kynurenine has been researched along with Colitis in 11 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, colitis was induced with intra-rectal injection of three concentrations of acetic acid (4, 6 and 8 v/v)." | 8.12 | Sodium Selenite Modulates IDO1/Kynurenine, TLR4, NF-κB and Bcl2/Bax Pathway and Mitigates Acetic Acid-Induced Colitis in Rat. ( Ala, M; Dehpour, AR; Jafari, RM; Nematian, H; Shadboorestan, A, 2022) |
| "To investigate role of kynurenine 3-monooxygenase (KMO) in TNBS-induced colitis and involvement of Trp metabolites in maintenance of intestinal homeostasis." | 7.96 | Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. ( Ando, T; Hara, A; Hattori, T; Hirata, A; Hoshi, M; Nakamoto, K; Saito, K; Tashita, C; Tezuka, H; Tomita, H; Yamamoto, Y, 2020) |
| "Serotonin system also increases colorectal cancer cells proliferation and metastasis while, indole metabolites can profoundly decrease colorectal cancer growth." | 6.82 | Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. ( Ala, M, 2022) |
| "Depression can be associated with chronic systemic inflammation, and production of peripheral proinflammatory cytokines and upregulation of the kynurenine pathway have been implicated in pathogenesis of depression." | 4.31 | Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. ( Bibb, JA; Chakraborti, A; Funakoshi, H; Kanai, M; Kawahara, Y; Kuroiwa, M; Murakami, Y; Nishi, A; Ohnishi, YN; Shuto, T; Sin, R; Sotogaku, N; Sugiyama, K, 2023) |
| " The analysis revealed that genes involved in tryptophan (Trp) metabolism are upregulated in Crohn's disease (CD) and ulcerative colitis (UC) and return to baseline after successful treatment with infliximab." | 4.02 | Alterations in Kynurenine and NAD ( Kurzepa, J; Parada-Turska, J; Wnorowska, S; Wnorowski, A, 2021) |
| "To investigate role of kynurenine 3-monooxygenase (KMO) in TNBS-induced colitis and involvement of Trp metabolites in maintenance of intestinal homeostasis." | 3.96 | Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice. ( Ando, T; Hara, A; Hattori, T; Hirata, A; Hoshi, M; Nakamoto, K; Saito, K; Tashita, C; Tezuka, H; Tomita, H; Yamamoto, Y, 2020) |
| " Guided by an unbiased metabolomics screen, we identified tryptophan (Trp) metabolism as a major modifying pathway in interferon-γ (IFNγ)-dominant murine colitis." | 3.85 | Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia. ( Alexeev, EE; Battista, KD; Colgan, SP; Curtis, VF; Gerich, ME; Glover, LE; Kao, DJ; Kitzenberg, DA; Kominsky, DJ; Lanis, JM, 2017) |
| "C57Bl6 wild-type (control), IDO1-/-, Rag1-/-, and Rag1/IDO1 double-knockout mice were exposed to azoxymethane and dextran sodium sulfate to induce colitis and tumorigenesis." | 3.79 | IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice. ( Bishnupuri, KS; Ciorba, MA; Foster, L; Kerr, TA; Marinshaw, JM; Newberry, RD; Rao, MS; Stenson, WF; Thaker, AI, 2013) |
| "Serotonin system also increases colorectal cancer cells proliferation and metastasis while, indole metabolites can profoundly decrease colorectal cancer growth." | 2.82 | Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system. ( Ala, M, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 7 (63.64) | 2.80 |
| Authors | Studies |
|---|---|
| Wnorowski, A | 1 |
| Wnorowska, S | 1 |
| Kurzepa, J | 1 |
| Parada-Turska, J | 1 |
| Ala, M | 2 |
| Jafari, RM | 1 |
| Nematian, H | 1 |
| Shadboorestan, A | 1 |
| Dehpour, AR | 1 |
| Zhao, LP | 2 |
| Wu, J | 2 |
| Quan, W | 2 |
| Zhou, Y | 2 |
| Hong, H | 2 |
| Niu, GY | 2 |
| Huang, SB | 2 |
| Qiao, CM | 2 |
| Zhao, WJ | 2 |
| Cui, C | 2 |
| Shen, YQ | 2 |
| Li, T | 1 |
| Sin, R | 1 |
| Sotogaku, N | 1 |
| Ohnishi, YN | 1 |
| Shuto, T | 1 |
| Kuroiwa, M | 1 |
| Kawahara, Y | 1 |
| Sugiyama, K | 1 |
| Murakami, Y | 1 |
| Kanai, M | 1 |
| Funakoshi, H | 1 |
| Chakraborti, A | 1 |
| Bibb, JA | 1 |
| Nishi, A | 1 |
| Tashita, C | 1 |
| Hoshi, M | 1 |
| Hirata, A | 1 |
| Nakamoto, K | 1 |
| Ando, T | 1 |
| Hattori, T | 1 |
| Yamamoto, Y | 1 |
| Tezuka, H | 1 |
| Tomita, H | 1 |
| Hara, A | 1 |
| Saito, K | 1 |
| Agus, A | 1 |
| Planchais, J | 1 |
| Sokol, H | 1 |
| Thaker, AI | 1 |
| Rao, MS | 1 |
| Bishnupuri, KS | 1 |
| Kerr, TA | 1 |
| Foster, L | 1 |
| Marinshaw, JM | 1 |
| Newberry, RD | 1 |
| Stenson, WF | 1 |
| Ciorba, MA | 1 |
| Lanis, JM | 1 |
| Alexeev, EE | 1 |
| Curtis, VF | 1 |
| Kitzenberg, DA | 1 |
| Kao, DJ | 1 |
| Battista, KD | 1 |
| Gerich, ME | 1 |
| Glover, LE | 1 |
| Kominsky, DJ | 1 |
| Colgan, SP | 1 |
| Bercik, P | 1 |
| Verdu, EF | 1 |
| Foster, JA | 1 |
| Macri, J | 1 |
| Potter, M | 1 |
| Huang, X | 1 |
| Malinowski, P | 1 |
| Jackson, W | 1 |
| Blennerhassett, P | 1 |
| Neufeld, KA | 1 |
| Lu, J | 1 |
| Khan, WI | 1 |
| Corthesy-Theulaz, I | 1 |
| Cherbut, C | 1 |
| Bergonzelli, GE | 1 |
| Collins, SM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Involvement of the Gut Microbiota and Its Metabolites in the Pathophysiology of Calcified Aortic Stenosis[NCT06021535] | 100 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972] | Phase 2 | 16 participants (Actual) | Interventional | 2013-05-31 | Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenine and Colitis
| Article | Year |
|---|---|
Tryptophan metabolites modulate inflammatory bowel disease and colorectal cancer by affecting immune system.
Topics: Colitis; Colorectal Neoplasms; Humans; Indoles; Inflammatory Bowel Diseases; Kynurenine; Serotonin; | 2022 |
Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease.
Topics: Autistic Disorder; Colitis; Communicable Diseases; Crohn Disease; Gastrointestinal Microbiome; Gastr | 2018 |
9 other studies available for kynurenine and Colitis
| Article | Year |
|---|---|
Alterations in Kynurenine and NAD
Topics: Colitis; Humans; Inflammatory Bowel Diseases; Infliximab; Kynurenine; Metabolic Networks and Pathway | 2021 |
Sodium Selenite Modulates IDO1/Kynurenine, TLR4, NF-κB and Bcl2/Bax
Pathway and Mitigates Acetic Acid-Induced Colitis in Rat.
Topics: Acetic Acid; Animals; Colitis; Colon; Kynurenine; NF-kappa B; Rats; Signal Transduction; Sodium Sele | 2022 |
DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.
Topics: Brain; Colitis; Gastrointestinal Microbiome; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenin | 2023 |
DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.
Topics: Animals; Brain; Colitis; Gastrointestinal Microbiome; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflamma | 2022 |
Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Ky | 2023 |
Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Homeostasis; Immunosupp | 2020 |
IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Proliferation; Colitis; Colitis, Ulcerative; | 2013 |
Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Humans; Indol | 2017 |
Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.
Topics: Animals; Anxiety; Behavior, Animal; Brain-Derived Neurotrophic Factor; Chronic Disease; Colitis; Cyt | 2010 |