kynurenine has been researched along with Chronic Kidney Failure in 25 studies
Kynurenine: A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
kynurenine : A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown." | 7.75 | The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. ( Domaniewski, T; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function have shown that hyperkynureninemia in 22." | 7.70 | Kynurenine and neopterin in chronic glomerulonephritis. ( Bratslavska, O; Fuchs, D; Groma, V; Martinsons, A; Rudzite, V; Widner, B, 1999) |
| "Patients with end-stage renal disease (ESRD) exhibit features of a hypercoagulable state, which may contribute to atherosclerosis." | 5.35 | Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients. ( Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown." | 3.75 | The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease. ( Domaniewski, T; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "Increased oxidative stress (SOX), inflammation and accelerated atherosclerosis have been reported in end-stage renal disease (ESRD), but their associations with kynurenine pathway activation remain unknown." | 3.75 | Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease. ( Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function have shown that hyperkynureninemia in 22." | 3.70 | Kynurenine and neopterin in chronic glomerulonephritis. ( Bratslavska, O; Fuchs, D; Groma, V; Martinsons, A; Rudzite, V; Widner, B, 1999) |
| "Serum samples of 32 patients with ESRD (n = 13) and CKD (n = 19) were analyzed using chemical isotope labeling liquid chromatography-mass spectrometry metabolomics approach." | 1.91 | Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients. ( Abdel Rahman, A; Alabdaljabar, MS; Dahabiyeh, LA; Hussein, MH; Jacob, M; Nimer, RM; Sabi, EM; Sumaily, KM, 2023) |
| "Kynurenines were positively associated with vWF, TM, sICAM-1 and sVCAM-1, whereas sP-selectin was inversely associated with the most of kynurenines." | 1.36 | Kynurenine pathway - a new link between endothelial dysfunction and carotid atherosclerosis in chronic kidney disease patients. ( Myśliwiec, M; Pawlak, D; Pawlak, K, 2010) |
| "Patients with end-stage renal disease (ESRD) exhibit features of a hypercoagulable state, which may contribute to atherosclerosis." | 1.35 | Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients. ( Mysliwiec, M; Pawlak, D; Pawlak, K, 2009) |
| "We conclude that chronic renal failure is associated with the accumulation of L-kynurenine metabolites, which may be involved in the pathogenesis of certain uremic syndromes." | 1.32 | Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure. ( Buczko, W; Matys, T; Pawlak, D; Tankiewicz, A, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.00) | 18.7374 |
| 1990's | 1 (4.00) | 18.2507 |
| 2000's | 14 (56.00) | 29.6817 |
| 2010's | 6 (24.00) | 24.3611 |
| 2020's | 3 (12.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, M | 1 |
| Wang, Q | 1 |
| Kou, S | 1 |
| Li, X | 1 |
| Jiang, Z | 1 |
| Sun, L | 1 |
| Huang, X | 1 |
| Dahabiyeh, LA | 1 |
| Nimer, RM | 1 |
| Sumaily, KM | 1 |
| Alabdaljabar, MS | 1 |
| Jacob, M | 1 |
| Sabi, EM | 1 |
| Hussein, MH | 1 |
| Abdel Rahman, A | 1 |
| Liu, JJ | 1 |
| Ching, J | 1 |
| Wee, HN | 1 |
| Liu, S | 1 |
| Gurung, RL | 1 |
| Lee, J | 1 |
| M, Y | 1 |
| Zheng, H | 1 |
| Lee, LS | 1 |
| Ang, K | 1 |
| Shao, YM | 1 |
| Kovalik, JP | 1 |
| Subramaniam, T | 1 |
| Sum, CF | 1 |
| Sharma, K | 1 |
| Kestenbaum, BR | 1 |
| Lim, SC | 1 |
| Silva, RE | 1 |
| Baldim, JL | 1 |
| Chagas-Paula, DA | 1 |
| Soares, MG | 1 |
| Lago, JHG | 1 |
| Gonçalves, RV | 1 |
| Novaes, RD | 1 |
| Yilmaz, N | 1 |
| Ustundag, Y | 1 |
| Kivrak, S | 1 |
| Kahvecioglu, S | 1 |
| Celik, H | 1 |
| Kivrak, I | 1 |
| Huysal, K | 1 |
| Pawlak, K | 8 |
| Domaniewski, T | 2 |
| Mysliwiec, M | 8 |
| Pawlak, D | 15 |
| Brzosko, S | 1 |
| Schefold, JC | 1 |
| Zeden, JP | 1 |
| Fotopoulou, C | 1 |
| von Haehling, S | 1 |
| Pschowski, R | 1 |
| Hasper, D | 1 |
| Volk, HD | 1 |
| Schuett, C | 1 |
| Reinke, P | 1 |
| Myśliwiec, P | 2 |
| Myśliwiec, H | 1 |
| Dadan, J | 1 |
| Buczko, W | 8 |
| Kowalewska, A | 1 |
| Buraczewska-Buczko, A | 1 |
| Kato, A | 1 |
| Suzuki, Y | 1 |
| Suda, T | 1 |
| Suzuki, M | 1 |
| Fujie, M | 1 |
| Takita, T | 1 |
| Furuhashi, M | 1 |
| Maruyama, Y | 1 |
| Chida, K | 1 |
| Hishida, A | 1 |
| Lahdou, I | 1 |
| Sadeghi, M | 1 |
| Daniel, V | 1 |
| Schenk, M | 1 |
| Renner, F | 1 |
| Weimer, R | 1 |
| Löb, S | 1 |
| Schmidt, J | 1 |
| Mehrabi, A | 1 |
| Schnitzler, P | 1 |
| Königsrainer, A | 1 |
| Döhler, B | 1 |
| Opelz, G | 1 |
| Terness, P | 1 |
| Topczewska-Bruns, J | 3 |
| Chabielska, E | 2 |
| Tankiewicz, A | 6 |
| Matys, T | 1 |
| Koda, M | 1 |
| Wołczyński, S | 1 |
| Martinsons, A | 1 |
| Rudzite, V | 1 |
| Groma, V | 1 |
| Bratslavska, O | 1 |
| Widner, B | 1 |
| Fuchs, D | 1 |
| Holmes, EW | 1 |
25 other studies available for kynurenine and Chronic Kidney Failure
| Article | Year |
|---|---|
A sensitive UPLC-MS/MS method for the simultaneous determination of the metabolites in the tryptophan pathway in rat plasma.
Topics: Acute Kidney Injury; Animals; Biomarkers; Chromatography, High Pressure Liquid; Chromatography, Liqu | 2022 |
Metabolomics profiling distinctively identified end-stage renal disease patients from chronic kidney disease patients.
Topics: Biomarkers; Disease Progression; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Kynure | 2023 |
Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Disease Progression; Humans; Kidney Failure, Chronic; Kynurenic Acid; Kyn | 2023 |
Predictive metabolomic signatures of end-stage renal disease: A multivariate analysis of population-based data.
Topics: Biomarkers; Case-Control Studies; Cresols; Female; Humans; Kidney Failure, Chronic; Kynurenine; Male | 2018 |
Serum indoleamine 2,3 dioxygenase and tryptophan and kynurenine ratio using the UPLC-MS/MS method, in patients undergoing peritoneal dialysis, hemodialysis, and kidney transplantation.
Topics: Adult; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Indoleamine-Pyrro | 2016 |
The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.
Topics: Adult; Age Factors; Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Case-Control Stud | 2009 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Huma | 2009 |
Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease.
Topics: Biomarkers; Endothelium, Vascular; Female; Humans; Kidney Failure, Chronic; Kynurenine; Male; Middle | 2009 |
Hypercoagulability is independently associated with kynurenine pathway activation in dialysed uraemic patients.
Topics: Adult; Aged; Blood Coagulation; Female; Humans; Kidney Failure, Chronic; Kynurenine; Lipoproteins; M | 2009 |
[Tryptophan and its metabolites in renal allograft recipients].
Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine | 2009 |
Kynurenine and its metabolites--kynurenic acid and anthranilic acid are associated with soluble endothelial adhesion molecules and oxidative status in patients with chronic kidney disease.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Intercellular Adhesion Molecule-1; Kidney Failure | 2009 |
Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment.
Topics: Adult; Aged; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Female; Fibrinolysis; Hum | 2010 |
Kynurenine pathway - a new link between endothelial dysfunction and carotid atherosclerosis in chronic kidney disease patients.
Topics: Adult; Carotid Artery Diseases; Cell Adhesion Molecules; Chromatography, High Pressure Liquid; Cross | 2010 |
Relationship between an increased serum kynurenine/tryptophan ratio and atherosclerotic parameters in hemodialysis patients.
Topics: Adult; Aged; Ankle Brachial Index; Atherosclerosis; Carotid Arteries; Female; Humans; Indoleamine-Py | 2010 |
Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection.
Topics: Acute Disease; Adult; Aged; Biopsy; Female; Graft Rejection; Humans; Kidney Cortex Necrosis; Kidney | 2010 |
Increased levels of 3-hydroxykynurenine in different brain regions of rats with chronic renal insufficiency.
Topics: Animals; Brain; Kidney Failure, Chronic; Kynurenine; Male; Rats; Rats, Wistar; Signal Transduction; | 2002 |
Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Dioxygenases; Enzyme Activation; Kidney Failure, Chr | 2003 |
Kynurenine metabolism in central nervous system in experimental chronic renal failure.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Kidney Failure, Chronic; Kynurenin | 2003 |
Mechanism of inhibitory effect of 3-hydroxykynurenine on erythropoiesis in patients with renal insufficiency.
Topics: Adult; Aged; Anemia; Case-Control Studies; Cell Line; Erythropoiesis; Erythropoietin; Female; Humans | 2003 |
Kidney and liver kynurenine pathway enzymes in chronic renal failure.
Topics: Animals; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kidney Failure, Chronic; Kynurenine; Kynureni | 2003 |
Kynurenine and neopterin in chronic glomerulonephritis.
Topics: Biomarkers; Chronic Disease; Creatinine; Fasting; Glomerular Filtration Rate; Glomerulonephritis; Gl | 1999 |
Kynurenine and its metabolites in the rat with experimental renal insufficiency.
Topics: Animals; Drinking; Eating; Kidney Failure, Chronic; Kynurenine; Male; Quinolinic Acid; Rats; Rats, W | 2001 |
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynureni | 2002 |
Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Kidney Failure, Chronic; Kynurenine; Liver; M | 1988 |