kynurenine has been researched along with Disease Exacerbation in 53 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 8.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "The aim of this study was to evaluate the kynurenine pathway (KP) and amino acids profile, using mass spectrometry, in the cerebrospinal fluid (CSF) of 42 amyotrophic lateral sclerosis (ALS) patients at the diagnosis and 40 controls to detect early disorders of these pathways." | 8.02 | Some CSF Kynurenine Pathway Intermediates Associated with Disease Evolution in Amyotrophic Lateral Sclerosis. ( Alarcan, H; Andres, C; Bakkouche, SE; Benz-De Bretagne, I; Blasco, H; Chaumond, R; Corcia, P; Emond, P; Lefèvre, A; Veyrat-Durebex, C; Vourc'h, P, 2021) |
| "Proteins isolated from the nuclei of normal lenses and lenses with and types I to IV nuclear cataract were hydrolyzed in 6 M HCl, and the levels of kynurenine-lysine and kynurenine-histidine were determined by HPLC." | 7.72 | Protein-bound kynurenine decreases with the progression of age-related nuclear cataract. ( Parker, NR; Sheil, M; Truscott, RJ; Vazquez, S, 2004) |
| "The kynurenine pathway has been implicated in both the physiological processes of the central nervous system and in the pathomechanism of several neurological disorders as well." | 6.58 | Kynurenine System and Multiple Sclerosis, Pathomechanism and Drug Targets with An Emphasis on Laquinimod. ( Annus, A; Majlath, Z; Vecsei, L, 2018) |
| "Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies worldwide." | 5.46 | Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma. ( Cheng, J; Gao, X; Hou, X; Jin, H; Lv, J; Zheng, G, 2017) |
| "The aim of this paper is to elucidate the role of oxidative and nitrosative stress as well as the tryptophan catabolites pathway in the development of depression and the mechanism of action of antidepressant drugs, based on the available literature." | 4.95 | Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders. ( Czarny, P; Galecki, P; Sliwinski, T; Wigner, P, 2017) |
| "There was a significant accumulation of kynurenine and kynurenic acid (KYNA) in children and adults with ADPKD as compared to healthy subjects." | 4.31 | Kynurenines in polycystic kidney disease. ( Cadnapaphornchai, MA; Chonchol, M; Christians, U; Gitomer, BY; Hopp, K; Jackson, MJ; Klawitter, J; Smith, PH, 2023) |
| "The aim of this study was to evaluate the kynurenine pathway (KP) and amino acids profile, using mass spectrometry, in the cerebrospinal fluid (CSF) of 42 amyotrophic lateral sclerosis (ALS) patients at the diagnosis and 40 controls to detect early disorders of these pathways." | 4.02 | Some CSF Kynurenine Pathway Intermediates Associated with Disease Evolution in Amyotrophic Lateral Sclerosis. ( Alarcan, H; Andres, C; Bakkouche, SE; Benz-De Bretagne, I; Blasco, H; Chaumond, R; Corcia, P; Emond, P; Lefèvre, A; Veyrat-Durebex, C; Vourc'h, P, 2021) |
| "We biochemically altered the KP at different stages of the disease in experimental allergic encephalomyelitis (EAE) mouse model of MS and at two different enzymatic levels of the KP (IDO-1 (indoleamine 2,3 dioxygenase)) and KMO (kynurenine monooxygenase)." | 3.96 | Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression. ( Brew, BJ; Guillemin, GJ; Lim, CK; Sundaram, G, 2020) |
| " Here we report that kynurenine produced by glioblastoma cells activates aryl hydrocarbon receptor (AHR) in TAMs to modulate their function and T cell immunity." | 3.91 | Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39. ( Antel, J; Barroso, A; Chao, CC; de Lima, KA; Farez, MF; Gabriely, G; Getz, G; Ghannam, S; Gutiérrez-Vázquez, C; Healy, L; Kenison, J; Mascanfroni, ID; Mayo, L; Prat, A; Quintana, FJ; Reardon, DA; Robson, SC; Rothhammer, V; Rothweiler, S; Sherr, D; Takenaka, MC; Tjon, EC; Vandeventer, T; Weiner, HL; Wheeler, MA; Zandee, S; Zhang, H, 2019) |
| "Kynurenine, the metabolite generated by IDO, increases in the supernatant of fibroblasts co-cultured with COX-2-overexpressing breast cancer cells." | 3.80 | Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression. ( Chen, JY; Hou, MF; Hung, WC; Kuo, CC; Li, CF; Tsai, KK, 2014) |
| "New data from Favre and colleagues strengthen the link between activation of the tryptophan oxidation (TOx) pathway--via the indoleamine 2,3-dioxygenase enzymes IDO1 and IDO2--and chronic inflammation in progressive HIV disease." | 3.76 | Insights into therapy: tryptophan oxidation and HIV infection. ( Murray, MF, 2010) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Proteins isolated from the nuclei of normal lenses and lenses with and types I to IV nuclear cataract were hydrolyzed in 6 M HCl, and the levels of kynurenine-lysine and kynurenine-histidine were determined by HPLC." | 3.72 | Protein-bound kynurenine decreases with the progression of age-related nuclear cataract. ( Parker, NR; Sheil, M; Truscott, RJ; Vazquez, S, 2004) |
| "In the SUPPORT study, adult pancreatic cancer patients were randomized to intervention programs of 6-month (1) a Supervised moderate-to-high-intensity progressive resistance training or (2) unsupervised Home-based resistance training, or (3) to a standard care patient Control group." | 3.01 | Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients. ( Clauss, D; Pal, A; Schmidt, ME; Steindorf, K; Ulrich, CM; Wiskemann, J; Zimmer, P, 2021) |
| "The kynurenine pathway has been implicated in both the physiological processes of the central nervous system and in the pathomechanism of several neurological disorders as well." | 2.58 | Kynurenine System and Multiple Sclerosis, Pathomechanism and Drug Targets with An Emphasis on Laquinimod. ( Annus, A; Majlath, Z; Vecsei, L, 2018) |
| "Serum samples of 32 patients with ESRD (n = 13) and CKD (n = 19) were analyzed using chemical isotope labeling liquid chromatography-mass spectrometry metabolomics approach." | 1.91 | Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients. ( Abdel Rahman, A; Alabdaljabar, MS; Dahabiyeh, LA; Hussein, MH; Jacob, M; Nimer, RM; Sabi, EM; Sumaily, KM, 2023) |
| "Studies in Alzheimer's disease (AD) patients confirm KP dyshomeostasis in plasma and cerebrospinal fluid (CSF) which correlates with amyloid-β and tau pathology." | 1.72 | Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β. ( Bourgeat, P; Cespedes, M; Chatterjee, P; Doecke, JD; Fowler, CJ; Guillemin, GJ; Ittner, A; Jacobs, KR; Lim, CK; Lovejoy, DB; Martins, RN; Maruff, P; Masters, CL; Pertile, KK; Rainey-Smith, SR; Rembach, A; Rowe, CC; Rumble, RL; Trounson, B; Villemagne, VL, 2022) |
| "Comparing the tumor tissues from prostatic cancer patients, we found elevated expression of tryptophan 2, 3-dioxygenase 2 (TDO2), and elevated Trp metabolism in chemo-resistant tumor tissues." | 1.62 | Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner. ( Guan, W; Li, F; Zhang, Y; Zhang, Z; Zhao, Z, 2021) |
| "Advanced Bladder Cancer (BLCA) remains a clinical challenge that lacks effective therapeutic measures." | 1.56 | Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression. ( Arnold, JM; Bader, DA; Cao, Q; Coarfa, C; Devarakonda, V; Donepudi, SR; Dubrulle, J; Jain, AK; Karanam, B; Kavuri, SM; Lotan, Y; Ma, J; Maity, S; McGuire, SE; Putluri, N; Putluri, V; Rajapakshe, K; Sikora, AG; Sreekumar, A; Stossi, F; Vantaku, V; Villanueva, H; von Rundstedt, FC, 2020) |
| " Our results suggest that RT alters IDO-mediated immune status in NSCLC patients and that changes in this serum biomarker may be useful to predict outcomes and perhaps personalize RT dosage to improve survival." | 1.48 | IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients. ( Huang, L; Jin, JY; Jolly, S; Kong, FS; Li, L; Mellor, AL; Pi, W; Wang, W; Wu, H; Yan, L; Zang, Y, 2018) |
| "Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies worldwide." | 1.46 | Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma. ( Cheng, J; Gao, X; Hou, X; Jin, H; Lv, J; Zheng, G, 2017) |
| "In hospitalized patients with a COPD exacerbation, higher IDO and TPH activities independently predicted adverse short-term outcomes and TPH levels were also predictive of 18-month mortality." | 1.46 | Activation of the Serotonin Pathway is Associated with Poor Outcome in COPD Exacerbation: Results of a Long-Term Cohort Study. ( Bernasconi, L; Christ-Crain, M; Henzen, C; Hoess, C; Huber, A; Meier, MA; Mueller, B; Ottiger, M; Schuetz, P; Steuer, C; Thomann, R; Vögeli, A; Zimmerli, W, 2017) |
| "Disease progression was monitored by determination of viral load (VL), CD4(+) cell counts, haemoglobin and urinary/plasma neopterin, tryptophan and kynurenine concentrations." | 1.35 | Quality of life and immune activation in patients with HIV-infection. ( Fuchs, D; Kemmler, G; Mumelter, B; Sarcletti, M; Schroecksnadel, K; Weiss, G; Winkler, C; Zangerle, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (11.32) | 29.6817 |
| 2010's | 31 (58.49) | 24.3611 |
| 2020's | 16 (30.19) | 2.80 |
| Authors | Studies |
|---|---|
| Li, F | 1 |
| Zhao, Z | 1 |
| Zhang, Z | 2 |
| Zhang, Y | 1 |
| Guan, W | 1 |
| Cespedes, M | 1 |
| Jacobs, KR | 2 |
| Maruff, P | 1 |
| Rembach, A | 1 |
| Fowler, CJ | 1 |
| Trounson, B | 1 |
| Pertile, KK | 1 |
| Rumble, RL | 1 |
| Rainey-Smith, SR | 1 |
| Rowe, CC | 1 |
| Villemagne, VL | 1 |
| Bourgeat, P | 1 |
| Lim, CK | 4 |
| Chatterjee, P | 2 |
| Martins, RN | 2 |
| Ittner, A | 1 |
| Masters, CL | 1 |
| Doecke, JD | 1 |
| Guillemin, GJ | 5 |
| Lovejoy, DB | 3 |
| Ceballos, FC | 1 |
| Virseda-Berdices, A | 1 |
| Resino, S | 1 |
| Ryan, P | 1 |
| Martínez-González, O | 1 |
| Peréz-García, F | 1 |
| Martin-Vicente, M | 1 |
| Brochado-Kith, O | 1 |
| Blancas, R | 1 |
| Bartolome-Sánchez, S | 1 |
| Vidal-Alcántara, EJ | 1 |
| Albóniga-Díez, OE | 1 |
| Cuadros-González, J | 1 |
| Blanca-López, N | 1 |
| Martínez, I | 1 |
| Martinez-Acitores, IR | 1 |
| Barbas, C | 1 |
| Fernández-Rodríguez, A | 1 |
| Jiménez-Sousa, MÁ | 1 |
| Klawitter, J | 2 |
| Jackson, MJ | 1 |
| Smith, PH | 1 |
| Hopp, K | 1 |
| Chonchol, M | 1 |
| Gitomer, BY | 1 |
| Cadnapaphornchai, MA | 1 |
| Christians, U | 1 |
| Chen, Y | 1 |
| Zhang, J | 1 |
| Yang, Y | 1 |
| Xiang, K | 1 |
| Li, H | 2 |
| Sun, D | 1 |
| Chen, L | 1 |
| Dahabiyeh, LA | 1 |
| Nimer, RM | 1 |
| Sumaily, KM | 1 |
| Alabdaljabar, MS | 1 |
| Jacob, M | 1 |
| Sabi, EM | 1 |
| Hussein, MH | 1 |
| Abdel Rahman, A | 1 |
| Liu, JJ | 1 |
| Ching, J | 1 |
| Wee, HN | 1 |
| Liu, S | 1 |
| Gurung, RL | 1 |
| Lee, J | 1 |
| M, Y | 1 |
| Zheng, H | 1 |
| Lee, LS | 1 |
| Ang, K | 1 |
| Shao, YM | 1 |
| Kovalik, JP | 1 |
| Subramaniam, T | 1 |
| Sum, CF | 1 |
| Sharma, K | 1 |
| Kestenbaum, BR | 1 |
| Lim, SC | 1 |
| Wu, PY | 1 |
| Yu, IS | 1 |
| Lin, YC | 1 |
| Chang, YT | 1 |
| Chen, CC | 1 |
| Lin, KH | 1 |
| Tseng, TH | 1 |
| Kargren, M | 1 |
| Tai, YL | 1 |
| Shen, TL | 1 |
| Liu, YL | 1 |
| Wang, BJ | 1 |
| Chang, CH | 1 |
| Chen, WM | 1 |
| Juan, HF | 1 |
| Huang, SF | 1 |
| Chan, YY | 1 |
| Liao, YF | 1 |
| Hsu, WM | 1 |
| Lee, H | 1 |
| Karpińska, G | 1 |
| Dobrowolski, JC | 1 |
| Yinda, CK | 1 |
| Rector, A | 1 |
| Zeller, M | 1 |
| Conceição-Neto, N | 1 |
| Heylen, E | 1 |
| Maes, P | 1 |
| Ghogomu, SM | 1 |
| Van Ranst, M | 1 |
| Matthijnssens, J | 1 |
| Arthanari, SK | 1 |
| Vanitha, J | 1 |
| Ganesh, M | 1 |
| Venkateshwaran, K | 1 |
| de Lama Caro-Patón, G | 1 |
| García-Salido, A | 1 |
| Iglesias-Bouzas, MI | 1 |
| Guillén, M | 1 |
| Cañedo-Villaroya, E | 1 |
| Martínez-Romera, I | 1 |
| Serrano-González, A | 1 |
| Casado-Flores, J | 1 |
| Gale, P | 2 |
| Chen, X | 2 |
| Lucero-Prisno, DE | 1 |
| Abdullah, AS | 1 |
| Huang, J | 1 |
| Laurence, C | 1 |
| Liang, X | 1 |
| Ma, Z | 1 |
| Mao, Z | 1 |
| Ren, R | 1 |
| Wu, S | 1 |
| Wang, N | 1 |
| Wang, P | 2 |
| Wang, T | 2 |
| Yan, H | 1 |
| Zou, Y | 1 |
| Olsen, KM | 1 |
| Gabler, NK | 1 |
| Rademacher, CJ | 1 |
| Schwartz, KJ | 1 |
| Schweer, WP | 1 |
| Gourley, GG | 1 |
| Patience, JF | 1 |
| Rauch, JC | 1 |
| Stokes, RS | 1 |
| Shike, DW | 1 |
| Luebbe, KM | 1 |
| Stalker, LA | 1 |
| Klopfenstein, TJ | 1 |
| Funston, RN | 1 |
| Unger, PA | 1 |
| Lighaam, LC | 1 |
| Vermeulen, E | 1 |
| Kruithof, S | 1 |
| Makuch, M | 1 |
| Culver, EL | 1 |
| van Bruggen, R | 1 |
| Remmerswaal, EBM | 1 |
| Ten Berge, IJM | 1 |
| Emmens, RW | 1 |
| Niessen, HWM | 1 |
| Barnes, E | 1 |
| Wolbink, GJ | 1 |
| van Ham, SM | 1 |
| Rispens, T | 1 |
| Liang, JX | 1 |
| Lin, J | 1 |
| Liu, J | 1 |
| Wang, X | 1 |
| Zhang, T | 1 |
| Li, J | 1 |
| Wu, Y | 2 |
| Venier, M | 1 |
| Salamova, A | 1 |
| Gonçales, VR | 1 |
| Lian, J | 1 |
| Gautam, S | 1 |
| Tilley, RD | 1 |
| Gooding, JJ | 1 |
| Kandel, YR | 1 |
| Bradley, CA | 1 |
| Chilvers, MI | 1 |
| Mathew, FM | 1 |
| Tenuta, AU | 1 |
| Smith, DL | 1 |
| Wise, KA | 1 |
| Mueller, DS | 1 |
| Lu, N | 1 |
| Lu, M | 1 |
| Liu, P | 1 |
| Xu, H | 1 |
| Qiu, X | 1 |
| Hu, S | 1 |
| Bai, S | 1 |
| Wu, J | 1 |
| Xue, S | 1 |
| Dai, X | 1 |
| Dharmage, SC | 1 |
| Abramson, MJ | 1 |
| Erbas, B | 1 |
| Bennett, CM | 1 |
| Svanes, C | 1 |
| Hui, J | 1 |
| Axelrad, C | 1 |
| Lowe, AJ | 1 |
| Lodge, CJ | 1 |
| Hoshi, M | 1 |
| Osawa, Y | 1 |
| Nakamoto, K | 1 |
| Morita, N | 1 |
| Yamamoto, Y | 2 |
| Ando, T | 1 |
| Tashita, C | 1 |
| Nabeshima, T | 1 |
| Saito, K | 3 |
| Gianesello, L | 1 |
| Del Prete, D | 1 |
| Ceol, M | 1 |
| Priante, G | 1 |
| Calò, LA | 1 |
| Anglani, F | 1 |
| Vekaria, HJ | 1 |
| Hubbard, WB | 1 |
| Scholpa, NE | 1 |
| Spry, ML | 1 |
| Gooch, JL | 1 |
| Prince, SJ | 1 |
| Schnellmann, RG | 1 |
| Sullivan, PG | 1 |
| Zhang, Q | 1 |
| Hu, R | 1 |
| Gu, Z | 1 |
| Zhang, M | 1 |
| Peng, Y | 1 |
| Feng, L | 1 |
| Li, X | 3 |
| Zhao, C | 1 |
| Sarfaraz, K | 1 |
| Gao, L | 1 |
| Wang, H | 1 |
| Wan, C | 1 |
| Leng, J | 1 |
| Yang, P | 1 |
| Gao, X | 2 |
| Gao, J | 1 |
| Emam, HE | 1 |
| Saad, NM | 1 |
| Abdallah, AEM | 1 |
| Ahmed, HB | 1 |
| Palombo, M | 1 |
| Ianus, A | 1 |
| Guerreri, M | 1 |
| Nunes, D | 1 |
| Alexander, DC | 1 |
| Shemesh, N | 1 |
| Zhang, H | 2 |
| Xiong, Q | 1 |
| Liu, YS | 1 |
| Hu, LX | 1 |
| Shi, ZQ | 1 |
| Ying, GG | 1 |
| Chen, R | 1 |
| Hong, X | 1 |
| Yan, S | 1 |
| Zha, J | 1 |
| Gu, H | 1 |
| Zhong, Q | 1 |
| Zeng, Y | 1 |
| Zhang, S | 1 |
| Bu, Y | 1 |
| Farghali, M | 1 |
| Mayumi, M | 1 |
| Syo, K | 1 |
| Satoshi, A | 1 |
| Seiichi, Y | 1 |
| Takashima, S | 1 |
| Ono, H | 1 |
| Ap, Y | 1 |
| Yamashiro, T | 1 |
| Ahmed, MM | 1 |
| Kotb, S | 1 |
| Iwasaki, M | 1 |
| Ihara, I | 1 |
| Umetsu, K | 1 |
| Hu, B | 1 |
| Wang, Y | 2 |
| Quan, J | 1 |
| Huang, K | 1 |
| Gu, X | 1 |
| Zhu, J | 1 |
| Yan, Y | 1 |
| Wu, P | 1 |
| Yang, L | 1 |
| Zhao, J | 1 |
| Koók, L | 1 |
| Nemestóthy, N | 1 |
| Bélafi-Bakó, K | 1 |
| Bakonyi, P | 1 |
| Luo, X | 1 |
| Zhang, F | 1 |
| Li, Q | 1 |
| Xia, Q | 1 |
| Li, Z | 1 |
| Ye, W | 1 |
| Li, S | 1 |
| Ge, C | 1 |
| Zakkula, A | 1 |
| Pulipati, S | 1 |
| Dittakavi, S | 1 |
| Bestha, RM | 1 |
| Zainuddin, M | 1 |
| Trivedi, RK | 1 |
| Mullangi, R | 1 |
| Lo, GH | 1 |
| Lin, CW | 1 |
| Tai, CM | 1 |
| Perng, DS | 1 |
| Chen, IL | 1 |
| Yeh, JH | 1 |
| Lin, HC | 1 |
| Rocha, GS | 1 |
| Silva, MKL | 1 |
| Cesarino, I | 1 |
| Hazzaa, SM | 1 |
| Abdelaziz, SAM | 1 |
| Abd Eldaim, MA | 1 |
| Abdel-Daim, MM | 1 |
| Elgarawany, GE | 1 |
| Larsson, P | 1 |
| Ljuslinder, I | 1 |
| Öhlund, D | 1 |
| Myte, R | 1 |
| Löfgren-Burström, A | 1 |
| Zingmark, C | 1 |
| Ling, A | 1 |
| Edin, S | 1 |
| Palmqvist, R | 1 |
| Murthi, P | 1 |
| Rajaraman, G | 1 |
| Erwich, JJHM | 1 |
| Dimitriadis, E | 1 |
| Yoon, HG | 1 |
| Oh, D | 1 |
| Ahn, YC | 1 |
| Noh, JM | 1 |
| Pyo, H | 1 |
| Cho, WK | 1 |
| Song, YM | 1 |
| Park, M | 1 |
| Hwang, NY | 1 |
| Sun, JM | 1 |
| Kim, HK | 1 |
| Zo, JI | 1 |
| Shim, YM | 1 |
| Persano, A | 1 |
| Quaranta, F | 1 |
| Taurino, A | 1 |
| Siciliano, PA | 1 |
| Iannacci, J | 1 |
| Malekbala, MR | 1 |
| Soltani, S | 1 |
| Abdul Rashid, S | 1 |
| Abdullah, LC | 1 |
| Rashid, U | 1 |
| Nehdi, IA | 1 |
| Choong, TSY | 1 |
| Teo, SH | 1 |
| Xu, P | 1 |
| Yan, F | 1 |
| Zhao, Y | 1 |
| Sun, S | 1 |
| Ying, L | 1 |
| Quinzi, V | 1 |
| Caruso, S | 1 |
| Mummolo, S | 1 |
| Nota, A | 1 |
| Angelone, AM | 1 |
| Mattei, A | 1 |
| Gatto, R | 1 |
| Marzo, G | 1 |
| Xin, W | 1 |
| Severino, J | 1 |
| Venkert, A | 1 |
| Yu, H | 1 |
| Knorr, D | 1 |
| Yang, JM | 1 |
| Carlson, L | 1 |
| Hicks, R | 1 |
| De Rosa, I | 1 |
| Beckmann, NA | 1 |
| Bitsch, RG | 1 |
| Schonhoff, M | 1 |
| Siebenrock, KA | 1 |
| Schwarze, M | 1 |
| Jaeger, S | 1 |
| Sundaram, G | 1 |
| Brew, BJ | 2 |
| Pal, A | 1 |
| Zimmer, P | 1 |
| Clauss, D | 1 |
| Schmidt, ME | 1 |
| Ulrich, CM | 1 |
| Wiskemann, J | 1 |
| Steindorf, K | 1 |
| Cheng, Y | 1 |
| Li, Y | 1 |
| Benkowitz, P | 1 |
| Lamina, C | 1 |
| Köttgen, A | 1 |
| Sekula, P | 1 |
| Matheus, LHG | 1 |
| Dalmazzo, SV | 1 |
| Brito, RBO | 1 |
| Pereira, LA | 1 |
| de Almeida, RJ | 1 |
| Camacho, CP | 1 |
| Dellê, H | 1 |
| Sobash, PT | 1 |
| Kolhe, R | 1 |
| Karim, NA | 1 |
| Guddati, AK | 1 |
| Jillella, A | 1 |
| Kota, V | 1 |
| Sumitomo, M | 1 |
| Takahara, K | 1 |
| Zennami, K | 1 |
| Nagakawa, T | 1 |
| Maeda, Y | 2 |
| Shiogama, K | 1 |
| Muto, Y | 1 |
| Nukaya, T | 1 |
| Takenaka, M | 1 |
| Fukaya, K | 1 |
| Ichino, M | 1 |
| Sasaki, H | 1 |
| Shiroki, R | 1 |
| Alarcan, H | 1 |
| Chaumond, R | 1 |
| Emond, P | 1 |
| Benz-De Bretagne, I | 1 |
| Lefèvre, A | 1 |
| Bakkouche, SE | 1 |
| Veyrat-Durebex, C | 1 |
| Vourc'h, P | 1 |
| Andres, C | 1 |
| Corcia, P | 1 |
| Blasco, H | 1 |
| Sandi, D | 1 |
| Fricska-Nagy, Z | 1 |
| Bencsik, K | 1 |
| Vécsei, L | 3 |
| Cheng, J | 1 |
| Jin, H | 1 |
| Hou, X | 1 |
| Lv, J | 1 |
| Zheng, G | 1 |
| Meier, MA | 1 |
| Ottiger, M | 1 |
| Vögeli, A | 1 |
| Steuer, C | 1 |
| Bernasconi, L | 1 |
| Thomann, R | 1 |
| Christ-Crain, M | 1 |
| Henzen, C | 1 |
| Hoess, C | 1 |
| Zimmerli, W | 1 |
| Huber, A | 1 |
| Mueller, B | 1 |
| Schuetz, P | 1 |
| Wang, W | 1 |
| Huang, L | 1 |
| Jin, JY | 1 |
| Jolly, S | 1 |
| Zang, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of a Treatment Switch From Protease Inhibitor to Raltegravir-based ART on Myeloid Cell Inflammation in HIV-infected Patients.[NCT02691065] | Phase 4 | 6 participants (Actual) | Interventional | 2017-01-20 | Completed | ||
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for kynurenine and Disease Exacerbation
| Article | Year |
|---|---|
Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression.
Topics: Disease Progression; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Neurodegenerati | 2022 |
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia.
Topics: Antineoplastic Agents; Cell Differentiation; Dendritic Cells; Disease Progression; Gene Expression R | 2020 |
Neurodegeneration in Multiple Sclerosis: Symptoms of Silent Progression, Biomarkers and Neuroprotective Therapy-Kynurenines Are Important Players.
Topics: Animals; Biomarkers; Disease Progression; Humans; Kynurenine; Molecular Targeted Therapy; Multiple S | 2021 |
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progressio | 2017 |
Indoleamine 2,3-dioxygenase as a novel therapeutic target for Huntington's disease.
Topics: Animals; Disease Progression; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynu | 2019 |
Kynurenine System and Multiple Sclerosis, Pathomechanism and Drug Targets with An Emphasis on Laquinimod.
Topics: Animals; Brain; Disease Progression; Drug Development; Humans; Kynurenine; Molecular Targeted Therap | 2018 |
3 trials available for kynurenine and Disease Exacerbation
| Article | Year |
|---|---|
Topics: Acetaminophen; Administration, Oral; Adolescent; Adsorption; Adult; Allyl Compounds; Amylopectin; Am | 2013 |
Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients.
Topics: Biomarkers; Disease Progression; Down-Regulation; Humans; Interleukin-6; Kynurenine; Metabolic Netwo | 2021 |
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; | 2003 |
44 other studies available for kynurenine and Disease Exacerbation
| Article | Year |
|---|---|
Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner.
Topics: Animals; ATP-Binding Cassette Transporters; Basic Helix-Loop-Helix Transcription Factors; Cell Line, | 2021 |
Systemic perturbations of the kynurenine pathway precede progression to dementia independently of amyloid-β.
Topics: 3-Hydroxyanthranilic Acid; Alzheimer Disease; Amyloid beta-Peptides; Australia; Biomarkers; Cognitiv | 2022 |
Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation.
Topics: COVID-19; Cross-Sectional Studies; Cytokines; Disease Progression; Female; Humans; Kynurenine; Male; | 2022 |
Kynurenines in polycystic kidney disease.
Topics: Adult; Child; Disease Progression; Glomerular Filtration Rate; Humans; Inflammation; Kidney; Kynuren | 2023 |
Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Kynure | 2023 |
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kyn | 2023 |
Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Line, Tumor; Cell | 2019 |
Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.
Topics: Animals; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Kynurenine; Mice; Signal | 2020 |
The relationship between blood metabolites of the tryptophan pathway and kidney function: a bidirectional Mendelian randomization analysis.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Indican; Indoles; Kynurenine; M | 2020 |
1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression.
Topics: Aged; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytoc | 2020 |
Tryptophan 2,3-dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell | 2021 |
Some CSF Kynurenine Pathway Intermediates Associated with Disease Evolution in Amyotrophic Lateral Sclerosis.
Topics: Age of Onset; Aged; Aged, 80 and over; Amino Acids; Amyotrophic Lateral Sclerosis; Biomarkers; Case- | 2021 |
Disturbed tryptophan metabolism correlating to progression and metastasis of esophageal squamous cell carcinoma.
Topics: 5-Hydroxytryptophan; Aged; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Diseas | 2017 |
Activation of the Serotonin Pathway is Associated with Poor Outcome in COPD Exacerbation: Results of a Long-Term Cohort Study.
Topics: Aged; Aged, 80 and over; Biomarkers; C-Reactive Protein; Calcitonin; Chromatography, Liquid; Disease | 2017 |
IDO Immune Status after Chemoradiation May Predict Survival in Lung Cancer Patients.
Topics: Adenocarcinoma; Aged; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; C | 2018 |
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine | 2017 |
Plasma Tryptophan-Kynurenine Metabolites Are Altered in Human Immunodeficiency Virus Infection and Associated With Progression of Carotid Artery Atherosclerosis.
Topics: Adult; Biomarkers; Carotid Arteries; Carotid Artery Diseases; Disease Progression; Female; HIV Infec | 2018 |
Alterations in serum kynurenine pathway metabolites in individuals with high neocortical amyloid-β load: A pilot study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Asymptomatic Diseases; Biomarkers | 2018 |
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Female; Humans | 2018 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Ky | 2019 |
Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39.
Topics: Animals; Antigens, CD; Apyrase; Brain Neoplasms; Cell Line, Tumor; Disease Progression; Glioblastoma | 2019 |
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.
Topics: Aldehyde Oxidase; Animals; Cell Line, Tumor; Disease Progression; Enhancer of Zeste Homolog 2 Protei | 2020 |
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokin | 2013 |
Cancer/stroma interplay via cyclooxygenase-2 and indoleamine 2,3-dioxygenase promotes breast cancer progression.
Topics: Adult; Aged; Animals; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Coculture Techni | 2014 |
Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma.
Topics: Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Disease Progression; Female; Human T-lymp | 2015 |
Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms.
Topics: Adult; Disease Progression; Female; Humans; Kynurenine; Male; Middle Aged; Multiple Sclerosis; Trypt | 2016 |
Influence of Hepatitis C Virus Sustained Virological Response on Immunosuppressive Tryptophan Catabolism in ART-Treated HIV/HCV Coinfected Patients.
Topics: Adult; Anti-HIV Agents; Biomarkers; Coinfection; Disease Progression; Female; Hepacivirus; Hepatitis | 2016 |
The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.
Topics: Adenoma; Animals; CD8 Antigens; Cyclooxygenase 2; Diethylnitrosamine; Disease Progression; Forkhead | 2016 |
Activity of the kynurenine pathway and its interplay with immunity in patients with pulmonary arterial hypertension.
Topics: Adult; Aged; Area Under Curve; Case-Control Studies; Disease Progression; Echocardiography, Doppler; | 2016 |
Lung cancer-derived galectin-1 contributes to cancer associated fibroblast-mediated cancer progression and immune suppression through TDO2/kynurenine axis.
Topics: A549 Cells; Animals; Cancer-Associated Fibroblasts; Carcinoma, Lewis Lung; Cell Line, Tumor; Cocultu | 2016 |
Metabolomic Analysis of Gastric Cancer Progression within the Correa's Cascade Using Ultraperformance Liquid Chromatography-Mass Spectrometry.
Topics: Adenocarcinoma; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Disease Progression; Female | 2016 |
Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression.
Topics: Adult; Biomarkers; Cohort Studies; Computer Simulation; Demography; Disease Progression; Female; Fol | 2017 |
Oxidative modifications of blood serum proteins in myasthenia gravis.
Topics: Adult; Advanced Oxidation Protein Products; Aged; Aged, 80 and over; Autoantibodies; Benzothiazoles; | 2017 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer.
Topics: Aged; Disease Progression; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung Ne | 2010 |
Insights into therapy: tryptophan oxidation and HIV infection.
Topics: 3-Hydroxyanthranilic Acid; Anti-Inflammatory Agents; Antiviral Agents; Dendritic Cells; Disease Prog | 2010 |
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Topics: 3-Hydroxyanthranilic Acid; Biopsy; CD4 Lymphocyte Count; CD4-CD8 Ratio; Cells, Cultured; Colon, Sigm | 2010 |
Indoleamine 2,3-dioxygenase (IDO) activity influence tumor growth in the TRAMP prostate cancer model.
Topics: Adenocarcinoma; Animals; Blotting, Western; Disease Progression; Immunohistochemistry; Indoleamine-P | 2010 |
Tryptophan degradation and neopterin levels in treated rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Disease Progression; | 2012 |
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
Topics: Animals; Autocrine Communication; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Disease Progress | 2011 |
Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis.
Topics: Animals; Axons; Cell Division; Cytokines; Disease Models, Animal; Disease Progression; Encephalomyel | 2002 |
Protein-bound kynurenine decreases with the progression of age-related nuclear cataract.
Topics: Aged; Aged, 80 and over; Aging; Cataract; Chromatography, High Pressure Liquid; Crystallins; Disease | 2004 |
Diminished quality of life in patients with cancer correlates with tryptophan degradation.
Topics: Aged; Disease Progression; Fatigue; Female; Humans; Immunity, Cellular; Karnofsky Performance Status | 2007 |
Quality of life and immune activation in patients with HIV-infection.
Topics: Acquired Immunodeficiency Syndrome; Adult; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Depress | 2008 |