kynurenine has been researched along with Delirium in 5 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Delirium: A disorder characterized by CONFUSION; inattentiveness; disorientation; ILLUSIONS; HALLUCINATIONS; agitation; and in some instances autonomic nervous system overactivity. It may result from toxic/metabolic conditions or structural brain lesions. (From Adams et al., Principles of Neurology, 6th ed, pp411-2)
| Excerpt | Relevance | Reference |
|---|---|---|
| "BACKGROUNDThe kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation." | 8.31 | Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. ( Fang, EF; Figved, W; Frihagen, F; Giil, LM; Godø, A; Halaas, NB; Hassel, B; Henjum, K; Idland, AV; Knapskog, AB; McCann, A; Myrstad, M; Neerland, BE; Pollmann, CT; Quist-Paulsen, E; Raeder, J; Selbæk, G; Ueland, PM; Watne, LO; Zetterberg, H, 2023) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| "BACKGROUNDThe kynurenine pathway (KP) has been identified as a potential mediator linking acute illness to cognitive dysfunction by generating neuroactive metabolites in response to inflammation." | 4.31 | Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients. ( Fang, EF; Figved, W; Frihagen, F; Giil, LM; Godø, A; Halaas, NB; Hassel, B; Henjum, K; Idland, AV; Knapskog, AB; McCann, A; Myrstad, M; Neerland, BE; Pollmann, CT; Quist-Paulsen, E; Raeder, J; Selbæk, G; Ueland, PM; Watne, LO; Zetterberg, H, 2023) |
| "Indoleamine 2,3-dioxygenase (IDO) and the tryptophan-kynurenine pathway (TRP-KP) are upregulated in ageing and could be implicated in the pathogenesis of delirium." | 4.31 | Lipopolysaccharide-Induced Delirium-like Behaviour in a Rat Model of Chronic Cerebral Hypoperfusion Is Associated with Increased Indoleamine 2,3-Dioxygenase Expression and Endotoxin Tolerance. ( Ahmad, NS; Ang, HP; Embong, H; Makpol, S; Nasaruddin, ML; Tan, JK; Wan Zaidi, WA, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 5 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanova, M | 1 |
| Kohout, P | 1 |
| Watne, LO | 3 |
| Pollmann, CT | 3 |
| Neerland, BE | 3 |
| Quist-Paulsen, E | 3 |
| Halaas, NB | 3 |
| Idland, AV | 3 |
| Hassel, B | 3 |
| Henjum, K | 3 |
| Knapskog, AB | 3 |
| Frihagen, F | 3 |
| Raeder, J | 3 |
| Godø, A | 3 |
| Ueland, PM | 3 |
| McCann, A | 3 |
| Figved, W | 3 |
| Selbæk, G | 3 |
| Zetterberg, H | 3 |
| Fang, EF | 3 |
| Myrstad, M | 3 |
| Giil, LM | 3 |
| Heimberger, AB | 1 |
| Lukas, RV | 1 |
| Phing, AH | 1 |
| Makpol, S | 2 |
| Nasaruddin, ML | 2 |
| Wan Zaidi, WA | 2 |
| Ahmad, NS | 2 |
| Embong, H | 2 |
| Ang, HP | 1 |
| Tan, JK | 1 |
2 reviews available for kynurenine and Delirium
| Article | Year |
|---|---|
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.
Topics: Aged; Brain Diseases; Delirium; Humans; Immune System; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
3 other studies available for kynurenine and Delirium
| Article | Year |
|---|---|
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
The kynurenine pathway implicated in patient delirium: possible indications for indoleamine 2,3 dioxygenase inhibitors.
Topics: Delirium; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Tryptophan | 2023 |
Lipopolysaccharide-Induced Delirium-like Behaviour in a Rat Model of Chronic Cerebral Hypoperfusion Is Associated with Increased Indoleamine 2,3-Dioxygenase Expression and Endotoxin Tolerance.
Topics: Animals; Brain Ischemia; Delirium; Endotoxin Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynure | 2023 |