Page last updated: 2024-10-18

kynurenine and Heart Failure

kynurenine has been researched along with Heart Failure in 10 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"Protocatechuic acid (3,4-dihydroxybenzoic acid) prevents oxidative stress, inflammation and cardiac hypertrophy."8.31Protocatechuic acid prevents isoproterenol-induced heart failure in mice by downregulating kynurenine-3-monooxygenase. ( Bai, L; Han, X; He, X; Jeon, MJ; Jeong, MH; Jeong, SM; Kee, HJ; Kee, SJ; Kim, SH; Zhou, H, 2023)
"Metabolites of the kynurenine pathway (mKP) relate to important aspects of heart failure pathophysiology, such as inflammation, energy-homeostasis, apoptosis, and oxidative stress."7.96Plasma kynurenines and prognosis in patients with heart failure. ( Giil, LM; Lund, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Pedersen, EK; Slettom, G; Solvang, SH; Ueland, PM; Ulvik, A, 2020)
"It was our objective to increase the body of data regarding the value of kynurenine as a biomarker in chronic heart failure (CHF)."7.91Plasma Kynurenine Predicts Severity and Complications of Heart Failure and Associates with Established Biochemical and Clinical Markers of Disease. ( Armbruster, FP; Bankovic, D; Boschann, F; Dschietzig, TB; Kellner, KH; Klüsener, R; Meinitzer, A; Melzer, C; Mitrovic, V; Ruppert, J; Sasse, K, 2019)
"Kynurenine is a circulating metabolite from the essential amino acid tryptophan."6.82Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure - Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF). ( Anker, SD; Doehner, W; Dschietzig, TB; Ebner, N; Konishi, M; Schefold, JC; Springer, J; von Haehling, S, 2016)
"Protocatechuic acid (3,4-dihydroxybenzoic acid) prevents oxidative stress, inflammation and cardiac hypertrophy."4.31Protocatechuic acid prevents isoproterenol-induced heart failure in mice by downregulating kynurenine-3-monooxygenase. ( Bai, L; Han, X; He, X; Jeon, MJ; Jeong, MH; Jeong, SM; Kee, HJ; Kee, SJ; Kim, SH; Zhou, H, 2023)
"Metabolites of the kynurenine pathway (mKP) relate to important aspects of heart failure pathophysiology, such as inflammation, energy-homeostasis, apoptosis, and oxidative stress."3.96Plasma kynurenines and prognosis in patients with heart failure. ( Giil, LM; Lund, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Pedersen, EK; Slettom, G; Solvang, SH; Ueland, PM; Ulvik, A, 2020)
"It was our objective to increase the body of data regarding the value of kynurenine as a biomarker in chronic heart failure (CHF)."3.91Plasma Kynurenine Predicts Severity and Complications of Heart Failure and Associates with Established Biochemical and Clinical Markers of Disease. ( Armbruster, FP; Bankovic, D; Boschann, F; Dschietzig, TB; Kellner, KH; Klüsener, R; Meinitzer, A; Melzer, C; Mitrovic, V; Ruppert, J; Sasse, K, 2019)
"Kynurenine is a circulating metabolite from the essential amino acid tryptophan."2.82Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure - Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF). ( Anker, SD; Doehner, W; Dschietzig, TB; Ebner, N; Konishi, M; Schefold, JC; Springer, J; von Haehling, S, 2016)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's4 (40.00)24.3611
2020's5 (50.00)2.80

Authors

AuthorsStudies
Bekfani, T1
Bekhite, M1
Neugebauer, S1
Derlien, S1
Hamadanchi, A1
Nisser, J1
Hilse, MS1
Haase, D1
Kretzschmar, T1
Wu, MF1
Lichtenauer, M1
Kiehntopf, M1
von Haehling, S2
Schlattmann, P1
Lehmann, G1
Franz, M1
Möbius-Winkler, S1
Schulze, C1
Bai, L1
Han, X1
Kee, HJ1
He, X1
Kim, SH1
Jeon, MJ1
Zhou, H1
Jeong, SM1
Kee, SJ1
Jeong, MH1
Lund, A1
Nordrehaug, JE1
Slettom, G1
Solvang, SH1
Pedersen, EK1
Midttun, Ø1
Ulvik, A1
Ueland, PM1
Nygård, O1
Giil, LM1
Sousa, A1
Ribeiro, C1
Gonçalves, VMF1
Barbosa, J1
Peixoto, B1
Andrade, A1
Silva, P1
Andrade, JP1
Leal, S1
Razquin, C1
Ruiz-Canela, M1
Toledo, E1
Hernández-Alonso, P1
Clish, CB1
Guasch-Ferré, M1
Li, J1
Wittenbecher, C1
Dennis, C1
Alonso-Gómez, A1
Fitó, M1
Liang, L1
Corella, D1
Gómez-Gracia, E1
Estruch, R1
Fiol, M1
Lapetra, J1
Serra-Majem, L1
Ros, E1
Aros, F1
Salas-Salvadó, J1
Hu, FB1
Martínez-González, MA1
Su, J1
Wang, J1
Ma, Y1
Li, Q1
Yang, Y1
Huang, L1
Wang, H1
Li, H1
Wang, Z1
Tong, J1
Huang, D1
Bai, X1
Yu, M1
Bu, L1
Fei, J1
Huang, F1
Dschietzig, TB2
Kellner, KH1
Sasse, K1
Boschann, F1
Klüsener, R1
Ruppert, J1
Armbruster, FP1
Bankovic, D1
Meinitzer, A1
Mitrovic, V1
Melzer, C1
Zhang, Y1
Blasco-Colmenares, E1
Harms, AC1
London, B1
Halder, I1
Singh, M1
Dudley, SC1
Gutmann, R1
Guallar, E1
Hankemeier, T1
Tomaselli, GF1
Cheng, A1
Konishi, M1
Ebner, N1
Springer, J1
Schefold, JC1
Doehner, W1
Anker, SD1
Schroecksnadel, K1
Wirleitner, B1
Fuchs, D1

Trials

2 trials available for kynurenine and Heart Failure

ArticleYear
Metabolomics of the tryptophan-kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet.
    The American journal of clinical nutrition, 2021, 11-08, Volume: 114, Issue:5

    Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Diet, Mediterranean; Female; Hea

2021
Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure - Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF).
    Circulation journal : official journal of the Japanese Circulation Society, 2016, Dec-22, Volume: 81, Issue:1

    Topics: Age Factors; Aged; Body Mass Index; Disease-Free Survival; Female; Heart Failure; Humans; Kidney; Ky

2016

Other Studies

8 other studies available for kynurenine and Heart Failure

ArticleYear
Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker.
    Cells, 2022, 05-18, Volume: 11, Issue:10

    Topics: Biomarkers; Heart Failure; Humans; Kynurenine; Metabolomics; Stroke Volume

2022
Protocatechuic acid prevents isoproterenol-induced heart failure in mice by downregulating kynurenine-3-monooxygenase.
    Journal of cellular and molecular medicine, 2023, Volume: 27, Issue:16

    Topics: Animals; Cardiomegaly; Heart Failure; Isoproterenol; Kynurenine; Kynurenine 3-Monooxygenase; Mice; M

2023
Plasma kynurenines and prognosis in patients with heart failure.
    PloS one, 2020, Volume: 15, Issue:1

    Topics: Aged; Biomarkers; Case-Control Studies; Coronary Artery Disease; Female; Heart Failure; Humans; Kynu

2020
Development and validation of a liquid chromatography method using UV/fluorescence detection for the quantitative determination of metabolites of the kynurenine pathway in human urine: Application to patients with heart failure.
    Journal of pharmaceutical and biomedical analysis, 2021, May-10, Volume: 198

    Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Heart Failure; Humans; Kynurenine; Mal

2021
Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression.
    The FEBS journal, 2019, Volume: 286, Issue:14

    Topics: Animals; Brain; Chronic Disease; Cytokines; Depression; Heart Failure; Hypothalamo-Hypophyseal Syste

2019
Plasma Kynurenine Predicts Severity and Complications of Heart Failure and Associates with Established Biochemical and Clinical Markers of Disease.
    Kidney & blood pressure research, 2019, Volume: 44, Issue:4

    Topics: Aged; Aged, 80 and over; Biomarkers; Chronic Disease; Female; Heart Failure; Humans; Immunoassay; Ky

2019
Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2016, Volume: 18, Issue:9

    Topics: Aged; Amines; Arginine; Biomarkers; Death, Sudden, Cardiac; Defibrillators, Implantable; Electric Co

2016
Anemia and congestive heart failure.
    Circulation, 2003, Aug-12, Volume: 108, Issue:6

    Topics: Anemia; Causality; Cell Division; Chronic Disease; Comorbidity; Dioxygenases; Heart Failure; Hematop

2003