kynurenine has been researched along with Communicable Diseases in 5 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Communicable Diseases: An illness caused by an infectious agent or its toxins that occurs through the direct or indirect transmission of the infectious agent or its products from an infected individual or via an animal, vector or the inanimate environment to a susceptible animal or human host.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We hypothesize that: (1) L-tryptophan (Trp) is greatly utilized and not depleted in pregnancy; (2) fetal tolerance is achieved in part through immunosuppressive kynurenine (Kyn) metabolites produced by the flux of plasma free (non-albumin-bound) Trp down the Kyn pathway; (3) the role of indoleamine 2,3-dioxygenase (IDO) in infection is not related to limitation of an essential amino acid, but is rather associated with stress responses and the production of Kyn metabolites that regulate the activities of antigen presenting cells and T-cells, as well as increased NAD(+) synthesis in IDO-expressing cells; (4) Trp depletion is not a host defence mechanism, but is a consequence of Trp utilization." | 8.93 | The end of the road for the tryptophan depletion concept in pregnancy and infection. ( Badawy, AA; Moffett, JR; Namboodiri, AM, 2016) |
| "We hypothesize that: (1) L-tryptophan (Trp) is greatly utilized and not depleted in pregnancy; (2) fetal tolerance is achieved in part through immunosuppressive kynurenine (Kyn) metabolites produced by the flux of plasma free (non-albumin-bound) Trp down the Kyn pathway; (3) the role of indoleamine 2,3-dioxygenase (IDO) in infection is not related to limitation of an essential amino acid, but is rather associated with stress responses and the production of Kyn metabolites that regulate the activities of antigen presenting cells and T-cells, as well as increased NAD(+) synthesis in IDO-expressing cells; (4) Trp depletion is not a host defence mechanism, but is a consequence of Trp utilization." | 4.93 | The end of the road for the tryptophan depletion concept in pregnancy and infection. ( Badawy, AA; Moffett, JR; Namboodiri, AM, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agus, A | 1 |
| Planchais, J | 1 |
| Sokol, H | 1 |
| Dharnidharka, VR | 1 |
| Al Khasawneh, E | 1 |
| Gupta, S | 1 |
| Shuster, JJ | 1 |
| Theriaque, DW | 1 |
| Shahlaee, AH | 1 |
| Garrett, TJ | 1 |
| Badawy, AA | 1 |
| Namboodiri, AM | 1 |
| Moffett, JR | 1 |
| Combes, V | 1 |
| Guillemin, GJ | 1 |
| Chan-Ling, T | 1 |
| Hunt, NH | 1 |
| Grau, GE | 1 |
| PIAZZA, M | 1 |
| TANCREDI, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Involvement of the Gut Microbiota and Its Metabolites in the Pathophysiology of Calcified Aortic Stenosis[NCT06021535] | 100 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for kynurenine and Communicable Diseases
| Article | Year |
|---|---|
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Topics: Autistic Disorder; Colitis; Communicable Diseases; Crohn Disease; Gastrointestinal Microbiome; Gastr | 2018 |
The end of the road for the tryptophan depletion concept in pregnancy and infection.
Topics: Antigen-Presenting Cells; Communicable Diseases; Female; Fetus; Humans; Immune Tolerance; Indoleamin | 2016 |
The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.
Topics: Astrocytes; Communicable Diseases; Endothelial Cells; Humans; Inflammation; Kynurenine; Neurons; Qui | 2012 |
2 other studies available for kynurenine and Communicable Diseases
| Article | Year |
|---|---|
Verification of association of elevated serum IDO enzyme activity with acute rejection and low CD4-ATP levels with infection.
Topics: Acute Disease; Adenosine Triphosphate; Adolescent; Analysis of Variance; Biomarkers; CD4-Positive T- | 2013 |
Tryptophan-nicotinic acid metabolism in subjects recently or long since recovered from viral hepatitis.
Topics: Communicable Diseases; Hepatitis; Hepatitis A; Kynurenine; Niacin; Nicotinic Acids; Tryptophan | 1963 |