kynurenine has been researched along with Diabetes Mellitus, Type 2 in 21 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In individuals with prediabetes, 3-hydroxykynurenine (OR per SD 0." | 8.02 | Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. ( Bakker, L; Dagnelie, PC; Eussen, SJPM; Köhler, S; Midttun, Ø; Ramakers, IHGB; Schram, MT; Stehouwer, CDA; Ueland, PM; van Boxtel, MPJ; van der Kallen, CJH; van Greevenbroek, MMJ; Verhey, FRJ; Wesselius, A, 2021) |
| " We assessed downstream tryptophan metabolites of the kynurenine pathway as predictors of acute myocardial infarction in patients with suspected stable angina pectoris." | 7.81 | Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. ( Eussen, SJ; Mellgren, G; Meyer, K; Midttun, Ø; Nilsen, DW; Nordrehaug, JE; Nygård, O; Pedersen, ER; Strand, E; Svingen, GF; Tuseth, N; Ueland, PM; Ulvik, A, 2015) |
| "Atherosclerosis is a chronic inflammatory disease of the small and medium arteries wall caused by maladaptive local immune responses, which underpins several cardiovascular diseases (CVD)." | 6.82 | Tryptophan Metabolism in Atherosclerosis and Diabetes. ( Gluvic, Z; Isenovic, ER; Obradovic, M; Sudar-Milovanovic, E; Zaric, B, 2022) |
| " In individuals with prediabetes, 3-hydroxykynurenine (OR per SD 0." | 4.02 | Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study. ( Bakker, L; Dagnelie, PC; Eussen, SJPM; Köhler, S; Midttun, Ø; Ramakers, IHGB; Schram, MT; Stehouwer, CDA; Ueland, PM; van Boxtel, MPJ; van der Kallen, CJH; van Greevenbroek, MMJ; Verhey, FRJ; Wesselius, A, 2021) |
| " We assessed downstream tryptophan metabolites of the kynurenine pathway as predictors of acute myocardial infarction in patients with suspected stable angina pectoris." | 3.81 | Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. ( Eussen, SJ; Mellgren, G; Meyer, K; Midttun, Ø; Nilsen, DW; Nordrehaug, JE; Nygård, O; Pedersen, ER; Strand, E; Svingen, GF; Tuseth, N; Ueland, PM; Ulvik, A, 2015) |
| "Atherosclerosis is a chronic inflammatory disease of the small and medium arteries wall caused by maladaptive local immune responses, which underpins several cardiovascular diseases (CVD)." | 2.82 | Tryptophan Metabolism in Atherosclerosis and Diabetes. ( Gluvic, Z; Isenovic, ER; Obradovic, M; Sudar-Milovanovic, E; Zaric, B, 2022) |
| "We recruited 40 type II diabetes mellitus (T2DM) patients with or without DKD from a single center for a cross-sectional study." | 1.91 | Serum metabolomics detected by LDI-TOF-MS can be used to distinguish between diabetic patients with and without diabetic kidney disease. ( Jin, J; Qian, F; Yu, M; Zhang, D; Zhao, L; Zhou, W, 2023) |
| "Half were diagnosed with type 2 diabetes." | 1.72 | The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites. ( Ashrafian, H; Darzi, A; Holmes, E; Lewis, MR; Penney, N; Purkayastha, S; Whiley, L; Yeung, KTD, 2022) |
| "Death rate is increased in type 2 diabetes." | 1.72 | Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. ( Adamski, J; Copetti, M; De Cosmo, S; Mastroianno, M; Menzaghi, C; Prehn, C; Salvemini, L; Scarale, MG; Trischitta, V, 2022) |
| "Type 2 diabetes is associated with an inflammatory phenotype in the pancreatic islets." | 1.72 | Kynurenine-3-monooxygenase expression is activated in the pancreatic endocrine cells by diabetes and its blockade improves glucose-stimulated insulin secretion. ( Armanet, M; Autier, V; Bailbé, D; Carbonne, C; Dairou, J; Domet, T; Gausseres, B; Guillemin, GJ; Kergoat, M; Lim, CK; Liu, J; Movassat, J; Pitasi, CL; Portha, B; Raynal, S; Zhen, D, 2022) |
| "Kynurenine levels were significantly lower in the group under RASis compared to the untreated group (1." | 1.56 | RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus. ( Benvenga, S; Bolignano, D; Buemi, M; Cernaro, V; Cigala, RM; Crea, F; De Stefano, C; Ferlazzo, VT; Gembillo, G; Genovese, ARR; Loddo, S; Macaione, V; Santoro, D; Vita, R, 2020) |
| "HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk." | 1.48 | Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction. ( Aukrust, P; Gaardbo, JC; Gelpi, M; Gerstoft, J; Hoel, H; Holm, K; Hov, JR; Hove-Skovsgaard, M; Kummen, M; Nielsen, SD; Nwosu, F; Rudi, K; Seljeflot, I; Trøseid, M; Ueland, PM; Ullum, H; Valeur, J, 2018) |
| "About 350 million people worldwide have type 2 diabetes (T2D)." | 1.42 | Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes. ( Oxenkrug, GF, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 14 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yeung, KTD | 1 |
| Penney, N | 1 |
| Whiley, L | 1 |
| Ashrafian, H | 1 |
| Lewis, MR | 1 |
| Purkayastha, S | 1 |
| Darzi, A | 1 |
| Holmes, E | 1 |
| Scarale, MG | 2 |
| Mastroianno, M | 2 |
| Prehn, C | 2 |
| Copetti, M | 2 |
| Salvemini, L | 2 |
| Adamski, J | 2 |
| De Cosmo, S | 1 |
| Trischitta, V | 2 |
| Menzaghi, C | 2 |
| Liu, J | 1 |
| Bailbé, D | 1 |
| Raynal, S | 1 |
| Carbonne, C | 1 |
| Zhen, D | 1 |
| Dairou, J | 2 |
| Gausseres, B | 1 |
| Armanet, M | 1 |
| Domet, T | 1 |
| Pitasi, CL | 1 |
| Movassat, J | 1 |
| Lim, CK | 1 |
| Guillemin, GJ | 1 |
| Autier, V | 1 |
| Kergoat, M | 1 |
| Portha, B | 1 |
| Matsuda, T | 1 |
| Suzuki, H | 1 |
| Sugano, Y | 1 |
| Suzuki, Y | 1 |
| Yamanaka, D | 1 |
| Araki, R | 1 |
| Yahagi, N | 1 |
| Sekiya, M | 1 |
| Kawakami, Y | 1 |
| Osaki, Y | 1 |
| Iwasaki, H | 1 |
| Hashimoto, K | 1 |
| Takahashi, SI | 1 |
| Hada, Y | 1 |
| Shimano, H | 1 |
| Lashgari, NA | 1 |
| Roudsari, NM | 1 |
| Shayan, M | 1 |
| Niazi Shahraki, F | 1 |
| Hosseini, Y | 1 |
| Momtaz, S | 1 |
| Abdolghaffari, AH | 1 |
| Qian, F | 1 |
| Zhao, L | 1 |
| Zhang, D | 1 |
| Yu, M | 1 |
| Zhou, W | 1 |
| Jin, J | 1 |
| Fontana, A | 1 |
| Schena, FP | 1 |
| Cosmo, S | 1 |
| Hu, Y | 1 |
| Li, J | 2 |
| Wang, B | 1 |
| Zhu, L | 2 |
| Li, Y | 1 |
| Ivey, KL | 1 |
| Lee, KH | 1 |
| Eliassen, AH | 1 |
| Chan, A | 1 |
| Huttenhower, C | 1 |
| Hu, FB | 2 |
| Qi, Q | 2 |
| Rimm, EB | 1 |
| Sun, Q | 1 |
| Liu, JJ | 1 |
| Ching, J | 1 |
| Wee, HN | 1 |
| Liu, S | 1 |
| Gurung, RL | 1 |
| Lee, J | 1 |
| M, Y | 1 |
| Zheng, H | 1 |
| Lee, LS | 1 |
| Ang, K | 1 |
| Shao, YM | 1 |
| Kovalik, JP | 1 |
| Subramaniam, T | 1 |
| Sum, CF | 1 |
| Sharma, K | 1 |
| Kestenbaum, BR | 1 |
| Lim, SC | 1 |
| Cernaro, V | 1 |
| Loddo, S | 1 |
| Macaione, V | 1 |
| Ferlazzo, VT | 1 |
| Cigala, RM | 1 |
| Crea, F | 1 |
| De Stefano, C | 1 |
| Genovese, ARR | 1 |
| Gembillo, G | 1 |
| Bolignano, D | 1 |
| Santoro, D | 1 |
| Vita, R | 1 |
| Buemi, M | 1 |
| Benvenga, S | 1 |
| Gürcü, S | 1 |
| Girgin, G | 1 |
| Yorulmaz, G | 1 |
| Kılıçarslan, B | 1 |
| Efe, B | 1 |
| Baydar, T | 1 |
| Yu, B | 1 |
| Moon, JY | 1 |
| Chai, JC | 1 |
| Merino, J | 1 |
| Hu, J | 1 |
| Ruiz-Canela, M | 1 |
| Rebholz, C | 1 |
| Wang, Z | 1 |
| Usyk, M | 1 |
| Chen, GC | 1 |
| Porneala, BC | 1 |
| Wang, W | 1 |
| Nguyen, NQ | 1 |
| Feofanova, EV | 1 |
| Grove, ML | 1 |
| Wang, TJ | 1 |
| Gerszten, RE | 1 |
| Dupuis, J | 1 |
| Salas-Salvadó, J | 1 |
| Bao, W | 1 |
| Perkins, DL | 1 |
| Daviglus, ML | 1 |
| Thyagarajan, B | 1 |
| Cai, J | 1 |
| Wang, T | 1 |
| Manson, JE | 1 |
| Martínez-González, MA | 1 |
| Selvin, E | 1 |
| Rexrode, KM | 1 |
| Clish, CB | 1 |
| Meigs, JB | 1 |
| Knight, R | 1 |
| Burk, RD | 1 |
| Boerwinkle, E | 1 |
| Kaplan, RC | 1 |
| Sudar-Milovanovic, E | 1 |
| Gluvic, Z | 1 |
| Obradovic, M | 1 |
| Zaric, B | 1 |
| Isenovic, ER | 1 |
| Bakker, L | 1 |
| Ramakers, IHGB | 1 |
| van Boxtel, MPJ | 1 |
| Schram, MT | 1 |
| Stehouwer, CDA | 1 |
| van der Kallen, CJH | 1 |
| Dagnelie, PC | 1 |
| van Greevenbroek, MMJ | 1 |
| Wesselius, A | 1 |
| Midttun, Ø | 3 |
| Ueland, PM | 4 |
| Verhey, FRJ | 1 |
| Eussen, SJPM | 1 |
| Köhler, S | 1 |
| Rebnord, EW | 1 |
| Strand, E | 2 |
| Svingen, GFT | 1 |
| Christensen, MHE | 1 |
| Mellgren, G | 2 |
| Njølstad, PR | 1 |
| Tell, GS | 1 |
| Nygård, OK | 1 |
| Pedersen, ER | 2 |
| Hoel, H | 1 |
| Hove-Skovsgaard, M | 1 |
| Hov, JR | 1 |
| Gaardbo, JC | 1 |
| Holm, K | 1 |
| Kummen, M | 1 |
| Rudi, K | 1 |
| Nwosu, F | 1 |
| Valeur, J | 1 |
| Gelpi, M | 1 |
| Seljeflot, I | 1 |
| Gerstoft, J | 1 |
| Ullum, H | 1 |
| Aukrust, P | 1 |
| Nielsen, SD | 1 |
| Trøseid, M | 1 |
| Laurans, L | 1 |
| Venteclef, N | 1 |
| Haddad, Y | 1 |
| Chajadine, M | 1 |
| Alzaid, F | 1 |
| Metghalchi, S | 1 |
| Sovran, B | 1 |
| Denis, RGP | 1 |
| Cardellini, M | 1 |
| Moreno-Navarrete, JM | 1 |
| Straub, M | 1 |
| Jegou, S | 1 |
| McQuitty, C | 1 |
| Viel, T | 1 |
| Esposito, B | 1 |
| Tavitian, B | 1 |
| Callebert, J | 1 |
| Luquet, SH | 1 |
| Federici, M | 1 |
| Fernandez-Real, JM | 1 |
| Burcelin, R | 1 |
| Launay, JM | 1 |
| Tedgui, A | 1 |
| Mallat, Z | 1 |
| Sokol, H | 1 |
| Taleb, S | 1 |
| Fu, H | 1 |
| Liu, X | 1 |
| Yu, W | 1 |
| Zheng, D | 1 |
| Wang, J | 1 |
| Tuseth, N | 1 |
| Eussen, SJ | 1 |
| Svingen, GF | 1 |
| Meyer, K | 1 |
| Ulvik, A | 1 |
| Nordrehaug, JE | 1 |
| Nilsen, DW | 1 |
| Nygård, O | 1 |
| Oxenkrug, GF | 1 |
| Mudry, JM | 1 |
| Alm, PS | 1 |
| Erhardt, S | 1 |
| Goiny, M | 1 |
| Fritz, T | 1 |
| Caidahl, K | 1 |
| Zierath, JR | 1 |
| Krook, A | 1 |
| Wallberg-Henriksson, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Very Low Calorie Ketogenic Diet on Microbiota, Adipose Tissue and Immunitary Regulation: Pilot Study on Patients With Metabolic Syndrome[NCT05275608] | 40 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
IDO/Kynurenine; novel insight for treatment of inflammatory diseases.
Topics: Animals; Cytokines; Diabetes Mellitus, Type 2; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; K | 2023 |
Tryptophan Metabolism in Atherosclerosis and Diabetes.
Topics: Animals; Atherosclerosis; Diabetes Mellitus, Type 2; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; K | 2022 |
1 trial available for kynurenine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effects of Branched-Chain Amino Acids on Skeletal Muscle, Glycemic Control, and Neuropsychological Performance in Elderly Persons with Type 2 Diabetes Mellitus: An Exploratory Randomized Controlled Trial.
Topics: Aged; Amino Acids, Branched-Chain; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Glycemic Control; | 2022 |
18 other studies available for kynurenine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites.
Topics: Adult; Biomarkers; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gastrectomy; Gastric Bypass; | 2022 |
Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Humans; Inflammation; Kynurenine; Tryptophan | 2022 |
Kynurenine-3-monooxygenase expression is activated in the pancreatic endocrine cells by diabetes and its blockade improves glucose-stimulated insulin secretion.
Topics: Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Type 2; Glucose; Humans; Insulin; Insulin Secr | 2022 |
Serum metabolomics detected by LDI-TOF-MS can be used to distinguish between diabetic patients with and without diabetic kidney disease.
Topics: Creatinine; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Kynu | 2023 |
Circulating metabolites improve the prediction of renal impairment in patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Follow-Up Studies; Glomerular Filtration Rate; Humans; Kynurenine | 2023 |
Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations.
Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Diet; Follow-Up Studies; Humans; Kynurenine; Mal | 2023 |
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kyn | 2023 |
RAS inhibition modulates kynurenine levels in a CKD population with and without type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Angiotensins; Correlation of Data; Cross-Sectional Studies; Diabetes Mellit | 2020 |
Neopterin and biopterin levels and tryptophan degradation in patients with diabetes.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Biopterins; Diabetes Mellitus, Type 1; Diabetes Mellitus | 2020 |
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.
Topics: Bacteria; Cohort Studies; Diabetes Mellitus, Type 2; Diet; Gastrointestinal Microbiome; Humans; Kynu | 2022 |
Associations between plasma kynurenines and cognitive function in individuals with normal glucose metabolism, prediabetes and type 2 diabetes: the Maastricht Study.
Topics: 3-Hydroxyanthranilic Acid; Aged; Biomarkers; Blood Glucose; Cognition; Cognitive Dysfunction; Cross- | 2021 |
The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease.
Topics: Aged; Coronary Artery Disease; Diabetes Mellitus, Type 2; Female; Humans; Kynurenine; Male; Middle A | 2017 |
Impact of HIV and Type 2 diabetes on Gut Microbiota Diversity, Tryptophan Catabolism and Endothelial Dysfunction.
Topics: Arginine; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Endothelium; Feces; Female; Gastrointe | 2018 |
Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health.
Topics: Animals; Diabetes Mellitus, Type 2; Fatty Liver; Gastrointestinal Microbiome; Health; Humans; Indole | 2018 |
[Screening of urinary biomarkers in patients with type 2 diabetes mellitus].
Topics: Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged | 2013 |
Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris.
Topics: Aged; Angina, Stable; Biomarkers; Coronary Angiography; Coronary Artery Disease; Diabetes Mellitus, | 2015 |
Increased Plasma Levels of Xanthurenic and Kynurenic Acids in Type 2 Diabetes.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agen | 2015 |
Direct effects of exercise on kynurenine metabolism in people with normal glucose tolerance or type 2 diabetes.
Topics: Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Exercise; Female; Follow | 2016 |