kynurenine has been researched along with Down Syndrome in 10 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B(6)); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome." | 7.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| "Some studies of children with Down syndrome have found mild abnormalities in the metabolism of pyridoxine (vitamin B(6)); therefore the present question is whether such abnormalities might also be present in the amniotic fluid of fetuses with Down syndrome." | 3.74 | Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid. ( Baggot, PJ; DeNicola, NG; Eliseo, AJ; Kalamarides, JA; Shoemaker, JD, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Powers, RK | 1 |
| Culp-Hill, R | 1 |
| Ludwig, MP | 1 |
| Smith, KP | 1 |
| Waugh, KA | 1 |
| Minter, R | 1 |
| Tuttle, KD | 1 |
| Lewis, HC | 1 |
| Rachubinski, AL | 1 |
| Granrath, RE | 1 |
| Carmona-Iragui, M | 1 |
| Wilkerson, RB | 1 |
| Kahn, DE | 1 |
| Joshi, M | 1 |
| Lleó, A | 1 |
| Blesa, R | 1 |
| Fortea, J | 1 |
| D'Alessandro, A | 1 |
| Costello, JC | 1 |
| Sullivan, KD | 1 |
| Espinosa, JM | 1 |
| Uberos, J | 1 |
| Romero, J | 1 |
| Molina-Carballo, A | 1 |
| Muñoz-Hoyos, A | 1 |
| MCCOY, EE | 2 |
| CHUNG, SI | 1 |
| GRIFFITHS, AW | 1 |
| RUNDLE, AT | 1 |
| STEWART, A | 1 |
| Klivényi, P | 1 |
| Toldi, J | 1 |
| Vécsei, L | 1 |
| Baggot, PJ | 1 |
| Eliseo, AJ | 1 |
| DeNicola, NG | 1 |
| Kalamarides, JA | 1 |
| Shoemaker, JD | 1 |
| Grimm, U | 1 |
| Knapp, A | 1 |
| Schmitz, W | 1 |
| Smetan, M | 1 |
| Schmitz, KW | 1 |
| Reddemann, H | 1 |
| Schulz, M | 1 |
| Schlenzka, K | 1 |
| Vassella, F | 1 |
| Colombo, JP | 1 |
| Gloor, RD | 1 |
| Rossi, E | 1 |
| Colombini, C | 1 |
| Ebadi, M | 1 |
| Chiancone, FM | 1 |
1 review available for kynurenine and Down Syndrome
| Article | Year |
|---|---|
Kynurenines in neurodegenerative disorders: therapeutic consideration.
Topics: AIDS Dementia Complex; Animals; Central Nervous System Diseases; Down Syndrome; Enzyme Inhibitors; H | 2004 |
9 other studies available for kynurenine and Down Syndrome
| Article | Year |
|---|---|
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Topics: Animals; Biosynthetic Pathways; Cell Line; Chromosomes, Human, Pair 21; Cytokines; Down Syndrome; Ge | 2019 |
Melatonin and elimination of kynurenines in children with Down's syndrome.
Topics: Child; Child, Preschool; Circadian Rhythm; Down Syndrome; Female; Humans; Kynurenic Acid; Kynurenine | 2010 |
THE EXCRETION OF TRYPTOPHAN METABOLITES FOLLOWING DEOXYPYRIDOXINE ADMINISTRATION IN MONGOLOID AND NONMONGOLOID PATIENTS.
Topics: Child; Down Syndrome; Humans; Kynurenine; Metabolism; Tryptophan; Urine; Vitamin B 6 Deficiency; Xan | 1964 |
LIVER FUNCTION AND HEPATITIS IN MONGOLISM.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Protein Electrophoresis; Chemist | 1965 |
Pyridoxine-related metabolite concentrations in normal and Down syndrome amniotic fluid.
Topics: Amniotic Fluid; Biomarkers; Case-Control Studies; Down Syndrome; Female; Humans; Kynurenine; Oxalic | 2008 |
[Tryptophan metabolism and oligophrenia (author's transl)].
Topics: Amino Acid Metabolism, Inborn Errors; Down Syndrome; Epilepsy; Hartnup Disease; Humans; Intellectual | 1978 |
[Studies on the L-tryptophan metabolism in children with Down's syndrome].
Topics: Child; Child, Preschool; Chromatography; Down Syndrome; Female; Humans; Infant; Kynurenine; Male; Mo | 1968 |
The metabolism of vitamin B6 in Down's syndrome.
Topics: Adolescent; Down Syndrome; Humans; Kynurenine; Male; Oxalates; Pyridoxine; Taurine; Tryptophan; Xant | 1969 |
[Functional exploration at various levels of the tryptophan--nicotinic acid metabolic line].
Topics: Diabetes Mellitus; Down Syndrome; Female; Humans; Hydroxyindoleacetic Acid; Hydroxylation; Kynurenin | 1972 |