Page last updated: 2024-10-18

kynurenine and Diathesis

kynurenine has been researched along with Diathesis in 14 studies

Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.

Research Excerpts

ExcerptRelevanceReference
"It has been shown that a possible pathogenetic mechanism of neurodegeneration in the mouse model of glaucoma (DBA/2J) may be an alteration of kynurenic acid (KYNA) in the retina."8.02Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma. ( Avitabile, T; Choragiewicz, T; Fiedorowicz, M; Grieb, P; Kamińska, A; Kocki, T; Nowakowska, D; Rejdak, R; Toro, MD; Turski, WA; Wertejuk, K; Wełniak-Kaminska, M; Zweifel, S, 2021)
"Obesity is a metabolic disease characterized by a state of chronic, low-grade inflammation and dominated by pro-inflammatory cytokines such as IL-6."5.62Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity. ( Albini, E; Belladonna, ML; Grohmann, U; Mondanelli, G; Orabona, C; Orecchini, E; Pallotta, MT; Ricci, G, 2021)
" We review the literature concerning SARS-CoV2 infiltration and infection in the CNS and the prospects of synergy between stress, inflammation, and kynurenine pathway function during illness and recovery from Covid-19."5.12Covid-19 interface with drug misuse and substance use disorders. ( Cisneros, IE; Cunningham, KA, 2021)
"It has been shown that a possible pathogenetic mechanism of neurodegeneration in the mouse model of glaucoma (DBA/2J) may be an alteration of kynurenic acid (KYNA) in the retina."4.02Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma. ( Avitabile, T; Choragiewicz, T; Fiedorowicz, M; Grieb, P; Kamińska, A; Kocki, T; Nowakowska, D; Rejdak, R; Toro, MD; Turski, WA; Wertejuk, K; Wełniak-Kaminska, M; Zweifel, S, 2021)
"Primary brain tumors, both malignant and benign, are diagnosed in adults at an incidence rate of approximately 23 people per 100 thousand."2.66The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors. ( Grishanova, AY; Perepechaeva, ML, 2020)
"Obesity is a metabolic disease characterized by a state of chronic, low-grade inflammation and dominated by pro-inflammatory cytokines such as IL-6."1.62Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity. ( Albini, E; Belladonna, ML; Grohmann, U; Mondanelli, G; Orabona, C; Orecchini, E; Pallotta, MT; Ricci, G, 2021)
"Paracoccidioides brasiliensis infection was more severe in 1MT treated than untreated macrophages of resistant and susceptible mice, concurrently with decreased production of kynurenines and IDO mRNA."1.40Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts. ( Araújo, EF; Bazan, SB; Calich, VL; Costa, TA; Feriotti, C; Loures, FV; Pina, A; Schanoski, AS, 2014)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's7 (50.00)24.3611
2020's6 (42.86)2.80

Authors

AuthorsStudies
Skorobogatov, K1
De Picker, L1
Verkerk, R1
Coppens, V1
Leboyer, M1
Müller, N1
Morrens, M1
Zádor, F2
Nagy-Grócz, G2
Kekesi, G1
Dvorácskó, S2
Szűcs, E2
Tömböly, C2
Horvath, G1
Benyhe, S2
Vécsei, L4
Boros, FA1
Perepechaeva, ML1
Grishanova, AY1
Fiedorowicz, M1
Choragiewicz, T1
Turski, WA1
Kocki, T1
Nowakowska, D1
Wertejuk, K1
Kamińska, A1
Avitabile, T1
Wełniak-Kaminska, M1
Grieb, P1
Zweifel, S1
Rejdak, R1
Toro, MD1
Joca, S1
Mondanelli, G1
Albini, E1
Orecchini, E1
Pallotta, MT1
Belladonna, ML1
Ricci, G1
Grohmann, U1
Orabona, C1
Cisneros, IE1
Cunningham, KA1
Sas, K1
Szabó, E1
Araújo, EF1
Loures, FV2
Bazan, SB2
Feriotti, C2
Pina, A2
Schanoski, AS1
Costa, TA1
Calich, VL2
Zelante, T2
Pieraccini, G1
Scaringi, L1
Aversa, F2
Romani, L2
de Luca, A1
Bozza, S1
Zagarella, S1
D'Angelo, C1
Perruccio, K1
Vacca, C1
Carvalho, A1
Cunha, C1
Felonato, M1
de Araujo, EF1
Silva, NM1
Rodrigues, CV1
Santoro, MM1
Reis, LF1
Alvarez-Leite, JI1
Gazzinelli, RT1

Reviews

8 reviews available for kynurenine and Diathesis

ArticleYear
Brain
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Biomarkers; Blood-Brain Barrier; Brain; Disease Models, Animal; Disease Susceptibility; Hum

2021
Kynurenines and the Endocannabinoid System in Schizophrenia: Common Points and Potential Interactions.
    Molecules (Basel, Switzerland), 2019, Oct-15, Volume: 24, Issue:20

    Topics: Animals; Biomarkers; Disease Susceptibility; Endocannabinoids; Humans; Kynurenine; Metabolic Network

2019
Immunomodulatory Effects of Genetic Alterations Affecting the Kynurenine Pathway.
    Frontiers in immunology, 2019, Volume: 10

    Topics: Animals; Biomarkers; Disease Susceptibility; Gene Expression Regulation, Enzymologic; Genetic Variat

2019
The Role of Aryl Hydrocarbon Receptor (AhR) in Brain Tumors.
    International journal of molecular sciences, 2020, Apr-20, Volume: 21, Issue:8

    Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Brain Neoplasms; Disease Management; Disease

2020
Pro-Inflammatory Cytokines: Potential Links between the Endocannabinoid System and the Kynurenine Pathway in Depression.
    International journal of molecular sciences, 2021, May-31, Volume: 22, Issue:11

    Topics: Animals; Biomarkers; Cytokines; Depression; Disease Susceptibility; Endocannabinoids; Humans; Inflam

2021
Covid-19 interface with drug misuse and substance use disorders.
    Neuropharmacology, 2021, 10-15, Volume: 198

    Topics: Adaptation, Psychological; Angiotensin-Converting Enzyme 2; Animals; Axons; Comorbidity; COVID-19; D

2021
Mitochondria, Oxidative Stress and the Kynurenine System, with a Focus on Ageing and Neuroprotection.
    Molecules (Basel, Switzerland), 2018, Jan-17, Volume: 23, Issue:1

    Topics: Aging; Animals; Brain; Cellular Senescence; Disease Susceptibility; DNA Damage; DNA Repair; DNA, Mit

2018
Learning from other diseases: protection and pathology in chronic fungal infections.
    Seminars in immunopathology, 2016, Volume: 38, Issue:2

    Topics: Animals; Disease Resistance; Disease Susceptibility; Fungi; Host-Pathogen Interactions; Humans; Immu

2016

Other Studies

6 other studies available for kynurenine and Diathesis

ArticleYear
Tryptophan Pathway Abnormalities in a Murine Model of Hereditary Glaucoma.
    International journal of molecular sciences, 2021, Jan-21, Volume: 22, Issue:3

    Topics: Animals; Biomarkers; Disease Models, Animal; Disease Susceptibility; Genetic Diseases, Inborn; Glauc

2021
Pathogenetic Interplay Between IL-6 and Tryptophan Metabolism in an Experimental Model of Obesity.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Adipose Tissue; Animals; Biomarkers; Cytokines; Diet, High-Fat; Disease Models, Animal; Disease Susc

2021
Indoleamine 2,3-dioxygenase controls fungal loads and immunity in Paracoccidioidomicosis but is more important to susceptible than resistant hosts.
    PLoS neglected tropical diseases, 2014, Volume: 8, Issue:11

    Topics: Animals; Cytokines; Dendritic Cells; Disease Susceptibility; Host-Pathogen Interactions; Indoleamine

2014
Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO.
    Cellular & molecular immunology, 2010, Volume: 7, Issue:6

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Aspergillus fumigatus; Disease Susceptibility; Down-

2010
Anti-CD25 treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Animals; Antibodies; Cell Movement; Disease Resistance; Disease Susceptibility; Forkhead Transcripti

2012
Expression of indoleamine 2,3-dioxygenase, tryptophan degradation, and kynurenine formation during in vivo infection with Toxoplasma gondii: induction by endogenous gamma interferon and requirement of interferon regulatory factor 1.
    Infection and immunity, 2002, Volume: 70, Issue:2

    Topics: Acute Disease; Animals; Disease Susceptibility; DNA-Binding Proteins; Gene Expression; Interferon Re

2002