kynurenine has been researched along with Graft vs Host Disease in 7 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influence cGVHD severity and manifestation (fibrosing versus gastrointestinal [GI] cGVHD)." | 8.02 | Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease. ( Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T, 2021) |
| " A driver of fibrosis is the kynurenine (Kyn) pathway, and Kyn metabolism patterns and cytokines may influence cGVHD severity and manifestation (fibrosing versus gastrointestinal [GI] cGVHD)." | 4.02 | Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease. ( Di Pasquale, P; Dischinger, K; Dreger, P; Luft, T; Monteagudo, E; Müller-Tidow, C; Orsatti, L; Radujkovic, A; Speziale, R; Stiehl, T, 2021) |
| "Kynurenine levels were directly correlated with severity and clinical course of GVHD: Mean urinary quinolinic acid levels were 4." | 1.37 | Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase. ( Ammer, J; Andreesen, R; Edinger, M; Holler, B; Holler, E; Kreutz, M; Landfried, K; Oefner, PJ; Peter, K; Schulz, U; Waldhier, MC; Wolff, D; Zhu, W, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Orsatti, L | 1 |
| Stiehl, T | 1 |
| Dischinger, K | 1 |
| Speziale, R | 1 |
| Di Pasquale, P | 1 |
| Monteagudo, E | 1 |
| Müller-Tidow, C | 1 |
| Radujkovic, A | 1 |
| Dreger, P | 1 |
| Luft, T | 1 |
| Hippen, KL | 1 |
| O'Connor, RS | 1 |
| Lemire, AM | 1 |
| Saha, A | 1 |
| Hanse, EA | 1 |
| Tennis, NC | 1 |
| Merkel, SC | 1 |
| Kelekar, A | 1 |
| Riley, JL | 1 |
| Levine, BL | 1 |
| June, CH | 1 |
| Turka, LA | 1 |
| Kean, LS | 1 |
| MacMillan, ML | 1 |
| Miller, JS | 1 |
| Wagner, JE | 1 |
| Munn, DH | 2 |
| Blazar, BR | 2 |
| Lee, SM | 1 |
| Park, HY | 1 |
| Suh, YS | 1 |
| Yoon, EH | 1 |
| Kim, J | 1 |
| Jang, WH | 1 |
| Lee, WS | 1 |
| Park, SG | 1 |
| Choi, IW | 1 |
| Choi, I | 1 |
| Kang, SW | 1 |
| Yun, H | 1 |
| Teshima, T | 1 |
| Kwon, B | 1 |
| Seo, SK | 1 |
| Xu, J | 1 |
| Wei, J | 1 |
| Huang, M | 1 |
| Zhu, X | 1 |
| Guan, J | 1 |
| Yin, J | 1 |
| Xiao, Y | 1 |
| Zhang, Y | 1 |
| Schmid, PM | 1 |
| Bouazzaoui, A | 1 |
| Schmid, K | 1 |
| Birner, CM | 1 |
| Schach, C | 1 |
| Maier, LS | 1 |
| Holler, E | 2 |
| Endemann, DH | 1 |
| Jasperson, LK | 1 |
| Bucher, C | 1 |
| Panoskaltsis-Mortari, A | 1 |
| Mellor, AL | 1 |
| Landfried, K | 1 |
| Zhu, W | 1 |
| Waldhier, MC | 1 |
| Schulz, U | 1 |
| Ammer, J | 1 |
| Holler, B | 1 |
| Wolff, D | 1 |
| Edinger, M | 1 |
| Peter, K | 1 |
| Kreutz, M | 1 |
| Andreesen, R | 1 |
| Oefner, PJ | 1 |
7 other studies available for kynurenine and Graft vs Host Disease
| Article | Year |
|---|---|
Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease.
Topics: Adolescent; Adult; Aged; Chemokine CXCL9; Female; Fibrosis; Gene Expression Regulation; Graft vs Hos | 2021 |
In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines.
Topics: Animals; Bone Marrow Transplantation; Cells, Cultured; Graft vs Host Disease; Humans; Immune Toleran | 2017 |
Inhibition of acute lethal pulmonary inflammation by the IDO-AhR pathway.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Female; Graft vs Host Disease; Hematopoietic | 2017 |
Tryptophan metabolite analog, N-(3,4-dimethoxycinnamonyl) anthranilic acid, ameliorates acute graft-versus-host disease through regulating T cell proliferation and polarization.
Topics: Animals; Bone Marrow Transplantation; CD8-Positive T-Lymphocytes; Cell Proliferation; Cytokines; Fem | 2013 |
Vascular Alterations in a Murine Model of Acute Graft-Versus-Host Disease Are Associated with Decreased Serum Levels of Adiponectin and an Increased Activity and Vascular Expression of Indoleamine 2,3-Dioxygenase.
Topics: Acetylcholine; Adiponectin; Animals; Body Weight; Bone Marrow Transplantation; Cytokines; Disease Mo | 2016 |
Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality.
Topics: Animals; Apoptosis; Bone Marrow Transplantation; Clonal Anergy; Graft vs Host Disease; Immune Tolera | 2009 |
Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase.
Topics: Adolescent; Adult; Aged; Chromatography, Liquid; Gene Expression Regulation, Enzymologic; Graft vs H | 2011 |