kynurenine has been researched along with Experimental Pneumococcal Meningitis in 4 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pneumococcal meningitis is a lethal form of bacterial infection in the central nervous system that often causes lifelong neurological sequelae, despite therapeutic advances." | 5.40 | The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. ( Ball, HJ; Funakoshi, H; Hunt, NH; Kanai, M; McGregor, IS; McQuillan, JA; Nakamura, T; Too, LK, 2014) |
| "Acute bacterial meningitis (ABM) causes excessive activation of N-methyl-D-aspartate receptors (NMDAr), leading to cortical and hippocampal neuron death." | 1.91 | The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis. ( Campi-Azevedo, AC; Candiani, TMS; Cassiano, LMG; Coimbra, RS; de Oliveira, DB; Kohlhoff, M; Kroon, EG; Martins-Filho, OA, 2023) |
| "Pneumococcal meningitis is a lethal form of bacterial infection in the central nervous system that often causes lifelong neurological sequelae, despite therapeutic advances." | 1.40 | The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. ( Ball, HJ; Funakoshi, H; Hunt, NH; Kanai, M; McGregor, IS; McQuillan, JA; Nakamura, T; Too, LK, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cassiano, LMG | 1 |
| de Oliveira, DB | 1 |
| Candiani, TMS | 1 |
| Campi-Azevedo, AC | 1 |
| Martins-Filho, OA | 1 |
| Kroon, EG | 1 |
| Kohlhoff, M | 1 |
| Coimbra, RS | 3 |
| Too, LK | 1 |
| McQuillan, JA | 1 |
| Ball, HJ | 1 |
| Kanai, M | 1 |
| Nakamura, T | 1 |
| Funakoshi, H | 1 |
| McGregor, IS | 1 |
| Hunt, NH | 1 |
| Bellac, CL | 2 |
| Christen, S | 2 |
| Leib, SL | 2 |
4 other studies available for kynurenine and Experimental Pneumococcal Meningitis
| Article | Year |
|---|---|
The neurotoxic branch of the kynurenine pathway is highly activated in the central nervous system of patients with pneumococcal meningitis.
Topics: Central Nervous System; Child; Humans; Interleukin-10; Interleukin-6; Kynurenine; Meningitis, Bacter | 2023 |
The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.
Topics: Animals; Anti-Bacterial Agents; Ceftriaxone; Cognition; Disease Models, Animal; Female; Indoleamine- | 2014 |
Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis.
Topics: Animals; Animals, Newborn; Apoptosis; Chromatography, High Pressure Liquid; Cytokines; Disease Model | 2010 |
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Brain; Disease Models, Animal; Encephalitis; Enzyme A | 2006 |