kynurenine has been researched along with Hepatitis C in 5 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated 101 patients with chronic hepatitis C treated with PEG-IFN-α2a, and 40 controls, so as to determine the activation of indolamine 2,3-dioxygenase (IDO) and tryptophan (TRP) and their metabolites' concentrations/levels: kynurenine (KYN), kynurenic acid (KYNA) and anthranilic acid (AA)." | 7.88 | Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment. ( Inglot, M; Laskus, T; Malyszczak, K; Pawlak, D; Pawlowski, T; Radkowski, M; Zalewska, M, 2018) |
| "We evaluated 101 patients with chronic hepatitis C treated with PEG-IFN-α2a, and 40 controls, so as to determine the activation of indolamine 2,3-dioxygenase (IDO) and tryptophan (TRP) and their metabolites' concentrations/levels: kynurenine (KYN), kynurenic acid (KYNA) and anthranilic acid (AA)." | 3.88 | Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment. ( Inglot, M; Laskus, T; Malyszczak, K; Pawlak, D; Pawlowski, T; Radkowski, M; Zalewska, M, 2018) |
| "Indoleamine 2,3-dioxygenase (IDO) activity as determined by increases in serum kynurenine was measured in a group of hepatitis C patients treated with consensus interferon (IFN-con1)." | 3.71 | Induction of indoleamine 2,3-dioxygenase in vivo by IFN-con1. ( Ferris, M; Kwo, P; McDougle, CJ; Sweeten, TL; Taylor, MW, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pawlowski, T | 1 |
| Malyszczak, K | 1 |
| Inglot, M | 1 |
| Zalewska, M | 1 |
| Radkowski, M | 1 |
| Laskus, T | 1 |
| Pawlak, D | 1 |
| Schulz, S | 1 |
| Landi, A | 1 |
| Garg, R | 1 |
| Wilson, JA | 1 |
| van Drunen Littel-van den Hurk, S | 1 |
| Jenabian, MA | 1 |
| Mehraj, V | 1 |
| Costiniuk, CT | 1 |
| Vyboh, K | 1 |
| Kema, I | 1 |
| Rollet, K | 1 |
| Paulino Ramirez, R | 1 |
| Klein, MB | 1 |
| Routy, JP | 1 |
| Raison, CL | 1 |
| Dantzer, R | 1 |
| Kelley, KW | 1 |
| Lawson, MA | 1 |
| Woolwine, BJ | 1 |
| Vogt, G | 1 |
| Spivey, JR | 1 |
| Saito, K | 1 |
| Miller, AH | 1 |
| Sweeten, TL | 1 |
| Ferris, M | 1 |
| McDougle, CJ | 1 |
| Kwo, P | 1 |
| Taylor, MW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of a Treatment Switch From Protease Inhibitor to Raltegravir-based ART on Myeloid Cell Inflammation in HIV-infected Patients.[NCT02691065] | Phase 4 | 6 participants (Actual) | Interventional | 2017-01-20 | Completed | ||
| Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355] | 85 participants (Anticipated) | Observational | 2011-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for kynurenine and Hepatitis C
| Article | Year |
|---|---|
Alterations in the metabolism of tryptophan in patients with chronic hepatitis C six months after pegylated interferon-α 2a treatment.
Topics: Adult; Antiviral Agents; Depression; Depressive Disorder; Female; Hepatitis C; Hepatitis C, Chronic; | 2018 |
Indolamine 2,3-dioxygenase expression by monocytes and dendritic cell populations in hepatitis C patients.
Topics: Adult; Aged; Case-Control Studies; Chemokines; Cytokines; Dendritic Cells; Female; Gene Expression; | 2015 |
Influence of Hepatitis C Virus Sustained Virological Response on Immunosuppressive Tryptophan Catabolism in ART-Treated HIV/HCV Coinfected Patients.
Topics: Adult; Anti-HIV Agents; Biomarkers; Coinfection; Disease Progression; Female; Hepacivirus; Hepatitis | 2016 |
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.
Topics: Adult; Antiviral Agents; Chemokine CCL2; Chromatography, High Pressure Liquid; Cytokines; Depression | 2010 |
Induction of indoleamine 2,3-dioxygenase in vivo by IFN-con1.
Topics: Enzyme Induction; Hepatitis C; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon Type I; Inte | 2001 |