kynurenine has been researched along with Cryptogenic Infantile Spasms in 8 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results highlight the importance of tryptophan-kynurenine metabolism in infantile spasms and provide evidence for new-targeted therapies such as indoleamine 2,3-dioxygenase 1 inhibition or microbiota manipulation to promote kynurenic acid production as a strategy to reduce spasms in infantile spasms." | 8.12 | Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms. ( Barrett, KT; Choudhary, A; Mayengbam, S; Mu, C; Rho, JM; Scantlebury, MH; Shearer, J, 2022) |
| "These results highlight the importance of tryptophan-kynurenine metabolism in infantile spasms and provide evidence for new-targeted therapies such as indoleamine 2,3-dioxygenase 1 inhibition or microbiota manipulation to promote kynurenic acid production as a strategy to reduce spasms in infantile spasms." | 4.12 | Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms. ( Barrett, KT; Choudhary, A; Mayengbam, S; Mu, C; Rho, JM; Scantlebury, MH; Shearer, J, 2022) |
| "The 18 patients had either West syndrome (12 patients) or Lennox-Gastaut syndrome (6 patients), which was intractable to antiepileptic drug therapy and to adrenocorticotrophic hormone." | 1.29 | Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites. ( Kawase, S; Matsuo, S; Mitsufuji, N; Nishimura, A; Sawada, T; Takeuchi, Y; Tominaga, M; Yamazoe, I, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Mu, C | 1 |
| Choudhary, A | 1 |
| Mayengbam, S | 1 |
| Barrett, KT | 1 |
| Rho, JM | 2 |
| Shearer, J | 1 |
| Scantlebury, MH | 1 |
| CAREDDU, P | 1 |
| Takeuchi, Y | 3 |
| Tominaga, M | 1 |
| Mitsufuji, N | 1 |
| Yamazoe, I | 1 |
| Kawase, S | 1 |
| Nishimura, A | 1 |
| Matsuo, S | 1 |
| Sawada, T | 2 |
| Yamamoto, H | 2 |
| Shindo, I | 1 |
| Egawa, B | 2 |
| Horiguchi, K | 2 |
| Matsushita, H | 1 |
| Kawano, H | 1 |
| Sakai, H | 1 |
| Yoshimoto, K | 1 |
| Takano, T | 1 |
| Abe, J | 1 |
| Takikita, S | 1 |
| Ohno, M | 1 |
| Kaku, A | 1 |
| Yamada, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenine and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies | 2004 |
Thyrotropin-releasing hormone: role in the treatment of West syndrome and related epileptic encephalopathies.
Topics: Child; Epilepsy; Humans; Infant; Kynurenine; Spasms, Infantile; Thyrotropin-Releasing Hormone | 2001 |
6 other studies available for kynurenine and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms.
Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Kynurenine; Rats; Seizures; Sp | 2022 |
[CHANGES IN TRYPTOPHAN METABOLISM IN THE WINKING-NODDING SPASM IN INFANTS].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Blinking; Blood Chemical Analysis; Chromatogra | 1963 |
Thyrotropin-releasing hormone in treatment of intractable epilepsy: neurochemical analysis of CSF monoamine metabolites.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Homovanillic Acid; Humans; Hydrox | 1995 |
Kynurenic acid is decreased in cerebrospinal fluid of patients with infantile spasms.
Topics: Asphyxia Neonatorum; Brain; Chromatography, High Pressure Liquid; Electroencephalography; Female; Hu | 1994 |
TRH increases cerebrospinal fluid concentration of kynurenine.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electrodes; Epilepsy; Female; Humans; Infant; | 1999 |
[Changes in CSF tryptophan metabolite levels in infantile spasms].
Topics: Female; Humans; Infant; Kynurenine; Male; Serotonin; Spasms, Infantile; Tryptophan | 1992 |