kynurenine has been researched along with Inflammatory Bowel Diseases in 12 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 9.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| "Serotonin system also increases colorectal cancer cells proliferation and metastasis while, indole metabolites can profoundly decrease colorectal cancer growth." | 6.82 | Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. ( Ala, M, 2022) |
| " A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression." | 5.12 | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease. ( Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y, 2021) |
| " The analysis revealed that genes involved in tryptophan (Trp) metabolism are upregulated in Crohn's disease (CD) and ulcerative colitis (UC) and return to baseline after successful treatment with infliximab." | 4.02 | Alterations in Kynurenine and NAD ( Kurzepa, J; Parada-Turska, J; Wnorowska, S; Wnorowski, A, 2021) |
| "Patients who were symptomatic had the highest depression and anxiety scores, together with increased intestinal expression of IL-1β, IL-6 and matrix metalloproteinase-9, increased circulating IL-6 and CRP, and an increased circulating kynurenine:tryptophan ratio." | 3.85 | Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease. ( Abautret-Daly, Á; Connor, TJ; de Francisco-García, R; Dempsey, E; Harkin, A; Medina, C; Parra-Blanco, A; Riestra, S; Rodrigo, L, 2017) |
| "Serotonin system also increases colorectal cancer cells proliferation and metastasis while, indole metabolites can profoundly decrease colorectal cancer growth." | 2.82 | Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. ( Ala, M, 2022) |
| "Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) characterized by variable phenotypes." | 1.40 | Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases. ( Bustamante, S; Campbell, B; Hejazi, L; Leong, RW; Pickford, R; Shin, S; Wasinger, VC; Yau, YY, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 8 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Haq, S | 1 |
| Grondin, JA | 1 |
| Khan, WI | 1 |
| Wnorowski, A | 1 |
| Wnorowska, S | 1 |
| Kurzepa, J | 1 |
| Parada-Turska, J | 1 |
| Desmons, A | 1 |
| Humbert, L | 1 |
| Eguether, T | 1 |
| Krasniqi, P | 1 |
| Rainteau, D | 1 |
| Mahdi, T | 1 |
| Kapel, N | 1 |
| Lamazière, A | 1 |
| Zhao, LP | 1 |
| Wu, J | 1 |
| Quan, W | 1 |
| Zhou, Y | 1 |
| Hong, H | 1 |
| Niu, GY | 1 |
| Li, T | 1 |
| Huang, SB | 1 |
| Qiao, CM | 1 |
| Zhao, WJ | 1 |
| Cui, C | 1 |
| Shen, YQ | 1 |
| Sheibani, M | 1 |
| Shayan, M | 1 |
| Khalilzadeh, M | 1 |
| Soltani, ZE | 1 |
| Jafari-Sabet, M | 1 |
| Ghasemi, M | 1 |
| Dehpour, AR | 1 |
| Li, X | 1 |
| Zhang, ZH | 1 |
| Zabed, HM | 1 |
| Yun, J | 1 |
| Zhang, G | 1 |
| Qi, X | 1 |
| Chen, LM | 1 |
| Bao, CH | 1 |
| Wu, Y | 1 |
| Liang, SH | 1 |
| Wang, D | 1 |
| Wu, LY | 1 |
| Huang, Y | 1 |
| Liu, HR | 1 |
| Wu, HG | 1 |
| Ala, M | 1 |
| Abautret-Daly, Á | 1 |
| Dempsey, E | 1 |
| Riestra, S | 1 |
| de Francisco-García, R | 1 |
| Parra-Blanco, A | 1 |
| Rodrigo, L | 1 |
| Medina, C | 1 |
| Connor, TJ | 1 |
| Harkin, A | 1 |
| Agus, A | 1 |
| Planchais, J | 1 |
| Sokol, H | 1 |
| Yau, YY | 1 |
| Leong, RW | 1 |
| Shin, S | 1 |
| Bustamante, S | 1 |
| Pickford, R | 1 |
| Hejazi, L | 1 |
| Campbell, B | 1 |
| Wasinger, VC | 1 |
| Forrest, CM | 1 |
| Gould, SR | 1 |
| Darlington, LG | 1 |
| Stone, TW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Involvement of the Gut Microbiota and Its Metabolites in the Pathophysiology of Calcified Aortic Stenosis[NCT06021535] | 100 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355] | 85 participants (Anticipated) | Observational | 2011-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for kynurenine and Inflammatory Bowel Diseases
| Article | Year |
|---|---|
Tryptophan-derived serotonin-kynurenine balance in immune activation and intestinal inflammation.
Topics: Animals; Gastrointestinal Microbiome; Humans; Inflammation; Inflammatory Bowel Diseases; Kynurenine; | 2021 |
Kynurenine pathway and its role in neurologic, psychiatric, and inflammatory bowel diseases.
Topics: Humans; Inflammatory Bowel Diseases; Kynurenine; Mental Disorders; Metabolic Networks and Pathways; | 2023 |
An Insight into the Roles of Dietary Tryptophan and Its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease.
Topics: Colitis, Ulcerative; Gastrointestinal Microbiome; Humans; Indoles; Inflammatory Bowel Diseases; Kynu | 2021 |
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inf | 2021 |
Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system.
Topics: Colitis; Colorectal Neoplasms; Humans; Indoles; Inflammatory Bowel Diseases; Kynurenine; Serotonin; | 2022 |
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Topics: Autistic Disorder; Colitis; Communicable Diseases; Crohn Disease; Gastrointestinal Microbiome; Gastr | 2018 |
6 other studies available for kynurenine and Inflammatory Bowel Diseases
| Article | Year |
|---|---|
Alterations in Kynurenine and NAD
Topics: Colitis; Humans; Inflammatory Bowel Diseases; Infliximab; Kynurenine; Metabolic Networks and Pathway | 2021 |
High performance liquid chromatography-tandem mass spectrometry quantification of tryptophan metabolites in human serum and stool - Application to clinical cohorts in Inflammatory Bowel Diseases.
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Humans; Inflammatory Bowel Diseases; K | 2022 |
DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.
Topics: Animals; Brain; Colitis; Gastrointestinal Microbiome; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflamma | 2022 |
Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease.
Topics: Adult; Aged; Anxiety; Biomarkers; C-Reactive Protein; Case-Control Studies; Colon; Depression; Femal | 2017 |
Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases.
Topics: Adult; Angiotensin II; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Female; G(M3) Gangl | 2014 |
Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease.
Topics: Adenosine; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Humans; Inflammatory Bowel Dise | 2003 |