Nagashima, F | 1 |
| Uchino, H | 1 |
| Nakajima, T | 1 |
| Laurans, L | 1 |
| Venteclef, N | 1 |
| Haddad, Y | 1 |
| Chajadine, M | 1 |
| Alzaid, F | 1 |
| Metghalchi, S | 1 |
| Sovran, B | 1 |
| Denis, RGP | 1 |
| Dairou, J | 1 |
| Cardellini, M | 1 |
| Moreno-Navarrete, JM | 1 |
| Straub, M | 1 |
| Jegou, S | 1 |
| McQuitty, C | 1 |
| Viel, T | 1 |
| Esposito, B | 1 |
| Tavitian, B | 1 |
| Callebert, J | 1 |
| Luquet, SH | 1 |
| Federici, M | 1 |
| Fernandez-Real, JM | 1 |
| Burcelin, R | 1 |
| Launay, JM | 2 |
| Tedgui, A | 1 |
| Mallat, Z | 1 |
| Sokol, H | 1 |
| Taleb, S | 1 |
| Rodriguez-Zas, SL | 2 |
| Wu, C | 1 |
| Southey, BR | 1 |
| Nixon, SE | 1 |
| Garcia, R | 1 |
| Zavala, C | 1 |
| Lawson, M | 1 |
| Romanova, EV | 1 |
| Sweedler, JV | 1 |
| Kelley, KW | 4 |
| Bansal, Y | 1 |
| Singh, R | 1 |
| Saroj, P | 1 |
| Sodhi, RK | 1 |
| Kuhad, A | 1 |
| Painold, A | 1 |
| Mörkl, S | 1 |
| Kashofer, K | 1 |
| Halwachs, B | 1 |
| Bengesser, S | 1 |
| Fellendorf, F | 1 |
| Schütze, G | 2 |
| Schwarz, MJ | 4 |
| Moll, N | 2 |
| Holzer, P | 1 |
| Holl, AK | 1 |
| Kapfhammer, HP | 2 |
| Gorkiewicz, G | 1 |
| Reininghaus, EZ | 2 |
| Clark, SM | 1 |
| Notarangelo, FM | 2 |
| Li, X | 1 |
| Schwarcz, R | 2 |
| Tonelli, LH | 1 |
| Wirthgen, E | 1 |
| Otten, W | 2 |
| Tuchscherer, M | 1 |
| Tuchscherer, A | 1 |
| Domanska, G | 1 |
| Brenmoehl, J | 1 |
| Günther, J | 1 |
| Ohde, D | 1 |
| Weitschies, W | 1 |
| Seidlitz, A | 1 |
| Scheuch, E | 1 |
| Kanitz, E | 1 |
| Ramírez, LA | 1 |
| Pérez-Padilla, EA | 1 |
| García-Oscos, F | 1 |
| Salgado, H | 1 |
| Atzori, M | 1 |
| Pineda, JC | 1 |
| Minhas, PS | 1 |
| Liu, L | 1 |
| Moon, PK | 1 |
| Joshi, AU | 1 |
| Dove, C | 1 |
| Mhatre, S | 1 |
| Contrepois, K | 1 |
| Lee, BA | 1 |
| Coronado, M | 1 |
| Bernstein, D | 1 |
| Snyder, MP | 1 |
| Migaud, M | 1 |
| Majeti, R | 1 |
| Mochly-Rosen, D | 1 |
| Rabinowitz, JD | 1 |
| Andreasson, KI | 1 |
| Clària, J | 1 |
| Moreau, R | 1 |
| Fenaille, F | 1 |
| Amorós, A | 1 |
| Junot, C | 1 |
| Gronbaek, H | 1 |
| Coenraad, MJ | 1 |
| Pruvost, A | 1 |
| Ghettas, A | 1 |
| Chu-Van, E | 1 |
| López-Vicario, C | 1 |
| Oettl, K | 1 |
| Caraceni, P | 1 |
| Alessandria, C | 1 |
| Trebicka, J | 1 |
| Pavesi, M | 1 |
| Deulofeu, C | 1 |
| Albillos, A | 1 |
| Gustot, T | 1 |
| Welzel, TM | 1 |
| Fernández, J | 1 |
| Stauber, RE | 1 |
| Saliba, F | 1 |
| Butin, N | 1 |
| Colsch, B | 1 |
| Moreno, C | 1 |
| Durand, F | 1 |
| Nevens, F | 1 |
| Bañares, R | 1 |
| Benten, D | 1 |
| Ginès, P | 1 |
| Gerbes, A | 1 |
| Jalan, R | 1 |
| Angeli, P | 1 |
| Bernardi, M | 1 |
| Arroyo, V | 1 |
| de Oliveira, FR | 1 |
| Fantucci, MZ | 1 |
| Adriano, L | 1 |
| Valim, V | 1 |
| Cunha, TM | 1 |
| Louzada-Junior, P | 1 |
| Rocha, EM | 1 |
| Jabs, DA | 1 |
| Van Natta, ML | 1 |
| Trang, G | 1 |
| Jones, NG | 1 |
| Milush, JM | 1 |
| Cheu, R | 1 |
| Klatt, NR | 1 |
| Danis, RP | 1 |
| Hunt, PW | 2 |
| Solvang, SH | 1 |
| Nordrehaug, JE | 1 |
| Nygård, O | 7 |
| Vedeler, CA | 1 |
| Aarsland, D | 1 |
| Refsum, H | 1 |
| Smith, AD | 1 |
| Herrstedt, A | 1 |
| Bay, ML | 1 |
| Simonsen, C | 1 |
| Sundberg, A | 1 |
| Egeland, C | 1 |
| Thorsen-Streit, S | 1 |
| Djurhuus, SS | 1 |
| Magne Ueland, P | 1 |
| Pedersen, BK | 1 |
| Bo Svendsen, L | 1 |
| de Heer, P | 1 |
| Christensen, JF | 1 |
| Hojman, P | 1 |
| Sühs, KW | 1 |
| Novoselova, N | 1 |
| Kuhn, M | 1 |
| Seegers, L | 1 |
| Kaever, V | 1 |
| Müller-Vahl, K | 1 |
| Trebst, C | 1 |
| Skripuletz, T | 1 |
| Stangel, M | 1 |
| Pessler, F | 1 |
| Murthi, P | 1 |
| Vaillancourt, C | 1 |
| Sforzini, L | 1 |
| Nettis, MA | 1 |
| Barone, P | 1 |
| Blauth, M | 1 |
| Su, J | 1 |
| Wang, J | 2 |
| Ma, Y | 1 |
| Li, Q | 1 |
| Yang, Y | 1 |
| Huang, L | 1 |
| Wang, H | 1 |
| Li, H | 1 |
| Wang, Z | 1 |
| Tong, J | 1 |
| Huang, D | 1 |
| Bai, X | 1 |
| Yu, M | 1 |
| Bu, L | 1 |
| Fei, J | 1 |
| Huang, F | 1 |
| Garcez, ML | 1 |
| Jacobs, KR | 1 |
| Ishihara, Y | 1 |
| Haarmann-Stemmann, T | 1 |
| Kado, NY | 1 |
| Vogel, CFA | 1 |
| Teshigawara, T | 1 |
| Mouri, A | 1 |
| Kubo, H | 1 |
| Nakamura, Y | 1 |
| Shiino, T | 1 |
| Okada, T | 1 |
| Morikawa, M | 1 |
| Nabeshima, T | 1 |
| Ozaki, N | 1 |
| Yamamoto, Y | 1 |
| Saito, K | 1 |
| Huang, JY | 1 |
| Larose, TL | 1 |
| Luu, HN | 1 |
| Wang, R | 1 |
| Alcala, K | 1 |
| Caporaso, NE | 1 |
| Purdue, MP | 1 |
| Ziegler, RG | 1 |
| Lan, Q | 1 |
| Prentice, RL | 1 |
| Pettinger, M | 1 |
| Thomson, CA | 1 |
| Wu, J | 1 |
| Haiman, CA | 1 |
| Stampfer, MJ | 1 |
| Han, J | 1 |
| Hveem, K | 1 |
| Xiang, YB | 1 |
| Li, HL | 1 |
| Gao, YT | 1 |
| Ulvi, A | 1 |
| Buring, JE | 1 |
| Lee, IM | 1 |
| Relton, C | 1 |
| Golia, MT | 1 |
| Poggini, S | 1 |
| Garofalo, S | 1 |
| Ciano Albanese, N | 1 |
| Viglione, A | 1 |
| Ajmone-Cat, MA | 1 |
| St-Pierre, A | 1 |
| Brunello, N | 1 |
| Limatola, C | 1 |
| Branchi, I | 1 |
| Maggi, L | 1 |
| Kruse, JL | 1 |
| Cho, JH | 1 |
| Olmstead, R | 1 |
| Hwang, L | 1 |
| Faull, K | 1 |
| Eisenberger, NI | 1 |
| Irwin, MR | 1 |
| Theofylaktopoulou, D | 2 |
| Vollset, SE | 3 |
| Eussen, SJ | 4 |
| Wick, W | 1 |
| Opitz, C | 1 |
| Pertl, MM | 1 |
| Hevey, D | 1 |
| Boyle, NT | 1 |
| Hughes, MM | 1 |
| Collier, S | 1 |
| O'Dwyer, AM | 1 |
| Kennedy, MJ | 1 |
| da Silva, VR | 1 |
| Rios-Avila, L | 3 |
| Lamers, Y | 1 |
| Ralat, MA | 1 |
| Quinlivan, EP | 1 |
| Garrett, TJ | 1 |
| Coats, B | 2 |
| Shankar, MN | 1 |
| Percival, SS | 1 |
| Chi, YY | 2 |
| Muller, KE | 1 |
| Stacpoole, PW | 2 |
| Gregory, JF | 3 |
| Kubicova, L | 1 |
| Hadacek, F | 1 |
| Chobot, V | 1 |
| Metz, R | 2 |
| Smith, C | 1 |
| DuHadaway, JB | 2 |
| Chandler, P | 1 |
| Baban, B | 1 |
| Merlo, LM | 1 |
| Pigott, E | 1 |
| Keough, MP | 1 |
| Rust, S | 1 |
| Mellor, AL | 3 |
| Mandik-Nayak, L | 1 |
| Muller, AJ | 1 |
| Prendergast, GC | 2 |
| Apalset, EM | 1 |
| Gjesdal, CG | 1 |
| Eide, GE | 1 |
| Walker, AK | 1 |
| Quak, J | 1 |
| Doornbos, B | 1 |
| Roest, AM | 1 |
| Duivis, HE | 1 |
| Vogelzangs, N | 1 |
| Nolen, WA | 1 |
| Penninx, BW | 1 |
| de Jonge, P | 1 |
| Bessede, A | 1 |
| Pallotta, MT | 1 |
| Matino, D | 1 |
| Servillo, G | 1 |
| Brunacci, C | 1 |
| Bicciato, S | 1 |
| Mazza, EM | 1 |
| Vacca, C | 2 |
| Iannitti, R | 1 |
| Tissi, L | 1 |
| Belladonna, ML | 1 |
| Orabona, C | 1 |
| Bianchi, R | 1 |
| Della Fazia, MA | 1 |
| Piobbico, D | 1 |
| Zelante, T | 3 |
| Nakamura, T | 2 |
| Gilot, D | 1 |
| Denison, MS | 1 |
| Boon, L | 1 |
| Iorio, A | 1 |
| Veyret, B | 1 |
| Romani, L | 4 |
| Zuo, H | 2 |
| Bay-Richter, C | 1 |
| Linderholm, KR | 1 |
| Samuelsson, M | 2 |
| Träskman-Bendz, L | 2 |
| Allison, DJ | 1 |
| Ditor, DS | 1 |
| Coutinho, LG | 1 |
| Christen, S | 2 |
| Bellac, CL | 1 |
| Fontes, FL | 1 |
| Souza, FR | 1 |
| Grandgirard, D | 1 |
| Leib, SL | 1 |
| Agnez-Lima, LF | 1 |
| Maghzal, GJ | 2 |
| Winter, S | 1 |
| Wurzer, B | 1 |
| Chong, BH | 1 |
| Holmdahl, R | 1 |
| Stocker, R | 4 |
| Hol, JW | 1 |
| Stolker, RJ | 1 |
| Klimek, M | 1 |
| Stronks, DL | 1 |
| Fekkes, D | 1 |
| Zinellu, A | 2 |
| Sotgia, S | 2 |
| Mangoni, AA | 2 |
| Sanna, M | 1 |
| Satta, AE | 2 |
| Carru, C | 2 |
| Becker, K | 1 |
| Überall, F | 1 |
| Polyzos, KA | 1 |
| Ovchinnikova, O | 1 |
| Agardh, H | 1 |
| Pirault, J | 1 |
| Gisterå, A | 1 |
| Assinger, A | 1 |
| Laguna-Fernandez, A | 1 |
| Bäck, M | 1 |
| Ketelhuth, DF | 1 |
| Yi, SQ | 1 |
| Yang, M | 1 |
| Duan, KM | 1 |
| Murray, C | 1 |
| Griffin, ÉW | 1 |
| O'Loughlin, E | 1 |
| Lyons, A | 1 |
| Sherwin, E | 1 |
| Ahmed, S | 1 |
| Stevenson, NJ | 1 |
| Cunningham, C | 1 |
| Liu, D | 1 |
| Song, P | 1 |
| Zou, MH | 1 |
| Oxenkrug, GF | 2 |
| Bipath, P | 1 |
| Levay, PF | 1 |
| Viljoen, M | 1 |
| Santhanam, S | 1 |
| Alvarado, DM | 1 |
| Eleftheriadis, T | 1 |
| Pissas, G | 1 |
| Antoniadi, G | 1 |
| Liakopoulos, V | 1 |
| Stefanidis, I | 1 |
| Jenabian, MA | 1 |
| Mehraj, V | 1 |
| Costiniuk, CT | 1 |
| Vyboh, K | 1 |
| Kema, I | 1 |
| Rollet, K | 1 |
| Paulino Ramirez, R | 1 |
| Klein, MB | 1 |
| de Bie, J | 1 |
| Guest, J | 1 |
| Grant, R | 2 |
| Talarowska, M | 1 |
| Georgin-Lavialle, S | 1 |
| Moura, DS | 1 |
| Salvador, A | 1 |
| Chauvet-Gelinier, JC | 1 |
| Damaj, G | 1 |
| Côté, F | 1 |
| Soucié, E | 1 |
| Chandesris, MO | 1 |
| Barète, S | 1 |
| Grandpeix-Guyodo, C | 1 |
| Bachmeyer, C | 1 |
| Alyanakian, MA | 1 |
| Aouba, A | 1 |
| Lortholary, O | 1 |
| Dubreuil, P | 1 |
| Teyssier, JR | 1 |
| Trojak, B | 1 |
| Haffen, E | 1 |
| Vandel, P | 1 |
| Bonin, B | 1 |
| Hermine, O | 1 |
| Gaillard, R | 1 |
| Bryleva, EY | 1 |
| Zepf, FD | 1 |
| Stewart, RM | 1 |
| Buras, A | 1 |
| Waszkiewicz, N | 1 |
| Szulc, A | 1 |
| Antunes, MS | 1 |
| Ruff, JR | 1 |
| de Oliveira Espinosa, D | 1 |
| Gomes, NS | 1 |
| Brooks, AK | 1 |
| Smith, RA | 1 |
| Janda, TM | 1 |
| Larsson, MK | 1 |
| Bhat, M | 1 |
| Orhan, F | 1 |
| Oliveros, A | 1 |
| Ståhl, S | 1 |
| Liu, XC | 1 |
| Choi, DS | 1 |
| Sandberg, K | 1 |
| Engberg, G | 1 |
| Lee, R | 1 |
| Fanning, JR | 1 |
| Christensen, K | 1 |
| Larkin, PB | 1 |
| Sathyasaikumar, KV | 1 |
| Muchowski, PJ | 1 |
| Sotgiu, E | 1 |
| Ena, S | 1 |
| Sellgren, CM | 1 |
| Grit, J | 1 |
| Pålsson, E | 1 |
| Landén, M | 1 |
| Lundgren, K | 1 |
| Brundin, P | 1 |
| Deac, OM | 1 |
| Mills, JL | 1 |
| Gardiner, CM | 1 |
| Shane, B | 1 |
| Quinn, L | 1 |
| Fan, R | 1 |
| Lu, Z | 1 |
| Brody, LC | 1 |
| Molloy, AM | 1 |
| Zhang, GF | 1 |
| Han, JF | 1 |
| Guo, J | 1 |
| Xie, ZM | 1 |
| Pan, W | 1 |
| Yang, JJ | 1 |
| Sun, KJ | 1 |
| Kosek, MN | 1 |
| Mduma, E | 1 |
| Kosek, PS | 1 |
| Lee, GO | 1 |
| Svensen, E | 1 |
| Pan, WKY | 1 |
| Olortegui, MP | 1 |
| Bream, JH | 1 |
| Patil, C | 1 |
| Asayag, CR | 1 |
| Sanchez, GM | 1 |
| Caulfield, LE | 1 |
| Gratz, J | 1 |
| Yori, PP | 1 |
| Barat, P | 1 |
| Meiffred, MC | 1 |
| Brossaud, J | 1 |
| Corcuff, JB | 1 |
| Thibault, H | 1 |
| Morales, J | 1 |
| Gao, X | 1 |
| Sternberg, JM | 1 |
| Forrest, CM | 3 |
| Dalton, RN | 1 |
| Turner, C | 1 |
| Rodgers, J | 1 |
| Kennedy, PGE | 1 |
| Rauch, P | 1 |
| Maget, A | 1 |
| Herzog-Eberhard, S | 1 |
| Zelzer, S | 1 |
| Tesch, T | 1 |
| Bannert, E | 1 |
| Kluess, J | 1 |
| Frahm, J | 1 |
| Hüther, L | 1 |
| Kersten, S | 1 |
| Breves, G | 1 |
| Renner, L | 1 |
| Kahlert, S | 1 |
| Rothkötter, HJ | 1 |
| Dänicke, S | 1 |
| Gylling, B | 1 |
| Myte, R | 1 |
| Schneede, J | 1 |
| Hallmans, G | 1 |
| Häggström, J | 1 |
| Johansson, I | 1 |
| Van Guelpen, B | 1 |
| Palmqvist, R | 1 |
| Backhaus, C | 1 |
| Rahman, H | 1 |
| Scheffler, S | 1 |
| Laatsch, H | 1 |
| Hardeland, R | 1 |
| Pawlak, K | 2 |
| Domaniewski, T | 1 |
| Mysliwiec, M | 2 |
| Pawlak, D | 2 |
| Mackay, GM | 2 |
| Christofides, J | 1 |
| Bridel, MA | 1 |
| Mitchell, S | 1 |
| Cowlard, R | 1 |
| Darlington, LG | 2 |
| Brzosko, S | 1 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Serbecic, N | 1 |
| Lahdou, I | 1 |
| Scheuerle, A | 1 |
| Höftberger, R | 1 |
| Aboul-Enein, F | 1 |
| Stankovic, R | 1 |
| Cullen, KM | 1 |
| Meininger, V | 2 |
| Garner, B | 1 |
| Coggan, S | 1 |
| Brew, BJ | 2 |
| Müller, N | 4 |
| Di Pucchio, T | 1 |
| Danese, S | 1 |
| De Cristofaro, R | 1 |
| Rutella, S | 1 |
| Lin, HM | 1 |
| Barnett, MP | 1 |
| Roy, NC | 1 |
| Joyce, NI | 1 |
| Zhu, S | 1 |
| Armstrong, K | 1 |
| Helsby, NA | 1 |
| Ferguson, LR | 1 |
| Rowan, DD | 1 |
| Liu, H | 1 |
| McKenzie, G | 1 |
| Witting, PK | 1 |
| Stasch, JP | 1 |
| Hahn, M | 1 |
| Changsirivathanathamrong, D | 2 |
| Wu, BJ | 1 |
| Ball, HJ | 1 |
| Thomas, SR | 1 |
| Kapoor, V | 1 |
| Celermajer, DS | 2 |
| Keaney, JF | 1 |
| Hunt, NH | 2 |
| Hofmann, F | 1 |
| Murray, MF | 1 |
| Favre, D | 1 |
| Mold, J | 1 |
| Kanwar, B | 1 |
| Loke, P | 1 |
| Seu, L | 1 |
| Barbour, JD | 1 |
| Lowe, MM | 1 |
| Jayawardene, A | 1 |
| Aweeka, F | 1 |
| Douek, DC | 1 |
| Brenchley, JM | 1 |
| Martin, JN | 1 |
| Hecht, FM | 1 |
| Deeks, SG | 1 |
| McCune, JM | 1 |
| Brouns, R | 1 |
| Aerts, T | 1 |
| De Surgeloose, D | 1 |
| Wauters, A | 1 |
| Scharpé, S | 2 |
| De Deyn, PP | 1 |
| Le Floc'h, N | 1 |
| Merlot, E | 1 |
| Cosi, C | 1 |
| Mannaioni, G | 1 |
| Cozzi, A | 1 |
| Carlà, V | 1 |
| Sili, M | 1 |
| Cavone, L | 1 |
| Maratea, D | 1 |
| Moroni, F | 1 |
| Jrad-Lamine, A | 1 |
| Henry-Berger, J | 1 |
| Gourbeyre, P | 1 |
| Damon-Soubeyrand, C | 1 |
| Lenoir, A | 1 |
| Combaret, L | 1 |
| Saez, F | 1 |
| Kocer, A | 1 |
| Tone, S | 1 |
| Zhu, W | 1 |
| Oefner, PJ | 1 |
| Munn, DH | 1 |
| Gharbi, N | 1 |
| Cadet, R | 1 |
| Aitken, RJ | 1 |
| Drevet, JR | 1 |
| Midttun, O | 1 |
| Ringdal Pedersen, E | 1 |
| Ebbing, M | 1 |
| Bleie, O | 1 |
| Schartum-Hansen, H | 1 |
| Myint, AM | 5 |
| Sublette, ME | 1 |
| Galfalvy, HC | 1 |
| Lapidus, M | 1 |
| Grunebaum, MF | 1 |
| Oquendo, MA | 1 |
| Mann, JJ | 1 |
| Steiner, J | 1 |
| Bogerts, B | 1 |
| Sarnyai, Z | 1 |
| Walter, M | 1 |
| Gos, T | 1 |
| Bernstein, HG | 1 |
| Rajbhandari, D | 1 |
| Mak, WM | 1 |
| Woolfe, C | 1 |
| Duflou, J | 1 |
| Gebski, V | 1 |
| dos Remedios, CG | 1 |
| Oxford, L | 1 |
| Millar, K | 1 |
| Higgins, MJ | 1 |
| Knubel, CP | 1 |
| Martínez, FF | 1 |
| Acosta Rodríguez, EV | 1 |
| Altamirano, A | 1 |
| Rivarola, HW | 1 |
| Diaz Luján, C | 1 |
| Fretes, RE | 1 |
| Cervi, L | 1 |
| Motrán, CC | 1 |
| Anacker, C | 1 |
| Cattaneo, A | 1 |
| Choudhury, S | 1 |
| Musaelyan, K | 1 |
| Thuret, S | 1 |
| Price, J | 1 |
| Kuijpers, T | 1 |
| Lutter, R | 1 |
| Combes, V | 1 |
| Chan-Ling, T | 1 |
| Grau, GE | 1 |
| Christensen, MH | 1 |
| Pedersen, EK | 1 |
| Nordbø, Y | 1 |
| Varhaug, JE | 1 |
| Lien, EA | 1 |
| Kwon, S | 1 |
| Lee, B | 1 |
| Yeom, M | 1 |
| Sur, BJ | 1 |
| Kim, M | 1 |
| Kim, ST | 1 |
| Lee, H | 1 |
| Hahm, DH | 1 |
| Weiner, J | 1 |
| Parida, SK | 1 |
| Maertzdorf, J | 1 |
| Black, GF | 1 |
| Repsilber, D | 1 |
| Telaar, A | 1 |
| Mohney, RP | 1 |
| Arndt-Sullivan, C | 1 |
| Ganoza, CA | 1 |
| Faé, KC | 1 |
| Walzl, G | 1 |
| Kaufmann, SH | 1 |
| Tan, L | 2 |
| Yu, JT | 1 |
| Harden, JL | 1 |
| Egilmez, NK | 1 |
| Kolodziej, L | 1 |
| Kita, T | 1 |
| Morrison, PF | 1 |
| Heyes, MP | 1 |
| Markey, SP | 1 |
| Bonaccorso, S | 1 |
| Ombelet, W | 1 |
| Bosmans, E | 2 |
| Shader, RI | 1 |
| Pertovaara, M | 1 |
| Heliövaara, M | 1 |
| Raitala, A | 1 |
| Oja, SS | 1 |
| Knekt, P | 1 |
| Hurme, M | 1 |
| Mihaylova, I | 1 |
| Ruyter, MD | 1 |
| Kubera, M | 1 |
| De Luca, A | 2 |
| Montagnoli, C | 1 |
| D'Angelo, C | 1 |
| Bistoni, F | 1 |
| Fioretti, MC | 1 |
| Segal, BH | 1 |
| Holmes, EW | 1 |
| Russell, PM | 1 |
| Kinzler, GJ | 1 |
| Reckard, CR | 1 |
| Flanigan, RC | 1 |
| Thompson, KD | 1 |
| Bermes, EW | 1 |
| Peterhans, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Genetic Risk Factors Predictive of the Occurrence of Maternally Diagnosed Perinatal Depression in Women[NCT05175755] | 3,000 participants (Anticipated) | Interventional | 2023-09-25 | Not yet recruiting | |||
| Observational Study on T Regulatory Cells in Hemodialysis Patients[NCT02981992] | 30 participants (Actual) | Observational | 2011-02-28 | Completed | |||
| Effects of 3-month Probiotic Mix Supplementation (L. Helveticus R-0052, B. Longum R-0175) on Gut Microbiota and Metabolome, Endocannabinoid and Immune Systems Activation, Along With Symptoms of Fatigue in Professional Dancers[NCT05567653] | 60 participants (Anticipated) | Interventional | 2022-09-21 | Recruiting | |||
| Possible Links Between Inflammation and Lipid Metabolism[NCT03392701] | 10 participants (Actual) | Interventional | 2017-12-20 | Completed | |||
| Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal[NCT05751837] | Phase 1 | 6 participants (Anticipated) | Interventional | 2023-03-16 | Recruiting | ||
| TransplantLines Insulin Resistance and Inflammation Biobank and Cohort Study[NCT03272854] | 606 participants (Actual) | Observational [Patient Registry] | 2001-08-31 | Active, not recruiting | |||
| Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients With Metabolic Syndrome[NCT05275608] | 40 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
| The Effects of Daily Anti-inflammatory Supplementation on Foundation Pain Index Scores in Chronic Opiate Patients[NCT05896878] | 20 participants (Anticipated) | Interventional | 2023-07-10 | Enrolling by invitation | |||
| Assessing the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation as an Anti-inflammatory Treatment Following Spinal Cord Injury[NCT05730049] | 30 participants (Anticipated) | Interventional | 2023-04-30 | Not yet recruiting | |||
| Vitamin B6 Effects on One-Carbon Metabolism[NCT01128244] | Phase 2/Phase 3 | 13 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Vitamin B6 Dependence of One-Carbon Metabolism[NCT00877812] | 45 participants (Actual) | Interventional | 2008-01-31 | Completed | |||
| Effect of a Treatment Switch From Protease Inhibitor to Raltegravir-based ART on Myeloid Cell Inflammation in HIV-infected Patients.[NCT02691065] | Phase 4 | 6 participants (Actual) | Interventional | 2017-01-20 | Completed | ||
| A Randomized Controlled Trial of Adjunctive Siltuximab in Schizophrenia[NCT02796859] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| An Open-Label Trial of Tocilizumab in Schizophrenia[NCT01696929] | Phase 1 | 8 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| A Randomised Double Blind Study of the Effects of Homocysteine Lowering Therapy on Mortality and Cardiac Events in Patients Undergoing Coronary Angiography[NCT00354081] | Phase 3 | 3,096 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| A Longitudinal Study of Inflammatory Pathways in Depression[NCT04159207] | 160 participants (Anticipated) | Observational | 2019-10-01 | Recruiting | |||
| Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis[NCT04700579] | 150 participants (Anticipated) | Observational [Patient Registry] | 2021-03-04 | Recruiting | |||
| Pregnancy and Anxious Thoughts: The Role of the Immune and Endocrine Systems[NCT03664128] | 157 participants (Actual) | Observational | 2016-06-24 | Completed | |||
| [NCT00113737] | 0 participants | Interventional | 1998-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
For all subjects, the concentration of plasma cystathionine in fasting blood samples taken before and after the supplementation period will provide a functional measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | micromol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Cystathionine Concentration | 0.14 | 0.13 |
For all subjects, the concentration of plasma pyridoxal phosphate in fasting blood samples taken before and after the supplementation period will provide a direct measure of vitamin B6 nutritional status. (NCT01128244)
Timeframe: Fasting blood samples will be taken at baseline and after 28 days of vitamin B6 supplementation.
| Intervention | nmol/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Plasma Pyridoxal Phosphate Concentration | 25.8 | 143 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of homocysteine remethylation from serine-derived carbon before and after vitamin B6 supplementation. These flux values may be slightly higher than flux of total homocysteine remethylation in Outcome Measure 1 because of the small contribution of methionine salvage to the flux measured in Outcome Measure 2. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Homocysteine Remethylation Flux From Serine | 6.60 | 6.92 |
For all subjects, analysis of blood samples before and after vitamin B6 supplementation will allow evaluation of discriminating biomarkers using targeted metabolite profile analysis of one-carbon metabolism and tryptophan catabolism constituents. Also, we will conduct exploratory evaluation and potential identification of new biomarkers using metabolomics analysis on subjects before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: April, 2010 - June, 2014
| Intervention | microl/L (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Secondary Analysis: Plasma 3-hydroxykynurenine Concentration | 25.9 | 27.3 |
Data from analysis of serine, methionine and leucine in the timed blood samples of all subjects will provide a measurement of the metabolic rate of total remethylation of homocysteine before and after vitamin B6 supplementation. (NCT01128244)
Timeframe: Blood samples will be taken prior to infusion and at 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, 6, 7.5, and 9h. Infusions will be conducted at baseline and after 28 days
| Intervention | micromol/(kg x hr) (Mean) | |
|---|---|---|
| Baseline prior to vitamin supplementation | After 28-days of vitamin supplementation | |
| Total Homocysteine Remethylation Flux | 6.07 | 5.63 |
The Brief Assessment of Cognition in Schizophrenia (BACS) is the metric used to characterize cognition in this study. The BACS consists of 6 subscales: Verbal Memory (range 0-75), Working Memory (range 0-28), Motor Speed (range 0-100), Verbal Fluency (measure is total number of words generated in two 60 second trials), Attention and Processing speed (range 0-110), and Executive Function (range 0-22). For each subscale, higher scores reflect better cognition. For each subscale, a Standard Deviation Score was calculated based on normative data (Keefe et al. Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS). Schizophrenia Research 102 (2008) 108-115). The BACS composite score is calculated as the average Standard Deviation Score of the 6 subscale scores. The change in BACS composite score was calculated as the BACS composite score at 8 weeks minus the BACS composite score at baseline. (NCT01696929)
Timeframe: Change in BACS composite score from baseline to 8 weeks
| Intervention | Change in BACS Composite Score (Mean) |
|---|---|
| Tocilizumab | 0.7 |
The Positive and Negative Symptoms Scale (PANSS) is the metric used to characterize psychotic symptoms in this study. The PANSS consists of 30 items, each scored 1-7. The range for the PANSS total score is 30-210. There are 3 subscales - PANSS positive score (range 7-49), PANSS negative score (range 7-49), and PANSS general score (range 16-112). PANSS total score is the summation of these 3 subscales. Higher values for the total and subscale scores reflect more severe psychopathology. A positive change in PANSS total score reflects an increase in psychopathology. A negative change in PANSS total score reflects a decrease in psychopathology. (NCT01696929)
Timeframe: Change in PANSS total score from baseline to 8 weeks
| Intervention | Change in PANSS Total Score (Mean) |
|---|---|
| Tocilizumab | -2.6 |
84 reviews available for kynurenine and Innate Inflammatory Response
| Article | Year |
|---|---|
Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.
Topics: Animals; Gastrointestinal Microbiome; Humans; Inflammation; Inflammatory Bowel Diseases; Kynurenine; | 2021 |
HIV-Associated Neurotoxicity: The Interplay of Host and Viral Proteins.
Topics: AIDS Dementia Complex; Anti-Retroviral Agents; Astrocytes; Central Nervous System; Genome; HIV Envel | 2021 |
Redressing the interactions between stem cells and immune system in tissue regeneration.
Topics: Animals; Cell Adhesion Molecules; Cell Differentiation; Cell Proliferation; COVID-19; Humans; Immune | 2021 |
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
Role and Perspectives of Inflammation and C-Reactive Protein (CRP) in Psychosis: An Economic and Widespread Tool for Assessing the Disease.
Topics: Biomarkers; Blood-Brain Barrier; C-Reactive Protein; Humans; Inflammation; Kynurenine; Risk Factors; | 2021 |
The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors.
Topics: Animals; Drug Design; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Inflammati | 2022 |
Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process.
Topics: Aging; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2022 |
Neurological Infection, Kynurenine Pathway, and Parasitic Infection by
Topics: Animals; Humans; Inflammation; Kynurenine; Neospora; Nervous System Diseases; Parasitic Diseases; Si | 2021 |
Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation.
Topics: Adaptive Immunity; Amino Acid Transport Systems, Neutral; Angiotensin-Converting Enzyme 2; Basic Hel | 2022 |
Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease.
Topics: Biomarkers; Coronary Artery Disease; Humans; Inflammation; Kynurenine; Tryptophan | 2021 |
COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route.
Topics: COVID-19; Depression; Depressive Disorder, Major; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infl | 2022 |
An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway.
Topics: Animals; Biomarkers; Ecosystem; Inflammation; Kynurenine; Mammals; Tryptophan | 2022 |
The role and mechanism of tryptophan - kynurenine metabolic pathway in depression.
Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Metabolic Networks and Pat | 2023 |
The Interrelation between Oxidative Stress, Depression and Inflammation through the Kynurenine Pathway.
Topics: Cytokines; Depression; Humans; Inflammation; Kynurenine; Oxidative Stress; Tryptophan | 2023 |
HIV and comorbidities - the importance of gut inflammation and the kynurenine pathway.
Topics: Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; NAD | 2023 |
Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response.
Topics: Colitis, Ulcerative; Comorbidity; Depression; Humans; Inflammation; Kynurenine; Tryptophan | 2023 |
Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Female; Inflammation; Kynurenine; Mammals; Pregnancy; Tryp | 2023 |
A unified model of the biology of peripartum depression.
Topics: Biology; Depression; Depression, Postpartum; Depressive Disorder, Treatment-Resistant; Female; Human | 2023 |
IDO/Kynurenine; novel insight for treatment of inflammatory diseases.
Topics: Animals; Cytokines; Diabetes Mellitus, Type 2; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; K | 2023 |
Glucocorticoid Hormones as Modulators of the Kynurenine Pathway in Chronic Pain Conditions.
Topics: Chronic Pain; Cytokines; Glucocorticoids; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; In | 2023 |
Modulation of T cells by tryptophan metabolites in the kynurenine pathway.
Topics: Autoimmune Diseases; Humans; Inflammation; Kynurenine; T-Lymphocytes; Tryptophan | 2023 |
Research progress on the kynurenine pathway in the prevention and treatment of Parkinson's disease.
Topics: Central Nervous System; Humans; Inflammation; Kynurenine; Parkinson Disease | 2023 |
Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review.
Topics: Blood Platelets; Cytokines; Dysbiosis; Humans; Inflammation; Kynurenine; Neuroinflammatory Diseases; | 2023 |
Dietary Kynurenine Pathway Metabolites-Source, Fate, and Chromatographic Determinations.
Topics: Animals; Chromatography; Diet; Humans; Inflammation; Kynurenine; Mammals; Tryptophan | 2023 |
Microbiome and Mental Health, Specifically as It Relates to Adolescents.
Topics: Adolescent; Brain; Depression; Diet, Healthy; Gastrointestinal Microbiome; Humans; Hypothalamo-Hypop | 2019 |
Kynurenine signaling through the aryl hydrocarbon receptor: Implications for aging and healthspan.
Topics: Aging; Animals; Basic Helix-Loop-Helix Transcription Factors; Humans; Inflammation; Kynurenine; Long | 2020 |
IDO activation, inflammation and musculoskeletal disease.
Topics: Animals; Arthritis, Rheumatoid; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2020 |
Effects of inflammation on the kynurenine pathway in schizophrenia - a systematic review.
Topics: Humans; Inflammation; Kynurenine; Psychotic Disorders; Schizophrenia | 2020 |
Inflammation-Induced Tryptophan Breakdown is Related With Anemia, Fatigue, and Depression in Cancer.
Topics: Anemia; Animals; Depression; Fatigue; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ky | 2020 |
More than a cell biosensor: aryl hydrocarbon receptor at the intersection of physiology and inflammation.
Topics: Animals; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Kynurenine; Receptors, Aryl Hy | 2020 |
Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines.
Topics: Alzheimer Disease; Anti-Inflammatory Agents; Biomarkers; Cytokines; Humans; Huntington Disease; Infl | 2020 |
AhR and IDO1 in pathogenesis of Covid-19 and the "Systemic AhR Activation Syndrome:" a translational review and therapeutic perspectives.
Topics: Air Pollutants; Betacoronavirus; Calcitriol; Coronavirus Infections; COVID-19; COVID-19 Drug Treatme | 2020 |
Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?
Topics: Animals; Cognition; COVID-19; Humans; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Neuropro | 2021 |
Latest developments in tryptophan metabolism: Understanding its role in B cell immunity.
Topics: B-Lymphocytes; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2021 |
Pro-Inflammatory Cytokines: Potential Links between the Endocannabinoid System and the Kynurenine Pathway in Depression.
Topics: Animals; Biomarkers; Cytokines; Depression; Disease Susceptibility; Endocannabinoids; Humans; Inflam | 2021 |
Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis.
Topics: Bipolar Disorder; Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan | 2021 |
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inf | 2021 |
Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Bipolar Disorder; Cytokines; Depressive Di | 2021 |
Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications.
Topics: Animals; Humans; Inflammation; Kynurenine; Mental Disorders; Neurodegenerative Diseases | 2021 |
The Kynurenine Pathway in Traumatic Brain Injury: Implications for Psychiatric Outcomes.
Topics: Brain Injuries, Traumatic; Humans; Inflammation; Kynurenine; Quinolinic Acid; Receptors, N-Methyl-D- | 2022 |
Covid-19 interface with drug misuse and substance use disorders.
Topics: Adaptation, Psychological; Angiotensin-Converting Enzyme 2; Animals; Axons; Comorbidity; COVID-19; D | 2021 |
Crosstalk between Tryptophan Metabolism and Cardiovascular Disease, Mechanisms, and Therapeutic Implications.
Topics: Cardiovascular Diseases; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Liv | 2017 |
The Interactions Between Kynurenine, Folate, Methionine and Pteridine Pathways in Obesity.
Topics: Animals; Folic Acid; Humans; Inflammation; Kynurenine; Methionine; Obesity; Pteridines; Signal Trans | 2017 |
Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.
Topics: Brain; Depression; Exercise; Gastrointestinal Microbiome; Gastrointestinal Tract; Humans; Inflammati | 2017 |
The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis.
Topics: Adaptive Immunity; Animals; Atherosclerosis; Cardiovascular Diseases; Cytokines; Humans; Immunity, I | 2019 |
Neuroinflammation and the Immune-Kynurenine Pathway in Anxiety Disorders.
Topics: Animals; Anxiety Disorders; Humans; Inflammation; Kynurenine; Signal Transduction | 2018 |
Mechanisms of poststroke fatigue.
Topics: Fatigue; Humans; Inflammation; Kynurenine; Signal Transduction; Stroke; Tryptophan | 2018 |
Inflammation-induced depression: Its pathophysiology and therapeutic implications.
Topics: Animals; Depression; Humans; Inflammation; Kynurenine; Serotonin; Tryptophan | 2017 |
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progressio | 2017 |
Targeting metabotropic glutamate receptors for the treatment of neuroinflammation.
Topics: Animals; Central Nervous System Diseases; Humans; Inflammation; Kynurenine; Mental Disorders; Microg | 2018 |
Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines.
Topics: Alzheimer Disease; Animals; Central Nervous System; Disease Models, Animal; Energy Metabolism; Gluta | 2018 |
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; | 2018 |
Neurological and Inflammatory Manifestations in Sjögren's Syndrome: The Role of the Kynurenine Metabolic Pathway.
Topics: Animals; Autoimmunity; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nervous Sy | 2018 |
RETRACTED: Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus.
Topics: Diabetes, Gestational; Embryonic Development; Female; Fetal Development; Homeostasis; Humans; Inflam | 2020 |
Inflammation in cancer and depression: a starring role for the kynurenine pathway.
Topics: Antidepressive Agents; Depression; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infl | 2019 |
The 'Yin' and the 'Yang' of the kynurenine pathway: excitotoxicity and neuroprotection imbalance in stress-induced disorders.
Topics: Animals; Brain; Cytokines; Depressive Disorder, Major; Excitatory Amino Acid Agents; Humans; Hypotha | 2019 |
Microbiota Alterations in Alzheimer's Disease: Involvement of the Kynurenine Pathway and Inflammation.
Topics: Alzheimer Disease; Animals; Gastrointestinal Microbiome; Humans; Inflammation; Kynurenine; Oxidative | 2019 |
[Immune modulation by tryptophan metabolism: relevance for autoimmune and tumor diseases].
Topics: Animals; Autoimmune Diseases; Brain; Dietary Supplements; Disease Models, Animal; Dose-Response Rela | 2013 |
Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?
Topics: Animals; Blood-Brain Barrier; Depressive Disorder; Glutamic Acid; Humans; Indoleamine-Pyrrole 2,3,-D | 2014 |
The common inflammatory etiology of depression and cognitive impairment: a therapeutic target.
Topics: Animals; Cognition Disorders; Depression; Humans; Inflammation; Kynurenine; Signal Transduction; Try | 2014 |
The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment.
Topics: Animals; Cell Proliferation; Dendritic Cells; Humans; Immunity, Cellular; Immunotherapy; Indoleamine | 2015 |
Immune-Mediated Metabolic Kynurenine Pathways Are Involved in the Postoperative Cognitive Dysfunction after Cardiopulmonary Bypass.
Topics: Biomarkers; Biosynthetic Pathways; Brain; Cardiopulmonary Bypass; China; Cognition Disorders; Humans | 2015 |
Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation.
Topics: Adult; Aged; Animals; Cardiovascular Diseases; Female; Humans; Immune System Diseases; Inflammation; | 2015 |
Direct and Functional Biomarkers of Vitamin B6 Status.
Topics: Amino Acids; Biomarkers; Body Mass Index; Female; Health Status; Humans; Infant; Infant, Newborn; In | 2015 |
Therapeutic targeting of inflammation and tryptophan metabolism in colon and gastrointestinal cancer.
Topics: Colon; Gastrointestinal Neoplasms; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infl | 2016 |
Cognition and Emotions in Recurrent Depressive Disorders - The Role of Inflammation and the Kynurenine Pathway.
Topics: Animals; Cognition; Depressive Disorder; Emotions; Humans; Inflammation; Kynurenine; Recurrence; Sig | 2016 |
Kynurenine pathway metabolites and suicidality.
Topics: Animals; Cytokines; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Suicide | 2017 |
[Depression and inflammation in rheumatic diseases].
Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2016 |
Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches.
Topics: Animals; Depressive Disorder; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Neu | 2017 |
COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Cytokines; Depres | 2010 |
COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Cytokines; Depres | 2010 |
COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Cytokines; Depres | 2010 |
COX-2 inhibitors as antidepressants and antipsychotics: clinical evidence.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Cyclooxygenase 2 Inhibitors; Cytokines; Depres | 2010 |
Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds.
Topics: Animals; Autoimmunity; Drug Evaluation, Preclinical; Enzyme Inhibitors; Humans; Immune Tolerance; In | 2010 |
Tryptophan metabolism, from nutrition to potential therapeutic applications.
Topics: Animals; Drug Therapy; Humans; Infections; Inflammation; Kynurenine; Nutritional Status; Tryptophan | 2011 |
Inflammation-associated depression: from serotonin to kynurenine.
Topics: Animals; Cytokines; Depression; Disease Models, Animal; Humans; Inflammation; Kynurenine; Models, Bi | 2011 |
Kynurenine pathway in schizophrenia: pathophysiological and therapeutic aspects.
Topics: Animals; Anti-Inflammatory Agents; Antipsychotic Agents; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenas | 2011 |
Bridging the gap between the immune and glutamate hypotheses of schizophrenia and major depression: Potential role of glial NMDA receptor modulators and impaired blood-brain barrier integrity.
Topics: Blood-Brain Barrier; Depressive Disorder, Major; Glutamic Acid; Humans; Inflammation; Kynurenine; Ne | 2012 |
The kynurenine system and immunoregulation.
Topics: Animals; Humans; Immune Tolerance; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammat | 2012 |
Inflammation and repeated infections in CGD: two sides of a coin.
Topics: Animals; Female; Granulomatous Disease, Chronic; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Infla | 2012 |
The role of the kynurenine metabolism in major depression.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Trypto | 2012 |
The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.
Topics: Astrocytes; Communicable Diseases; Endothelial Cells; Humans; Inflammation; Kynurenine; Neurons; Qui | 2012 |
Inflammation in schizophrenia.
Topics: Antipsychotic Agents; Brain; Humans; Inflammation; Kynurenine; Macrophages; Microglia; Monocytes; Sc | 2012 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Hunting | 2012 |
Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.
Topics: Animals; Autoimmunity; Cell Lineage; Dendritic Cells; Gene Expression Regulation; Humans; Immune Tol | 2012 |
Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Inflammation; Kynurenine; Models, Neurological; Moto | 2005 |
IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi.
Topics: Animals; Cytokines; Fungi; Humans; Immune Reconstitution Inflammatory Syndrome; Indoleamine-Pyrrole | 2008 |
10 trials available for kynurenine and Innate Inflammatory Response
| Article | Year |
|---|---|
Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging.
Topics: Bicarbonates; C-Reactive Protein; Cross-Over Studies; Down-Regulation; Female; Hemodiafiltration; Hu | 2019 |
Toward a neuroprotective shift: Eight weeks of high intensity interval training reduces the neurotoxic kynurenine activity concurrently to impulsivity in emotionally impulsive humans - A randomized controlled trial.
Topics: Animals; High-Intensity Interval Training; Humans; Impulsive Behavior; Inflammation; Kynurenine; Mic | 2021 |
Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial.
Topics: Administration, Intravenous; Adolescent; Adult; C-Reactive Protein; Cross-Over Studies; Humans; Infl | 2021 |
Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial.
Topics: Administration, Intravenous; Adolescent; Adult; C-Reactive Protein; Cross-Over Studies; Humans; Infl | 2021 |
Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial.
Topics: Administration, Intravenous; Adolescent; Adult; C-Reactive Protein; Cross-Over Studies; Humans; Infl | 2021 |
Intravenous administration of LPS activates the kynurenine pathway in healthy male human subjects: a prospective placebo-controlled cross-over trial.
Topics: Administration, Intravenous; Adolescent; Adult; C-Reactive Protein; Cross-Over Studies; Humans; Infl | 2021 |
Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
Topics: Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Echocardiography; Female; Humans; Hyp | 2017 |
Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism.
Topics: Aged; Anxiety; Depression; Exercise; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; | 2019 |
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynur | 2019 |
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic A | 2015 |
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic A | 2015 |
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic A | 2015 |
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives o
Topics: Adult; Biomarkers; Carbon; Contraceptives, Oral, Hormonal; Female; Humans; Inflammation; Kynurenic A | 2015 |
Impact of cholesterol lowering treatment on plasma kynurenine and tryptophan concentrations in chronic kidney disease: relationship with oxidative stress improvement.
Topics: Aged; Allantoin; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Res | 2015 |
Kynurenine metabolites and inflammation markers in depressed patients treated with fluoxetine or counselling.
Topics: Adult; Antidepressive Agents; Biomarkers; Counseling; Depression; Drug Therapy, Combination; Female; | 2009 |
Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation.
Topics: Adult; Anxiety; Depression; Female; Humans; Immunity; Inflammation; Interleukin-6; Interleukin-8; Ky | 2002 |
180 other studies available for kynurenine and Innate Inflammatory Response
| Article | Year |
|---|---|
Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms.
Topics: Alcoholism; Gastrointestinal Microbiome; Humans; Inflammation; Kynurenic Acid; Kynurenine; Quinolini | 2021 |
Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia.
Topics: Glycogen Synthase Kinase 3; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Induced Pluripotent Stem C | 2022 |
The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder.
Topics: Bipolar Disorder; Cognitive Dysfunction; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptopha | 2022 |
Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.
Topics: Animals; Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Dioxygenases; Fibroblasts; Inflammat | 2022 |
Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study.
Topics: C-Reactive Protein; Depression; Humans; Indoles; Inflammation; Kynurenine; Obesity; Tryptophan | 2022 |
Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis.
Topics: Animals; Female; Gastrointestinal Microbiome; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflamma | 2022 |
Kynurenine pathway of tryptophan metabolism in patients with familial Mediterranean fever.
Topics: Case-Control Studies; Familial Mediterranean Fever; Humans; Inflammation; Kynurenine; Tryptophan | 2023 |
Editorial: Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Tryptophan | 2022 |
Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites.
Topics: Chromatography, Liquid; Humans; Inflammation; Kynurenine; Nitric Oxide; Pilot Projects; Pterins; Tan | 2022 |
Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Humans; Inflammation; Kynurenine; Tryptophan | 2022 |
Inflammation and serotonin deficiency in major depressive disorder: molecular docking of antidepressant and anti-inflammatory drugs to tryptophan and indoleamine 2,3-dioxygenases.
Topics: Anti-Inflammatory Agents; Antidepressive Agents; Depressive Disorder, Major; Humans; Indoleamine-Pyr | 2022 |
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic | 2022 |
Metabolites and growth factors produced by airway epithelial cells induce tolerance in macrophages.
Topics: Epithelial Cells; Granulocyte Colony-Stimulating Factor; Humans; Inflammation; Interleukin-10; Kynur | 2022 |
Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19.
Topics: Biomarkers; Chromatography, Liquid; COVID-19; Humans; Inflammation; Kynurenine; Metabolomics; SARS-C | 2022 |
Kynurenines in polycystic kidney disease.
Topics: Adult; Child; Disease Progression; Glomerular Filtration Rate; Humans; Inflammation; Kidney; Kynuren | 2023 |
Plasma metabolomic profiling reflects the malnourished and chronic inflammatory state in recessive dystrophic epidermolysis bullosa.
Topics: Chromatography, Liquid; Epidermolysis Bullosa Dystrophica; Fibrosis; Glutamates; Glutamine; Humans; | 2022 |
A combination of neuroimaging and plasma metabolomic analysis suggests inflammation is associated with white matter structural connectivity in major depressive disorder.
Topics: Brain; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Lysophosphatidylcholines; Magne | 2022 |
Tryptophan Modulatory Role in European Seabass (
Topics: Animal Feed; Animals; Bass; Disease Resistance; Hydrocortisone; Inflammation; Kynurenine; Membrane G | 2022 |
A kynurenine pathway enzyme aminocarboxymuconate-semialdehyde decarboxylase may be involved in treatment-resistant depression, and baseline inflammation status of patients predicts treatment response: a pilot study.
Topics: Biomarkers; Depression; Depressive Disorder, Treatment-Resistant; Electroconvulsive Therapy; Humans; | 2022 |
Involvement of kynurenine pathway between inflammation and glutamate in the underlying etiopathology of CUMS-induced depression mouse model.
Topics: Animals; Depression; Disease Models, Animal; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; In | 2022 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Systemic Activation of the Kynurenine Pathway in Graves Disease With and Without Ophthalmopathy.
Topics: Biomarkers; Graves Disease; Graves Ophthalmopathy; Humans; Inflammation; Interferon-gamma; Kynurenin | 2023 |
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium.
Topics: Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Inflammation; Interferon-gamma; Kyn | 2023 |
Impaired kynurenine metabolism in patients with primary Sjögren's syndrome.
Topics: Chromatography, Liquid; Humans; Inflammation; Kynurenine; Sjogren's Syndrome; Tandem Mass Spectromet | 2023 |
A Vegetarian Diet Significantly Changes Plasma Kynurenine Concentrations.
Topics: Biomarkers; Diet, Vegetarian; Female; Humans; Inflammation; Kynurenine; Riboflavin; Tryptophan | 2023 |
Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder.
Topics: Depressive Disorder, Major; Dioxygenases; Humans; Inflammation; Kynurenine; Quality of Life; Tryptop | 2023 |
PTSD, Immune System, and Inflammation.
Topics: Humans; Hypothalamo-Hypophyseal System; Immune System; Inflammation; Kynurenine; Pituitary-Adrenal S | 2023 |
Body fat and components of sarcopenia relate to inflammation, brain volume, and neurometabolism in older adults.
Topics: Adipose Tissue; Aged; Aged, 80 and over; Biomarkers; Brain; Creatine; Encephalitis; Hand Strength; H | 2023 |
A tryptophan metabolite prevents depletion of circulating endothelial progenitor cells in systemic low-grade inflammation.
Topics: Animals; C-Reactive Protein; Endothelial Progenitor Cells; Inflammation; Kynurenine; Lipopolysacchar | 2023 |
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocyto | 2023 |
Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis.
Topics: Adult; HIV Infections; Humans; Inflammation; Kynurenine; Meningitis, Cryptococcal; Tryptophan; Tuber | 2023 |
Monitoring of strength, inflammation and muscle function in allogenic stem-cell transplantation patients - a pilot study for novel biomarker and risk stratification determination.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Fatigue; Female; Galectin 3; Hematopoietic Stem Cell Tr | 2023 |
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Critical Illness; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice | 2023 |
The effect of inflammation, SARS-CoV-2 infection, age and mental health on serotonin, and kynurenine and catecholamine pathway metabolites.
Topics: COVID-19; Cross-Sectional Studies; Dopamine; Humans; Inflammation; Kynurenine; Mental Health; Phenyl | 2023 |
Does smoking influence tryptophan metabolism in periodontal inflammation? A cross-sectional study.
Topics: Biomarkers; Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenine; Periodontal Di | 2023 |
Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ky | 2023 |
Simultaneous separation and detection of nine kynurenine pathway metabolites by reversed-phase liquid chromatography-mass spectrometry: Quantitation of inflammation in human cerebrospinal fluid and plasma.
Topics: Chromatography, Liquid; Chromatography, Reverse-Phase; Humans; Inflammation; Kynurenine; Tandem Mass | 2023 |
Correlation between immune-related Tryptophan-Kynurenine pathway and severity of severe pneumonia and inflammation-related polyunsaturated fatty acids.
Topics: Arachidonic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Ac | 2023 |
A mood state-specific interaction between kynurenine metabolism and inflammation is present in bipolar disorder.
Topics: Adult; Affect; Biomarkers; Bipolar Disorder; C-Reactive Protein; Depression; Female; Humans; Inflamm | 2020 |
Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits.
Topics: Adult; Anxiety Disorders; Arachidonic Acids; Cohort Studies; Endocannabinoids; Female; Glycerides; H | 2019 |
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infec | 2020 |
Why Am I Getting Fat? Exploring Immune-Metabolic Pathways to Central Fat Accumulation in Persons With HIV.
Topics: Abdominal Fat; HIV; HIV Infections; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathway | 2020 |
Impaired metabolism of kynurenine and its metabolites in CSF of parkinson's disease.
Topics: Aged; Case-Control Studies; Cytokines; Female; Humans; Inflammation; Interferon-gamma; Interleukin-1 | 2020 |
Inflammation and kynurenine pathway dysregulation in post-partum women with severe and suicidal depression.
Topics: Adult; Cross-Sectional Studies; Depression, Postpartum; Female; Humans; Inflammation; Kynurenine; Po | 2020 |
Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Cognitive Dysfunction; Enzyme Inhibi | 2020 |
Associations among peripheral and central kynurenine pathway metabolites and inflammation in depression.
Topics: Depression; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan | 2020 |
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; I | 2020 |
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans.
Topics: Carotid Artery Diseases; Down-Regulation; Humans; Inflammation; Kynurenic Acid; Kynurenine; Macropha | 2021 |
Kynurenines link chronic inflammation to functional decline and physical frailty.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arginine; Chronic Disease; Cytokines; Disease Models, Anima | 2020 |
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in hidradenitis suppurativa.
Topics: Adult; Axilla; Female; Fibroblasts; Hidradenitis Suppurativa; Host Microbial Interactions; Humans; I | 2020 |
C-Reactive Protein as a Possible Predictor of Trail-Making Performance in Individuals with Psychiatric Disorders.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Cognitive Dysfunction; Female; Humans; Inflammation; In | 2020 |
Kynurenine pathway dysregulation in postpartum depression.
Topics: Depression, Postpartum; Female; Humans; Inflammation; Kynurenine; Postpartum Period; Suicidal Ideati | 2021 |
Regarding letter on "Kynurenine pathway dysregulation in postpartum depression", by Achtyes et al, 2020.
Topics: Depression, Postpartum; Female; Humans; Inflammation; Kynurenine; Postpartum Period; Suicidal Ideati | 2021 |
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Fem | 2020 |
Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.
Topics: Animals; Antiviral Agents; Female; Hepatitis Viruses; Hepatitis, Viral, Animal; Hepatocytes; Humans; | 2020 |
Plasma Kynurenine to Tryptophan Ratio Is Negatively Associated with Linear Growth of Children Living in a Slum of Bangladesh: Results from a Community-Based Intervention Study.
Topics: Bangladesh; Biomarkers; Chromatography, Liquid; Cohort Studies; Female; Growth and Development; Grow | 2020 |
Associations between estrogen and progesterone, the kynurenine pathway, and inflammation in the post-partum.
Topics: Depression, Postpartum; Estrogens; Female; Humans; Inflammation; Kynurenine; Postpartum Period; Preg | 2021 |
Differential effects on blood and cerebrospinal fluid immune protein markers and kynurenine pathway metabolites from aerobic physical exercise in healthy subjects.
Topics: Adult; Biomarkers; Chromatography, Liquid; Exercise; Female; Humans; Inflammation; Kynurenine; Male; | 2021 |
Early-Life Stress Modulates Gut Microbiota and Peripheral and Central Inflammation in a Sex-Dependent Manner.
Topics: Animals; Animals, Newborn; Cytokines; Female; Gastrointestinal Microbiome; Hippocampus; Inflammation | 2021 |
Inflammation, negative affect, and amyloid burden in Alzheimer's disease: Insights from the kynurenine pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cognitive Dysfunction; Humans; Inflammation; Kynurenine | 2021 |
Association of Markers of Inflammation, the Kynurenine Pathway and B Vitamins with Age and Mortality, and a Signature of Inflammaging.
Topics: Aged; Biomarkers; Cohort Studies; Humans; Inflammation; Kynurenine; Vitamin B Complex | 2022 |
Gut ACE2 Expression, Tryptophan Deficiency, and Inflammatory Responses The Potential Connection That Should Not Be Ignored During SARS-CoV-2 Infection.
Topics: Angiotensin-Converting Enzyme 2; Animals; COVID-19; Cytokines; Epithelial Cells; Inflammation; Intes | 2021 |
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults.
Topics: Aged; Aged, 80 and over; Biomarkers; Body Mass Index; C-Reactive Protein; Carbon; Female; Humans; In | 2021 |
The association between plasma tryptophan catabolites and depression: The role of symptom profiles and inflammation.
Topics: Depression; Depressive Disorder, Major; Humans; Inflammation; Kynurenic Acid; Kynurenine; Tryptophan | 2021 |
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.
Topics: Animals; Biogenic Amines; Cell Line, Tumor; Dendritic Cells; Disease Models, Animal; Endothelial Cel | 2021 |
The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene.
Topics: Animals; Biomarkers; C-Reactive Protein; Inflammation; Kynurenine; Male; Mice; Polymorphism, Single | 2021 |
Hypoxic preconditioning protects against ischemic kidney injury through the IDO1/kynurenine pathway.
Topics: Animals; Hypoxia; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ischemia; Kidney; Kynurenine; | 2021 |
Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease.
Topics: Adult; Aged; Anxiety; Biomarkers; C-Reactive Protein; Case-Control Studies; Colon; Depression; Femal | 2017 |
Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets.
Topics: Biomarkers; Humans; Hyperglycemia; Hypoxia; Inflammation; Insulin; Insulin Secretion; Islets of Lang | 2017 |
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Dep | 2017 |
The tryptophan/kynurenine pathway, systemic inflammation, and long-term outcome after kidney transplantation.
Topics: Adult; Biomarkers; Chromatography, Liquid; Female; Graft Rejection; Graft Survival; Humans; Inflamma | 2017 |
Rescue of IL-1β-induced reduction of human neurogenesis by omega-3 fatty acids and antidepressants.
Topics: Antidepressive Agents; Cell Culture Techniques; Cytokines; Depression; Depressive Disorder, Major; D | 2017 |
Possible changes of New-Generation inflammation markers with occupational lead exposure.
Topics: Adult; Biomarkers; Chromatography, High Pressure Liquid; Hospitals; Humans; Indoleamine-Pyrrole 2,3, | 2017 |
IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYC
Topics: Adult; Autoimmunity; Bacterial Translocation; Biomarkers; Cytokines; Depression, Postpartum; Depress | 2017 |
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?
Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative | 2017 |
Total sleep time and kynurenine metabolism associated with mood symptom severity in bipolar disorder.
Topics: Adult; Affect; Biomarkers; Bipolar Disorder; Depression; Female; Humans; Inflammation; Kynurenine; M | 2018 |
Activation of indoleamine 2, 3- dioxygenase pathway by olanzapine augments antidepressant effects of venlafaxine in mice.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Depression; Depressive Disord | 2017 |
HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution.
Topics: Adult; Antibodies, Viral; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Coinfec | 2017 |
Associations Among Obesity, Inflammation, and Tryptophan Catabolism in Pregnancy.
Topics: Adult; Biomarkers; Body Mass Index; Cross-Sectional Studies; Female; Humans; Indoleamine-Pyrrole 2,3 | 2018 |
Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone.
Topics: Animals; Brain; Cytokines; Dexamethasone; Glucocorticoids; Inflammation; Kynurenine; Lipopolysacchar | 2018 |
Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.
Topics: Adult; Bariatric Surgery; Biomarkers; C-Reactive Protein; Female; Glycated Hemoglobin; Humans; Infla | 2018 |
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointe | 2018 |
Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.
Topics: Animals; Brain; Cell Line; Homeostasis; Hypothalamo-Hypophyseal System; Inflammation; Interleukin-1b | 2018 |
Psychosocial stress and inflammation driving tryptophan breakdown in children and adolescents: A cross-sectional analysis of two cohorts.
Topics: Adolescent; C-Reactive Protein; Child; Cohort Studies; Cross-Sectional Studies; Cytokines; Depressio | 2018 |
Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.
Topics: Adolescent; Adult; Aged; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Col | 2018 |
Fish oil ameliorates sickness behavior induced by lipopolysaccharide in aged mice through the modulation of kynurenine pathway.
Topics: Aging; Anhedonia; Animals; Behavior, Animal; Biomarkers; Body Weight; Brain; Cytokines; Fish Oils; I | 2018 |
The NRF2‑PGC‑1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, synoviolin, in a cecal ligation/perforation‑induced septic mouse model.
Topics: Animals; Cecum; Disease Models, Animal; Humans; Inflammation; Kynurenine; Mice; NF-E2-Related Factor | 2018 |
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Topics: Animals; Diabetes Mellitus, Type 2; Fatty Liver; Gastrointestinal Microbiome; Health; Humans; Indole | 2018 |
Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms.
Topics: Acetylation; Animals; Depression; Disease Models, Animal; Histones; Indoleamine-Pyrrole 2,3,-Dioxyge | 2018 |
Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized-mice model of depression.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain Ch | 2018 |
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; K | 2018 |
A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode.
Topics: Biomarkers; Bipolar Disorder; Case-Control Studies; Cross-Sectional Studies; Depression; Depressive | 2019 |
Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood.
Topics: Animals; Brain; Cytokines; Disease Models, Animal; Female; Gene Expression; Inflammation; Kynurenine | 2019 |
Effects of 1-Methyltryptophan on Immune Responses and the Kynurenine Pathway after Lipopolysaccharide Challenge in Pigs.
Topics: Animals; Cytokines; Fibroblasts; Immunity; Inflammation; Kynurenine; Lipopolysaccharides; Lung; Meta | 2018 |
Macrophage de novo NAD
Topics: Aging; Animals; Cells, Cultured; Homeostasis; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase | 2019 |
Orchestration of Tryptophan-Kynurenine Pathway, Acute Decompensation, and Acute-on-Chronic Liver Failure in Cirrhosis.
Topics: Acute-On-Chronic Liver Failure; Aged; Bacterial Infections; Case-Control Studies; Europe; Female; He | 2019 |
Association of Age-related Macular Degeneration With Mortality in Patients With Acquired Immunodeficiency Syndrome; Role of Systemic Inflammation.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antigens, CD; Biomarkers; C-Reactive Protein; Case-Contro | 2019 |
The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study.
Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Cognition; Cross-Sectional Studies; Female; H | 2019 |
Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoimmune Diseases; Biomarkers; Central Nervous System | 2019 |
How acute and chronic physical disease may influence mental health - An Analysis of neurotransmitter precursor amino acid levels.
Topics: Acute Disease; Adult; Aged; Amino Acids; Anxiety Disorders; C-Reactive Protein; Chronic Disease; Dep | 2019 |
Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression.
Topics: Animals; Brain; Chronic Disease; Cytokines; Depression; Heart Failure; Hypothalamo-Hypophyseal Syste | 2019 |
Interleukin 33 Expression Induced by Aryl Hydrocarbon Receptor in Macrophages.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Exons; Humans; Inflammation; Interleukin-33; | 2019 |
Changes in tryptophan metabolism during pregnancy and postpartum periods: Potential involvement in postpartum depressive symptoms.
Topics: Adult; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Postpartum Period; Preg | 2019 |
Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3).
Topics: Adenocarcinoma of Lung; Adult; Aged; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Squamous C | 2020 |
Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression.
Topics: Animals; Anti-Inflammatory Agents; Brain-Derived Neurotrophic Factor; Cyclooxygenase Inhibitors; Cyt | 2019 |
Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin.
Topics: Aging; Anhedonia; Animals; Behavior, Animal; Body Weight; Chronic Disease; Depression; Hindlimb Susp | 2013 |
A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aging; Biomarkers; Body Mass Index; Creatinine; Female; Humans; Inf | 2013 |
C-reactive protein predicts fatigue independently of depression in breast cancer patients prior to chemotherapy.
Topics: Biomarkers; Breast Neoplasms; C-Reactive Protein; Cytokines; Depression; Fatigue; Female; Humans; In | 2013 |
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
Topics: Adult; Biomarkers; Creatine; Cystathionine; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine | 2013 |
Quinolinic acid: neurotoxin or oxidative stress modulator?
Topics: Hormesis; Humans; Hydrogen Peroxide; Inflammation; Iron; Kynurenine; Neurotoxins; Oxidative Stress; | 2013 |
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cytokines; Dendritic Cells; Female; Gene Exp | 2014 |
Interferon (IFN)-γ-mediated inflammation and the kynurenine pathway in relation to bone mineral density: the Hordaland Health Study.
Topics: Aged; Biomarkers; Bone Density; Female; Humans; Inflammation; Inflammation Mediators; Interferon-gam | 2014 |
Evidence for increased catabolism of vitamin B-6 during systemic inflammation.
Topics: Aged; Biomarkers; Body Mass Index; C-Reactive Protein; Cross-Sectional Studies; Dietary Supplements; | 2014 |
Does tryptophan degradation along the kynurenine pathway mediate the association between pro-inflammatory immune activity and depressive symptoms?
Topics: Adolescent; Adult; Aged; Case-Control Studies; Depression; Depressive Disorder, Major; Female; Human | 2014 |
Aryl hydrocarbon receptor control of a disease tolerance defence pathway.
Topics: Animals; Bacterial Infections; Disease Resistance; Endotoxemia; Enzyme Activation; Gene Expression R | 2014 |
Interferon-γ-induced inflammatory markers and the risk of cancer: the Hordaland Health Study.
Topics: Adult; Aged; Biomarkers, Tumor; C-Reactive Protein; Female; Follow-Up Studies; Humans; Inflammation; | 2014 |
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.
Topics: Adult; Cytokines; Depressive Disorder; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Mal | 2015 |
The kynurenine pathway is involved in bacterial meningitis.
Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Cytokines; Female; Humans; Inflammation; Ky | 2014 |
Tryptophan catabolism is unaffected in chronic granulomatous disease.
Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan | 2014 |
Romani & Puccetti reply.
Topics: Animals; Granulomatous Disease, Chronic; Inflammation; Kynurenine; Tryptophan | 2014 |
The tryptophan kynurenine pathway, neopterin and IL-6 during vulvectomy and abdominal hysterectomy.
Topics: Adult; Aged; Biomarkers; Female; Humans; Hysterectomy; Inflammation; Interleukin-6; Kynurenine; Midd | 2014 |
Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammat | 2015 |
Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C.
Topics: Animals; Brain; Illness Behavior; Immunity, Innate; Inflammation; Interferon Type I; Interleukin-1be | 2015 |
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agen | 2015 |
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highl | 2015 |
Kynurenine, by activating aryl hydrocarbon receptor, decreases erythropoietin and increases hepcidin production in HepG2 cells: A new mechanism for anemia of inflammation.
Topics: Anemia; Erythropoietin; Hep G2 Cells; Hepcidins; Humans; Inflammation; Kynurenine; Receptors, Aryl H | 2016 |
Influence of Hepatitis C Virus Sustained Virological Response on Immunosuppressive Tryptophan Catabolism in ART-Treated HIV/HCV Coinfected Patients.
Topics: Adult; Anti-HIV Agents; Biomarkers; Coinfection; Disease Progression; Female; Hepacivirus; Hepatitis | 2016 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynureni | 2016 |
Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis.
Topics: Depression; Depressive Disorder, Major; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflam | 2016 |
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study.
Topics: Aged; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Kynurenine; Longitudinal Studies | 2016 |
Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle.
Topics: Depression; Depressive Disorder; Exercise; Humans; Inflammation; Kynurenine; Muscle, Skeletal; Stres | 2016 |
Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice.
Topics: Amyloid beta-Peptides; Animals; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Hippo | 2016 |
Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus.
Topics: Adrenal Cortex Hormones; Animals; Gene Expression Regulation; Hippocampus; Indoleamine-Pyrrole 2,3,- | 2016 |
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.
Topics: Animals; Brain; Immune System; Inflammation; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; | 2016 |
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynu | 2016 |
Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice.
Topics: Animals; Brain; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; | 2016 |
Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease.
Topics: Allantoin; Anticholesteremic Agents; Arginine; Biomarkers; Cholesterol; Endothelium; Ezetimibe; Fema | 2016 |
An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.
Topics: Adolescent; Adult; Aged; Alleles; Carboxy-Lyases; Case-Control Studies; Child; Female; Humans; Infla | 2016 |
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
Topics: 3-Hydroxyanthranilic Acid; Adolescent; Adult; Biomarkers; Body Mass Index; C-Reactive Protein; Cross | 2016 |
Acute single dose of ketamine relieves mechanical allodynia and consequent depression-like behaviors in a rat model.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Freund's Adjuv | 2016 |
Plasma Tryptophan and the Kynurenine-Tryptophan Ratio are Associated with the Acquisition of Statural Growth Deficits and Oral Vaccine Underperformance in Populations with Environmental Enteropathy.
Topics: Anthropometry; Antibodies; Antibodies, Viral; Child Development; Child, Preschool; Citrulline; Cohor | 2016 |
Inflammatory, endocrine and metabolic correlates of fatigue in obese children.
Topics: Adolescent; Anhedonia; Apathy; Body Mass Index; C-Reactive Protein; Child; Fatigue; Female; Humans; | 2016 |
Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation.
Topics: Animals; Depression; Female; Hippocampus; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Lipo | 2016 |
Kynurenine Pathway Activation in Human African Trypanosomiasis.
Topics: Adolescent; Adult; Aged; Biomarkers; Central Nervous System; Female; Humans; Inflammation; Interfero | 2017 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflamm | 2017 |
Relationships between body temperatures and inflammation indicators under physiological and pathophysiological conditions in pigs exposed to systemic lipopolysaccharide and dietary deoxynivalenol.
Topics: Animal Feed; Animals; Biomarkers; Body Temperature; Inflammation; Kynurenine; Lipopolysaccharides; S | 2018 |
Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Colorectal Neoplasms; Female; Humans; Inflammation; K | 2017 |
NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.
Topics: 3-Hydroxyanthranilic Acid; Acetylcysteine; Aminophenols; Chromatography, Thin Layer; Diazonium Compo | 2008 |
The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.
Topics: Adult; Age Factors; Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Stud | 2009 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells.
Topics: Apoptosis; Cell Line; Cell Proliferation; Culture Media, Conditioned; Cytokines; Endothelium, Cornea | 2009 |
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2, | 2010 |
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease.
Topics: Animals; Chromatography, Liquid; Cluster Analysis; Crohn Disease; Disease Models, Animal; Germ-Free | 2010 |
Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
Topics: Adenylyl Cyclases; Animals; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Endo | 2010 |
Ido brings down the pressure in systemic inflammation.
Topics: Animals; Blood Pressure; Coronary Vessels; Endothelium-Dependent Relaxing Factors; Endothelium, Vasc | 2010 |
Insights into therapy: tryptophan oxidation and HIV infection.
Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Prog | 2010 |
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigm | 2010 |
The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Brain Ischemia; Free Radical Scavengers; Humans; | 2010 |
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders.
Topics: Aging; Animals; Humans; Inflammation; Interferon-gamma; Kynurenine; Mental Disorders; Metabolic Synd | 2011 |
G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast.
Topics: Analgesics; Animals; Antidepressive Agents, Second-Generation; Dose-Response Relationship, Drug; Dru | 2011 |
Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state.
Topics: Animals; Epididymis; Gene Expression Regulation, Enzymologic; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2011 |
Low plasma vitamin B-6 status affects metabolism through the kynurenine pathway in cardiovascular patients with systemic inflammation.
Topics: Adult; Aged; C-Reactive Protein; Coronary Disease; Female; Humans; Inflammation; Kynurenine; Male; M | 2011 |
Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Cytokines; Depressive Disorder, Major; Duloxetine Hy | 2011 |
Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypotension; Indoleamine-Pyrrole 2,3,-Dioxygenase; I | 2011 |
Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery.
Topics: Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Cognition; Coronary Artery Bypass; En | 2011 |
3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease.
Topics: Animals; Chagas Disease; Chronic Disease; Female; Inflammation; Interferon-gamma; Kynurenine; Mice; | 2011 |
Interleukin-1β: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis.
Topics: Cell Differentiation; Cell Line; Hippocampus; Humans; Inflammation; Interleukin-1beta; Kynurenine; M | 2012 |
Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectoris.
Topics: Aged; Angina, Stable; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Dietary Supplements; | 2012 |
Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Female; Humans; Hyperparathyroidism, Primary; Immunity, C | 2012 |
Modulatory effects of acupuncture on murine depression-like behavior following chronic systemic inflammation.
Topics: Acupuncture Therapy; Animals; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Chronic | 2012 |
Biomarkers of inflammation, immunosuppression and stress with active disease are revealed by metabolomic profiling of tuberculosis patients.
Topics: Biomarkers; Case-Control Studies; Cluster Analysis; Female; Humans; Immune Tolerance; Indoleamine-Py | 2012 |
An exploratory study of the interplay between decreased concentration of tryptophan, accumulation of kynurenines, and inflammatory arthritis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Arthritis, Experimental; | 2012 |
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflamm | 2002 |
Kynurenine--an old pathway retraced.
Topics: Animals; Depressive Disorder, Major; Humans; Hydrolases; Inflammation; Interferons; Kynurenine; orth | 2006 |
The activity of the immunoregulatory enzyme indoleamine 2,3-dioxygenase is decreased in smokers.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Chromatography, High Pressure Liquid; Cohort Studies; Co | 2006 |
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; | 2007 |
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Topics: Animals; Aspergillosis; Aspergillus fumigatus; Chronic Disease; Disease Models, Animal; Granulomatou | 2008 |
Oxidative tryptophan metabolism in renal allograft recipients: increased kynurenine synthesis is associated with inflammation and OKT3 therapy.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Biomarkers; Creatinine; Female; Graft Rejection; Gram-Ne | 1992 |
Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases.
Topics: Animals; Antioxidants; Female; Free Radicals; Inflammation; Kinetics; Kynurenine; Liposomes; Lung; M | 1990 |