kynurenine has been researched along with HIV Coinfection in 53 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| ": The aim of this study was to assess the performance of kynurenine/tryptophan ratio for tuberculosis (TB) case-finding among antiretroviral therapy (ART)-naive people with HIV (PWH), and to investigate other factors associated with kynurenine/tryptophan ratio in this population." | 8.12 | Kynurenine/tryptophan ratio for detection of active tuberculosis in adults with HIV prior to antiretroviral therapy. ( Björkman, P; Jansson, M; Mulleta, D; Olsson, O; Skogmar, S; Tesfaye, F, 2022) |
| "The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection." | 8.02 | Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 7.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| "Activation of the kynurenine pathway is associated with the severity and fatal outcomes of AIDS patients with pneumocystis pneumonia." | 7.91 | Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study. ( Dai, X; Dong, X; Guo, Y; Hu, C; Huang, Y; Su, J; Wang, M; Zhou, Q; Zhu, B, 2019) |
| " We fitted random-effects regression models to estimate the associations between plasma tryptophan, plasma kynurenine, dietary diversity, and self-reported depression symptom severity." | 7.80 | Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans. ( Bangsberg, DR; Haberer, JE; Huang, Y; Hunt, PW; Kembabazi, A; Martin, JN; Martinez, P; Muzoora, C; Tsai, AC; Weiser, SD, 2014) |
| "The aim of the study was to investigate the association between human immunodeficiency virus (HIV)-related gut microbiota changes, alterations in the kynurenine (Kyn) pathway of tryptophan (Trp) metabolism, and visceral adipose tissue in the context of HIV infection." | 4.12 | Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation. ( Benfield, T; Gelpi, M; Hansen, SH; Hov, JR; Høgh, J; Kofoed, KF; Midttun, Ø; Nielsen, SD; Raju, SC; Trøseid, M; Ueland, PM; Ueland, T; Vestad, B, 2022) |
| ": The aim of this study was to assess the performance of kynurenine/tryptophan ratio for tuberculosis (TB) case-finding among antiretroviral therapy (ART)-naive people with HIV (PWH), and to investigate other factors associated with kynurenine/tryptophan ratio in this population." | 4.12 | Kynurenine/tryptophan ratio for detection of active tuberculosis in adults with HIV prior to antiretroviral therapy. ( Björkman, P; Jansson, M; Mulleta, D; Olsson, O; Skogmar, S; Tesfaye, F, 2022) |
| "The results from this study suggest that alterations in the kynurenine pathway of tryptophan metabolism are associated with the presence of depression in the context of HIV infection." | 4.02 | Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV. ( Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM, 2021) |
| " We investigated associations between abdominal adipose tissue, alterations in kynurenine pathway of tryptophan metabolism, and systemic inflammation in people with HIV (PWH)." | 3.96 | Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus. ( Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H, 2020) |
| "Activation of the kynurenine pathway is associated with the severity and fatal outcomes of AIDS patients with pneumocystis pneumonia." | 3.91 | Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study. ( Dai, X; Dong, X; Guo, Y; Hu, C; Huang, Y; Su, J; Wang, M; Zhou, Q; Zhu, B, 2019) |
| "These results indicate that Tg26/ApoE serve as a new mouse model for HIV-induced atherogenesis, and aid in understanding the role of tryptophan catabolism in the pathogenesis of HIV atherosclerosis/CVD." | 3.91 | Elevated indoleamine-2,3-dioxygenase enzyme activity in a novel mouse model of HIV-associated atherosclerosis. ( Chen, Y; Dai, S; Gordon, J; Kearns, AC; Lehmicke, G; Liu, F; Qin, X; Rappaport, J; Velasquez, S, 2019) |
| " We fitted random-effects regression models to estimate the associations between plasma tryptophan, plasma kynurenine, dietary diversity, and self-reported depression symptom severity." | 3.80 | Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans. ( Bangsberg, DR; Haberer, JE; Huang, Y; Hunt, PW; Kembabazi, A; Martin, JN; Martinez, P; Muzoora, C; Tsai, AC; Weiser, SD, 2014) |
| "New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway--via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2--and chronic inflammation in progressive HIV disease." | 3.76 | Insights into therapy: tryptophan oxidation and HIV infection. ( Murray, MF, 2010) |
| "Kynurenine (Kyn) is a circulating tryptophan (Trp) catabolite generated by enzymes including IDO1 that are induced by inflammatory cytokines such as interferon-gamma." | 3.01 | The kynurenine pathway in HIV, frailty and inflammaging. ( Belin de Chantemèle, E; Bensreti, H; Elengickal, A; Hamrick, MW; McGee-Lawrence, ME; Sultana, S, 2023) |
| "Aprepitant treatment offers an opportunity to target inflammation and mood disorders frequently co-existing in chronic HIV infection." | 3.01 | Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV. ( Douglas, SD; Evans, DL; Kinder, A; Pappa, V; Rappaport, J; Spitsin, S, 2021) |
| " Ten CNS toxicities were graded according to the ACTG adverse events scale." | 1.51 | Tryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir. ( Boasso, A; Fuchs, D; Higgs, C; Keegan, MR; Nelson, M; Winston, A, 2019) |
| "HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk." | 1.48 | Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction. ( Aukrust, P; Gaardbo, JC; Gelpi, M; Gerstoft, J; Hoel, H; Holm, K; Hov, JR; Hove-Skovsgaard, M; Kummen, M; Nielsen, SD; Nwosu, F; Rudi, K; Seljeflot, I; Trøseid, M; Ueland, PM; Ullum, H; Valeur, J, 2018) |
| "Disease progression was monitored by determination of viral load (VL), CD4(+) cell counts, haemoglobin and urinary/plasma neopterin, tryptophan and kynurenine concentrations." | 1.35 | Quality of life and immune activation in patients with HIV-infection. ( Fuchs, D; Kemmler, G; Mumelter, B; Sarcletti, M; Schroecksnadel, K; Weiss, G; Winkler, C; Zangerle, R, 2008) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (5.66) | 18.2507 |
| 2000's | 6 (11.32) | 29.6817 |
| 2010's | 26 (49.06) | 24.3611 |
| 2020's | 18 (33.96) | 2.80 |
| Authors | Studies |
|---|---|
| Jadhav, S | 2 |
| Nema, V | 2 |
| Ghare, S | 1 |
| Singhal, R | 1 |
| Bryant, V | 1 |
| Gautam, S | 1 |
| Tirumala, CC | 1 |
| Srisailam, PK | 1 |
| Reyes-Vega, A | 1 |
| Ghooray, D | 1 |
| McClain, CJ | 1 |
| Hoffman, K | 1 |
| Petrosino, J | 1 |
| Bryant, K | 1 |
| Govind, V | 1 |
| Cohen, R | 1 |
| Cook, RL | 1 |
| Barve, S | 1 |
| Gelpi, M | 5 |
| Vestad, B | 1 |
| Raju, SC | 1 |
| Hansen, SH | 1 |
| Høgh, J | 1 |
| Midttun, Ø | 4 |
| Ueland, PM | 6 |
| Ueland, T | 1 |
| Benfield, T | 1 |
| Kofoed, KF | 1 |
| Hov, JR | 2 |
| Trøseid, M | 5 |
| Nielsen, SD | 6 |
| Sharma, VK | 1 |
| Singh, TG | 1 |
| Prabhakar, NK | 1 |
| Mannan, A | 1 |
| Olsson, O | 1 |
| Skogmar, S | 1 |
| Tesfaye, F | 1 |
| Mulleta, D | 1 |
| Jansson, M | 1 |
| Björkman, P | 1 |
| Rogando, AC | 1 |
| Weber, KM | 1 |
| Xing, J | 1 |
| Xue, X | 1 |
| Yohannes, T | 1 |
| Morack, R | 1 |
| Qi, Q | 2 |
| Clish, C | 1 |
| Bullock, K | 2 |
| Gustafson, D | 1 |
| Anastos, K | 2 |
| Sharma, A | 1 |
| Burgess, HJ | 1 |
| French, AL | 1 |
| Makar, P | 1 |
| MacCann, R | 1 |
| Landay, AL | 2 |
| Mallon, PWG | 1 |
| Ardiansyah, E | 1 |
| Avila-Pacheco, J | 1 |
| Nhat, LTH | 1 |
| Dian, S | 1 |
| Vinh, DN | 1 |
| Hai, HT | 1 |
| Alisjahbana, B | 1 |
| Netea, MG | 1 |
| Estiasari, R | 1 |
| Tram, TTB | 1 |
| Donovan, J | 1 |
| Heemskerk, D | 1 |
| Chau, TTH | 1 |
| Bang, ND | 1 |
| Ganiem, AR | 1 |
| Ruslami, R | 1 |
| Koeken, VACM | 1 |
| Hamers, RL | 1 |
| Imran, D | 1 |
| Maharani, K | 1 |
| Kumar, V | 1 |
| Clish, CB | 2 |
| van Crevel, R | 1 |
| Thwaites, G | 1 |
| van Laarhoven, A | 1 |
| Thuong, NTT | 1 |
| Sultana, S | 1 |
| Elengickal, A | 1 |
| Bensreti, H | 1 |
| Belin de Chantemèle, E | 1 |
| McGee-Lawrence, ME | 1 |
| Hamrick, MW | 1 |
| Mocroft, A | 1 |
| Lebech, AM | 1 |
| Ullum, H | 4 |
| Lundgren, J | 1 |
| Guaraldi, G | 1 |
| Milic, J | 1 |
| Lee, J | 1 |
| Lee, JY | 1 |
| Meade, CS | 1 |
| Cohn, M | 1 |
| Chahine, A | 1 |
| Dilworth, SE | 1 |
| Magidson, JF | 1 |
| Gouse, H | 1 |
| Fuchs, D | 7 |
| Carrico, AW | 1 |
| Adu-Gyamfi, CG | 1 |
| Snyman, T | 1 |
| Makhathini, L | 1 |
| Otwombe, K | 2 |
| Darboe, F | 1 |
| Penn-Nicholson, A | 1 |
| Fisher, M | 1 |
| Savulescu, D | 2 |
| Hoffmann, C | 1 |
| Chaisson, R | 2 |
| Martinson, N | 2 |
| Scriba, TJ | 1 |
| George, JA | 1 |
| Suchard, MS | 1 |
| Schnittman, SR | 1 |
| Deitchman, AN | 1 |
| Beck-Engeser, G | 1 |
| Ahn, H | 1 |
| York, VA | 1 |
| Hartig, H | 1 |
| Hecht, FM | 2 |
| Martin, JN | 6 |
| Deeks, SG | 3 |
| Aweeka, FT | 1 |
| Hunt, PW | 8 |
| Drivsholm, N | 1 |
| Knudsen, AD | 1 |
| Faurholt-Jepsen, M | 1 |
| Kirkegaard-Klitbo, DM | 1 |
| Adu-Gyamfi, C | 1 |
| Mikhathani, L | 1 |
| Salazar-Austin, N | 1 |
| George, J | 1 |
| Suchard, M | 1 |
| Spitsin, S | 1 |
| Pappa, V | 1 |
| Kinder, A | 1 |
| Evans, DL | 1 |
| Rappaport, J | 2 |
| Douglas, SD | 1 |
| Lee, S | 1 |
| Byakwaga, H | 3 |
| Boum, Y | 2 |
| Burdo, TH | 1 |
| Williams, KC | 1 |
| Lederman, MM | 1 |
| Huang, Y | 8 |
| Tracy, RP | 1 |
| Cao, H | 2 |
| Haberer, JE | 3 |
| Kembabazi, A | 3 |
| Bangsberg, DR | 3 |
| Hartling, HJ | 1 |
| Yap, SH | 1 |
| Abdullah, NK | 1 |
| McStea, M | 1 |
| Takayama, K | 1 |
| Chong, ML | 1 |
| Crisci, E | 1 |
| Larsson, M | 2 |
| Azwa, I | 1 |
| Kamarulzaman, A | 1 |
| Leong, KH | 1 |
| Woo, YL | 1 |
| Rajasuriar, R | 1 |
| Hua, S | 1 |
| Scott, JM | 1 |
| Hanna, DB | 1 |
| Wang, T | 1 |
| Haberlen, SA | 1 |
| Shah, SJ | 1 |
| Glesby, MJ | 1 |
| Lazar, JM | 1 |
| Burk, RD | 1 |
| Hodis, HN | 1 |
| Post, WS | 1 |
| Kaplan, RC | 1 |
| Hoel, H | 1 |
| Hove-Skovsgaard, M | 1 |
| Gaardbo, JC | 2 |
| Holm, K | 1 |
| Kummen, M | 1 |
| Rudi, K | 1 |
| Nwosu, F | 1 |
| Valeur, J | 1 |
| Seljeflot, I | 1 |
| Gerstoft, J | 1 |
| Aukrust, P | 1 |
| Chen, J | 2 |
| Xun, J | 1 |
| Yang, J | 1 |
| Ji, Y | 1 |
| Liu, L | 2 |
| Qi, T | 2 |
| Wang, Z | 1 |
| Zhang, R | 2 |
| Shen, Y | 2 |
| Ponte, R | 1 |
| Mehraj, V | 2 |
| Routy, JP | 4 |
| Lu, H | 2 |
| Keegan, MR | 1 |
| Winston, A | 1 |
| Higgs, C | 1 |
| Boasso, A | 2 |
| Nelson, M | 1 |
| Wang, M | 1 |
| Dong, X | 1 |
| Su, J | 1 |
| Dai, X | 1 |
| Guo, Y | 1 |
| Hu, C | 1 |
| Zhou, Q | 1 |
| Zhu, B | 1 |
| Kearns, AC | 1 |
| Velasquez, S | 1 |
| Liu, F | 1 |
| Dai, S | 1 |
| Chen, Y | 1 |
| Lehmicke, G | 1 |
| Gordon, J | 1 |
| Qin, X | 1 |
| Nzowa, LK | 1 |
| Teponno, RB | 1 |
| Tapondjou, LA | 1 |
| Verotta, L | 1 |
| Liao, Z | 1 |
| Graham, D | 1 |
| Zink, MC | 1 |
| Barboni, L | 1 |
| Louie, A | 1 |
| Yang, Q | 1 |
| Massenkoff, N | 1 |
| Xu, C | 1 |
| Gee, W | 1 |
| Martinez, P | 1 |
| Tsai, AC | 1 |
| Muzoora, C | 2 |
| Weiser, SD | 2 |
| Bennett, J | 1 |
| McCune, JM | 2 |
| Jenabian, MA | 3 |
| Patel, M | 1 |
| Kema, I | 3 |
| Vyboh, K | 3 |
| Kanagaratham, C | 2 |
| Radzioch, D | 2 |
| Thébault, P | 1 |
| Lapointe, R | 1 |
| Gilmore, N | 1 |
| Ancuta, P | 2 |
| Tremblay, C | 2 |
| Shao, J | 1 |
| Cai, R | 1 |
| El-Far, M | 1 |
| Costiniuk, CT | 2 |
| Thomas, R | 1 |
| Baril, JG | 1 |
| LeBlanc, R | 1 |
| Allam, O | 1 |
| Ahmad, A | 1 |
| Lebouché, B | 1 |
| Bipath, P | 1 |
| Levay, PF | 1 |
| Viljoen, M | 1 |
| Rollet, K | 1 |
| Paulino Ramirez, R | 1 |
| Klein, MB | 1 |
| Trøsied, M | 1 |
| Stiksrud, B | 1 |
| Douet, V | 1 |
| Tanizaki, N | 1 |
| Franke, A | 1 |
| Li, X | 1 |
| Chang, L | 1 |
| Lee, SA | 1 |
| Mefford, JA | 1 |
| Witte, JS | 1 |
| Haas, DW | 1 |
| Mclaren, PJ | 1 |
| Mushiroda, T | 1 |
| Kubo, M | 1 |
| Kroetz, DL | 1 |
| Avelino-Silva, VI | 1 |
| Miyaji, KT | 1 |
| Simoes, M | 1 |
| Lima, SB | 1 |
| Freire, MS | 1 |
| Caiaffa-Filho, HH | 1 |
| Hong, MA | 1 |
| Costa, DA | 1 |
| Dias, JZ | 1 |
| Cerqueira, NB | 1 |
| Nishiya, AS | 1 |
| Sabino, EC | 1 |
| Sartori, AM | 1 |
| Kallas, EG | 1 |
| Murray, MF | 1 |
| Favre, D | 1 |
| Mold, J | 1 |
| Kanwar, B | 1 |
| Loke, P | 1 |
| Seu, L | 1 |
| Barbour, JD | 1 |
| Lowe, MM | 1 |
| Jayawardene, A | 1 |
| Aweeka, F | 1 |
| Douek, DC | 1 |
| Brenchley, JM | 1 |
| Samikkannu, T | 1 |
| Rao, KV | 1 |
| Gandhi, N | 1 |
| Saxena, SK | 1 |
| Nair, MP | 1 |
| Kandanearatchi, A | 1 |
| Brew, BJ | 1 |
| Neurauter, G | 1 |
| Zangerle, R | 2 |
| Widner, B | 1 |
| Quirchmair, G | 1 |
| Sarcletti, M | 2 |
| Herbeuval, JP | 1 |
| Hardy, AW | 1 |
| Anderson, SA | 1 |
| Dolan, MJ | 1 |
| Shearer, GM | 1 |
| Kwidzinski, E | 1 |
| Bechmann, I | 1 |
| Suh, HS | 1 |
| Zhao, ML | 1 |
| Rivieccio, M | 1 |
| Choi, S | 1 |
| Connolly, E | 1 |
| Zhao, Y | 1 |
| Takikawa, O | 1 |
| Brosnan, CF | 1 |
| Lee, SC | 1 |
| Schroecksnadel, K | 1 |
| Winkler, C | 1 |
| Mumelter, B | 1 |
| Weiss, G | 1 |
| Kemmler, G | 1 |
| Gisslén, M | 1 |
| Norkrans, G | 1 |
| Hagberg, L | 1 |
| Wachter, H | 2 |
| Look, MP | 1 |
| Altfeld, M | 1 |
| Kreuzer, KA | 1 |
| Riezler, R | 1 |
| Stabler, SP | 1 |
| Allen, RH | 1 |
| Sauerbruch, T | 1 |
| Rockstroh, JK | 1 |
| Heyes, MP | 1 |
| Saito, K | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Möller, AA | 1 |
| Reibnegger, G | 1 |
| Werner, ER | 1 |
| Werner-Felmayer, G | 1 |
| Dierich, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention (SEAL)[NCT06005298] | 120 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| Effect of a Treatment Switch From Protease Inhibitor to Raltegravir-based ART on Myeloid Cell Inflammation in HIV-infected Patients.[NCT02691065] | Phase 4 | 6 participants (Actual) | Interventional | 2017-01-20 | Completed | ||
| FULL TITLE: Camu Camu Effects on Circulating LPS and Systemic Immune Activation in ART-treated Participants: The Camu Camu Pilot Study[NCT04058392] | Phase 1 | 22 participants (Actual) | Interventional | 2020-11-09 | Completed | ||
| Immunogenicity and Safety of the CoronaVac Vacccine in Patients With Autoimmune Rheumatic Diseases and People Living With HIV/AIDS[NCT04754698] | Phase 4 | 2,067 participants (Anticipated) | Interventional | 2021-02-09 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for kynurenine and HIV Coinfection
| Article | Year |
|---|---|
HIV-Associated Neurotoxicity: The Interplay of Host and Viral Proteins.
Topics: AIDS Dementia Complex; Anti-Retroviral Agents; Astrocytes; Central Nervous System; Genome; HIV Envel | 2021 |
Kynurenine Metabolism and Alzheimer's Disease: The Potential Targets and Approaches.
Topics: Alzheimer Disease; HIV Infections; Humans; Kynurenine; Oxidative Stress; Tryptophan | 2022 |
HIV and comorbidities - the importance of gut inflammation and the kynurenine pathway.
Topics: Gastrointestinal Microbiome; HIV Infections; Humans; Inflammation; Kynurenine; NAD | 2023 |
The kynurenine pathway in HIV, frailty and inflammaging.
Topics: Aged; Cytokines; Frailty; HIV Infections; Humans; Kynurenine; Tryptophan | 2023 |
The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.
Topics: Central Nervous System Diseases; Cognition Disorders; HIV; HIV Infections; Humans; Kynurenine; Quino | 2012 |
IDO expression in the brain: a double-edged sword.
Topics: Animals; Brain; Candidiasis; Cytomegalovirus Infections; Encephalomyelitis, Autoimmune, Experimental | 2007 |
3 trials available for kynurenine and HIV Coinfection
| Article | Year |
|---|---|
Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV.
Topics: Adult; Anti-HIV Agents; Aprepitant; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combina | 2021 |
HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells.
Topics: Antibodies, Monoclonal; CD4 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Coculture Techniq | 2007 |
Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Drug Therapy, Combination; Female; HI | 2000 |
44 other studies available for kynurenine and HIV Coinfection
| Article | Year |
|---|---|
Age-Associated Gut Dysbiosis, Marked by Loss of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites in Older People Living With HIV.
Topics: Aged; Cross-Sectional Studies; Dysbiosis; HIV Infections; Humans; Kynurenine; Middle Aged; Pilot Pro | 2022 |
Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation.
Topics: Gastrointestinal Microbiome; HIV; HIV Infections; Humans; Intra-Abdominal Fat; Kynurenine; Tryptopha | 2022 |
Kynurenine/tryptophan ratio for detection of active tuberculosis in adults with HIV prior to antiretroviral therapy.
Topics: Adult; Anti-Retroviral Agents; HIV Infections; Humans; Kynurenine; RNA; Tryptophan; Tuberculosis | 2022 |
The IDOze Study: The Link Between Sleep Disruption and Tryptophan-Kynurenine Pathway Activation in Women With Human Immunodeficiency Virus.
Topics: Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2022 |
The NeuroinflammatoryPotential of HIV-1 NefVariants in Modulating the Gene Expression Profile of Astrocytes.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Astrocytes; Chemokine CXCL10; Cytokines; Gene Expression Prof | 2022 |
Tryptophan metabolism determines outcome in tuberculous meningitis: a targeted metabolomic analysis.
Topics: Adult; HIV Infections; Humans; Inflammation; Kynurenine; Meningitis, Cryptococcal; Tryptophan; Tuber | 2023 |
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infec | 2020 |
Why Am I Getting Fat? Exploring Immune-Metabolic Pathways to Central Fat Accumulation in Persons With HIV.
Topics: Abdominal Fat; HIV; HIV Infections; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathway | 2020 |
Tryptophan degradation is associated with risk-taking propensity in methamphetamine users with treated HIV infection.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biotransformation; Cross-Sectional St | 2020 |
Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis.
Topics: Adult; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; Humans; Kynurenine; La | 2020 |
Abnormal Levels of Some Biomarkers of Immune Activation Despite Very Early Treatment of Human Immunodeficiency Virus.
Topics: Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Chemokine CXCL | 2021 |
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Mi | 2021 |
Plasma Kynurenine-to-Tryptophan Ratio, a Highly Sensitive Blood-Based Diagnostic Tool for Tuberculosis in Pregnant Women Living With Human Immunodeficiency Virus (HIV).
Topics: Diagnostic Tests, Routine; Female; HIV; HIV Infections; Humans; Kynurenine; Pregnancy; Pregnant Wome | 2021 |
Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy.
Topics: Adult; Anti-HIV Agents; Biomarkers; Cohort Studies; Female; Fibrin Fibrinogen Degradation Products; | 2017 |
Tryptophan catabolism and immune activation in primary and chronic HIV infection.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes | 2017 |
HIV/Human herpesvirus co-infections: Impact on tryptophan-kynurenine pathway and immune reconstitution.
Topics: Adult; Antibodies, Viral; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; Coinfec | 2017 |
Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis.
Topics: Adult; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Disease Progression; Female; HIV Infec | 2018 |
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointe | 2018 |
Plasma Indoleamine 2,3-Dioxygenase Activity Is Associated With the Size of the Human Immunodeficiency Virus Reservoir in Patients Receiving Antiretroviral Therapy.
Topics: Adult; Anti-Retroviral Agents; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; DNA, Viral; Female; HIV In | 2019 |
Tryptophan metabolism and its relationship with central nervous system toxicity in people living with HIV switching from efavirenz to dolutegravir.
Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte | 2019 |
Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study.
Topics: Adult; Antifungal Agents; Area Under Curve; Biomarkers; Chromatography, High Pressure Liquid; Cohort | 2019 |
Elevated indoleamine-2,3-dioxygenase enzyme activity in a novel mouse model of HIV-associated atherosclerosis.
Topics: Animals; Aorta; Aortic Diseases; Atherosclerosis; Cytokines; Diet, High-Fat; Disease Models, Animal; | 2019 |
Two new tryptophan derivatives from the seed kernels of Entada rheedei: effects on cell viability and HIV infectivity.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Line; Cell Survival; Dopamine; Fabaceae; Glutamic Ac | 2013 |
A simple LC-MS/MS method for determination of kynurenine and tryptophan concentrations in human plasma from HIV-infected patients.
Topics: Chromatography, Liquid; HIV; HIV Infections; Humans; Kynurenine; Limit of Detection; Tandem Mass Spe | 2013 |
Reversal of the Kynurenine pathway of tryptophan catabolism may improve depression in ART-treated HIV-infected Ugandans.
Topics: Adult; Antiretroviral Therapy, Highly Active; Depression; Female; HIV Infections; Humans; Indoleamin | 2014 |
The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy.
Topics: Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Female; HIV Infections; Hu | 2014 |
Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection.
Topics: Adult; CD4-Positive T-Lymphocytes; CD40 Ligand; Female; HIV Infections; Humans; Immune Tolerance; Im | 2014 |
Anti-retroviral therapy decreases but does not normalize indoleamine 2,3-dioxygenase activity in HIV-infected patients.
Topics: Adult; Anti-Retroviral Agents; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Indoleamine-Pyr | 2014 |
Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection.
Topics: Adult; Aged; Anti-Retroviral Agents; Biomarkers; Dendritic Cells; HIV Infections; Humans; Intestinal | 2015 |
Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection.
Topics: Adult; Aged; Anti-Retroviral Agents; Biomarkers; Dendritic Cells; HIV Infections; Humans; Intestinal | 2015 |
Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection.
Topics: Adult; Aged; Anti-Retroviral Agents; Biomarkers; Dendritic Cells; HIV Infections; Humans; Intestinal | 2015 |
Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection.
Topics: Adult; Aged; Anti-Retroviral Agents; Biomarkers; Dendritic Cells; HIV Infections; Humans; Intestinal | 2015 |
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highl | 2015 |
Influence of Hepatitis C Virus Sustained Virological Response on Immunosuppressive Tryptophan Catabolism in ART-Treated HIV/HCV Coinfected Patients.
Topics: Adult; Anti-HIV Agents; Biomarkers; Coinfection; Disease Progression; Female; Hepacivirus; Hepatitis | 2016 |
Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up.
Topics: Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Comb | 2015 |
Polymorphism of Kynurenine Pathway-Related Genes, Kynurenic Acid, and Psychopathological Symptoms in HIV.
Topics: Adult; Female; HIV Infections; Humans; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Middle Ag | 2016 |
Host genetic predictors of the kynurenine pathway of tryptophan catabolism among treated HIV-infected Ugandans.
Topics: Adult; Anti-Retroviral Agents; Female; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; | 2016 |
CD4/CD8 Ratio and KT Ratio Predict Yellow Fever Vaccine Immunogenicity in HIV-Infected Patients.
Topics: Adult; Antibodies, Neutralizing; Antibodies, Viral; CD4-CD8 Ratio; Female; HIV Infections; Humans; I | 2016 |
Insights into therapy: tryptophan oxidation and HIV infection.
Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Prog | 2010 |
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigm | 2010 |
Human immunodeficiency virus type 1 clade B and C Tat differentially induce indoleamine 2,3-dioxygenase and serotonin in immature dendritic cells: Implications for neuroAIDS.
Topics: AIDS Dementia Complex; Blotting, Western; Cell Separation; Dendritic Cells; Flow Cytometry; Gene Exp | 2010 |
Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection.
Topics: Adult; Anti-HIV Agents; Case-Control Studies; Female; HIV Infections; HIV-1; Humans; Immune Toleranc | 2003 |
Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response.
Topics: Astrocytes; Cells, Cultured; Cytokines; Cytomegalovirus; Cytomegalovirus Infections; Encephalitis, V | 2007 |
Quality of life and immune activation in patients with HIV-infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Depress | 2008 |
Increase of tryptophan in serum and in cerebrospinal fluid of patients with HIV infection during zidovudine therapy.
Topics: Anti-HIV Agents; Biopterins; Chromatography, High Pressure Liquid; HIV Infections; HIV Seropositivit | 1996 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |
Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection.
Topics: Adult; Biopterins; Chromatography, High Pressure Liquid; Female; HIV Infections; HIV Seropositivity; | 1991 |