kynurenine has been researched along with Colitis, Mucous in 10 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of this study was to evaluate the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan (TRP) intake in irritable bowel syndrome with diarrhea predominance (IBS-D) in relation to its metabolism via the serotonin and kynurenine pathways." | 9.69 | The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome. ( Blasiak, J; Blonska, A; Chojnacki, C; Chojnacki, J; Konrad, P; Poplawski, T, 2023) |
| "Utilising the acute tryptophan depletion (ATD) protocol, the aim of this study was to examine if manipulating peripheral levels of tryptophan regulates cognitive performance in irritable bowel syndrome and also to determine for the first time if the ATD protocol alters kynurenine supply to the central nervous system." | 9.20 | Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome. ( Allen, AP; Clarke, G; Cryan, JF; Dinan, TG; Kennedy, PJ; O'Neill, A; Quigley, EM, 2015) |
| "Irregularities of serotonin function in irritable bowel syndrome (IBS) may be due to changes in the metabolism of the serotonin precursor l-tryptophan." | 9.14 | Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome. ( Afzal, M; Badawy, AA; Christmas, DM; Creed, T; Davies, SJ; Hince, D; Nutt, DJ; Potokar, JP; Probert, C; Smithson, J, 2010) |
| "Our objectives are to demonstrate whether the kynurenine pathway is activated in diarrhea-type irritable bowel syndrome (IBS-D) patients, and whether the neurotoxic metabolite quinolinic acid (QUIN) is out of balance with the neuroprotective metabolite kynurenic acid (KYNA), and further explore whether this can lead to increase of N-methyl D-aspartate receptor 2B (NMDAR2B) expression in the enteric nervous system and in turn leads to intestinal symptoms and mood disorders." | 7.96 | Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome. ( Bai, Y; Cui, Z; Li, P; Li, Y; Wang, D; Wang, Y; Zhang, J; Zheng, J, 2020) |
| " The purpose of this study was to evaluate the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan (TRP) intake in irritable bowel syndrome with diarrhea predominance (IBS-D) in relation to its metabolism via the serotonin and kynurenine pathways." | 5.69 | The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome. ( Blasiak, J; Blonska, A; Chojnacki, C; Chojnacki, J; Konrad, P; Poplawski, T, 2023) |
| "Utilising the acute tryptophan depletion (ATD) protocol, the aim of this study was to examine if manipulating peripheral levels of tryptophan regulates cognitive performance in irritable bowel syndrome and also to determine for the first time if the ATD protocol alters kynurenine supply to the central nervous system." | 5.20 | Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome. ( Allen, AP; Clarke, G; Cryan, JF; Dinan, TG; Kennedy, PJ; O'Neill, A; Quigley, EM, 2015) |
| "Irregularities of serotonin function in irritable bowel syndrome (IBS) may be due to changes in the metabolism of the serotonin precursor l-tryptophan." | 5.14 | Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome. ( Afzal, M; Badawy, AA; Christmas, DM; Creed, T; Davies, SJ; Hince, D; Nutt, DJ; Potokar, JP; Probert, C; Smithson, J, 2010) |
| "Our objectives are to demonstrate whether the kynurenine pathway is activated in diarrhea-type irritable bowel syndrome (IBS-D) patients, and whether the neurotoxic metabolite quinolinic acid (QUIN) is out of balance with the neuroprotective metabolite kynurenic acid (KYNA), and further explore whether this can lead to increase of N-methyl D-aspartate receptor 2B (NMDAR2B) expression in the enteric nervous system and in turn leads to intestinal symptoms and mood disorders." | 3.96 | Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome. ( Bai, Y; Cui, Z; Li, P; Li, Y; Wang, D; Wang, Y; Zhang, J; Zheng, J, 2020) |
| "Changes in KP were reported in both migraine and FGIDs." | 2.72 | Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders. ( Blasiak, J; Chojnacki, C; Chojnacki, J; Fila, M; Pawlowska, E; Szczepanska, J, 2021) |
| "Kynurenines have been implicated in the neuroendocrine regulatory processes." | 2.52 | [Stress and the kynurenine pathway]. ( Majláth, Z; Vécsei, L, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fila, M | 1 |
| Chojnacki, J | 2 |
| Pawlowska, E | 1 |
| Szczepanska, J | 1 |
| Chojnacki, C | 3 |
| Blasiak, J | 2 |
| Błońska, A | 1 |
| Konrad, P | 2 |
| Chojnacki, M | 1 |
| Podogrocki, M | 1 |
| Poplawski, T | 2 |
| Blonska, A | 1 |
| Li, P | 1 |
| Zheng, J | 1 |
| Bai, Y | 1 |
| Wang, D | 1 |
| Cui, Z | 1 |
| Li, Y | 1 |
| Zhang, J | 1 |
| Wang, Y | 1 |
| Berstad, A | 1 |
| Raa, J | 1 |
| Valeur, J | 1 |
| Kennedy, PJ | 1 |
| Allen, AP | 1 |
| O'Neill, A | 1 |
| Quigley, EM | 2 |
| Cryan, JF | 2 |
| Dinan, TG | 2 |
| Clarke, G | 3 |
| Majláth, Z | 1 |
| Vécsei, L | 1 |
| Fitzgerald, P | 2 |
| Cassidy Eugene, M | 1 |
| Scully, P | 1 |
| Barry, S | 1 |
| Quigley Eamonn, MM | 1 |
| Shanahan, F | 1 |
| Cryan, J | 1 |
| Dinan Timothy, G | 1 |
| Cassidy, EM | 1 |
| Christmas, DM | 1 |
| Badawy, AA | 1 |
| Hince, D | 1 |
| Davies, SJ | 1 |
| Probert, C | 1 |
| Creed, T | 1 |
| Smithson, J | 1 |
| Afzal, M | 1 |
| Nutt, DJ | 1 |
| Potokar, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression[NCT01304355] | 85 participants (Anticipated) | Observational | 2011-01-31 | Recruiting | |||
| The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression: a Proof of Concept Randomized Controlled Trial[NCT02155972] | Phase 2 | 16 participants (Actual) | Interventional | 2013-05-31 | Terminated (stopped due to The trial was terminated because of inability to recruit the needed number of participants) | ||
| Pilot Study Aimed to Determine the Optimal Design for the UCLA/Danone Probiotic Intervention Study Related to Stress[NCT05026333] | 100 participants (Actual) | Interventional | 2021-06-25 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for kynurenine and Colitis, Mucous
| Article | Year |
|---|---|
Kynurenine Pathway of Tryptophan Metabolism in Migraine and Functional Gastrointestinal Disorders.
Topics: Animals; Brain; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Kynurenine; Migraine Disorders; | 2021 |
[Stress and the kynurenine pathway].
Topics: Animals; Humans; Intestines; Irritable Bowel Syndrome; Kynurenine; Mental Disorders; Microcirculatio | 2015 |
3 trials available for kynurenine and Colitis, Mucous
| Article | Year |
|---|---|
The Usefulness of the Low-FODMAP Diet with Limited Tryptophan Intake in the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome.
Topics: Chromatography, Liquid; Diarrhea; Diet; Fermentation; FODMAP Diet; Humans; Irritable Bowel Syndrome; | 2023 |
Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.
Topics: Adolescent; Adult; Cross-Over Studies; Double-Blind Method; Female; Hippocampus; Humans; Irritable B | 2015 |
Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome.
Topics: Adult; Affect; Amino Acids, Neutral; Case-Control Studies; Dairy Products; Diarrhea; Diet; Female; H | 2010 |
5 other studies available for kynurenine and Colitis, Mucous
| Article | Year |
|---|---|
Changes in Tryptophan Metabolism on Serotonin and Kynurenine Pathways in Patients with Irritable Bowel Syndrome.
Topics: Chromatography, Liquid; Humans; Hydroxyindoleacetic Acid; Irritable Bowel Syndrome; Kynurenic Acid; | 2023 |
Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome.
Topics: Diarrhea; Female; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Kynurenic Acid; Kynurenine; M | 2020 |
Tryptophan: 'essential' for the pathogenesis of irritable bowel syndrome?
Topics: Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Irritable Bowel Syndrome; Kynurenine; Oxid | 2014 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Tryptophan catabolism in females with irritable bowel syndrome: relationship to interferon-gamma, severity of symptoms and psychiatric co-morbidity.
Topics: Adult; Anxiety Disorders; Chromatography, High Pressure Liquid; Comorbidity; Depressive Disorder, Ma | 2008 |
Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Cohort Studies; Enzyme Activation; Humans; Indoleamin | 2009 |
Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Cohort Studies; Enzyme Activation; Humans; Indoleamin | 2009 |
Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Cohort Studies; Enzyme Activation; Humans; Indoleamin | 2009 |
Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.
Topics: Adult; Aged; Biomarkers; Case-Control Studies; Cohort Studies; Enzyme Activation; Humans; Indoleamin | 2009 |