kynurenine has been researched along with Epilepsy in 27 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 8.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "Neurokynurenines (NK) possessing various neuroactivities, are involved in many abnormalities in stress, anxiety, depression, alcoholism, epilepsy, neurologic diseases." | 7.72 | Neurokynurenines--seizures or/and anxiety in children with epilepsy? ( Melnikova, NV, 2003) |
| "Seizure frequency was recorded using seizure diaries." | 6.79 | The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy. ( Aalbers, MW; Aldenkamp, AP; Kessels, AG; Klinkenberg, S; Leenen, L; Majoie, HJ; Rijkers, K; van den Borne, CJ; Verschuure, P; Vles, JS, 2014) |
| "The kynurenine pathway (KP) is the main path for tryptophan metabolism, and it represents a multitude of potential sites for drug discovery in neuroscience, including pain, stroke, and epilepsy." | 5.41 | Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers. ( Abou-Kassem, D; Al-Karagholi, MA; Ashina, M; Bergquist, J; Hansen, JM; Hansted, AK; Jansen-Olesen, I; Ubhayasekera, K; Vécsei, L, 2021) |
| " In both groups, they measure tryptophan metabolites before and after L-tryptophan overload, the dosage being 100/mg/kg of body weight." | 5.27 | [Tryptophan metabolism in children with epilepsy]. ( Bayés García, R; del Castillo, ML; Maldonado Lozano, J; Molina Font, JA; Narbona López, E; Núñez del Carril, J; Robles Vizcaíno, C, 1984) |
| "The kynurenine blood level was found to correlate with seizures." | 5.27 | [Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma]. ( Buzdin, VV; Ivanova, NA; Nikitina, ZS; Ryzhov, IV, 1988) |
| "There was a statistically significant decrease of CSF kynurenic acid in patients with epileptic spasms compared to OND (p<0." | 4.12 | Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids. ( Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J, 2022) |
| "Neurokynurenines (NK) possessing various neuroactivities, are involved in many abnormalities in stress, anxiety, depression, alcoholism, epilepsy, neurologic diseases." | 3.72 | Neurokynurenines--seizures or/and anxiety in children with epilepsy? ( Melnikova, NV, 2003) |
| "The role of the endogenous convulsant kynurenine (K) in the mechanisms of the development of epileptic seizures in alcoholic persons was studied on a clinical material of 63 patients suffering from alcoholism with the presence on the EEG of paroxysmal alterations without epileptic fits (n = 28) and alcoholic epilepsy (n = 35), epileptic patients not abusing alcohol (n = 20), and practically healthy subjects (n = 10)." | 3.68 | [Pathogenic role of the endogenous convulsant kynurenine in the mechanisms of development of epileptic attacks in alcoholics]. ( Eryshev, OF; Gromov, SA; Kartasheva, EV; Ryzhov, IV, 1991) |
| "Seizure frequency was recorded using seizure diaries." | 2.79 | The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy. ( Aalbers, MW; Aldenkamp, AP; Kessels, AG; Klinkenberg, S; Leenen, L; Majoie, HJ; Rijkers, K; van den Borne, CJ; Verschuure, P; Vles, JS, 2014) |
| "The 18 patients had either West syndrome (12 patients) or Lennox-Gastaut syndrome (6 patients), which was intractable to antiepileptic drug therapy and to adrenocorticotrophic hormone." | 1.29 | Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites. ( Kawase, S; Matsuo, S; Mitsufuji, N; Nishimura, A; Sawada, T; Takeuchi, Y; Tominaga, M; Yamazoe, I, 1995) |
| "The 5-hydroxytryptophan content was much higher in both El groups." | 1.28 | Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice. ( Mori, A; Suzuki, S, 1992) |
| " In both groups, they measure tryptophan metabolites before and after L-tryptophan overload, the dosage being 100/mg/kg of body weight." | 1.27 | [Tryptophan metabolism in children with epilepsy]. ( Bayés García, R; del Castillo, ML; Maldonado Lozano, J; Molina Font, JA; Narbona López, E; Núñez del Carril, J; Robles Vizcaíno, C, 1984) |
| "The kynurenine blood level was found to correlate with seizures." | 1.27 | [Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma]. ( Buzdin, VV; Ivanova, NA; Nikitina, ZS; Ryzhov, IV, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (37.04) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 6 (22.22) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, J | 1 |
| Kothur, K | 1 |
| Innes, EA | 1 |
| Han, VX | 1 |
| Jones, HF | 1 |
| Patel, S | 1 |
| Tsang, E | 1 |
| Webster, R | 1 |
| Gupta, S | 1 |
| Troedson, C | 1 |
| Menezes, MP | 1 |
| Antony, J | 1 |
| Ardern-Holmes, S | 1 |
| Tantsis, E | 1 |
| Mohammad, S | 1 |
| Wienholt, L | 1 |
| Pires, AS | 1 |
| Heng, B | 1 |
| Guillemin, GJ | 1 |
| Guller, A | 1 |
| Gill, D | 1 |
| Bandodkar, S | 1 |
| Dale, RC | 1 |
| Al-Karagholi, MA | 1 |
| Hansen, JM | 1 |
| Abou-Kassem, D | 1 |
| Hansted, AK | 1 |
| Ubhayasekera, K | 1 |
| Bergquist, J | 1 |
| Vécsei, L | 2 |
| Jansen-Olesen, I | 1 |
| Ashina, M | 1 |
| Klinkenberg, S | 1 |
| van den Borne, CJ | 1 |
| Aalbers, MW | 1 |
| Verschuure, P | 1 |
| Kessels, AG | 1 |
| Leenen, L | 1 |
| Rijkers, K | 1 |
| Aldenkamp, AP | 1 |
| Vles, JS | 1 |
| Majoie, HJ | 1 |
| Vamos, E | 1 |
| Pardutz, A | 1 |
| Klivenyi, P | 1 |
| Toldi, J | 1 |
| Chugani, DC | 2 |
| Melnikova, NV | 1 |
| Rho, JM | 1 |
| Young, SN | 1 |
| Joseph, MH | 1 |
| Gauthier, S | 1 |
| Narbona López, E | 1 |
| Maldonado Lozano, J | 1 |
| del Castillo, ML | 1 |
| Bayés García, R | 1 |
| Robles Vizcaíno, C | 1 |
| Núñez del Carril, J | 1 |
| Molina Font, JA | 1 |
| Takeuchi, Y | 3 |
| Tominaga, M | 1 |
| Mitsufuji, N | 1 |
| Yamazoe, I | 1 |
| Kawase, S | 1 |
| Nishimura, A | 1 |
| Matsuo, S | 1 |
| Sawada, T | 2 |
| Du, F | 1 |
| Williamson, J | 1 |
| Bertram, E | 1 |
| Lothman, E | 1 |
| Okuno, E | 1 |
| Schwarcz, R | 1 |
| Scharfman, HE | 1 |
| Ofer, A | 1 |
| Muñóz-Hoyos, A | 1 |
| Molina-Carballo, A | 1 |
| Rodríguez-Cabezas, T | 1 |
| Uberos-Fernández, J | 1 |
| Ruiz-Cosano, C | 1 |
| Acuña-Castroviejo, D | 1 |
| Matsushita, H | 1 |
| Kawano, H | 1 |
| Sakai, H | 1 |
| Yoshimoto, K | 1 |
| Stone, TW | 1 |
| Takano, T | 1 |
| Abe, J | 1 |
| Takikita, S | 1 |
| Ohno, M | 1 |
| Grimm, U | 1 |
| Knapp, A | 1 |
| Schmitz, W | 1 |
| Smetan, M | 1 |
| Schmitz, KW | 1 |
| Reddemann, H | 1 |
| Schulz, M | 1 |
| Schlenzka, K | 1 |
| Suzuki, S | 1 |
| Mori, A | 1 |
| Gromov, SA | 1 |
| Eryshev, OF | 1 |
| Kartasheva, EV | 1 |
| Ryzhov, IV | 2 |
| Guilarte, TR | 1 |
| Wagner, HN | 1 |
| Ivanova, NA | 1 |
| Buzdin, VV | 1 |
| Nikitina, ZS | 1 |
| Raine, DN | 1 |
| Hansson, O | 4 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for kynurenine and Epilepsy
| Article | Year |
|---|---|
The role of kynurenines in disorders of the central nervous system: possibilities for neuroprotection.
Topics: Alzheimer Disease; Animals; Brain; Brain Diseases; Brain Ischemia; Epilepsy; Humans; Huntington Dise | 2009 |
α-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions.
Topics: Biomarkers; Brain; Epilepsy; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kinetics; Kynurenine; Pos | 2011 |
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies | 2004 |
Serotonin in autism and pediatric epilepsies.
Topics: Animals; Autistic Disorder; Brain; Child; Electroencephalography; Epilepsy; Humans; Kynurenine; Magn | 2004 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neu | 2001 |
Thyrotropin-releasing hormone: role in the treatment of West syndrome and related epileptic encephalopathies.
Topics: Child; Epilepsy; Humans; Infant; Kynurenine; Spasms, Infantile; Thyrotropin-Releasing Hormone | 2001 |
2 trials available for kynurenine and Epilepsy
| Article | Year |
|---|---|
Phase 1 study to access safety, tolerability, pharmacokinetics, and pharmacodynamics of kynurenine in healthy volunteers.
Topics: Adult; Animals; Blood Flow Velocity; Cerebrovascular Circulation; Cross-Over Studies; Dose-Response | 2021 |
The effects of vagus nerve stimulation on tryptophan metabolites in children with intractable epilepsy.
Topics: Adolescent; Affect; Biotransformation; Child; Child, Preschool; Double-Blind Method; Drug Resistance | 2014 |
19 other studies available for kynurenine and Epilepsy
| Article | Year |
|---|---|
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epi | 2022 |
Neurokynurenines--seizures or/and anxiety in children with epilepsy?
Topics: Adolescent; Anxiety; Child; Child, Preschool; Epilepsy; Humans; Kynurenine; Seizures; Xanthurenates | 2003 |
Studies on kynurenine in human cerebrospinal fluid: lowered levels in epilepsy.
Topics: Adolescent; Adult; Aged; Amino Acids; Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Humans; Hy | 1983 |
[Tryptophan metabolism in children with epilepsy].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Kynurenine; Male; Pyridoxine; | 1984 |
Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Humans; Hydrox | 1995 |
Kynurenine pathway enzymes in a rat model of chronic epilepsy: immunohistochemical study of activated glial cells.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Astrocytes; Cell Death; Cerebral Cortex; Chronic Dis | 1993 |
Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices.
Topics: Animals; Anticonvulsants; Buffers; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino | 1997 |
Relationships between methoxyindole and kynurenine pathway metabolites in plasma and urine in children suffering from febrile and epileptic seizures.
Topics: 3-Hydroxyanthranilic Acid; Child; Child, Preschool; Circadian Rhythm; Epilepsy; Female; Humans; Infa | 1997 |
TRH increases cerebrospinal fluid concentration of kynurenine.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electrodes; Epilepsy; Female; Humans; Infant; | 1999 |
[Tryptophan metabolism and oligophrenia (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Down Syndrome; Epilepsy; Hartnup Disease; Humans; Intellectual | 1978 |
Regional distribution of tyrosine, tryptophan, and their metabolites in the brain of epileptic El mice.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine | 1992 |
[Pathogenic role of the endogenous convulsant kynurenine in the mechanisms of development of epileptic attacks in alcoholics].
Topics: Adult; Alcoholism; Cerebral Cortex; Electroencephalography; Epilepsy; Female; Humans; Kynurenine; Ma | 1991 |
3-Hydroxykynurenine as a possible mechanism of epileptic seizures associated with neonatal vitamin B6 deficiency.
Topics: Animals; Animals, Newborn; Brain; Epilepsy; Female; Kynurenine; Pregnancy; Rats; Synaptic Transmissi | 1986 |
[Elevated kynurenine concentration in the blood serum of children with epilepsy and bronchial asthma].
Topics: Adolescent; Asthma; Child; Child, Preschool; Chronic Disease; Epilepsy; Female; Humans; Kynurenine; | 1988 |
Effect of treatment on tryptophan metabolism in childhood epilepsy.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Central Nervous System Diseases; Child; Child, | 1969 |
Tryptophan loading and pyridoxine treatment in children with epilepsy.
Topics: Child; Epilepsy; Humans; Kynurenine; Pyridoxine; Tryptophan; Vitamin B 6 Deficiency; Xanthurenates | 1969 |
Tryptophan load test and pyridoxine treatment in epileptic children.
Topics: Epilepsy; Humans; Hydrolases; Kinetics; Kynurenine; ortho-Aminobenzoates; Pyridoxine; Tryptophan; Vi | 1967 |
Kinetics of urinary excretion of 3-hydroxykynurenine and 3-hydroxyanthranilic acid after tryptophan loading in man.
Topics: Adolescent; Adult; Child; Chromatography, Thin Layer; Epilepsy; Female; Humans; Hydrolases; Kynureni | 1968 |
Tryptophan load tests in children with epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography; Epilepsy; Female; Humans; Kynurenine; Ma | 1968 |