kynurenine has been researched along with Critical Illness in 7 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now." | 8.31 | Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. ( Baillie, JK; Baily, J; Binnie, M; Bochkina, NA; Garden, OJ; Hayes, AJ; Homer, NZM; Howie, SEM; Iredale, JP; Just, G; Liddle, J; McGuire, K; Mole, DJ; Murray, TBJ; Neyton, LPA; O'Kelly, J; Skouras, C; Uings, I; Webster, SP; Zheng, X, 2023) |
| "It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major trauma patients." | 7.76 | Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients. ( Domanska, G; Fusch, G; Gruendling, M; Haas, JP; Holtfreter, B; Reinke, P; Schefold, JC; Schuett, C; Westerholt, A; Zeden, JP, 2010) |
| " In this review, we highlight these pathways as sources of serotonin and melatonin, which then regulate neurotransmission, influence circadian rhythm, cognitive functions, and the development of delirium." | 5.12 | Tryptophan: A Unique Role in the Critically Ill. ( Kanova, M; Kohout, P, 2021) |
| "Kynurenine monooxygenase (KMO) blockade protects against multiple organ failure caused by acute pancreatitis (AP), but the link between KMO and systemic inflammation has eluded discovery until now." | 4.31 | Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. ( Baillie, JK; Baily, J; Binnie, M; Bochkina, NA; Garden, OJ; Hayes, AJ; Homer, NZM; Howie, SEM; Iredale, JP; Just, G; Liddle, J; McGuire, K; Mole, DJ; Murray, TBJ; Neyton, LPA; O'Kelly, J; Skouras, C; Uings, I; Webster, SP; Zheng, X, 2023) |
| "It has recently been shown that an increased plasma level of the tryptophan catabolite kynurenine is an early indicator for the development of sepsis in major trauma patients." | 3.76 | Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients. ( Domanska, G; Fusch, G; Gruendling, M; Haas, JP; Holtfreter, B; Reinke, P; Schefold, JC; Schuett, C; Westerholt, A; Zeden, JP, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 3 (42.86) | 2.80 |
| Authors | Studies |
|---|---|
| Kanova, M | 1 |
| Kohout, P | 1 |
| Sigurdsson, MI | 1 |
| Kobayashi, H | 1 |
| Amrein, K | 1 |
| Nakahira, K | 1 |
| Rogers, AJ | 1 |
| Pinilla-Vera, M | 1 |
| Baron, RM | 1 |
| Fredenburgh, LE | 1 |
| Lasky-Su, JA | 1 |
| Christopher, KB | 1 |
| Hayes, AJ | 1 |
| Zheng, X | 1 |
| O'Kelly, J | 1 |
| Neyton, LPA | 1 |
| Bochkina, NA | 1 |
| Uings, I | 1 |
| Liddle, J | 1 |
| Baillie, JK | 1 |
| Just, G | 1 |
| Binnie, M | 1 |
| Homer, NZM | 1 |
| Murray, TBJ | 1 |
| Baily, J | 1 |
| McGuire, K | 1 |
| Skouras, C | 1 |
| Garden, OJ | 1 |
| Webster, SP | 1 |
| Iredale, JP | 1 |
| Howie, SEM | 1 |
| Mole, DJ | 1 |
| Voils, SA | 1 |
| Shahin, MH | 1 |
| Garrett, TJ | 1 |
| Frye, RF | 1 |
| Schefold, JC | 2 |
| Fritschi, N | 1 |
| Fusch, G | 2 |
| Bahonjic, A | 1 |
| Doehner, W | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Storm, C | 1 |
| Schroeder, T | 1 |
| Zeden, JP | 1 |
| Holtfreter, B | 1 |
| Reinke, P | 1 |
| Domanska, G | 1 |
| Haas, JP | 1 |
| Gruendling, M | 1 |
| Westerholt, A | 1 |
| Schuett, C | 1 |
| Adams Wilson, JR | 1 |
| Morandi, A | 1 |
| Girard, TD | 1 |
| Thompson, JL | 1 |
| Boomershine, CS | 1 |
| Shintani, AK | 1 |
| Ely, EW | 1 |
| Pandharipande, PP | 1 |
1 review available for kynurenine and Critical Illness
| Article | Year |
|---|---|
Tryptophan: A Unique Role in the Critically Ill.
Topics: Critical Illness; Delirium; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; | 2021 |
6 other studies available for kynurenine and Critical Illness
| Article | Year |
|---|---|
Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study.
Topics: Adult; Amino Acids, Branched-Chain; Clinical Trials as Topic; Critical Illness; Fatty Acids; Female; | 2022 |
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis.
Topics: Acute Disease; Animals; Critical Illness; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice | 2023 |
Metabolomic association between venous thromboembolism in critically ill trauma patients and kynurenine pathway of tryptophan metabolism.
Topics: Adult; Case-Control Studies; Critical Illness; Female; Humans; Kynurenine; Male; Metabolomics; Trypt | 2018 |
Influence of core body temperature on Tryptophan metabolism, kynurenines, and estimated IDO activity in critically ill patients receiving target temperature management following cardiac arrest.
Topics: Aged; Body Temperature; Coma; Critical Illness; Female; Germany; Heart Arrest; Humans; Hypothermia, | 2016 |
Excessive tryptophan catabolism along the kynurenine pathway precedes ongoing sepsis in critically ill patients.
Topics: Adult; Critical Illness; Female; Humans; Kynurenine; Male; Middle Aged; NAD; Renal Insufficiency; Se | 2010 |
The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*.
Topics: Acute Disease; Aged; Brain Diseases; Critical Illness; Female; Humans; Kynurenine; Male; Metabolic N | 2012 |