kynurenine has been researched along with Crohn Disease in 10 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both the Crohn's disease exclusion diet combined with partial enteral nutrition (CDED+PEN) and exclusive enteral nutrition (EEN) can induce remission in mild-to-moderate pediatric Crohn's disease and are associated with a marked decrease in fecal kynurenine levels." | 3.30 | Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways. ( Benninga, MA; Boneh, RS; de Jonge, WJ; Emond, P; Ghiboub, M; Lefèvre, A; Sovran, B; Van Limbergen, JE; Verburgt, CM; Wine, E, 2023) |
| "Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) characterized by variable phenotypes." | 1.40 | Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases. ( Bustamante, S; Campbell, B; Hejazi, L; Leong, RW; Pickford, R; Shin, S; Wasinger, VC; Yau, YY, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghiboub, M | 2 |
| Penny, S | 1 |
| Verburgt, CM | 2 |
| Boneh, RS | 2 |
| Wine, E | 2 |
| Cohen, A | 1 |
| Dunn, KA | 1 |
| Pinto, DM | 1 |
| Benninga, MA | 2 |
| de Jonge, WJ | 2 |
| Levine, A | 1 |
| Van Limbergen, JE | 2 |
| Sovran, B | 1 |
| Lefèvre, A | 1 |
| Emond, P | 1 |
| Manzella, CR | 1 |
| Jayawardena, D | 1 |
| Pagani, W | 1 |
| Li, Y | 1 |
| Alrefai, WA | 1 |
| Bauer, J | 1 |
| Jung, B | 1 |
| Weber, CR | 1 |
| Gill, RK | 1 |
| Agus, A | 1 |
| Planchais, J | 1 |
| Sokol, H | 1 |
| Yau, YY | 1 |
| Leong, RW | 1 |
| Shin, S | 1 |
| Bustamante, S | 1 |
| Pickford, R | 1 |
| Hejazi, L | 1 |
| Campbell, B | 1 |
| Wasinger, VC | 1 |
| Lee, A | 1 |
| Kanuri, N | 2 |
| Zhang, Y | 1 |
| Sayuk, GS | 1 |
| Li, E | 1 |
| Ciorba, MA | 2 |
| Lin, HM | 1 |
| Barnett, MP | 1 |
| Roy, NC | 1 |
| Joyce, NI | 1 |
| Zhu, S | 1 |
| Armstrong, K | 1 |
| Helsby, NA | 1 |
| Ferguson, LR | 1 |
| Rowan, DD | 1 |
| Gupta, NK | 1 |
| Thaker, AI | 1 |
| Riehl, TE | 1 |
| Rowley, CW | 1 |
| Stenson, WF | 1 |
| Forrest, CM | 1 |
| Gould, SR | 1 |
| Darlington, LG | 1 |
| Stone, TW | 1 |
| Torres, MI | 1 |
| López-Casado, MA | 1 |
| Lorite, P | 1 |
| Ríos, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Partial Enteral Nutririon (Modulen) With a Unique Diet to Exclusive Enteral Nutrition (Modulen) for the Treatment of Pediatric Crohn's Disease. A Prospective Randomized Controlled Trial.[NCT01728870] | 74 participants (Actual) | Interventional | 2013-01-31 | Completed | |||
| Involvement of the Gut Microbiota and Its Metabolites in the Pathophysiology of Calcified Aortic Stenosis[NCT06021535] | 100 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355] | 85 participants (Anticipated) | Observational | 2011-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for kynurenine and Crohn Disease
| Article | Year |
|---|---|
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Topics: Autistic Disorder; Colitis; Communicable Diseases; Crohn Disease; Gastrointestinal Microbiome; Gastr | 2018 |
2 trials available for kynurenine and Crohn Disease
| Article | Year |
|---|---|
Metabolome Changes With Diet-Induced Remission in Pediatric Crohn's Disease.
Topics: Arginine; Ceramides; Child; Crohn Disease; Diet; Humans; Kynurenine; Metabolome; Prospective Studies | 2022 |
Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
Topics: Child; Crohn Disease; Diet; Humans; Kynurenine; Melatonin; Prospective Studies; Quinolinic Acid; Rem | 2023 |
7 other studies available for kynurenine and Crohn Disease
| Article | Year |
|---|---|
Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients.
Topics: Adolescent; Adult; Biopsy; C-Reactive Protein; Colitis, Ulcerative; Colon; Crohn Disease; Cytokines; | 2020 |
Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases.
Topics: Adult; Angiotensin II; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Female; G(M3) Gangl | 2014 |
IDO1 and IDO2 non-synonymous gene variants: correlation with crohn's disease risk and clinical phenotype.
Topics: Adult; Case-Control Studies; Crohn Disease; Female; Genetic Predisposition to Disease; Humans; Indol | 2014 |
Metabolomic analysis identifies inflammatory and noninflammatory metabolic effects of genetic modification in a mouse model of Crohn's disease.
Topics: Animals; Chromatography, Liquid; Cluster Analysis; Crohn Disease; Disease Models, Animal; Germ-Free | 2010 |
Serum analysis of tryptophan catabolism pathway: correlation with Crohn's disease activity.
Topics: Adult; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid; Crohn Disease; Female | 2012 |
Levels of purine, kynurenine and lipid peroxidation products in patients with inflammatory bowel disease.
Topics: Adenosine; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Humans; Inflammatory Bowel Dise | 2003 |
Tryptophan metabolism and indoleamine 2,3-dioxygenase expression in coeliac disease.
Topics: Biopsy; Celiac Disease; Child; Child, Preschool; Chromatography, High Pressure Liquid; Crohn Disease | 2007 |