kynurenine has been researched along with Encephalitis in 18 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Encephalitis: Inflammation of the BRAIN due to infection, autoimmune processes, toxins, and other conditions. Viral infections (see ENCEPHALITIS, VIRAL) are a relatively frequent cause of this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 5.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| " The toxic effects of 3-hydroxy-L-kynurenine are mediated by free radicals." | 2.48 | Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: novel therapeutic strategies for neurodegenerative disorders. ( Fülöp, F; Klivényi, P; Szalárdy, L; Toldi, J; Vécsei, L; Zádori, D, 2012) |
| "Although some ITES syndromes have recognisable MRI neuroimaging phenotypes, there are otherwise few biomarkers of disease." | 1.91 | CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes. ( Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J, 2023) |
| "Quinolinic acid is an excitotoxic kynurenine pathway metabolite, the concentration of which increases in human brain during immune activation." | 1.30 | Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation. ( Beagles, KE; Chen, CY; Heyes, MP; Kawai, K; Li, J; Markey, SP; Nowak, TS; Proescholdt, MA; Proescholdt, MG; Saito, K; Zito, MA, 1997) |
| "Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction." | 1.28 | Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. ( Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 6 (33.33) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Vints, WAJ | 1 |
| Kušleikienė, S | 1 |
| Sheoran, S | 1 |
| Valatkevičienė, K | 1 |
| Gleiznienė, R | 1 |
| Himmelreich, U | 1 |
| Pääsuke, M | 1 |
| Česnaitienė, VJ | 1 |
| Levin, O | 1 |
| Verbunt, J | 1 |
| Masiulis, N | 1 |
| Dale, RC | 1 |
| Thomas, T | 1 |
| Patel, S | 1 |
| Han, VX | 1 |
| Kothur, K | 1 |
| Troedson, C | 1 |
| Gupta, S | 1 |
| Gill, D | 1 |
| Malone, S | 1 |
| Waak, M | 1 |
| Calvert, S | 1 |
| Subramanian, G | 1 |
| Andrews, PI | 1 |
| Kandula, T | 1 |
| Menezes, MP | 1 |
| Ardern-Holmes, S | 1 |
| Mohammad, S | 1 |
| Bandodkar, S | 1 |
| Yan, J | 1 |
| Quist-Paulsen, E | 1 |
| Ormaasen, V | 1 |
| Kran, AB | 1 |
| Dunlop, O | 1 |
| Ueland, PM | 1 |
| Ueland, T | 1 |
| Eikeland, R | 1 |
| Aukrust, P | 1 |
| Nordenmark, TH | 1 |
| van der Velpen, V | 1 |
| Rosenberg, N | 1 |
| Maillard, V | 1 |
| Teav, T | 1 |
| Chatton, JY | 1 |
| Gallart-Ayala, H | 1 |
| Ivanisevic, J | 1 |
| Heisler, JM | 1 |
| O'Connor, JC | 1 |
| Myint, AM | 1 |
| Schwarz, MJ | 1 |
| Steinbusch, HW | 1 |
| Leonard, BE | 1 |
| Möller, T | 1 |
| Kang, A | 1 |
| Hao, H | 1 |
| Zheng, X | 1 |
| Liang, Y | 1 |
| Xie, Y | 1 |
| Xie, T | 1 |
| Dai, C | 1 |
| Zhao, Q | 1 |
| Wu, X | 1 |
| Xie, L | 1 |
| Wang, G | 1 |
| Zádori, D | 1 |
| Klivényi, P | 1 |
| Szalárdy, L | 1 |
| Fülöp, F | 1 |
| Toldi, J | 1 |
| Vécsei, L | 1 |
| Erhardt, S | 1 |
| Lim, CK | 1 |
| Linderholm, KR | 1 |
| Janelidze, S | 1 |
| Lindqvist, D | 1 |
| Samuelsson, M | 1 |
| Lundberg, K | 1 |
| Postolache, TT | 1 |
| Träskman-Bendz, L | 1 |
| Guillemin, GJ | 2 |
| Brundin, L | 1 |
| Kita, T | 1 |
| Morrison, PF | 1 |
| Heyes, MP | 4 |
| Markey, SP | 3 |
| Smythe, G | 1 |
| Takikawa, O | 2 |
| Brew, BJ | 1 |
| Roy, EJ | 1 |
| Kranz, DM | 1 |
| Brown, AR | 1 |
| Thomas, DL | 1 |
| Bellac, CL | 1 |
| Coimbra, RS | 1 |
| Christen, S | 1 |
| Leib, SL | 1 |
| Saito, K | 3 |
| Major, EO | 1 |
| Milstien, S | 1 |
| Vickers, JH | 1 |
| Chen, CY | 1 |
| Proescholdt, MG | 1 |
| Nowak, TS | 1 |
| Li, J | 1 |
| Beagles, KE | 1 |
| Proescholdt, MA | 1 |
| Zito, MA | 1 |
| Kawai, K | 1 |
| Chiarugi, A | 1 |
| Calvani, M | 1 |
| Meli, E | 1 |
| Traggiai, E | 1 |
| Moroni, F | 1 |
| Crowley, JS | 1 |
| Davis, LE | 1 |
| Demitrack, MA | 1 |
| Der, M | 1 |
| Dilling, LA | 1 |
| Elia, J | 1 |
| Kruesi, MJ | 1 |
| Lackner, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Kynurenine Pathway Metabolites in Perinatal Depression and Suicidality[NCT02566980] | 209 participants (Actual) | Observational | 2014-10-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for kynurenine and Encephalitis
| Article | Year |
|---|---|
Neuropsychiatric disorders related to interferon and interleukins treatment.
Topics: Animals; Brain; Brain Diseases, Metabolic; Cytokines; Encephalitis; Humans; Interferons; Interleukin | 2009 |
Neuroinflammation in Huntington's disease.
Topics: Calcium; Complement System Proteins; Encephalitis; Ferritins; Humans; Huntington Disease; Kynurenine | 2010 |
Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: novel therapeutic strategies for neurodegenerative disorders.
Topics: Animals; Brain Ischemia; Encephalitis; Humans; Huntington Disease; Kynurenine; Mitochondria | 2012 |
15 other studies available for kynurenine and Encephalitis
| Article | Year |
|---|---|
Body fat and components of sarcopenia relate to inflammation, brain volume, and neurometabolism in older adults.
Topics: Adipose Tissue; Aged; Aged, 80 and over; Biomarkers; Brain; Creatine; Encephalitis; Hand Strength; H | 2023 |
CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.
Topics: Biomarkers; Brain Diseases; Chromatography, Liquid; Encephalitis; Humans; Kynurenine; Neopterin; Neu | 2023 |
Encephalitis and aseptic meningitis: short-term and long-term outcome, quality of life and neuropsychological functioning.
Topics: Adult; Aged; Biomarkers; Brain Damage, Chronic; Encephalitis; Female; Follow-Up Studies; Humans; Kyn | 2019 |
Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS.
Topics: Alzheimer Disease; Animals; Chromatography, High Pressure Liquid; Encephalitis; Female; Humans; Kynu | 2021 |
Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory.
Topics: Animals; Cytokines; Depression; Encephalitis; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lipo | 2015 |
Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy.
Topics: Animals; Anorexia; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; Blood-Brain Ba | 2011 |
Connecting inflammation with glutamate agonism in suicidality.
Topics: Adult; Aged; Encephalitis; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Interl | 2013 |
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflamm | 2002 |
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.
Topics: Astrocytes; Brain; Brain Chemistry; Cells, Cultured; Coculture Techniques; Encephalitis; Humans; Imm | 2005 |
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynureni | 2005 |
Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Brain; Disease Models, Animal; Encephalitis; Enzyme A | 2006 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3, | 1993 |
Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation.
Topics: Animals; Astrocytes; Brain Ischemia; Encephalitis; Gerbillinae; Immune System; Injections, Intraperi | 1997 |
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
Topics: Cell Death; Cells, Cultured; Culture Media, Conditioned; Cytokines; Encephalitis; Enzyme Inhibitors; | 2001 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynuren | 1992 |